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中华神经外科疾病研究杂志 2014年第5期13卷 433-433页

作者： Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V icolaro n Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P Laboratory of Oncology "IRCCS Casa Sollievo della Sofferenza" Laboratory of Genetics "IRCCS Casa Sollievo della Sofferenza" Department of Biosciences Biotechnology and BiopharmaceuticsUniversity of Bari "Aldo Moro" LTTA Department of MorphologySurgery and Experimental MedicineHuman Anatomy BranchUniversity of Ferrara Department of neurosurgery "IRCCS Casa Sollievo della Sofferenza " Department of Pathology "IRCCS Casa Sollievo della Sofferenza" Unit of Biostatistics "IRCCS Casa Sollievo della Sofferenza" Department of Oncology "IRCCS Casa Sollievo della Sofferenza" CIR Laboratory for Molecular Medicine and Biotechnology University Campus Biomedico

Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRnA( miRnA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRnA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRnA signature resulted by array analysis. The prognostic performances of the confirmed miRnAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRnAs distinguishing grade II gliomas from higher grade ***-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRnAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRnAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRnAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas.

关键词：神经外科学疾病临床研究医学

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