Malaria Characteristics in Children with Sickle Cell Disease

作     者：Indou Deme/Ly Cheikh Binetou Fall Awa Kane Ibrahima Diop Aminata Mbaye Yaaye Joor Dieng Denika Estelle Liapoui Idrissa Demba Ba Abou Ba Aliou Thiongane Papa Moctar Faye Amadou Lamine Fall Ibrahima Diagne Ousmane Ndiaye Indou Deme/Ly;Cheikh Binetou Fall;Awa Kane;Ibrahima Diop;Aminata Mbaye;Yaaye Joor Dieng;Denika Estelle Liapoui;Idrissa Demba Ba;Abou Ba;Aliou Thiongane;Papa Moctar Faye;Amadou Lamine Fall;Ibrahima Diagne;Ousmane Ndiaye

作者机构：Cheikh Anta Diop University Dakar Senegal Gaston Berger University Saint-Louis Senegal 

出 版 物：《Open Journal of Pediatrics》 (儿科学期刊（英文）)

年 卷 期：2022年第12卷第1期

页      面：125-130页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Malaria Sickle Cell Disease Children 

摘      要：Background: The relationship between sickle cell disease and malaria is the subject of much controversy. However, there is a lack of data in our services. Our objective was to study the epidemiological, diagnostic and evolutionary characteristics of malaria in children with sickle cell disease followed in a specialized setting. Patients and Methods: We conducted a retrospective, descriptive, and analytical study of children with sickle cell disease (SCD) who presented with malaria and were followed at the Ambulatory Care Unit for Sickle Cell Children and Adolescents (USAD) at the Albert Royer National Children’s Hospital in Dakar, from January 1st, 2017, to December 31th, 2019. We included all the followed pediatric patients, less than 16 years, with sickle cell disease who presented at least one episode of malaria, confirmed by a positive thick drop, during this 3 years. We did not include patients with incomplete records or those older than 16 years. The clinical and biological signs, the follow up was collected and analyzed with Excel package 2019. Results: Of 3773 patients followed for sickle cell disease, 21 had presented malaria. The frequency was 0.5% or 7 cases/year. However, we exploited the data of 14 of them. The sex ratio was 6 boys for a girl and the mean age at admission was 7.3 years. The highest number of malaria cases was observed in 2018 and the peak frequency was observed in November with 8 cases (57.1%). Fever was the most frequent symptom, observed in 10 patients (71.4%). All patients were SS homozygous, with a mean baseline hemoglobin level of 7.5g/dl. All patients had a positive thick blood smear and Plasmodium falciparum was the only species found in the blood smear, with a mean parasite density of 1693 parasites/ml of blood. All patients had anemia, with a mean hemoglobin level of 7.74 g/dl. Twelve patients (85.7%) were hospitalized and had all received injectable artesunate followed by oral Artemisinin Combination Ther