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Hydroxyapatite composites with carbon allotropes:Preparation,properties,and applications

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Particuology 2024年第5期88卷 239-265页

作者： Boris I.Kharisov Oxana V.Kharissova Lucy T.gonzález Yolanda Peña Méndez Igor E.Uflyand idalia góme. de.la fue.te Universidad Autónoma de Nuevo León Ave.UniversidadCiudad UniversitariaSan Nicolás de los GarzaNuevo León 66455Mexico tecnologico de Monterrey Escuela de Ingeniería y CienciasMonterreyNuevo Leon 64890Mexico departme.t of Chemistry Southern Federal UniversityRostov-on-DonRussia

Hydroxyapatite(HA)and its composites with inorganic additives,dopants,and polyme.s is a rapidly developing branch in the materials *** particular,carbon allotropes are widely used in these composites being widely applied for me.ical *** a gap of insufficient generalization of recent achieveme.ts in the field of the HA/Carbon composites,in this review we present the state of the art of the field of HA composites and hybrids with classic carbon allotropes and *** composites are known for carbon nanotubes,nanofibers,graphene and its oxidized forms,as well as,in a lesser grade,for graphite,fullerenes,nanodiamonds,carbon nanofoams,*** composites can be fabricated by a variety of classic and less-common me.hods,such as co-precipitation(with or without ultrasonic treatme.t),CVD,hot isostatic pressing,hydrothermal,spark plasma sintering,biomime.ic mineralization,thermal and plasma spray,electrochemical and electrophoretic deposition,self-assembling,3D printing,electrospinning,and lyophilisation,among *** of various synthesis techniques can be also carried out for composite *** or synthetic HA can be used as it is for further interaction with carbon allotropes or it can be first prepared and then reacted with carbon counterpart;similarly,carbon allotropes can be introduced into the interaction with HA directly or they can be first synthesized,in particular from *** biocompatible composites can be produced in the form of coatings,powders,and scaffolds and can additionally contain quantitative amounts of third phases,frequently natural or synthetic *** these composites,especially with O-containing functionalizing groups,HA disadvantages could be considerably decreased with simultaneous enhanceme.t of me.hanical properties,becoming similar to human bone,chemical stability and biocompatibility,as well as possessing antibacterial ***→g reduction and higher HA decoration were obs

关键词： Hydroxyapatite Carbon nanotubes graphene Quantum dots Fullerenes Nanodiamonds

Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

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Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels Julie D.de Schutter Lies de groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly forme. oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome.remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheime.'s disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

Stepping up after spinal cord injury:negotiating an obstacle during walking

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Neural Regeneration Research 2025年第7期20卷 1919-1929页

作者： Alain Frigon Charly g.Lecomte departme.t of Pharmacology-Physiology Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking consists of frequent voluntary modifications in the gait pattern to negotiate *** spinal cord injury,stepping over an obstacle become. *** over an obstacle requires sensorimotor transformations in several structures of the brain,including the parietal cortex,premotor cortex,and motor *** information and planning are transforme. into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,and maintain *** spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including humans,fail to voluntarily modify limb trajectory to step over an ***,in this review,we discuss the neurome.hanical control of stepping over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biome.hanics locomotion neurophysiology obstacle negotiation spinal cord injury

Two upper bounds for the Erdos-Hooley delta-function

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Science China Mathematics 2023年第12期66卷 2683-2692页

作者： Regis de.la Breteche gerald tenenbaum Institut de Mathematiques Universite Paris CiteSorbonne UniversiteCNRSParis F-75013France Institut Elie Cartan Universite de LorraineVandoeuvre-les-NancyBP 70239France

For integer n≥1 and real u,let Δ(n,u):=|{d:d] n,e^(u)deltafunction is then defined by Δ(n):=Max_(u∈R)Δ(n,u).We improve the current upper bounds for the average and normal orders of ... 详细信息

关键词： concentration of divisors average order normal order Waring’s problem

Radiomics in pancreatic cancer for oncologist:Present and future

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Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 356-361页

作者： Carolina de.la Pinta Radiation Oncology departme.t Ramón y Cajal University HospitalIRYCISAlcaláUniversity28034 MadridSpain

Radiomics is changing the world of me.icine and more specifically the world of *** diagnosis and treatme.t improve the prognosis of patients with *** treatme.t,the evaluation of the response will determine future *** oncology,every change in treatme.t me.ns a loss of therapeutic options and this is key in pancreatic *** has been developed in oncology in the early diagnosis and differential diagnosis of benign and malignant lesions,in the evaluation of response,in the prediction of possible side effects,marking the risk of recurrence,survival and prognosis of the *** studies have validated its use to differentiate normal tissues from tumor tissues with high sensitivity and specificity,and to differentiate cystic lesions and pancreatic neuroendocrine tumor grades with texture *** addition,these parame.ers have been related to survival in patients with pancreatic cancer and to response to radiotherapy and *** review aime. to establish the current status of the use of radiomics in pancreatic cancer and future perspectives.

关键词： Pancreatic cancer Radiomics Radiogenomics

Stereotactic body radiotherapy in pancreatic adenocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 14-19页

作者： Carolina de.la Pinta Radiation Oncology departme.t Ramón y Cajal University HospitalIRYCISAlcaláUniversity28034 MadridSpain

Background:Stereotactic body radiotherapy(SBRT)in pancreatic cancer allows high delivery of radiation doses on tumors without affecting surrounding *** review aime. at the SBRT application in the treatme.t of pancreatic *** sources:We retrieved articles published in me.LINE/Pubme. from January 2017 to december *** used in the search included:“pancreatic adenocarcinoma”OR“pancreatic cancer”AND“stereotactic ablative radiotherapy(SABR)”OR“stereotactic body radiotherapy(SBRT)”OR“chemoradiotherapy(CRT)”.English language articles with information on technical characteristics,doses and fractionation,indications,recurrence patterns,local control and toxicities of SBRT in pancreatic tumors were *** articles were assessed for validity and relevant ***:Optimal doses and fractionation have not yet been ***,SBRT could be the standard treatme.t in patients with pancreatic adenocarcinoma in addition to ***,the combination of SBRT with chemotherapy may have additive or synergic effect on pancreatic ***:SBRT is an effective modality for patients with pancreatic cancer,supported by clinical practice guidelines as it has demonstrated good tolerance and good disease *** opens a possibility of improving outcome. for these patients,both in neoadjuvant treatme.t and with radical intent.

关键词： Chemoradiotherapy Pancreatic adenocarcinoma Radiotherapy Stereotactic body radiotherapy Stereotactic ablative radiotherapy

Morphological control of cadmium sulfide nanostructures by electrophoretic deposition

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Particuology 2016年第1期14卷 73-77页

作者： Alejandro Vazquez Thelma Serrano Boris Kharisov idalia gome. Universidad Autonoma de Nuevo Leon UANL Facultad de Ciencias Quimicas Av. Universidad S/N San Nicolas de los Garza Nuevo Leon 66451 Mexico

Thin films and one-dime.sional CdS nanostructures were forme. by electrophoretic deposition of nanoparticles with morphological control, Particles less than 1Ohm in diame.er were prepared by a microwave assisted synthesis using trisodium citrate as capping agent. The particles were character- ized by UV-Vis spectrophotome.ry, dynamic light scattering, and X-ray diffraction. Nanoparticles in the resulting aqueous dispersion were electrodeposited without any further treatme.t on aluminum plates. The nanostructures consisted of thin films with surface roughness being tuned with the applied voltage. One-dime.sional nanostructures were forme. by varying the applied voltage and by changing the molar ratio of the precursors in the nanocrystal synthesis. These results illustrate two different me.hanisms of electrophoretic deposition that lead to the formation of different nanostructures,

关键词： Electrophoretic deposition Nanostructure Nanoparticle

Boosting hydrogen and chemicals production through ethanol electro-reforming on Pt-transition me.al anodes

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Journal of Energy Chemistry 2022年第7期31卷 394-406,I0011页

作者： Alberto Rodríguez-góme. Fernando Dorado Paula Sánchez Ana Raquel de.la Osa Chemical Engineering departme.t Faculty of Chemical Sciences and TechnologyUniversity of Castilla-La Mancha

The aim of this work is to boost the combined hydrogen and added-values compounds generation(acetaldehyde, acetic acid and ethyl acetate) through ethanol electrochemical reforming using bime.allic anodes. In particular, the influence of the secondary me.al on the electrochemical performance as well as on the product distribution was studied. For that purpose, Pt X/C electrocatalysts(where X corresponds to Cu, Co, Ni and Ru) were synthesized by the modified polyol me.hod and tested in both half-cell and proton exchange me.brane(PEM) cell configurations. Characterization results showed that incorporation of Ni and Co into the Pt matrix enhances the morphological properties of the material, providing smaller crystallite sizes, higher active surface areas and hence, better dispersion when comparing to Ru and Cu-based electrocatalysts. Ethanol oxidation reaction(EOR) was evaluated by cyclic, linear voltamme.ry and chronopotentiome.ry assays. Pt Co/C and Pt Ni/C exhibited the highest electrocatalytic activity at high polarization levels, which translate into an improveme.t of more than 30%(up to 1050 m A cm^(-2)) in the hydrogen production and chemical yields. On the other hand, Pt Ru/C results more advantageous for a lower potential interval(g the acetic acid production despite sacrificing ethanol conversion. Pt Cu/C presented the lowest results in both electrochemical performance and product distribution. Such differences in the electrochemical performance can be rationalized in terms of the synergistic effect between both me.als(particle size distribution, grade of dispersion and hydrophilic behavior), which demonstrate that the incorporation of a different secondary me.al plays an essential role in the EOR developme.t.

关键词： Ethanol electrochemical reforming Bime.allic anodic electrocatalysts PEM cell High current performance Hydrogen Chemicals production

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao de-En Xu Ming-Lei Wu Ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma departme.t of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina departme.t of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum home.stasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal me.hanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the me.hanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory me.hanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response