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The Neurologist in the Emergency Room: Prospective Study of the Neurological Emergency Group in Lombardia

Journal of Health Science 2019年第4期7卷 254-261页

作者： MariaLuisa Delodovici Marco Mauri Megi Meneri Marco Gallazzi Elena Ballabio Giuseppina Borutti Maria Vittoria Calloni Elisa Candeloro Bruno Censori Claudio De Piazza Laura Fusi Franca Mazzucchelli ignazio santilli Elisabetta Forapani Chiara Scaccabarozzi Maria Sessa Lucia Tancredi Massimiliano Braga Dept. of Neurology and Stroke Unit Ospedale di Circolo e Fondazione MacchiUniversità dell’InsubriaASST-Settelaghile Luigi Borri 57 21100 VareseItaly Dept. of Neurology Ospedale di Desio (MB) Director G. Mazzini 1 20832 Desio (MB)Italy Dept. of Neurology ASST Lecco-Ospedale A. Manzonidell’Eremo 9/11 23900 LeccoItaly Dept. of Neurology Ospedale di Cremona ASST Cremona Directorle Concordia 1 26100 CremonaItaly Dept. of Neurology Ospedale Sant’Anna ComoRavona 20 22042 SFermo della BattagliaComoItaly Dept. of Neurology Ospedale di Vimercate (MB) Santi Cosma e Damiano 10 20871 Vimercate (MB)Italy Dept. of Neurology Ospedale S. Carlo BorromeoA. Mosca 12 20152 MilanoItaly Dept. of Neurology Director Ospedale Civile di VogheraVolturno 14 Voghera 27058 (PV)Italy Dept. of Neurology Ospedale di Legnano ASST Ovest MilanesePapa Giovanni Paolo II20025 Legnano (MI)Italy Dept. of Neurology Fondazione IRCCS C. Mondino Mondino 2Pavia 27100Italy Dept. of Neurology ASST Papa Giovanni XXIII Piazza OMS 1 24127 BergamoItaly Dept. of Neurology Ospedale Valduce ComoDante Alighieri 11 22100 ComoItaly Dept. of Neurology Ospedale di Saronno ASST Valle olonaPiazzale Borella 1 Saronno 21047 (VA)Italy Dept. of Neurology Ospedale S. Antonio Abate Gallarate. Pastori 4 21013 Gallarate VareseItaly

Purpose of the work was to quantify the workloads and the neurologist’s commitment in ER, to verify the management of urgencies and appropriateness of neurological counseling requests. Neurologic emergencies are frequent in elderly patients and are associated with high morbidity and mortality. Due to the aging population, neurologic pathologies in emergency room (ER) are widely expected to increase. The role of the neurologist in this context is controversial. Methods: in 14 operative units of neurology a prospective collection of neurological evaluations in ER was carried out using boards of detection of the most frequent neurological clinical pictures seen in the course of a week. Data were collected from 738 cases. Attention was focused on cerebrovascular diseases (CVD), impairment of consciousness, epilepsy, headache, dizziness, head trauma and disorders of the peripheral nervous system (PNS). Achievements: neurological consultations were on average 5% of total accesses to ER. The most common pathology seen was ischemic stroke. After counseling most patients were discharged home. The CVD required the greatest commitment to the specialist. The usefulness of the specialized neurological “filter” has been confirmed in a non-simple operative context, aimed at optimizing the appropriateness of the hospitalization and the economy of the diagnostic path.

关键词： Emergency room neurological diseases neurology workload

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End-life Prediction of Commercial PLA Used for Food Packaging through Short Term TGA Experiments: Real Chance or Low Reliability?

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Chinese Journal of Polymer Science 2014年第6期32卷 681-689页

作者： ignazio Blanco Department of Industrial Engineering University of Catania

A long-term （about nine months） isothermal degradation experiment of two different commercial polylactide （PLA） samples used for food packaging was carried out at a relatively low temperature （423 K）. Thermooxidative degradations of the same polymers were carried out in a thermogravimetric （TG） analyser, at higher temperatures （453 K 〈 T 〈 523 K）, under isothermal heating conditions. The obtained set of experimental TG data was used to determine the apparent activation energy （Ea） of degradation through two isothermal kinetic methods. The results from long-term experiment evidenced considerable mass loss for both PLA samples in the investigated period, but the experimental data were not in agreement with those from the short-term degradations at higher temperatures, thus suggesting a different degradation kinetics, and, then a low reliability of the lifetime predictions for polymers in service or degradation forecasts for the end of their life based on experiments at higher temperatures.

关键词： Lifetime prediction Degradation activation energy Kinetics of polymer degradation Thermogravimetry.

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Relationship between pouch microbiota and pouchitis following restorative proctocolectomy for ulcerative colitis

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World Journal of Gastroenterology 2014年第29期20卷 9665-9674页

作者： Imerio Angriman Marco Scarpa ignazio Castagliuolo Department of Surgery Gastroenterology and OncologyUniversity of Padova Surgical Oncology Unit Veneto Institute of Oncology (IOV-IRCCS) Department of Molecular Medicine University of Padova

Restorative proctocolectomy with ileal pouch-anal anastomosis(IPAA)has become the surgical treatment of choice for many patients with medically refractory ulcerative colitis(UC)and familial adenomatous polyposis(FAP).UC patients with IPAA(UC-IPAA)are,nevertheless,susceptible to inflammatory and noninflammatory sequelae such as pouchitis,which is only rarely noted in FAP patients with *** is the most frequent long-term complication of UC-IPAA patients,with a cumulative prevalence of up to 50%.Although the aetiology of pouchitis remains unclear,accumulating evidence suggests that a dysbiosis of the pouch microbiota and an abnormal mucosal immune response are implicated in its *** using culture and molecular techniques have detected a dysbiosis of the pouch microbiota in patients with *** factors,genetic associations,and serological markers suggest that interactions between the host immune response and the pouch microbiota underlie the aetiology of this idiopathic inflammatory *** systematic review focuses on the dysbiosis of the microbiota that inhabit the pouch in UC and FAP patients and its interaction with the mucosal immune system.A metaanalysis was not attempted due to the highly heterogeneous microbiota composition and the different detection methods used by the various *** no specific bacterial species,genus,or family has as yet been identified as pathogenic,there is evidence that a dysbiosis characterized by decreased gut microbiota diversity in UC-IPAA patients may,in genetically predisposed subjects,lead to aberrant mucosal immune regulation triggering an inflammatory process.

关键词： Pouchitis Inflammation of the ileal pouch Microbiota Bacteria Microbiome Ileal-pouch-anal anastomosis Ulcerative colitis Crohn's disease Inflammatory bowel disease

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REVIEW ON JOHN W. HEAD＇S WORKS： GREAT LEGAL TRADITIONS -- CIVIL LAW, COMMON LAW AND CHINESE LAW IN HISTORICAL AND OPERATIONAL PERSPECTIVE

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Frontiers of Law in China-Selected Publications from Chinese Universities 2012年第4期7卷 702-706页

作者： ignazio Castellucci at School of Law University of Trento Trento Italy

John W. Head is a Robert W. Wagstaff Distinguished Professor at School of Law, University of Kansas, USA; his involvement in comparative and historical legal research dates back decades, with specific experiences in China and Asia as a researcher, teacher and legal consultant. This handbook on comparative legal traditions follows other books of his on Chinese law and legal history, published by Carolina Academic Press in 2009 （China＇s Legal Soul -- the Modern Chinese Legal Identity in Historical Context） and 2005 （Law Codes in Dynastic China, co-authored with Yanping Wang）.

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Dynamic carbon 13 breath tests for the study of liver function and gastric emptying

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Gastroenterology Report 2015年第1期3卷 12-21页

作者： Leonilde Bonfrate ignazio Grattagliano Giuseppe Palasciano Piero Portincasa Department of Biomedical Sciences and Human Oncology Clinica Medica‘A.Murri’University of Bari Medical SchoolBariItaly Italian College of General Practitioners Florence and BariItaly

In gastroenterological practice,breath tests(BTs)are diagnostic tools used for indirect,non-invasive assessment of several pathophysiological metabolic processes,by monitoring the appearance in breath of a metabolite of a specific *** substrates originally employed radioactive carbon 14(^(14)C)and,more recently,the stable carbon 13 isotope(^(13)C)has been introduced to label specific *** ingested^(13)C-substrate is metabolized,and exhaled^(13)CO_(2)is measured by mass spectrometry or infrared ***^(13)C-BTs evaluate specific(microsomal,cytosolic,and mitochondrial)hepatic metabolic pathways and can be employed in liver diseases(*** liver steatosis,non-alcoholic steato-hepatitis,liver fibrosis,cirrhosis,hepatocellular carcinoma,drug and alcohol effects).Another field of clinical application for^(13)C-BTs is the assessment of gastric emptying kinetics in response to liquids(^(13)C-acetate)or solids(^(13)C-octanoic acid in egg yolk or in a pre-packed muffin or the^(13)C-Spirulina platensis given with a meal or a biscuit).Studies have shown that^(13)C-BTs,used for gastric emptying studies,yield results that are comparable to scintigraphy and can be useful in detecting either delayed-(gastroparesis)or accelerated gastric emptying or changes of gastric kinetics due to pharmacological ***,^(13)C-BTs represent an indirect,cost-effective and easy method of evaluating dynamic liver function and gastric kinetics in health and disease,and several other potential applications are being studied.

关键词： breath tests stable isotope hepatic metabolism gastric motility scintigraphy

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Management of liver cirrhosis between primary care and specialists

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World Journal of Gastroenterology 2011年第18期17卷 2273-2282页

作者： ignazio Grattagliano Enzo Ubaldi Leonilde Bonfrate Piero Portincasa Italian College of General Practitioners (SIMG) Via del Pignoncino 9-11 50142 Firenze Italy Clinica Medica "A. Murri" Department of Internal and Public Medicine University Medical School of Bari

This article discusses a practical, evidence-based approach to the diagnosis and management of liver cirrhosis by focusing on etiology, severity, presence of complications, and potential home-managed treatments. Relevant literature from 1985 to 2010 (PubMed) was reviewed. The search criteria were peer-reviewed full papers published in English using the following MESH headings alone or in combination: "ascites", "liver fibrosis", "cirrhosis", "chronic hepatitis", "chronic liver disease", "decompensated cirrhosis", "hepatic encephalopathy", "hypertransaminasemia", "liver transplantation" and "portal hypertension". Forty-nine papers were selected based on the highest quality of evidence for each section and type (original, randomized controlled trial, guideline, and review article), with respect to specialist setting (Gastroenterology, Hepatology, and Internal Medicine) and primary care. Liver cirrhosis from any cause represents an emerging health issue due to the increasing prevalence of the disease and its complications worldwide. Primary care physicians play a key role in early identification of risk factors, in the management of patients for improving quality and length of life, and for preventing complications. Specialists, by contrast, should guide specific treatments, especially in the case of complications and for selecting patient candidates for liver transplantation. An integrated approach between specialists and primary care physicians is essential for providing better outcomes and appropriate home care for patients with liver cirrhosis.

关键词： Ascites Family medicine Hepatic encephalopathy Hypertransaminasemia Portal hypertension

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Characterization of artificial spherical particles for DEM validation studies

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Particuology 2012年第2期10卷 209-220页

作者： ignazio Cavarretta Catherine O'Sullivan Erdin Ibraim Martin Lings Simon Hamlin David Muir Wood Division of Civil Chemical and Environmental EngineeringFaculty of Engineering and Physical SciencesUniversity of SurreyGuildford GU27XHUK Department of Civil and Environmental Engineering Imperial College LondonLondon SW72AZUK Department of Civil Engineering University of BristolBristol BS81TRUK

This paper describes a study in which advanced particle-scale characterization was carried out on spherical particles that can be used in experimental tests to validate discrete element method （DEM） simulations. Two types of particle, alkaline and borosilicate glass beads, made from two different materials, were con- sidered. The particle shape, stiffness, contact friction properties and surface roughness were measured. The influences of hardness and roughness on the mechanical response of the particles were carefully considered. Compared to the alkaline beads, the borosilicate beads were more spherical and more uniform in size, and they exhibited mechanical characteristics closer to natural quartz sand. While only two material types were studied, the work has the broader implication as a methodology for selecting particles suitable for use in DEM studies and the key parameters that should be considered in the selection process are highlighted.

关键词： Particle characterizationGlass beadsDEM

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Scattering and absorption imaging of a highly fractured fluid-filled seismogenetic volume in a region of slow deformation

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Geoscience Frontiers 2020年第3期11卷 989-998页

作者： Ferdinando Napolitano Luca De Siena Anna Gervasi ignazio Guerra Roberto Scarpa Mario La Rocca Dipartimento di Fisica“E.R.Caianiello” Universita Degli Studi di SalernoVia Giovanni Paolo IIFiscianoSA84084Italy Institute of Geosciences Johannes Gutenberg University MainzJ.-J.-Becher-Weg 21MainzD-55128Germany University of Aberdeen School of GeosciencesGeology and Petroleum GeologyMeston BuildingKing’s CollegeAberdeenScotlandAB243UEUK Dipartimento di Biologia Ecologia e Scienze Della TerraUniversit a Della CalabriaPonte P.BucciArcavacata di RendeCS87036Italy Istituto Nazionale di Geofisica e Vulcanologia Sezione di Rende(CS)Ponte P.BucciArcavacata di RendeCS87036Italy

Regions of slow strain often produce swarm-like sequences,characterized by the lack of a clear mainshockaftershock *** comprehension of their underlying physical mechanisms is challenging and still *** used seismic recordings from the last Pollino swarm(2010-2014) and nearby to separate and map seismic scattering(from P peak-delays) and absorption(from late-time coda-wave attenuation) at different frequencies in the Pollino range and ***-scattering and high-absorption anomalies are markers of a fluid-filled fracture volume extending from SE to NW(1.5-6 Hz) across the *** increasing frequency,these anomalies approximately cover the area where the strongest earthquakes occurred from the sixteenth century until *** our interpretation,the NW fracture propagation ends where carbonates of the Lucanian Apennines begin,as marked by a high-scattering and low-absorption *** the highest frequency(12 Hz) the anomalies widen southward in the middle of the range,consistently marking the faults active during the recent Pollino *** results suggest that fracture healing has closed small-scale fractures across the SE faults that were active in the past centuries,and that the propagation of fluids may have played a crucial role in triggering the 2010-2014 Pollino *** that the fluid propagation ended at the carbonates barrier in the NW direction,fractures opened new paths to the South,favoring the nucleation of the last Pollino ***,the recently active faults in the middle of the seismogenic volume are marked by a high-scattering and highabsorption *** work provides evidence that attenuation parameters may track shape and dynamics of fluid-filled fracture networks in fault areas.

关键词： Polling Seismic attenuation Scattering Fluids Fractures Healing

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Rheumatic manifestations of hepatitis C virus chronicinfection:Indications for a correct diagnosis

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World Journal of Gastroenterology 2016年第4期22卷 1405-1410页

作者： Carlo Palazzi Emilio D’Amico Salvatore D’Angelo Michele Gilio ignazio Olivieri Rheumatology Department of Basilicata San Carlo HospitalPotenza and Madonna delle Grazie Hospital75100 MateraItaly Division of Internal Medicine San Massimo Hospital86027 PenneItaly

Hepatitis C virus(HCV) is a hepato- and lymphotropicagent that is able to induce several autoimmune rheumatic disorders: vasculitis, sicca syndrome, arthralgias/arthritis and fibromyalgia. The severity of clinical manifestations is variable and sometimes lifethreatening. HCV infection can mimic many primitive rheumatic diseases, therefore, it is mandatory to distinguish HCV-related manifestations from primitive ones because the prognosis and therapeutic strategies can be fairly dissimilar. The new direct-acting antivirals drugs can help to avoid the well-known risks of worsening or new onset of autoimmune diseases during the traditional interferon-based therapies.

关键词： Arthritis Cryoglobulinemia Diagnosis Hepatitis C virus Hepatitis C Rheumatic Sicca syndrome Vasculitis

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Smart biomaterials: Surfaces functionalized with proteolytically stable osteoblast-adhesive peptides

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Bioactive Materials 2017年第3期2卷 121-130页

作者： Annj Zamuner Paola Brun Michele Scorzeto Giuseppe Sica ignazio Castagliuolo Monica Dettin Department of Industrial Engineering University of PadovaVia F.Marzolo 935131PadovaItaly Department of Molecular Medicine University of PadovaVia A.Gabelli 6335121PadovaItaly Department of Biomedical Sciences University of PadovaVia U.Bassi 58/B35131PadovaItaly

Engineered scaffolds for bone tissue regeneration are designed to promote cell adhesion,growth,proliferation and ***,covalent and selective functionalization of glass and titanium surfaces with an adhesive peptide(HVP)mapped on[351e359]sequence of human Vitronectin allowed to selectively increase osteoblast attachment and adhesion strength in in vitro assays,and to promote osseointegration in in vivo *** the first time to our knowledge,in this study we investigated the resistance of adhesion sequences to proteolytic digestion:HVP was completely cleaved after 5 *** order to overcome the enzymatic degradation of the native peptide under physiological conditions we synthetized three analogues of HVP sequence.A retro-inverted peptide D-2HVP,composed of D amino acids,was completely stable in serum-containing *** addition,glass surfaces functionalized with D-2HVP increased human osteoblast adhesion as compared to the native peptide and maintained deposition of ***,D-2HVP increased expression of IBSP,VTN and SPP1 genes as compared to HVP functionalized *** internal reflection fluorescence microscope analysis showed cells with numerous filopodia spread on D-2HVP-functionalized ***,the D-2HVP sequence is proposed as new osteoblast adhesive peptide with increased bioactivity and high proteolytic resistance.

关键词： Adhesive sequences Retro-inverso peptides Surface grafting Proteolytic degradation Osteoblast TIRF

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