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Unraveling the role of formate in improving nitrogen removal via coupled partial denitrification-anammox

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FRONTIERS OF ENVIRONMENTAL SCIENCE & ENGINEERING 2024年第9期18卷 112-0页

作者： Zhu, Wanlu Xiao, Rui Xu, Min Chai, Wenbo Liu, Wenlong Jin, Zhengyu ikumi, David Lu, Huijie Zhejiang Univ Coll Environm & Resource Sci Key Lab Environm Remediat & Ecol Hlth Minist Educ Hangzhou 310058 Peoples R China Key Lab Water Pollut Control & Environm Safety Hangzhou 310058 Peoples R China China Natl Nucl Corp Beijing Res Inst Chem Engn & Met Beijing 100029 Peoples R China Zhejiang Univ Technol Coll Environm Hangzhou 310014 Peoples R China Minzu Univ China Coll Life & Environm Sci Key Lab Ecol & Environm Minor Areas Natl Ethn Affairs Commiss Beijing 100081 Peoples R China Univ Cape Town Dept Civil Engn Water Res Grp ZA-7700 Rondebosch South Africa

The addition of traditional carbon sources (e.g., acetate) could favor heterotrophic overgrowth in partial denitrification coupled with anammox (PD-A) systems, thus hindering the performance and stability of this novel wastewater nitrogen removal technology. Therefore, it is necessary to develop an effective, environmentally friendly, and inexpensive alternative. This study demonstrated the potential of formate to enhance the performance and community stability of PD-A under mainstream conditions. In a laboratory-scale biofilm reactor, formate addition (COD/NO3--N = 1.75) improved nitrogen removal efficiency (from 72.1 +/- 3.5% to 81.7 +/- 2.7%), EPS content (from 106.3 +/- 8.1 to 163.0 +/- 15.5 mg/gVSS) and increased anammox bacteria growth (predominantly Candidatus Brocadia, from 29.5 +/- 0.7% to 34.5 +/- 5.4%) while maintaining stable heterotrophs dominated by methylotrophic Desulfobacillus. FISH-NanoSIMS revealed a formate uptake using Ca. Brocadia and Desulfobacillus, with Ca. Brocadia being the major contributor to partial nitrate reduction to nitrite. Desulfobacillus can synthesize diverse hydrophobic amino acids and provide key nutrients for Ca. Brocadia. To achieve comparable nitrogen removal, the cost of the formate-driven PD-A process should be 11.2% lower than that of acetate. These results greatly enrich our understanding of C1 metabolism represented by formate in anammox communities and its application in the context of coupling partial denitrification-anammox toward enhanced nitrogen removal in global wastewater treatment systems.

关键词： Formate Mixotrophic growth Partial denitrification-anammox Metabolic interaction FISH-NanoSIMS NITRITATION REACTOR

Bacillus cereus Group Exhibits More Resistant to Chlorhexidine Rather Than Bacillus subtilis Group

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Influence of cognitive impairment on cardiac mortality after percutaneous coronary intervention in very elderly patients: a retrospective observational study

Open Journal of Medical Microbiology（医学微生物学） 2020年第3期

作者： Akira Okamoto Saki Otsuji Miho Kamako ikumi inoue Kokoro Tasaka Juntaro Kato

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Journal of Geriatric Cardiology 2019年第10期16卷 733-740页

作者： Tomoko Tomioka Ryokichi Takahashi Yosuke ikumi Shuhei Tanaka Yoshitaka Ito Hiroki Shioiri Jiro Koyama Kanichi inoue Department of Cardiology South-Miyagi Medical Center

Background Cognitive impairment (CI) increases cardiac mortality among very elderly patients. Percutaneous coronary intervention (PCI) for ischemic heart disease (IHD) patients is considered a favorable strategy for decreasing cardiac mortality. Here, we investigated the influence of CI on cardiac mortality after PCI in very elderly patients. Methods We performed a retrospective observational analysis of patients who received PCI between 2012 and 2014 at the South Miyagi Medical Center, Japan. IHD patients over 80 years old who underwent the Mini-Mental State Examination for CI screening during hospitalization and/or who had been diagnosed with CI were included. Participants were divided into CI and non-CI groups, and cardiac mortality and incidence of adverse cardiac events in a 3-year follow-up period were compared between groups. Statistical analyses were performed using the t-test,χ^2 test, and multivariable Cox regression analysis, with major comorbid illness and conventional cardiac risk factors as confounders. Results Of 565 patients, 95 were included (41 CI, 54 non-CI). Cardiac mortality during the follow-up period was significantly higher in the CI group (36%) compared with the non-CI group (13%)(OR = 4.3, 95% CI: 1.56–11.82, P < 0.05). CI was an independent cardiac prognostic factor after PCI and, for CI patients, living only with a CI partner was an independent predictor of cardiac death within three years. Conclusions CI significantly affected cardiac prognosis after PCI in very elderly patients, particularly those living with a CI partner. To improve patients’ prognoses, social background should be considered alongside conventional medical measures.

关键词： Cognitive impairments Family background Mortality Octogenarians Percutaneous coronary intervention

Current advances in humanized mouse models

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Cellular & Molecular Immunology 2012年第3期9卷 208-214页

作者： Ryoji Ito Takeshi Takahashi ikumi Katano Mamoru Ito Central Institute for Experimental Animals Kawasaki Japan

Humanized mouse models that have received human cells or tissue transplants are extremely useful in basic and applied human disease research. Highly immunodeficient mice, which do not reject xenografts and support cell and tissue differentiation and growth, are indispensable for generating additional appropriate models. Since the early 2000s, a series of immunodeficient mice appropriate for generating humanized mice has been successively developed by introducing the IL-2Rynull gene （e.g., NOD/SCID/7c＂uu and Rag2nu＂ycnun mice）. These strains show not only a high rate of human cell engraftment, but also generate well-differentiated multilineage human hematopoietic cells after human hematopoietic stem cell （HSC） transplantation. These humanized mice facilitate the analysis of human hematology and immunology in vivo. However, human hematopoietic cells developed from HSCs are not always phenotypically and functionally identical to those in humans. More recently, a new series of immunodeficient mice compensates for these disadvantages. These mice were generated by genetically introducing human cytokine genes into NODISCIDI？cn＂u and Rag2nulITcnUll mice. In this review, we describe the current knowledge of human hematopoietic cells developed in these mice. Various human disease mouse models using these humanized mice are summarized.

关键词： animal model immunodeficient mice immunology hematology humanized mice

Standardization of New Sliver Probe for Cooling Power Test of Polymer Quenchant

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材料热处理学报 2004年第5期25卷 447-452页

作者： Hideo YOKOTA Katsumi ICHITANI Kazuyoshi YAMAMOTO Hiroyuki ikumi Yasufumi SUGIURA Michiharu NARAZAKI Nippon Oil Corporation Yokohama JapanIdemitsu Kosan Co. Ltd. Chiba JapanDaido Chemical Industry Co. Ltd. Osaka JapanSanshin Kagaku Kogyo Co. Ltd. Tokyo JapanNippon Grease Co. Ltd. Osaka JapanUtsunomiya University Utsunomiya Japan

Technical committee for Japanese industrial standard of heat treating oils has studied on the new method for testing cooling power of aqueous quenchants. This method employed the cooling curve test of a new sliver rod probe, which has a metal-sheathed thermocouple at its geometrical center. The experimental study has clarified that this probe has the higher sensitivity and excellent durability. In order to standardize this probe for cooling power test of aqueous quenchants, the repeatability and reproducibility of test results etc. have been studied. D.O.P. (Di-2-ethylthexyl Phthalate) was used as reference quenching fluid for initial calibration and for periodic calibration verification of the probe and system. In addition, 10% brine was used to check the response capability of the probe and system to the sudden change of temperature. These procedures are established according to the experimental investigation. This new test method is going to be built in the revised version of JIS K 2242 "Heat treating oils" as the cooling power test method for aqueous quenchants.

关键词：聚合物淬火剂冷却动力试验冷却曲线银探测器

Female mice exhibit both sexual and social partner preferences for vocalizing males

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Integrative Zoology 2018年第6期13卷 735-744页

作者： Kensaku NOMOTO Mayu ikumi Monami OTSUKA Akari ASABA Masahiro KATO Nobuyoshi KOSHIDA Kazutaka MOGI Takefumi KIKUSUI Companion Animal Research Laboratory School of Veterinary MedicineAzabu UniversityKanagawaJapan Kato Acoustics Consulting Office KanagawaJapan Graduate School of Engineering Tokyo University of Agriculture and TechnologyTokyoJapan

Acoustic signals are widely used as courtship signals in the animal *** has long been known that male mice emit ultrasonic vocalizations(USVs)in the presence of female mice or in response to female *** observation led to the hypothesis that male USVs play a role in courtship *** previous studies showed that female mice have a social partner preference for vocalizing males,it is not known if they exhibit a sexual partner preference when given a *** address this issue,we examined the copulatory behaviors of female mice with either devocalized males(with or without the playback of the USVs)or sham-operated males in 2 different behavioral paradigms:the no-choice paradigm in the home cage of a male mouse(without choice of mating partners)or the mate-choice paradigm in a 3-chambered apparatus(with choice of mating partners).In the no-choice paradigm,female mice exhibited comparable sexual receptivity with sham-operated and devocalized *** addition,we found that female mice showed more approach behavior to-wards devocalized males when male USVs were played *** the mate-choice paradigm,female mice visited more frequently and stayed longer with sham-operated than devocalized ***,we showed that female mice received more intromissions from sham-operated males than devocalized *** summary,our results suggested that,although female mice can copulate equally with both devocalized and vocalizing males when given no choice of mating partner,female mice exhibit both sexual and social partner preferences for vocalizing males in the mate-choice paradigm.

关键词： mate choice mice sexual partner preference social partner preference ultrasonic vocalizations

Effect of the Position of Reaction-Site in Amphipathic-Type Thioester in Aqueous Amidation Reaction

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Advances in Chemical Engineering and Science 2015年第3期5卷 311-316页

作者： ikumi Otomo Chiaki Kuroda Department of Chemistry Rikkyo University Tokyo Japan

Amphipathic-type thioesters CH3(CH2)mCOS(CH2)nCOONa (m + n = 12) were synthesized and their reaction with various alkylamines was examined. Compounds having thioester moiety close to carboxylate (m = 10, n = 2) afforded the corresponding amides in good yields, while the substrate having thioester moiety distant from carboxylate (m = 2, n = 10) afforded the amides in relatively low yield. In all cases, the difference in yield due to the chain length of amine was not observed. The results indicated that the reaction took place effectively near the surface of micelle. However, the reaction was found to occur not only on micelle surface but also in solution.

关键词： Hydrophobic Effect Amides Thioesters

Rare histological subtype of invasive micropapillary carcinoma in the ampulla of Vater: A case report

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World Journal of Clinical Cases 2021年第11期9卷 2671-2678页

作者： Hirotsugu Noguchi Michiyo Higashi Tetsuya Idichi Hiroshi Kurahara Yuko Mataki Takashi Tasaki ikumi Kitazono Takao Ohtsuka Akihide Tanimoto Department of Pathology Kagoshima University Graduate School of Medical and Dental SciencesKagoshima 890-8544Japan Department of Digestive Surgery Breast and Thyroid SurgeryKagoshima University Graduate School of Medical and Dental SciencesKagoshima 890-8544Japan

BACKGROUND Carcinoma of the ampulla of Vater is an uncommon ampullo-pancreatobiliary neoplasm,and the most common histological type is adenocarcinoma with a tubular growth *** micropapillary carcinoma(IMPC)is an aggressive variant of adenocarcinoma in several organs that is associated with lymph node metastasis and poor *** was first described as a histological subtype of breast cancer;however,IMPC of the ampulla of Vater is extremely rare,with only three articles reported in the English *** SUMMARY We have reported a case of IMPC of the ampulla of Vater in an 80-year-old ***,the surface area of the carcinoma was composed of tubulopapillary structures mimicking intra-ampullary papillary-tubular neoplasm,and the deep invasive front area exhibited a pattern of *** carcinoma showed lymphatic invasion and extensive lymph node *** immunohistochemical study revealed mixed intestinal and gastric/pancreatobiliary *** This rare subtype tumor in the ampulla of Vater showed a histologically mixed phenotype and exhibited aggressive behavior.

关键词： Micropapillary carcinoma Rare histological subtype Ampulla of Vater Ampullo-pancreatobiliary region Intra-ampullary papillary-tubular neoplasm Case report

Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses

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Cellular & Molecular Immunology 2018年第11期15卷 953-962页

作者： Tomonori Yaguchi Asuka Kobayashi Takashi Inozume Kenji Morii Haruna Nagumo Hiroshi Nishio Takashi Iwata Yuyo Ka ikumi Katano Ryoji Ito Mamoru Ito Yutaka Kawakami Division of Cellular Signaling Institute for Advanced Medical ResearchKeio University School of MedicineTokyo 160-8582Japan Department of Dermatology Yamanashi University School of MedicineYamanashi 409-3898Japan Department of Obstetrics and Gynecology Keio University School of MedicineTokyo 160-8582Japan Central Institute for Experimental Animals Kanagawa 210-0821Japan

Immunodeficient mice engrafted with human peripheral blood cells are promising tools for in vivo analysis of human patient individual immune ***,when human peripheral blood mononuclear cells(PBMCs)are transferred into NOG(NOD/Shi-scid,IL-2rg null)mice,severe graft versus host disease(GVHD)hinders long term detailed *** of human PBMCs into newly developed murine MHC class I-and class II-deficient NOG(NOG-dKO;NOG-Iab,B2m-double-knockout)mice showed sufficient engraftment of human immune cells with little sign of *** with influenza vaccine resulted in an increase in influenza-specific human IgG Ab,indicating induction of antigen-specific B cells in the NOG-dKO *** with human dendritic cells pulsed with HLA-A2 restricted cytomegalovirus peptide induced specific cytotoxic T cells,indicating the induction of antigen-specific T cells in the NOG-dKO *** cell therapies(ACTs)using melanoma antigen recognized by T cells(MART-1)-specific TCR-transduced activated T cells showed strong tumor growth inhibition in NOG-dKO mice without any sign of GVHD accompanied by preferential expansion of the transferred MART-1-specific T *** using cultured human melanoma infiltrating T cells also showed anti-tumor effects against autologous melanoma cells in NOG-dKO mice,in which changes in human cancer phenotypes by immune intervention,such as increased CD271 expression,could be ***,NOG-dKO mice are useful tools for more detailed analysis of both the induction and effector phases of T-cell and B-cell responses for a longer period than regular NOG mice.

关键词： adoptive cell therapy humanized mouse vaccine