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Malaria Characteristics in Children with Sickle Cell Disease

Open Journal of Pediatrics 2022年第1期12卷 125-130页

作者： Indou Deme/Ly Cheikh Binetou Fall Awa Kane ibrahima Diop Aminata Mbaye Yaaye Joor Dieng Denika Estelle Liapoui Idrissa Demba Ba Abou Ba Aliou Thiongane Papa Moctar Faye Amadou Lamine Fall ibrahima diagne Ousmane Ndiaye Cheikh Anta Diop University Dakar Senegal Gaston Berger University Saint-Louis Senegal

Background: The relationship between sickle cell disease and malaria is the subject of much controversy. However, there is a lack of data in our services. Our objective was to study the epidemiological, diagnostic and evolutionary characteristics of malaria in children with sickle cell disease followed in a specialized setting. Patients and Methods: We conducted a retrospective, descriptive, and analytical study of children with sickle cell disease (SCD) who presented with malaria and were followed at the Ambulatory Care Unit for Sickle Cell Children and Adolescents (USAD) at the Albert Royer National Children’s Hospital in Dakar, from January 1st, 2017, to December 31th, 2019. We included all the followed pediatric patients, less than 16 years, with sickle cell disease who presented at least one episode of malaria, confirmed by a positive thick drop, during this 3 years. We did not include patients with incomplete records or those older than 16 years. The clinical and biological signs, the follow up was collected and analyzed with Excel package 2019. Results: Of 3773 patients followed for sickle cell disease, 21 had presented malaria. The frequency was 0.5% or 7 cases/year. However, we exploited the data of 14 of them. The sex ratio was 6 boys for a girl and the mean age at admission was 7.3 years. The highest number of malaria cases was observed in 2018 and the peak frequency was observed in November with 8 cases (57.1%). Fever was the most frequent symptom, observed in 10 patients (71.4%). All patients were SS homozygous, with a mean baseline hemoglobin level of 7.5g/dl. All patients had a positive thick blood smear and Plasmodium falciparum was the only species found in the blood smear, with a mean parasite density of 1693 parasites/ml of blood. All patients had anemia, with a mean hemoglobin level of 7.74 g/dl. Twelve patients (85.7%) were hospitalized and had all received injectable artesunate followed by oral Artemisinin Combination Ther

关键词： Malaria Sickle Cell Disease Children

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Acute Bilirubin Encephalopathy: A Propos of 151 Cases Collected during a Multicentric Study in Senegal

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Open Journal of Pediatrics 2023年第1期13卷 50-62页

作者： Serigne Tawa Ndiaye Yaye Joor K. B. Dieng Papa Moctar Faye Mohameth Mbodj Sofietou Dieye Khadim Bop Papa Souley Sow Amadou Sow Ndeye Fatou Sow ibrahima Diop Aziz Faye Sadio Konate ibrahima diagne Mousatapha Ndiaye Ousmane Ndiaye Centre Hospitalier National D’Enfants Albert Royer Dakar Senegal Centre Hospitalier Municipal Abass Ndao Dakar Senegal Gaston Berger University Saint Louis Senegal Cheikh Anta Diop University Dakar Senegal

Introduction: Bilirubin encephalopathy is a debilitating complication of severe neonatal unconjugated bilirubin jaundice. The aim of this study was to determine the frequency of occurrence of this complication and to describe the diagnostic and prognostic aspects in Senegal. Materials and Methods: This was a multicenter, descriptive and analytical study conducted in 32 neonatal units of various levels, with retrospective (January to December 2020) and prospective (January to August 2021) collection. All neonates hospitalized for acute bilirubin encephalopathy were included. The diagnostic criteria were the presence of jaundice associated with neurological signs (muscle tone disorders, abnormal movements, convulsions, etc.), with no other obvious etiology found. The data were entered and analyzed using SPSS version 23 software. The significance threshold was retained for a p-value Results: We registered 151 patients. The mean age was 6 days and the sex ratio was 2.5 (clear male predominance). The majority of newborns were from Dakar (51%). Twenty-two (22%) were premature and 32% had low birth weight. Half of the newborns (50%) came from home and 87% were exclusively breastfed. The average time to consult was 3 days. Neurological signs were dominated by decreased primitive reflexes (74%), abnormal movements (59%) and lethargy (50%). Dehydration (30%) and anemia (26%) were often associated. The mean bilirubin level was 416 umol/l. Neonatal infections (19%) and Rhesus (16.7%) and ABO (8.7) incompatibility were the main causes. One third (33%) of patients had received intensive phototherapy and only 2% had received exchange blood transfusion. The case fatality was 48.9%. Conclusion: Bilirubin encephalopathy remains a major concern in Senegal. It is associated with high mortality and numerous neurological sequelae. Progress in terms of early detection and appropriate management is urgently needed on a national scale.

关键词： Icterus Encephalopathy Phototherapy Lethality

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Eagle’s Syndrome in Children: A Case Report

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Open Journal of Pediatrics 2022年第2期12卷 320-324页

作者： Serigne Tawa Ndiaye Cheikh Diéne Niang Ciré Ndiaye Mohameth Mbodj Ndeye Fatou Sow Amadou Sow Faty Fall Papa Moctar Faye ibrahima diagne Ousmane Ndiaye Albert Royer National Children’s Hospital Dakar Senegal Cheikh Anta Diop University Dakar Senegal Abass Ndao Municipal Hospital Center Dakar Senegal Gaston Berger University Saint Louis Senegal

Eagle’s syndrome is a collection of symptoms caused by styloid process elongation or calcification of the stylohyoid ligament, measuring more than 2.5 centimeters. It is a radio-clinical entity characterized by a heterogeneous polymorphic symptomatology most often involving headaches, facial pain, dysphagia and a foreign body sensation in the throat. Its management is mainly surgical. It is a rarely diagnosed condition in children. Here we report a typical case of Eagle’s syndrome which was diagnosed in a 14-year-old child with a history of chronic right unilateral pharyngeal discomfort, odynophagia and oropharyngeal foreign body sensation. CT scan showed a long left styloid process. The patient underwent surgical removal of the elongated styloid process externally. The outcome was favorable after surgery.

关键词： Eagle’s Syndrome Styloid Process Child

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Quality of Well Water Used for Market Gardening from Lendeng Area Located in Common of Rufisque (Senegal)

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Journal of Agricultural Chemistry and Environment 2022年第4期11卷 277-284页

作者： Birame Ndiaye Momar Ndiaye Benita Pérez Cid Abdoulaye Diop ibrahima diagne Dame Cissé Cheikh Tidiane Dione Maoudo Hane Mame Mor Dione Sitor Diouf Seydou Ba Department of Chemistry Faculty of Science and Technology Cheikh Anta Diop University of Dakar Dakar Senegal Department of Analytical and Food Chemistry Faculty of Chemistry University of Vigo Vigo Spain

This study analysis was conducted to know the quality of well water around the market gardening area of Lendeng located in the common of Rufisque Est (Senegal). In this study, six groundwater samples were taken near the Lendeng market gardening area. The physicochemical parameters of water such as pH, temperature, electrical conductivity (EC), calcium (Ca2+), magnesium (Mg2+), potassium (K+), iron (Fe2+), chloride (Cl-), sulfate (SO3-4) and phosphate (PO3-4) were measured. The analysis results obtained show sulphate and phosphate have the highest levels. These results were compared to drinking water standards from the World Health Organization (WHO). The correlation coefficient ANOVA was applied to the test result of the samples. The statistical study showed that the well water in the market gardening area of Lendeng is not polluted.

关键词： Physicochemical Parameters Well Water Lendeng Market Gardening Rufisque

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COVID-19 Infection and Homozygous SS Sickle Cell Disease in Children: About Two Cases in Ziguinchor/Senegal

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Open Journal of Pediatrics 2020年第4期10卷 744-750页

作者： Lamine Thiam Noel Magloire Manga Chérif Mouhamadou Aidara Amadou Lamine Fall ibrahima diagne Ousmane Ndiaye Assane Seck University of Ziguinchor Ziguinchor Peace Hospital Ziguinchor Senegal Cheikh Anta Diop University in Dakar Albert Royer Children’s Hospital in Dakar Dakar Senegal Gaston Berger University of Saint Louis Saint Louis Regional Hospital Saint Louis Senegal

The World Health Organization declared that corona virus diseases-19 (COVID-19) is a public health emergency. The COVID-19 pandemic is more likely to cause disaster in developing area including West Africa due to limited medical resources. COVID-19 reportedly causes severer conditions in adults with advanced age and in patients with underlying comorbidities including sickle cell anemia. We recently experienced two pediatric patients with sickle cell disease (SS), who had COVID-19. We here highlight the difficulties of management and the severity of COVID-19 infection in children with homozygous sickle cell SS.

关键词： COVID 19 Infection Sickle Cell Disease Child

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Trace Metals in Mussels <i>Mytilus galloprovincialis</i>from Dakar Coast (Senegal)

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American Journal of Analytical Chemistry 2020年第3期11卷 137-145页

作者： Birame Ndiaye Momar Ndiaye Benita Pérez Cid Abdoulaye Diop ibrahima diagne Dame Cissé Cheikh Tidiane Dione Maoudo Hanne Department of Chemistry Faculty of Science and Technology Cheikh Anta Diop University Dakar Senegal Department of Analytical and Food Chemistry Faculty of Chemistry University of Vigo Vigo Spain

Mussel samples from the Dakar coast (Senegal) were analysed using Inductively Coupled Plasma-Mass Spectrometry (ICP-MS). Microwave acid digestion was also employed for metals (Mn, Pb, Cd, As) determination. Dakar coast usually receives numerous domestic and industrial discharges without prior treatment. The contents of Arsenic were, in all cases, higher than other metals. However, the bivalve molluscs present themselves as effective bio-monitors when assessing marine aquatic pollution by contaminants in the Dakar coast. The ANOVA analysis allows concluding that significant differences were found between mussels from different sampling points. In all cases, the February samples have in all cases a higher content than those collected in October.

关键词： Mytilus galloprovinciali Trace Element Dakar Coast Pollution

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Epidemiological, Diagnostic and Therapeutic Aspects of Cardiogenic Shock in Children at the Albert Royer Children’s Hospital in Dakar

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Open Journal of Pediatrics 2021年第4期11卷 669-675页

作者： Mohameth Mbodj Amadou Lamine Fall Aliou Thiongane ibrahima diagne Amadou Sow Serigne T. Ndiaye Khadim Bop Papa S. Sow Ousmane Ndiaye Albert Royer National Children Hospital Dakar Senegal Cheikh Anta Diop University Dakar Senegal Gaston Berger University Saint Louis Senegal Saint Louis Regional Hospital Saint Louis Senegal Abass Ndao Hospital Center Dakar Senegal

Introduction: The objective of this study was to evaluate the epidemiological, diagnostic and therapeutic aspects of cardiogenic shock in children at the Albert Royer Children’s Hospital in Dakar. Methods: This was a retrospective, descriptive and analytical study from January 2020 to February 2021, including all children aged 2 months to 16 years hospitalised for cardiogenic shock diagnosed on the basis of clinical and ultrasound criteria. Results: During the study, 38 patients were hospitalised for cardiogenic shock. The hospital prevalence was 4.2%. The mean age of onset of shock was 64 months, and there was a predominance of females with a sex ratio of 1.92. Consanguinity was found in 42% of the patients. Consanguinity was found in 42% of patients. Infection was identified as a trigger for cardiogenic shock in 18 (52.9%) of our patients. The most common type of heart disease was rheumatic heart disease in 12 (32%) of the patients. The mortality rate was 65.8%. Conclusion: Cardiogenic shock is a diagnostic and therapeutic emergency. Its prevalence and mortality are still high in developing countries.

关键词： Heart Disease Consanguinity CMDH Shortening Fraction Senegal

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Primary Immune Deficiencies (PID): Diagnosis Challenges

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Open Journal of Pediatrics 2021年第3期11卷 388-392页

作者： Indou Deme/ly Awa Kane Mame Sokhna Gueye ibrahima Diop Mame Tene Ndiaye Abou Ba Idrissa Demba Ba Babacar Niang Aliou Thiongane Yaay Joor Dieng Yaye Fatou Mbodj/Diop Ouafae Achnin Papa Moctar Faye Amadou Lamine Fall ibrahima diagne Tandakha Ndiaye Dièye Ousmane Ndiaye Albert Royer National Children’s Hospital Center Université Cheikh Anta Diop Dakar Senegal National Blood Transfusion Center Dakar Senegal Health Science Unit Gaston Berger University Saint -Louis Senegal

Background: Primary Immune Deficiencies (PID) are rare, under-determined diseases particularly in sub-Saharan Africa. The diagnosis is often suspected with uncommon clinical signs. Infections are the main diagnostic circumstances in infants. Confirmation is often difficult because some additional examinations are unavailable in many of our countries. Aim: Our aim was to share the challenge of diagnosis and treatment in PID. Case Presentation: It is about two infants, a boy and a girl, with early several infections. Both of them presented a hypo-gammaglobulinemia and to the boy, the immuno-phenotyping lymphocyte showed a decreased level of lymphocytes CD19. We are looking for genetic confirmation but it is not easy. The treatment of these infants requires a substitution for life of immunoglobulin which is unavailable in our countries. Conclusion: PID are suspected with atypical clinical signs. Confirmation genetic diagnosis is difficult in low income countries. To improve the follow up, we need to strengthen clinical-biological collaboration.

关键词： Primary Immune Deficiencies Hypo-Gammaglobulinemia Infants

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Results of the First 10 Cases of Coronary Bypass Surgery in Senegal

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World Journal of Cardiovascular Surgery 2024年第4期14卷 45-60页

作者： Papa Amath diagne Jean Claude Ndiogou Dione Papa Ousmane Ba Momar Sokhna Diop El Hadji Boubacar Ba Momar Dioum Marième Soda Mbaye Moussa Seck Diop Mory Camara Abdou Lahad Mbengue Abdou Aziz Thiaw Abdoul Khoudoss Diallo Moussa Mareme Samba Dialtabé ibrahima Guéssé Ba Anta Mbaye Sall Papa Salmaneba Amadou Gabriel Ciss Department of Cardiovascular and Thoracic Surgery FANN National University Hospital Dakar Senegal

This is a review of the first 10 coronary artery bypass surgeries performed by the local team. The mean age was 62 years old [45 - 74]. The patients were predominantly male, with a M/F ratio of 4:1. Cardiovascular risk factors were mainly myocardial infarction (MI) (60%), hypertension (50%), obesity (40%) and diabetes (30%), with at least two risk factors per patient. Angina was the main symptom (80%). The average time from presentation to surgery was 8 months. The mean Euroscore 2 was 2.92 ± 1.65 [1.33 - 6.60]. Coronary angiography revealed an average of 2 lesions per patient, with 3-vessel involvement in 70% of cases: the Interventricular artery (IVA) (100%), the right coronary artery (90%) and the circumflex artery (70%). On echocardiography, the mean Left ventricular ejection fraction (LVEF) was 59% [33% - 76%]. All patients underwent median sternotomy with bypass grafting. The average duration of the cardiopulmonary bypass was 150 min [46 - 275 min];that of aortic clamping, 120 min [43 - 232 min]. The grafts used were internal thoracic artery (ITA) in 100% of cases (80% on the left and 20% on the right), and the great saphenous vein (GSV) in 60% of cases (50% on the left and 10 on the right). Double bypass was performed in 60% of cases, single bypass in 30% and triple bypass in 10%. The bypasses were performed on the IVA (100%), the middle lateral of the circumflex (30%) and the bisector (20%). The average time to extubation was 11 hours and the length of stay in the intensive care unit was 7 days [03 - 17 days]. One patient had a reoperation on Day 0 post-op. The average hospital stay was 13 days [06 - 27 days]. Complications occurred in nine of the patients (90%), with a predominance of infectious and neurological complications. Overall operative mortality was 3%, all in intensive care.

关键词： Coronary Bypass Surgery Coronary Lesions Cardiac Surgery Senegal

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Acute Bilirubin Encephalopathy: A Propos of 151 Cases Collected during a Multicentric Study in Senegal

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Open Journal of Pediatrics 2023年第1期

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