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The labyrinth of nuclear reprogramming

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分子细胞生物学报:英文版 2011年第6期3卷 327-329页

作者： ignacio Sancho-Martinez Emmanuel Nivet Juan Carlos Izpisua Belmonte Gene Expression Laboratory Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Center for Regenerative Medicine in Barcelona Dr Aiguader 88Barcelona 08003Spain

Human embryonic stem cells(ESCs)have the capability to differentiate into all somatic cell types,a process that recapitu-lates the early stages of human ***,the use of ESCs raises several controversies,particularly concern-ing the ethical dilemma regarding the use of human embryonic material and the need for embryo *** discov-ery of induced pluripotent stem cell(iPSC)technology in 2006(Takahashi and Yamanaka,2006)opened the door for possible application of pluripotent stem-cell-related therapies in the clinic as well as for the generation of patient-derived pluripotent stem cells suitable for disease modeling in vitro.

关键词： programming destruction opened

Denervated muscle extract promotes recovery of muscle atrophy through activation of satellite cells. An experimental study

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Journal of Sport and Health Science 2019年第1期8卷 23-31页

作者： Eduardo Aguera Salvador Castilla Evelio Luque ignacio Jimena ignacio Ruz-Caracuel Fernando Leiva-Cepas Jos Pea Department of Neurology Maimonides Institute for Biomedical Research IMIBIC Reina Sofia University Hospital University of Cordoba Department of Critical Care and Emergency Reina Sofia University Hospital University of Cordoba Department of Morphological Sciences Section of Histology Faculty of Medicine and Nursing Maimonides Institute for Biomedical Research IMIBICReina Sofia University Hospital University of Cordoba

Purpose: The objective of the present study was to determine whether a denervated muscle extract(DmEx) could stimulate satellite cell response in denervated ***: Wistar rats were divided into 4 groups: normal rats, normal rats treated with DmEx, denervated rats, and denervated rats treated with DmEx. The soleus muscles were examined using immunohistochemical techniques for proliferating cell nuclear antigen, desmin, and myogenic differentiation antigen(MyoD), and electron microscopy was used for analysis of the satellite ***: The results indicate that while denervation causes activation of satellite cells, DmEx also induces myogenic differentiation of cells localized in the interstitial space and the formation of new muscle fibers. Although DmEx had a similar effect in nature on innervated and denervated muscles, this response was of greater magnitude in denervated vs. intact ***: Our study shows that treatment of denervated rats with DmEx potentiates the myogenic response in atrophic denervated muscles.

关键词： Muscle atrophy Muscle denervation Muscle extract Myogenic response Satellite cell Skeletal muscle

The role of behavioral changes and prompt treatment in the control of STIs

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Infectious Disease Modelling 2019年第1期4卷 1-10页

作者： Fernando Saldaňa ignacio Barradas CIMAT Guanajuato Gto36000 Mexico

In this paper,we study general recovery functions and treatment in the dynamics of an SIS model for sexually transmitted infections with nonzero partnership *** is shown how partnership dynamics influences the predicted prevalence at the steady state and the basic reproduction ***'s indices are used to evaluate the contribution of model parameters to the overall variance of R *** recovery functions studied here take into account that society's capacity to provide treatment is limited when the number of infected individuals is *** analysis is used to establish a relationship between an alert level of prevalence and the minimum recovery time that guarantees the eradication of the *** also show that a backward bifurcation can occur when there are delays in the treatment of infected individuals.

关键词： Recovery function Pair formation Sensibility analysis Behavioral interventions Sexually transmitted infections

Is the soil seed bank a reliable source for passive restoration of bush-cleared semi-arid rangelands of South Africa?

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Ecological Processes 2020年第1期9卷 1-16页

作者： Mthunzi Mndela Casper ignacio Madakadze Florence Nherera-Chokuda Sikhalazo Dube University of Pretoria P/Bag X20HatfieldPretoria 0028South Africa Agricultural Research Council APIP/Bag X02IrenePretoria 0062South Africa

Background:Bush clearing of encroached rangelands is crucial for restoration of herbaceous cover and *** after bush clearing depends largely on the soil seed bank(SSB)size and *** assess the potential of the SSB to facilitate post-clearing herbaceous restoration,we examined the SSB density,composition and diversity and similarity between SSB and aboveground vegetation(AGV).Methods:The study was conducted in semi-arid rangelands of Maseding and Kgomokgomo in North-West Province of South *** each rangeland,all woody plants in three 1250 m^(2) plots were cut using saws and loppers,with the stumps treated with *** observations were conducted in cleared and uncleared *** samples were collected at three depths(0-10,10-20 and 20-30 cm)in each microsite in April(pretreatment),August,October and December 2016 and in April and August *** was assessed using seedling emergence method,whereas pre-and post-clearing surveys of AGV were conducted in February 2016 and 2017,***:Cleared microsites had significantly(p<0.01)higher seed bank densities(1872 and 693 seeds m^(-2) at Maseding and Kgomokgomo,respectively)relative to uncleared microsites in August 2017,with grasses accounting for higher densities than other plant functional groups in the upper 0-10 *** grasses(Aristida congesta ***,Brachiaria eruciformis and Tragus berteronianus)and invasive forbs(Bidens pilosa and Schkuhria pinnata)dominated the SSB in cleared microsites at Maseding,whereas succulents(Portulaca spp.)and pioneer grasses(*** and Urochloa mosambicensis)were abundant at Kgomokgomo in August *** and AGV were dissimilar until December 2016;thereafter,similarity increased significantly(p<0.05)in cleared microsites(Sørensen’s coefficient=0.60 to 0.66 at Maseding and 0.43 to 0.52 at Kgomokgomo)compared to uncleared *** diversity was highest in August 2016 and April 2017 at Maseding,but

关键词： Bush clearing Seed bank density Seed bank diversity Sørensen’s coefficient

Structure-Preserving Finite-Element Schemes for the Euler-Poisson Equations

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Communications in Computational Physics 2023年第3期33卷 647-691页

作者： Matthias Maier John N.Shadid ignacio Tomas Department of Mathematics Texas A&M University3368 TAMUCollege StationTX 77843USA Sandia National Laboratories P.O.Box 5800MS 1320AlbuquerqueNM 87185USA Department of Mathematics and Statistics University of New MexicoMSC011115AlbuquerqueNM 87131USA Department of Mathematics&Statistics Texas Tech University2500 BroadwayLubbockTX 79409USA.

We discuss structure-preserving numerical discretizations for repulsive and attractive Euler-Poisson equations that find applications in fluid-plasma and selfgravitation *** scheme is fully discrete and structure preserving in the sense that it maintains a discrete energy law,as well as hyperbolic invariant domain properties,such as positivity of the density and a minimum principle of the specific entropy.A detailed discussion of algorithmic details is given,as well as proofs of the claimed *** present computational experiments corroborating our analytical findings and demonstrating the computational capabilities of the scheme.

关键词： Euler-Poisson equations operator splitting invariant domain preservation discrete energy balance.

Mechanical and thermodynamical stability of BiVO4 polymorphs using first-principles study

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Chinese Physics B 2017年第3期26卷 395-403页

作者： A K M Farid ui Islam Md Nurul Huda Liton H M Tariqul Islam Md Al Helal Md Kamruzzaman Department of Computer Science and Engineering Begum Rokeya University Rangpur Rangpur-5400 Bangladesh Department of Physics Begum Rokeya University Rangpur Rangpur-5400 Bangladesh Department of Chemistry Begum Rokeya University Rangpur Rangpur-5400 Bangladesh Department of Physics and Materials Science and Center of Super-Diamond and Advanced Films (COSDAF) City University of Hong Kong Hong Kong SAR China

First principles calculations of structural, electronic, mechanical, and thermodynamic properties of different poly- morphs of BiVO4 are performed using Bender-type plane/wave ultrasoft pseudopotentials within the generalized gradient approximation （GGA） in the flame of density functional theory （DFT）. The calculated structural and electronic properties are consistent with the previous theoretical and experimental results. The electronic structures reveal that m-BiVO4, op- BiVO4, and st-BiVO4 have indirect band gaps, on the other hand, zt-BiVO4 has a direct band gap. From the DOS and Mulliken＇s charge analysis, it is observed that only m-BiVO4 has 6s2 Bi lone pair. Bond population analysis indicates that st-BiVO4 shows a more ionic nature and a similar result is obtained from the elastic properties. From the elastic prop- erties, it is observed that st-BiVO4 is more mechanically stable than the others, st-BiVO4 is more ductile and useful for high electro-optical and electro-mechanical coupling devices. Our calculated thermodynamic properties confirm the similar characteristics found from electronic and elastic properties, m-BiVO4 is useful as photocatalysts, solid state electrolyte, and electrode and other polymorphs are applicable in electronic device fabrications.

关键词： BiVO4 crystal structure lone pair mechanical stability

Trabectedin therapy as an emerging treatment strategy for recurrent platinum-sensitive ovarian cancer

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Chinese Journal of Cancer 2015年第1期34卷 41-49页

作者： José Antonio López-Guerrero ignacio Romero Andrés Poveda Laboratory of Molecular Biology Fundación Instituto Valenciano de Oncología Clinical Area of Gynecological Cancer Fundación Instituto Valenciano de Oncología

Epithelial ovarian cancer(OC) is a common gynecologic malignancy in women. The standard treatment for OC is maximal cytoreductive surgical debulking followed by platinum-based chemotherapy. Despite the high response rate to primary therapy, approximately 85% of patients will develop recurrent ovarian cancer(ROC). This review identifies the clinical use of trabectedin in the treatment algorithm for ROC, with specific emphasis on platinum-sensitive ROC, for which trabectedin in combination with pegylated liposomal doxorubicin has been approved as a treatment protocol. The main mechanisms of action of trabectedin at the cellular level and in the tumor microenvironment is also discussed as bases for identifying biomarkers for selecting patients who may largely benefit from trabectedin-based therapies.

关键词：治疗方案卵巢癌敏感复发铂疗法恶性肿瘤聚乙二醇化

OTB-morph:One-time Biometrics via Morphing

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Machine Intelligence Research 2023年第6期20卷 855-871页

作者： Mahdi Ghafourian Julian Fierrez Ruben Vera-Rodriguez Aythami Morales ignacio Serna Biometrics and Data Pattern Analytics Laboratory(BiDA Lab) Universidad Autonoma de MadridMadrid28049Spain

Cancelable biometrics are a group of techniques to transform the input biometric to an irreversible feature intentionally using a transformation function and usually a key in order to provide security and privacy in biometric recognition *** transformation is repeatable enabling subsequent biometric *** paper introduces a new idea to be exploited as a transformation function for cancelable biometrics aimed at protecting templates against iterative optimization *** proposed scheme is based on time-varying keys(random biometrics in our case)and morphing *** experimental implementation of the proposed scheme is given for face *** results confirm that the proposed approach is able to withstand leakage attacks while improving the recognition performance.

关键词： Biometrics face recognition template protection morphing security

Evolution of radical hysterectomy for cervical cancer along the last two decades: single institution experience

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Chinese Journal of Cancer Research 2016年第2期28卷 215-220页

作者： Claudia Arispe Ana Isabel Pomares Javier De Santiago ignacio Zapardiel Gynecologic Oncology Department La Paz University Hospital

Background： The radical hysterectomy （RH） surgical technique has improved along the years. It is used for the treatment of cervical cancer, endometrial cancer when affecting the cervix, and upper vaginal carcinomas. Our aim was to describe the historical evolution of the technique after the introduction of laparoseopy at our institution. Methods： We performed a retrospective review of medical records of patients who underwent RH, grouped in three periods according to the year of surgery： 1990-1999, 2000-2009 and 2010-2013. Patients＇ characteristics, pathologic details, intraoperative and postoperative complications were analyzed and comoared throughout the time periods. Results： A total of 102 cases of RH were performed at our center during the study period. Among all data collected, the presence of necrosis, age, number of lymph nodes, surgery route, operating time, hospital stay, blood loss and transfusion requirement were statistically significant different among groups. Conversion to laparotomy rate was 19% for the second period compared to the absence of cases in the last one. No significant differences （P=0.124） were observed in the adjuvant treatment received among the three different groups. At the time of the last contact the patients free of disease were 12 （85.7%）, 53 （91.3%） and 26 （86.6%） respectively （P=0.406）. Regarding the disease-free interval, we found significant better outcomes in the group of laparotomy compared to laparoscopy （P=0.015）.Conclusions： Laparoscopic RH is an acceptable surgery with advantages like magnified vision of the operation＇s field, lower surgical complications, shorter hospital stay and earlier resumption to daily activities.

关键词： Gynaecological cancer radical hysterectomy (RH) laparoscopy cervical cancer