New insights into astrocyte diversity from the lens of transcriptional regulation and their implications for neurodegenerative disease treatments

作     者：Ibrahim Olabayode Saliu Guoyan Zhao Ibrahim Olabayode Saliu;Guoyan Zhao

作者机构：Department of GeneticsWashington University School of MedicineSt.LouisMOUSA Department of NeurologyDepartment of Pathology and ImmunologyWashington University School of MedicineSt.LouisMOUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2024年第19卷第11期

页      面：2335-2336页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：supported in part by the R21AG077643,R01NS123571,1U19NS130607,and 5T U24 HG012070(to GZ) in part by Alzheimer Association Fellowship Award 23AARFD-1029969(to IOS) 

主　　题：degenerative injuries 

摘      要：Astrocytes are a major glial cell type in the central nervous system,and they provide trophic and metabolic support to *** addition to these roles,they play crucial roles in modulating synaptic functions,development,and pruning(Brandebura et al.,2023).Astrocytes become reactive(activated)by undergoing morphological,molecular,and functional alterations in response to neuropathology such as in injuries and neurodegenerative diseases(NDs)(Escartin et al.,2021).