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Cathepsin B-responsive prodrugs for cancer-targeted therapy:Recent advances and progress for clinical translation

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Nano Research 2022年第8期15卷 7247-7266页

作者： seong ik Jeon Suah Yang Man Kyu Shim Kwangmeyung Kim Biomedical Research Institute Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea

The cathepsin B-responsive prodrugs are promising strategies to reduce the serious adverse effects of anticancer drugs by improving the cancer selectivity that can be specifically activated by overexpressed cathepsin B in targeted cancer ***,clinical translation of such therapeutic approaches has been restricted by low antitumor efficacy that is mainly attributable to undesirable pharmacokinetic profiles and inefficient tumor-targeting of cathepsin B-responsive prodrugs,due to their small-molecule *** recent decades,many researchers have widely investigated the drug delivery system(DDS)to improve the in vivo pharmacokinetic profiles and tumor-targeting efficiency of cathepsin B-responsive prodrugs via the application of polymers,dendrimers,antibodies,lipids,and inorganic nanoparticles as drug *** addition,the potential therapeutic efficacy of DDS for cathepsin B-responsive prodrugs is demonstrated in multiple studies and combinatorial treatment with typical therapeutic modalities can effectively overcome the challenges of tumor heterogeneity and multidrug *** this review,recent advances and progress of new DDS for cathepsin B-responsive prodrugs are outlined,and their clinical trials are ***,potential challenges and the outlooks for clinical translation of cathepsin B-responsive prodrugs are highlighted.

关键词： cathepsin B prodrug chemotherapy drug delivery system targeted cancer therapy

Development and Experimental Evaluation of Strip Shape Prediction Model for Sendzimir Rolling Mills

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Journal of Iron and Steel Research International 2013年第12期20卷 25-32页

作者： SHIN Jong-min HAN seong-ik KIM Jong-shik School of Mechanical Engineering Pusan National University School of Electrical Engineering Pusan National University

It is difficult to obtain the desired strip shape using Sendzimir rolling mills because small diameter work rolls can be easily deformed by the roiling force. To control the strip shape effectively, it is important to understand the relationship between the behavior of the shape actuator and the variation of the strip shape. A numerical model based on the contact element method was proposed for the prediction of strip shape. In this numerical model, the re- lationships between the actuating forces, the roll deflections, the thickness profiles of the entry and exit sides, and the strip shape were considered. The proposed numerical model for strip shape prediction was evaluated by computer simulation and experiment with respect to various AS-U roll and first intermediate roll positions.

关键词： Sendzimir rollingmill double acting AS-U roll strip shape prediction model contact element method

Improvement of Shape Recognition Performance of Sendzimir Mill Control Systems Using Echo State Neural Networks

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Journal of Iron and Steel Research International 2014年第3期21卷 321-327页

作者： Jung-hyun PARK seong-ik HAN Jong-shik KIM School of Mechanical Engineering Pusan National University School of Electrical Engineering Pusan National University

High rigidity twenty-high Sendzimir mills （ZRMs） are widely used for rolling stainless steels, silicon sheets, etc. A ZRM uses a small diameter work roll to produce massive rolling forces. Since a work roll with a small diameter can be bent easily, strips often have complex shapes with mixed quarter and deep edge waves in the shape of plates. In order to solve this problem, fuzzy neural network controls are generally used for shape： recognition in ZRM control systems. Among various neural network types, the multi-layer perceptron （MLP） is typically used in current ZRMs. However, an MLP causes the loss of a large amount of shape recognition data. To improve the shape recognition per- formance of ZRM control systems, echo state networks （ESNs） are proposed to be used. Through simulation re- sults, it is found that shape recognition performance could be improved using the proposed ESN method.

关键词： Sendzimir mill neural network multi-layer perceptron echo state network shape recognition

A taxonomic review of the genus Miaenia Pascoe, 1864(Coleoptera: Cerambycidae) from South Korea with a new record of M. tonsa(Bates)

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Journal of Forestry Research 2018年第3期29卷 822-829页

作者： ik Je choi Tae Sung Kwon Jongok Lim Silkworm and Insect Management Center Gyeongsangbuk-do Agricultural Resource Management Institute Forest Insect Pests and Disease Division Korea Forest Research Institute Division of Forest Biodiversity Korea National Arboretum

The cerambycid genus Miaenia Pascoe(Coleoptera: Cerambycoidea) of South Korea is taxonomically reviewed. Two species, Miaenia fasciata fasciata(Matsushita) and Miaenia maritima Tsherepanov have been recorded. In this paper, M. tonsa(Bates) is added to the Korean cerambycid fauna for the first time. A key to Korean Miaenia species, re-description and diagnostic illustrations, including male genitalia for each species, are provided.

关键词： Acanthocinini Cerambycidae Miaenia New species South Korea Taxonomy

Moth-eye Structured Polydimethylsiloxane Films for High-Efficiency Perovskite Solar Cells

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Nano-Micro Letters 2019年第3期11卷 271-280页

作者： Mincheol Kim Segeun Jang Jiwoo choi seong Min Kang Mansoo choi Global Frontier Center for Multiscale Energy Systems Seoul National UniversitySeoul151.744Republic of Korea Department of Mechanical and Aerospace Engineering Seoul National UniversitySeoul151.744Republic of Korea Department of Mechanical Engineering Hanbat National UniversityDaejeon34158Republic of Korea Department of Mechanical Engineering Chungnam National UniversityDaejeon34134Republic of Korea

Large-area polydimethylsiloxane(PDMS)films with variably sized moth-eye structures were fabricated to improve the efficiency of perovskite solar *** approach that incorporated photolithography,bilayer PDMS deposition and replication was used in the fabrication *** simply attaching the moth-eye PDMS films to the transparent substrates of perovskite solar cells,the optical properties of the devices could be tuned by changing the size of the moth-eye *** device with 300-nm moth-eye PDMS films greatly enhanced power conversion efficiency of ~21 % due to the antireflective effect of the moth-eye ***,beautiful coloration was observed on the 1000-nm moth-eye PDMS films through optical interference caused by the diffraction grating *** results imply that moth-eye PDMS films can greatly enhance the efficiency of perovskite solar cells and building-integrated photovoltaics.

关键词： Polydimethylsiloxane films Moth-eye Photolithography Perovskite solar cells Photovoltaic

Meso-porous silicon-coated carbon nanotube as an anode for lithium-ion battery

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Nano Research 2016年第7期9卷 2174-2181页

作者： Won-Sik Kim Jonghyun choi seong-Hyeon Hong Department of Materials Science and Engineering and Research Institute of Advanced Materials Seoul National University Seoul 151-744 Republic of Korea

Meso-porous Si-coated carbon nanotube （CNT） composite powders were prepared by combining a sol-gel method and the magnesiothermic reduction process. Meso-porous Si-coated CNT electrodes exhibit excellent cycle and rate performances as anodes in Li-ion batteries （LIBs）, which can be attributed to the efficient accommodation of volume change from meso-porous Si structure and the enhanced electrical conductivity from CNT core. This simple synthesis and subsequent reduction process provide a scalable route for the large-scale production of Si-C composite nanostructures, which can be utilized in a variety of applications, such as in photocatalysis, photoelectrochemical cells （PECs）, and LIBs.

关键词： meso-porous carbon nanotube (CNT) magnesiothermic reduction battery

Experience of limited pancreatic head resection for management of branch duct intraductal papillary mucinous neoplasm in a single center

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World Journal of Gastroenterology 2009年第23期15卷 2904-2907页

作者： Kwang Yeol Paik seong Ho choi Department of Surgery Kepco Medical Foundation Hanil General Hospital #388-1 Ssangmoon-Dong Dobong-Gu Seoul 132-033 South Korea Department of Surgery Samsung Medical Center College of Medicine Sungkyunkwan University #50 Irwon-Dong Gangnam-Gu Seoul 135-710 South Korea

AIM: To share our surgical experience and the outcome of limited pancreatic head resection for the management of branch duct intraductal papillary mucinous neoplasm (IPMN). METHODS: Between May 2005 and February 2008, nine limited pancreatic head resections (LPHR) were performed for IPMN of the pancreatic head. We reviewed the nine patients, retrospectively. RESULTS: Tumor was located in the uncinate process of the pancreas in all nine patients. Three patients had stents inserted in the main pancreatic duct due to injury. The mean size of tumor was 28.4 mm. Postoperative complications were found in f ive patients: 3 pancreatic leakages, a pancreatitis, and a duodenal stricture. Pancreatic leakages were improved by external drainage. No perioperative mortality was observed and all patients are recorded alive during the mean follow-up period of 17.2 mo. CONCLUSION: In selected patients after careful evaluation, LPHR can be used for the treatment of branch duct type IPMN. In order to avoid pancreatic ductal injury, preand intra-operative defi nite localization and careful operative techniques are required.

关键词： Limited pancreatic head resection Branchduct type Intraductal papillary mucinous neoplasm

Grade-4 commercially pure titanium with ultrahigh strength achieved by twinning-induced grain refinement through cryogenic deformation

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Journal of Materials Science & Technology 2021年第7期66卷 193-201页

作者： seong-Woo choi Jae Sukjeong Jong Woo Won Jae Keun Hong Yoon Suk choi Titanium Department.Korea Institute of Materials Science Changwon51508Republic of Korea School of Materials Science and Engineering Pusan National UniversityPusan.46241Republic of Korea Materials and Manufacturing Development Team Doosan Heavy Industries and ConstructionChangwon51711Republic of Korea

The yield strength of commercially pure(CP) Ti of ASTM grade 4, the strongest among all the CP-Ti grades, is too low for structural applications that require high-strength materials. Here, we demonstrate the strengthening of grade-4 CP Ti by cryogenic-temperature rolling(CTR), which enables deformation twinning in grade-4 CP Ti to achieve twinning-induced grain refinement. CTR activated {11.22} twinning and {10.12} twinning, which are the most common twinning systems in pure Ti, whereas room-temperature rolling(RTR) did not activate any twinning system. CTR with imposing an area reduction of just 30% significantly increased the yield strength of the CP Ti to 946 MPa, which is not achievable through typical processes performed at or above room temperature and is comparable to that of commercial Ti-6 Al-4 V. The significant increase in strength was due to microstructural strengthening caused by twinning-induced grain refinement, combined with dislocation accumulation. In contrast to RTR, CTR greatly increased the stress concentration at grain boundaries(GBs), which caused the unusual activation of twinning in the grade-4 CP Ti by facilitating twin nucleation at GBs. The stress concentration increased because CTR activated the slip to a lesser extent compared to RTR, thereby reducing the strain compatibility between neighboring grains. These results will contribute to development of ultrahigh-strength CP Ti and may thereby extend its use to structural applications that require high-strength materials.

关键词： Titanium Twinning Cryogenic deformation Grain refinement Tensile properties

Controlled afterglow luminescent particles for photochemical tissue bonding

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Light(Science & Applications) 2022年第11期11卷 2755-2765页

作者： seong-Jong Kim Minji choi Guosong Hong Sei Kwang Hahn Department of Materials Science and Engineering Pohang University of Science and Technology(POSTECH)77 Cheongam-roNam-guPohangGyeongbuk 37673Korea Department of Materials Science and Engineering Stanford UniversityStanfordCA 94305USA

Upconversion materials(UCMs)have been developed to convert tissue-penetrating near-infrared(NIR)light into visible ***,the low energy conversion effciency of UCMs has limited their further biophotonic ***,we developed controlled afterglow luminescent particles(ALPs)of ZnS:Ag,Co with strong and persistent green luminescence for photochemical tissue bonding(PTB).The co-doping of Ag^(+) and Co^(2+) ions into ZnS:Ag,Co particles with the proper vacancy formation of host ions resulted in high luminescence intensity and long-term *** addition,the ALPs of ZnS:Ag,Co could be recharged rapidly under short ultraviolet(UV)irradiation,which effectively activated rose bengal(RB)in hyaluronate-RB(HA-RB)conjugates for the crosslinking of dissected collagen layers without additional light *** remarkable PTB of ZnS:Ag,Co particles with HA-RB conjugates was confirmed by in vitro collagen fibrillogenesis assay,in vivo animal wound closure rate analysis,and in vivo tensile strength evaluation of incised skin *** together,we could confirm the feasibility of controlled ALPs for various biophotonic applications.

关键词： bonding fir closure