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Ciliotherapy： a novel intervention in polycystic k.dney disease

Journal of Geriatric Cardiology 2014年第1期11卷 63-73页

作者： Sarmed H. k.them Ashraf M. Mohieldin Shak.la Abdul-Majeed Sajida H. Ismail Qaiss H. Altaei ibrahim k. alshimmari Mohanned M. Alsaidi Hussein k.ammas Andromeda M. Nauli Bina Joe Surya M. Nauli Centerfor Hypertension and Personalized Medicine University of Toledo Health Science Building Room 312 3000 Arlington Ave. Toledo OH 43614 USA Department of Pharmacology University of Toledo Health Education Building Room 274 3000 Arlington Ave. Toledo OH 43614 USA College of Pharmacy University of Baghdad Bab-Almoadhum 14026 Baghdad Iraq k.dney Disease and Transplant Center Medical City Complex Bab-Almoadhum 14026 Baghdad Iraq Alk.dhumia Academic Hospital Bab-Almoadhum 14026 Baghdad Iraq pharmaceutical & Biomedical Sciences California Northstate University 10811 International Drive Rancho Cordova CA 95670 USA

Back.round Ciliopathies are a group of diseases associated with abnormal structure or function of primary cilia. Ciliopathies include polycystic k.dney disease （Pk.）, a pathology associated with vascular hypertension. We previously showed that cilia length regulates cilia function, and cilia function is required for nitric oxide （NO） biosynthesis in endothelial cells. Because patients with Pk. show abnormal sensory cilia function, the aim of our current study was to search for a targeted therapy focused on primary cilia, which we refer to as ＇cilio- therapy＇. Methods and Results In the present studies, our in vitro analyses refined fenoldopam as an equipotent and more specific dopa- minergic agonist to regulate cilia length and function. Our in vivo studies indicated that fenoldopam increased cilia length and serum NO thereby reducing blood pressure in a Pk. mouse model. Our crossover, multicenter, double-blind and placebo-controlled clinical study further indicated that cilia-targeting therapy showed an overall reduction in mean arterial pressure in Pk. patients. Conclusions Overall, our studies provide the first evidence of ciliotherapy as an innovative intervention in patients with abnormal primary cilia.

关键词： Primary cilium Blood pressure Mechanosensor Mechanotransduction Chemosensor Fluid-shear stress

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Classifying rock.urst with confidence:A novel conformal prediction approach

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International Journal of Mining Science and Technology 2024年第1期34卷 51-64页

作者： Bemah ibrahim Isaac Ahenk.rah University of South Australia UniSA STEMSA 5000Australia

The scientific community recognizes the seriousness of rock.ursts and the need for effective mitigation *** literature reports various successful applications of machine learning(ML)models for rock.urst assessment;however,a significant question remains unanswered:How reliable are these models,and at what confidence level are classifications made?Typically,ML models output single rock.urst grade even in the face of intricate and out-of-distribution samples,without any associated confidence *** the susceptibility of ML models to errors,it becomes imperative to quantify their uncertainty to prevent consequential *** address this issue,we propose a conformal prediction(CP)framework.built on traditional ML models(extreme gradient boosting and random forest)to generate valid classifications of rock.urst while producing a measure of confidence for its *** proposed framework.guarantees marginal coverage and,in most cases,conditional coverage on the test *** CP was evaluated on a rock.urst case in the Sanshandao Gold Mine in China,where it achieved high coverage and efficiency at applicable confidence ***,the CP identified several“confident”classifications from the traditional ML model as unreliable,necessitating expert verification for informed *** proposed framework.improves the reliability and accuracy of rock.urst assessments,with the potential to bolster user confidence.

关键词： Rock.urst Machine learning Uncertainty quantification Conformal prediction

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A numerical investigation into the effect of altering compression ratio, injection timing, and injection duration on the performance of a diesel engine fuelled with diesel-biodiesel-butanol blend

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Clean Energy 2024年第5期8卷 73-96页

作者： Abdulk.rim Youssef Amr ibrahim Mechanical Engineering Department Beirut Arab University115020 BeirutLebanon Mechanical Engineering Department Alexandria UniversityAlex 21544Egypt

Using renewable fuels for diesel engines can reduce both air pollution and dependence on fossil fuels.A computer simulation was constructed to predict the performance,combustion characteristics,and NOx emissions of a diesel engine fuelled with diesel-biodiesel-butanol *** simulation was validated by comparing the modelling results against experimental data and a good agreement between the results was *** fuels used for the validation were diesel(B0),biodiesel(B100),diesel-biodiesel blend(B50),and two diesel-biodiesel-butanol blends with 45%diesel-45%biodiesel-10%butanol(Bu10)and 40%diesel-40%biodiesel-20%butanol(Bu20)by *** results showed that the addition of butanol reduced NOx emissions but deteriorated the engine *** aim of the current work.was the numerical optimization of the different parameters to enhance the engine performance while using butanol to decrease NOx *** engine compression ratio(CR)varied from 14 to 24,in increments of *** injection timing(IT)was reduced from 30°before top dead centre(bTDC)to 5°bTDC in increments of 5°.Also,the fuel injection duration(IDur)was extended from 20°to 50°in increments of 10°.Results showed that the increase in the CR improved engine performance for the two investigated fuels,Bu10 and *** maximum engine brak. power(BP),thermal efficiency(BTE),and minimum brak.-specific fuel consumption(BSFC)of 1.46 k.,32.3%,and 0.273 k./k.h respectively,were obtained when the Bu10 fuel was injected under the optimum conditions of 24 CR,15°bTDC IT,and 40°*** these optimum conditions,the BP,BTE,and BSFC improved by 3%-3.5%for Bu10 and Bu20 fuel blends compared with the base engine conditions of a CR of 22,30°IDur,and 10°bTDC *** heat release rate during the premixed phase increased when the IT was advanced,while the mixing-controlled combustion phase was enhanced when the IT was *** emissions increased with increasing CR,while both an increase in IDur at con

关键词： compression ratio injection timing injection duration butanol biodiesel diesel

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New insights into astrocyte diversity from the lens of transcriptional regulation and their implications for neurodegenerative disease treatments

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Neural Regeneration Research 2024年第11期19卷 2335-2336页

作者： ibrahim Olabayode Saliu Guoyan Zhao Department of Genetics Washington University School of MedicineSt.LouisMOUSA Department of Neurology Department of Pathology and ImmunologyWashington University School of MedicineSt.LouisMOUSA

Astrocytes are a major glial cell type in the central nervous system,and they provide trophic and metabolic support to *** addition to these roles,they play crucial roles in modulating synaptic functions,development,and pruning(Brandebura et al.,2023).Astrocytes become reactive(activated)by undergoing morphological,molecular,and functional alterations in response to neuropathology such as in injuries and neurodegenerative diseases(NDs)(Escartin et al.,2021).

关键词： degenerative injuries

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Enhancing Wireless Sensor Network.Efficiency through Al-Biruni Earth Radius Optimization

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Computers, Materials & Continua 2024年第6期79卷 3549-3568页

作者： Reem ibrahim Alk.nhel Doaa Sami k.afaga Ahmed Mohamed Zak. Marwa M.Eid Abdyalaziz A.Al-Mooneam Abdelhameed ibrahim S.k.Towfek Department of Information Technology College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Computer Science and Intelligent Systems Research Center BlacksburgVirginia24060USA Delta Higher Institute for Engineering and Technology Mansoura35511Egypt Faculty of Artificial Intelligence Delta University for Science and TechnologyMansoura35712Egypt Artificial Intelligence and Computational Intelligence Research Center MeridenConnecticut06450USA School of ICT Faculty of EngineeringDesign and Information&Communications Technology(EDICT)Bahrain PolytechnicP.O.Box 33349Isa TownBahrain

The network. of wireless sensors provide the ground for a range of applications,including environmental moni-toring and industrial *** the network. can overcome obstacles lik. power and communication reliability and sensor coverage is the crux of network.*** infrastructure planning should be focused on increasing performance,and it should be affected by the detailed data about node *** work.recommends the creation of each sensor’s specs and radius of influence based on a particular geographical location,which will contribute to better network.planning and *** using the ARIMA model for time series forecasting and the Al-Biruni Earth Radius algorithm for optimization,our approach bridges the gap between successive terrains while seek.ng the equilibrium between exploration and *** implementing adaptive protocols according to varying environments and sensor constraints,our study aspires to improve overall network.*** compare the Al-Biruni Earth Radius algorithm along with Gray Wolf Optimization,Particle Swarm Optimization,Genetic Algorithms,and Whale Optimization about performance on real-world *** the most efficient in the optimization process,Biruni displays the lowest error rate at *** two other statistical techniques,lik. ANOVA,are also useful in discovering the factors influencing the nature of sensor data and network.specific *** to the multi-faceted support the comprehensive approach promotes,there is a chance to understand the dynamics that affect the optimization outcomes better so decisions about network.design can be *** delivering better performance and reliability for various in-situ applications,this research leads to a fusion of time series forecasters and a customized optimizer algorithm.

关键词： Wireless sensor network. optimization ARIMA model BER algorithm metaheuristic algorithms

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Enteric neuropathy in diabetes:Implications for gastrointestinal function

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World Journal of Gastroenterology 2024年第22期30卷 2852-2865页

作者： Mona Mohamed ibrahim Abdalla Department of Human Biology School of MedicineInternational Medical UniversityBukit Jalil 57000Kuala LumpurMalaysia

Diabetes,commonly k.own for its metabolic effects,also critically affects the enteric nervous system(ENS),which is essential in regulating gastrointestinal(GI)motility,secretion,and *** development of diabetes-induced enteric neuropathy can lead to various GI dysfunctions,such as gastroparesis and irregular bowel habits,primarily due to disruptions in the function of neuronal and glial cells within the ENS,as well as oxidative stress and *** editorial explores the pathophysiological mechanisms underlying the development of enteric neuropathy in diabetic ***,it discusses the latest advances in diagnostic approaches,emphasizing the need for early detection and intervention to mitigate GI complications in diabetic *** editorial also reviews current and emerging therapeutic strategies,focusing on pharmacological treatments,dietary management,and potential neuromodulatory ***,this editorial highlights the necessity of a multidisciplinary approach in managing enteric neuropathy in diabetes,aiming to enhance patient quality of life and address a frequently overlook.d complication of this widespread disease.

关键词： Diabetic neuropathy Gastrointestinal Insulin resistance Diabetes Enteric nervous system Enteric neuropathy

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Numerical modelling and simulation analysis of wind blades:a critical review

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Clean Energy 2024年第1期8卷 261-279页

作者： ibrahim Alrowwad Xiaojia Wang Ningling Zhou k.y Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 210096China

Wind energy has emerged as a promising renewable energy source and wind turbine technology has developed rapidly in recent *** wind turbine performance depends heavily on the design and optimization of wind *** work.offers a critical evaluation of the state of the art in the field of numerical modelling and simulation analysis,which have become crucial for the design and optimization of wind *** evaluation of the literature includes considerable research on the application of numerical methods for the structural and aerodynamic performance of wind blades under various operating situations,as well as for analysis and optimization of wind *** article illustrates how numerical techniques can be used to analyse wind blade performance and maximize design *** study of blade performance under various wind conditions has also been made possible through the use of simulation analysis,thus enhancing the efficiency and dependability of wind *** in wind turbine efficiency and dependability,and ultimately the move towards a more sustainable energy future,will be greatly helpful for the development of numerical modelling and simulation techniques.

关键词： wind blades simulations optimization numerical analysis mathematical modelling performance

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Relational Turk.sh Text Classification Using Distant Supervised Entities and Relations

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Computers, Materials & Continua 2024年第5期79卷 2209-2228页

作者： Halil ibrahim Ok.r k.dir Tohma Ahmet Sertbas Department of Computer Engineering Faculty of Engineering and Natural SciencesIskenderun Technical UniversityHatay31200Turkey Department of Computer Engineering Faculty of EngineeringIstanbul University-CerrahpasaIstanbul34310Turkey

Text classification,by automatically categorizing texts,is one of the foundational elements of natural language processing *** study investigates how text classification performance can be improved through the integration of entity-relation information obtained from the Wik.data(Wik.pedia database)database and BERTbased pre-trained Named Entity Recognition(NER)*** on a significant challenge in the field of natural language processing(NLP),the research evaluates the potential of using entity and relational information to extract deeper meaning from *** adopted methodology encompasses a comprehensive approach that includes text preprocessing,entity detection,and the integration of relational *** conducted on text datasets in both Turk.sh and English assess the performance of various classification algorithms,such as Support Vector Machine,Logistic Regression,Deep Neural Network.and Convolutional Neural *** results indicate that the integration of entity-relation information can significantly enhance algorithmperformance in text classification task. and offer new perspectives for information extraction and semantic analysis in NLP *** of this work.include the utilization of distant supervised entity-relation information in Turk.sh text classification,the development of a Turk.sh relational text classification approach,and the creation of a relational *** demonstrating potential performance improvements through the integration of distant supervised entity-relation information into Turk.sh text classification,this research aims to support the effectiveness of text-based artificial intelligence(AI)***,it mak.s significant contributions to the development ofmultilingual text classification systems by adding deeper meaning to text content,thereby providing a valuable addition to current NLP studies and setting an important reference point for future research.

关键词： Text classification relation extraction NER distant supervision deep learning machine learning

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(Sm/Eu/Tm)^(3+) doped tantalum semiconductor system for photovoltaic and electrochemical functionality amplification

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Journal of Rare Earths 2024年第8期42卷 1586-1594,I0007页

作者： Shaan Bibi Jaffri k.uram Shahzad Ahmad Isaac Abrahams ibrahim A.A Materials and Environmental Chemistry Lab Lab-E21Department of Environmental SciencesFatima Jinnah Women UniversityRawalpindiPakistan School of Physical and Chemical Sciences Queen Mary University of LondonLondonUnited Kingdom Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box 2455Riyadh11451Saudi Arabia

This work.reports the synthesis,characterization,and energy focused applications of the novel lanthanides co-doped tantalum pentoxide hetero-system(Sm^(3+)-Eu^(3+)-Tm^(3+):Ta_(2)O_(5)).Ln^(3+)-doped Ta_(2)O_(5) express excellent opto-electronic features reflected by the narrow band gap energy of 3.87 *** vibrations confirm the presence of Ta-O-Ta and Ta-O *** synthesized system possesses orthorhombic geometry with 59.46 nm particle *** the smoother and compact morphology,the synthesized material succeeds in augmenting the performance of different systems aimed at energy *** ambient perovsk.te solar cell device fabricated with the Ln^(3+)-doped Ta_(2)O_(5) as an electron transport layer excels in achieving an efficiency and fill factor of 14.17% and 76% under artificial *** device was mark.d by the negligible hysteresis behavior showing profound photovoltaic *** electrochemical activity of the Ln^(3+)-doped Ta_(2)O_(5) decorated electrode was evaluated for electrical charge storage potential with pseudocapacitive behavior,With the highest specific capacitance of 355.39 F/g and quick.r ionic diffusion rate,the designed electrode excels conventionally used ***-catalysis of water with Ln^(3+)-doped Ta_(2)O_(5) material indicates its capacity for H_(2) production with the lowest overpotential and Tafel slope values of 148 and 121.2 mV/dec,while the O_(2) generation is comparatively *** the stable electrochemical output,this rare earth modified material has the potential to replace conventionally used environmentally perilous and costly materials.

关键词： Lanthanide doping Rare earth materials Perovsk.te solar cells Supercapacitors Water splitting

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Insulin resistance as the molecular link.between diabetes and Alzheimer's disease

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World Journal of Diabetes 2024年第7期15卷 1430-1447页

作者： Mona Mohamed ibrahim Abdalla Department of Human Biology School of MedicineInternational Medical UniversityBukit Jalil 57000Kuala LumpurMalaysia

Diabetes mellitus(DM)and Alzheimer's disease(AD)are two major health concerns that have seen a rising prevalence *** studies have indicated a possible link.between DM and an increased risk.of developing ***,while primarily k.own for its role in regulating blood sugar,also plays a vital role in protecting brain *** resistance(IR),especially prevalent in type 2 diabetes,is believed to play a significant role in AD's *** insulin signalling becomes dysfunctional,it can negatively affect various brain functions,mak.ng individuals more susceptible to AD's defining features,such as the buildup of beta-amyloid plaques and tau protein *** research suggests that addressing insulin-related issues might help reduce or even reverse the brain changes link.d to *** review aims to explore the relationship between DM and AD,with a focus on the role of *** also explores the molecular mechanisms by which IR might lead to brain changes and assesses current treatments that target *** IR's role in the connection between DM and AD offers new possibilities for treatments and highlights the importance of continued research in this interdisciplinary field.

关键词： Alzheimer's disease Insulin resistance Obesity Dementia Diabetes Metabolic syndrome

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