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Chinese Journal of Polymer Science 2014年第6期32卷 681-689页

作者： ignazio blanco Department of Industrial Engineering University of Catania

A long-term （about nine months） isothermal degradation experiment of two different commercial polylactide （PLA） samples used for food packaging was carried out at a relatively low temperature （423 K）. Thermooxidative degradations of the same polymers were carried out in a thermogravimetric （TG） analyser, at higher temperatures （453 K 〈 T 〈 523 K）, under isothermal heating conditions. The obtained set of experimental TG data was used to determine the apparent activation energy （Ea） of degradation through two isothermal kinetic methods. The results from long-term experiment evidenced considerable mass loss for both PLA samples in the investigated period, but the experimental data were not in agreement with those from the short-term degradations at higher temperatures, thus suggesting a different degradation kinetics, and, then a low reliability of the lifetime predictions for polymers in service or degradation forecasts for the end of their life based on experiments at higher temperatures.

关键词： Lifetime prediction Degradation activation energy Kinetics of polymer degradation Thermogravimetry.

Relationship between pouch microbiota and pouchitis following restorative proctocolectomy for ulcerative colitis

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World Journal of Gastroenterology 2014年第29期20卷 9665-9674页

作者： Imerio Angriman Marco Scarpa ignazio Castagliuolo Department of Surgery Gastroenterology and OncologyUniversity of Padova Surgical Oncology Unit Veneto Institute of Oncology (IOV-IRCCS) Department of Molecular Medicine University of Padova

Restorative proctocolectomy with ileal pouch-anal anastomosis(IPAA)has become the surgical treatment of choice for many patients with medically refractory ulcerative colitis(UC)and familial adenomatous polyposis(FAP).UC patients with IPAA(UC-IPAA)are,nevertheless,susceptible to inflammatory and noninflammatory sequelae such as pouchitis,which is only rarely noted in FAP patients with *** is the most frequent long-term complication of UC-IPAA patients,with a cumulative prevalence of up to 50%.Although the aetiology of pouchitis remains unclear,accumulating evidence suggests that a dysbiosis of the pouch microbiota and an abnormal mucosal immune response are implicated in its *** using culture and molecular techniques have detected a dysbiosis of the pouch microbiota in patients with *** factors,genetic associations,and serological markers suggest that interactions between the host immune response and the pouch microbiota underlie the aetiology of this idiopathic inflammatory *** systematic review focuses on the dysbiosis of the microbiota that inhabit the pouch in UC and FAP patients and its interaction with the mucosal immune system.A metaanalysis was not attempted due to the highly heterogeneous microbiota composition and the different detection methods used by the various *** no specific bacterial species,genus,or family has as yet been identified as pathogenic,there is evidence that a dysbiosis characterized by decreased gut microbiota diversity in UC-IPAA patients may,in genetically predisposed subjects,lead to aberrant mucosal immune regulation triggering an inflammatory process.

关键词： Pouchitis Inflammation of the ileal pouch Microbiota Bacteria Microbiome Ileal-pouch-anal anastomosis Ulcerative colitis Crohn's disease Inflammatory bowel disease

REVIEW ON JOHN W. HEAD＇S WORKS： GREAT LEGAL TRADITIONS -- CIVIL LAW, COMMON LAW AND CHINESE LAW IN HISTORICAL AND OPERATIONAL PERSPECTIVE

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Frontiers of Law in China-Selected Publications from Chinese Universities 2012年第4期7卷 702-706页

作者： ignazio Castellucci at School of Law University of Trento Trento Italy

John W. Head is a Robert W. Wagstaff Distinguished Professor at School of Law, University of Kansas, USA; his involvement in comparative and historical legal research dates back decades, with specific experiences in China and Asia as a researcher, teacher and legal consultant. This handbook on comparative legal traditions follows other books of his on Chinese law and legal history, published by Carolina Academic Press in 2009 （China＇s Legal Soul -- the Modern Chinese Legal Identity in Historical Context） and 2005 （Law Codes in Dynastic China, co-authored with Yanping Wang）.

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Dynamic carbon 13 breath tests for the study of liver function and gastric emptying

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Gastroenterology Report 2015年第1期3卷 12-21页

作者： Leonilde Bonfrate ignazio Grattagliano Giuseppe Palasciano Piero Portincasa Department of Biomedical Sciences and Human Oncology Clinica Medica‘A.Murri’University of Bari Medical SchoolBariItaly Italian College of General Practitioners Florence and BariItaly

In gastroenterological practice,breath tests(BTs)are diagnostic tools used for indirect,non-invasive assessment of several pathophysiological metabolic processes,by monitoring the appearance in breath of a metabolite of a specific *** substrates originally employed radioactive carbon 14(^(14)C)and,more recently,the stable carbon 13 isotope(^(13)C)has been introduced to label specific *** ingested^(13)C-substrate is metabolized,and exhaled^(13)CO_(2)is measured by mass spectrometry or infrared ***^(13)C-BTs evaluate specific(microsomal,cytosolic,and mitochondrial)hepatic metabolic pathways and can be employed in liver diseases(*** liver steatosis,non-alcoholic steato-hepatitis,liver fibrosis,cirrhosis,hepatocellular carcinoma,drug and alcohol effects).Another field of clinical application for^(13)C-BTs is the assessment of gastric emptying kinetics in response to liquids(^(13)C-acetate)or solids(^(13)C-octanoic acid in egg yolk or in a pre-packed muffin or the^(13)C-Spirulina platensis given with a meal or a biscuit).Studies have shown that^(13)C-BTs,used for gastric emptying studies,yield results that are comparable to scintigraphy and can be useful in detecting either delayed-(gastroparesis)or accelerated gastric emptying or changes of gastric kinetics due to pharmacological ***,^(13)C-BTs represent an indirect,cost-effective and easy method of evaluating dynamic liver function and gastric kinetics in health and disease,and several other potential applications are being studied.

关键词： breath tests stable isotope hepatic metabolism gastric motility scintigraphy

Characterization of artificial spherical particles for DEM validation studies

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Particuology 2012年第2期10卷 209-220页

作者： ignazio Cavarretta Catherine O'Sullivan Erdin Ibraim Martin Lings Simon Hamlin David Muir Wood Division of Civil Chemical and Environmental EngineeringFaculty of Engineering and Physical SciencesUniversity of SurreyGuildford GU27XHUK Department of Civil and Environmental Engineering Imperial College LondonLondon SW72AZUK Department of Civil Engineering University of BristolBristol BS81TRUK

This paper describes a study in which advanced particle-scale characterization was carried out on spherical particles that can be used in experimental tests to validate discrete element method （DEM） simulations. Two types of particle, alkaline and borosilicate glass beads, made from two different materials, were con- sidered. The particle shape, stiffness, contact friction properties and surface roughness were measured. The influences of hardness and roughness on the mechanical response of the particles were carefully considered. Compared to the alkaline beads, the borosilicate beads were more spherical and more uniform in size, and they exhibited mechanical characteristics closer to natural quartz sand. While only two material types were studied, the work has the broader implication as a methodology for selecting particles suitable for use in DEM studies and the key parameters that should be considered in the selection process are highlighted.

关键词： Particle characterizationGlass beadsDEM

Scattering and absorption imaging of a highly fractured fluid-filled seismogenetic volume in a region of slow deformation

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Geoscience Frontiers 2020年第3期11卷 989-998页

作者： Ferdinando Napolitano Luca De Siena Anna Gervasi ignazio Guerra Roberto Scarpa Mario La Rocca Dipartimento di Fisica“E.R.Caianiello” Universita Degli Studi di SalernoVia Giovanni Paolo IIFiscianoSA84084Italy Institute of Geosciences Johannes Gutenberg University MainzJ.-J.-Becher-Weg 21MainzD-55128Germany University of Aberdeen School of GeosciencesGeology and Petroleum GeologyMeston BuildingKing’s CollegeAberdeenScotlandAB243UEUK Dipartimento di Biologia Ecologia e Scienze Della TerraUniversit a Della CalabriaPonte P.BucciArcavacata di RendeCS87036Italy Istituto Nazionale di Geofisica e Vulcanologia Sezione di Rende(CS)Ponte P.BucciArcavacata di RendeCS87036Italy

Regions of slow strain often produce swarm-like sequences,characterized by the lack of a clear mainshockaftershock *** comprehension of their underlying physical mechanisms is challenging and still *** used seismic recordings from the last Pollino swarm(2010-2014) and nearby to separate and map seismic scattering(from P peak-delays) and absorption(from late-time coda-wave attenuation) at different frequencies in the Pollino range and ***-scattering and high-absorption anomalies are markers of a fluid-filled fracture volume extending from SE to NW(1.5-6 Hz) across the *** increasing frequency,these anomalies approximately cover the area where the strongest earthquakes occurred from the sixteenth century until *** our interpretation,the NW fracture propagation ends where carbonates of the Lucanian Apennines begin,as marked by a high-scattering and low-absorption *** the highest frequency(12 Hz) the anomalies widen southward in the middle of the range,consistently marking the faults active during the recent Pollino *** results suggest that fracture healing has closed small-scale fractures across the SE faults that were active in the past centuries,and that the propagation of fluids may have played a crucial role in triggering the 2010-2014 Pollino *** that the fluid propagation ended at the carbonates barrier in the NW direction,fractures opened new paths to the South,favoring the nucleation of the last Pollino ***,the recently active faults in the middle of the seismogenic volume are marked by a high-scattering and highabsorption *** work provides evidence that attenuation parameters may track shape and dynamics of fluid-filled fracture networks in fault areas.

关键词： Polling Seismic attenuation Scattering Fluids Fractures Healing

Smart biomaterials: Surfaces functionalized with proteolytically stable osteoblast-adhesive peptides

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Bioactive Materials 2017年第3期2卷 121-130页

作者： Annj Zamuner Paola Brun Michele Scorzeto Giuseppe Sica ignazio Castagliuolo Monica Dettin Department of Industrial Engineering University of PadovaVia F.Marzolo 935131PadovaItaly Department of Molecular Medicine University of PadovaVia A.Gabelli 6335121PadovaItaly Department of Biomedical Sciences University of PadovaVia U.Bassi 58/B35131PadovaItaly

Engineered scaffolds for bone tissue regeneration are designed to promote cell adhesion,growth,proliferation and ***,covalent and selective functionalization of glass and titanium surfaces with an adhesive peptide(HVP)mapped on[351e359]sequence of human Vitronectin allowed to selectively increase osteoblast attachment and adhesion strength in in vitro assays,and to promote osseointegration in in vivo *** the first time to our knowledge,in this study we investigated the resistance of adhesion sequences to proteolytic digestion:HVP was completely cleaved after 5 *** order to overcome the enzymatic degradation of the native peptide under physiological conditions we synthetized three analogues of HVP sequence.A retro-inverted peptide D-2HVP,composed of D amino acids,was completely stable in serum-containing *** addition,glass surfaces functionalized with D-2HVP increased human osteoblast adhesion as compared to the native peptide and maintained deposition of ***,D-2HVP increased expression of IBSP,VTN and SPP1 genes as compared to HVP functionalized *** internal reflection fluorescence microscope analysis showed cells with numerous filopodia spread on D-2HVP-functionalized ***,the D-2HVP sequence is proposed as new osteoblast adhesive peptide with increased bioactivity and high proteolytic resistance.

关键词： Adhesive sequences Retro-inverso peptides Surface grafting Proteolytic degradation Osteoblast TIRF

Iron Mobilization and Mineralogical Alterations Induced by Iron-Deficient Cucumber Plants (Cucumis sativus L.) in a Calcareous Soil

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Pedosphere 2018年第1期28卷 59-69页

作者： Concetta Eliana GATTULLO Youry PII ignazio ALLEGRETTA Luca MEDICI Stefano CESCO Tanja MIMMO Roberto TERZANO Department of Soil Plant and Food Sciences University of Bari "Aldo Moro" Faculty of Science and Technology Free University of Bozen/Bolzano Institute of Methodologies for Environmental Analysis National Research Council of Italy (I.M.A.A.-C.N.R.)

Dicotyledons cope with ion(Fe) shortage by releasing low-molecular-weight organic compounds into the rhizosphere to mobilize Fe through reduction and complexation mechanisms. The effects induced by these root exudates on soil mineralogy and the connections between Fe mobilization and mineral weathering processes have not been completely clarified. In a batch experiment, we tested two different kinds of organic compounds commonly exuded by Fe-deficient plants, i.e., three organic acids(citrate, malate, and oxalate)and three flavonoids(rutin, quercetin, and genistein), alone or in combination, for their ability to mobilize Fe from a calcareous soil and modify its mineralogy. The effect of root exudates on soil mineralogy was assessed in vivo by cultivating Fe-deficient and Fe-sufficient cucumber plants(Cucumis sativus L.) in a RHIZOtest device. Mineralogical analyses were performed by X-ray powder diffraction. The batch experiment showed that citrate and, particularly, rutin(alone or combined with organic acids or genistein)promoted Fe mobilization from the soil. The combinations of rutin and organic acids modified the soil mineralogy by dissolving the amorphous fractions and promoting the formation of illite. These mineralogical alterations were significantly correlated with the amount of Fe mobilized from the soil. The RHIZOtest experiment revealed a drastic dissolution of amorphous components in the rhizosphere soil of Fe-deficient plants, possibly caused by the intense release of phenolics, amino acids, and organic acids, but without any formation of illite. Both batch and RHIZOtest experiments proved that exudates released by cucumber under Fe deficiency concurred to the rapid modification(on a day-scale) of the mineralogy of a calcareous soil.

关键词： flavonoids mineral weathering organic acids rhizosphere X-ray powder diffraction

Pathogenic role of oxidative and nitrosative stress in primary biliary cirrhosis

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World Journal of Gastroenterology 2014年第19期20卷 5746-5759页

作者： ignazio Grattagliano Giuseppe Calamita Tiziana Cocco David Q-H Wang Piero Portincasa Italian College of General Practitioners 50100 FlorenceBari 70124Italy Department of Bioscience Biotechnologyand Biopharmaceutics"Aldo Moro" University Medical SchoolBari 70124Italy Department of Basic Medical Science Neurosciencesand Sense Organs"Aldo Moro" University Medical SchoolBari 70124Italy Department of Internal Medicine Division of Gastroenterology and HepatologySaint Louis University School of MedicineSt.LouisMO 63104United States Clinica Medica "A.Murri" Department of Biomedical Sciences and Human Oncology"Aldo Moro" University Medical SchoolBari 70124Italy

Primary biliary cirrhosis is a multifactor autoimmune disease characterized by hepatic and systemic manifestations,with immune system dysregulation and abnormalities in the hepatic metabolism of bile salts,lipids,and nutrients,as well as destruction of membrane lipids and mitochondrial *** oxidative and nitrosative stress are associated with ongoing manifestations of the *** particular,abnormalities in nitric oxide metabolism and thiol oxidation already occur at early stages,thus leading to the hypothesis that these biochemical events play a pathogenic role in primary biliary ***,the association of these metabolic abnormalities with the progression of the disease may indicate some biochemical parameters as early diagnostic markers of disease evolution,and may open up the potential for pharmacological intervention to inhibit intra-and extra-cellular stress events for resuming hepatocellular *** following paragraphs summarize the current knowledge by outlining molecular mechanisms of the disease related to these stress events.

关键词： Aquaporins Bile salts Chronic cholestasis Glutathione Mitochondria Nitrosothiols Nitrotyrosine Protein sulfhydryls Thioredoxin

Inflammatory colonic carcinogenesis: A review on pathogenesis and immunosurveillance mechanisms in ulcerative colitis

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World Journal of Gastroenterology 2014年第22期20卷 6774-6785页

作者： Marco Scarpa ignazio Castagliuolo Carlo Castoro Anna Pozza Melania Scarpa Andromachi Kotsafti Imerio Angriman Surgical Oncology Unit Veneto Institute of Oncology (IOV-IRCCS)35128 PadovaItaly Department of Molecular Medicine University of Padova35128 PadovaItaly Department of Surgery Gastroenterology and OncologyUniversity of Padova35128 PadovaItaly

Ulcerative colitis(UC)is characterized by repeated flare-ups of inflammation that can lead to oncogenic insults to the colonic ***-associated carcinogenesis presents a different sequence of tumorigenic events compared to those that contribute to the development of sporadic colorectal *** fact,in UC,the early events are represented by oxidative DNA damage and DNA methylation that can produce an inhibition of oncosuppressor genes,mutation of p53,aneuploidy,and microsatellite *** of tumor suppressor and DNA mismatch repair gene promoter regions is an epigenetic mechanism of gene silencing that contribute to tumorigenesis and may represent the first step in inflammatory ***,p53 is frequently mutated in the early stages of UC-associated *** is an independentrisk factor for forthcoming carcinogenesis in *** cell-T-cell cross-talk mediated by CD80 is a key factor in controlling the progression from low to high grade dysplasia in UC-associated carcinogenesis.

关键词： Colorectal cancer Ulcerative colitis Carcinogenesis Immune surveillance