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Frontiers of Agricultural Science and Engineering 2021年第4期8卷 568-582页

作者： ian T.RILEY Department of Plant Production and Technologies Faculty of Agricultural Science and TechnologiesNi?de Omer Halisdemir UniversityNigde 51240Turkey

Agroecosystems in water-limited contexts—Mediterranean,semi-arid and arid climatic zones—are too frequently degraded systems that will not provide the needed ecosystem services to ensure a future of sustainable agricultural *** processes that have created this situation continue and are being accelerated by anthropogenic climate *** arboreal vegetation in these areas through agroforestry is an important strategy to conserve and improve their *** trees and shrubs in the Casuarinaceae have a unique set of adaptations for heat and water stress,and/or infertile to hostile *** Anatolia,Turkey is particularly at risk of increasing aridity and further ***,species of Allocasuarina and Casuarina have been evaluated for their potential use in agroecosystem improvement in semi-arid areas with a focus on Central *** on a semiquantitative environmental tolerance index and reported plant stature,eight species were identified as being of high(*** and ***)to moderate(***,***,***,***,*** and ***)priority for assessment,with none of these species having been adequately evaluated for agroforestry deployment in semi-arid agroecosystems in any context.

关键词： actinorhizal trees agroforestry climate change ecosystem restoration

Barriers that practitioners face when initiating insulin therapy in general practice settings and how they can be overcome

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World Journal of Diabetes 2017年第1期8卷 28-39页

作者： Abdulaziz Bin rsheed ian Chenoweth Department of Family and Community Medicine Prince Sultan Military Medical City Department of General Practice School of Primary Health Care Faculty of MedicineNursing and Health Sciences Monash University

AIM To explore primary care physicians' perspectives on possible barriers to the use of *** This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Eight electronic databases were searched(between January 1, 1994 and August 31, 2014) for relevant studies. A search for grey literature and a review of the references in the retrieved studies were also conducted. Studies that focused on healthcare providers' perspectives on possible barriers to insulin initiation with type 2 diabetic patients were included, as well as articles suggesting solutions for these barriers. Review articles and studies that only considered patients' perspectives were excluded. RESULTS A total of 19 studies met the inclusion criteria and were therefore included in this study: 10 of these studies used qualitative methods, 8 used quantitative methods and 1 used mixed methods. Studies included a range of different health care settings. The findings are reported under four broad categories: The perceptions of primary care physicians about the barriers to initiate insulin therapy for type 2 diabetes patients, how primary care physicians assess patients prior to initiating insulin, professional roles and possible solutions to overcome these barriers. The barriers described were many and covered doctor, patient, system and technological aspects. Interventions that focused on doctor training and support, or IT-based decision support were few, and did not result in significant improvement. CONCLUSION Primary care physicians' known delay in insulin initiation is multifactorial. Published reports of attempts to find solutions for these barriers were limited in number.

关键词： Diabetes Insulin Initiation Delay Barriers Primary care physicians

Nitric oxide: orchestrating hypoxia regulation through mitochondrial respiration and the endoplasmic reticulum stress response

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Cell Research 2005年第1期15卷 63-65页

作者： ian G. CHARLES,Salvador MONCADA Wolfson Institute for Biomedical Research University College London The Cruciform Building Gower Street London WC1E 6BT UK Wolfson Institute for Biomedical Research University College London The Cruciform Building Gower Street London WC1E 6BT UK

Mitochondria have long been considered to be the powerhouse of the living cell, generating energy in the form of the molecule ATP via the process of oxidative phosphorylation. In the past 20 years, it has been recognised that they also play an important role in the implementation of apoptosis, or programmed cell death. More recently it has become evident that mitochondria also participate in the orchestration of cellular defence *** physiological concentrations, the gaseous molecule nitric oxide (NO) inhibits the mitochondrial enzyme cytochrome c oxidase (complex IV) in competition with oxygen. This interaction underlies the mitochondrial actions of NO, which range from the physiologi- cal regulation of cell respiration, through mitochondrial signalling, to the development of “metabolic hypoxia” – a situation in which, although oxygen is available, the cell is unable to utilise it.

关键词： nitric oxide hypoxia mitochondria endoplasmic reticulum stress.

Body image in paediatric burns: a review

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Burns & Trauma 2018年第2期6卷 93-98页

作者： ian C.C.King Department of Plastic and Reconstructive Surgery St George's HospitalTootingLondon SW170QTUK

Burn injuries in children can result in life-long disfigurement. As medical and surgical techniques of burn management improve survival prospects more than ever before, body image adjustment is increasingly a central consideration in the care of burn-injured individuals. An appreciation that both physiological and psychosocial processes underpin such injuries is key to understanding wound healing. Perceptions of idealized body images in Western society challenge children and their families as they grow up with and adapt to disfigurement from burns. Whilst many studies have examined the psychosocial recovery of adults with burn injuries, few have considered the impact on burn-injured children. This paper explores the models of body image and discusses the relevance of these to research and practice in understanding how to manage burns in children.

关键词： Burns Body image Children Paediatric burns Wound healing

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关系型数据库性能测试技术研究

计算机仿真 2024年第4期41卷 494-499页

作者：熊婧廉建芳杨攀飞华中科技大学湖北武汉430000 工业和信息化部电子第五研究所广东广州1510000 基础软硬件性能与可靠性测评工业和信息化部重点实验室广东广州510000

当前TPC-E基准测试系统存在的同种事务连续聚集和测试断尾会导致测试事务用例不佳,造成测试结果不准确。为此提出基于事务混合队列和延迟结束策略的事务分发控制方法来保障测试事务用例比从源头上最大限度接近基准规定。事务混合队列实... 详细信息

当前TPC-E基准测试系统存在的同种事务连续聚集和测试断尾会导致测试事务用例不佳,造成测试结果不准确。为此提出基于事务混合队列和延迟结束策略的事务分发控制方法来保障测试事务用例比从源头上最大限度接近基准规定。事务混合队列实现对测试事务用例混合比的整体控制。延迟结束策略消除了测试断尾造成的事务混合比波动。此外,为了降低资源损耗提出了动态线程池模型。上述模型能够在请求过多的情况下有效提高系统响应,在请求较少的情况下有效利用系统资源。最后将队列缓存机制引入测试系统。将高并发事物发送请求缓存到队列中,缓解了大量线程聚集创建带来的资源瞬时抢占问题。实验验证了测试系统的有效性、稳定性以及适配性。

关键词：事务分发控制动态线程池队列缓存高并发

Genome and metabolic engineering in non-conventional yeasts:Current advances and applications

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Synthetic and Systems Biotechnology 2017年第3期2卷 198-207页

作者： Ann-Kathrin Lobs Cory Schwartz ian Wheeldon Department of Chemical and Environmental Engineering UC RiversideRiversideUSA

Microbial production of chemicals and proteins from biomass-derived andwaste sugar streams is a rapidly growing area of research and *** the model yeast Saccharomyces cerevisiae is an excellent host for the conversion of glucose to ethanol,production of other chemicals from alternative substrates often requires extensive strain *** avoid complex and intensive engineering of ***,other yeasts are often selected as hosts for bioprocessing based on their natural capacity to produce a desired product:for example,the efficient production and secretion of proteins,lipids,and primary metabolites that have value as commodity *** when using yeasts with beneficial native phenotypes,metabolic engineering to increase yield,titer,and production rate is *** non-conventional yeasts Kluyveromyces lactis,***,Scheffersomyces stipitis,Yarrowia lipolytica,Hansenula polymorpha and Pichia pastoris have been developed as eukaryotic hosts because of their desirable phenotypes,including thermotolerance,assimilation of diverse carbon sources,and high protein ***,advanced metabolic engineering in these yeasts has been *** review outlines the challenges of using non-conventional yeasts for strain and pathway engineering,and discusses the developed solutions to these problems and the resulting applications in industrial biotechnology.

关键词： CRISPR-Cas9 Kluyveromyces lactis Kluyveromyces marxianus Scheffersomyces stipitis Yarrowia lipolytica Hansenula polymorpha Pichia pastoris

Protein Complexes Implicated in RNA Editing in Plant Organelles

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Molecular Plant 2017年第10期10卷 1255-1257页

作者： Bernard Gutmann Santana Royan ian Small ARC Centre of Excellence in Plant Energy Biology School of Molecular Sciences The University of Western Australia Crawley WA 6009 Australia

Even after 30 years of active research, RNA editing in plant organelles remains an enigma. Why do most plants post- transcriptionally alter hundreds or thousands of nucleotides in organellar transcripts？ How do they achieve such an effective and targeted process？ What is known is that in almost all plants, RNA editing is essential for correct synthesis of the photosynthetic and respiratory machinery in mitochondria and chloroplasts. The sites to be edited are defined by a large class of sequence-specific RNA binding proteins： pentatricopeptide repeat （PPR） proteins （Barkan and Small, 2014）. However, genetic and biochemical evidence has long suggested that other factors must be involved too. Two recent papers in Proceedings of the National Academy of Sciences USA provide exciting new evidence for protein complexes implicated in RNA editing using known mitochondrial or piastid PPR editing factors as bait in pull-down assays （Andres-Colás et al., 2017; Guillaumot et al., 2017）.

关键词： PENTATRICOPEPTIDE REPEAT PROTEINS MITOCHONDRIA PLASTIDS

Construction and Production of FluorescentPapillom avirus-like Particles

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Journal of Huazhong University of Science and Technology(Medical Sciences) 1999年第3期19卷 170-174,180页

作者： PENG Shiwen ZHOU Jian ian H Frazer Department of Pediatrics Xiehe HospitalTongji Medical UniversityWuhan 430022 Center for Immunology and Cancer Research University of QueenslandPrincess Alexandra HospitalWoolloongabbaQld4102Australia

The green fluorescent protein (GFP) from the jellyfish Aequorea victoria has attracted widespread interest since it was demonstrated to be fluorescent in vivo when expressed in other organisms. In order to investigate papillomavirus life cycle which hampered by the unavailability of conventional cell culture system, we constructed a chimeric bovine papillomavirus (BPV) type 1 virus like particles (VLPs) containing GFP. It was found that fluorescent VLPs could be assembled from L2 protein in which GFP is inserted into the N terminal region of L2 (aa 88). The fluorescent VLPs could also be assembled from a GFP/L2 fusion protein in which part of the L2 sequence had been deleted. In vitro , fluorescent VLPs could bind to CV 1 cells, and this VLP/cell interaction could be analyzed by FACS assay. These results demonstrated that GFP could incorporate into BPV1 VLPs without disruption of the VLP structure. Fluorescent VLPs might be a useful tool for study of papillomavirus virus/cell interaction.

关键词： papillomavirus \ virus like particles \ green fluorescent protein

Integration of Chinese Medicine and Western Medicine in Clinical Practice(Patient Care):Past,Present,and A Proposed Model for the Future

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Chinese Journal of Integrative Medicine 2013年第2期19卷 83-85页

作者： ian Tsang Simon Huang Barry Koehler Division of Rheumatology Department of MedicineUniversity of British ColumbiaVancouverBCCanada

Historic Background Chinese medicine （CM） has over 2,000 years of history in China and was the only health care system providing care for Chinese prior to the introduction of Western medicine （WM） into China. WM was slowly introduced into China by missionaries from the middle 17th century to the beginning of the 19th century. By 1840, WM began to take root in China. Western hospitals, clinics, medical schools and nursing schools spread rapidly throughout the country. At that time, with the might and power portrayed by Western countries,

关键词： Patient Care Past,Present,and A Proposed Model for the Future WM

Psychological Outcomes in Disaster Responders: A Systematic Review and Meta-Analysis on the Effect of Social Support

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International Journal of Disaster Risk Science 2018年第3期9卷 344-358页

作者： Johnrev Guilaran ian de Terte Krzysztof Kaniasty Christine Stephens School of Psychology Massey University Division of Social Sciences University of the Philippines Visayas Department of Psychology Indiana University of Pennsylvania Polish Academy of Sciences

Disaster response work is associated with various psychological outcomes. In post-disaster conditions,social support is generally observed to impact mental health, particularly for survivors. This review was conducted to survey the extent of social support effectiveness on disaster responder groups. Published quantitative social support studies on police, emergency medical responders,rescue and recovery workers, firefighters, and military responders were searched in various academic databases using keyword searches, a reference list search, and a citation search that resulted in 24 studies with 90 effect sizes being included in the final data base. Articles were coded and effect sizes were averaged using the Hedges–Vevea Random Effects model. Nineteen categories of psychological outcomes(for example, anxiety, depression,posttraumatic stress symptoms, and psychological distress)and eight classifications of support were coded. Social support was found to be associated with anxiety, burnout,depression, job control, job satisfaction, psychological distress, turnover intentions, and work engagement, with mean effect sizes from-0.36 to 0.57. Most studies measured perceived social support and negative *** support correlated with outcomes in police responders and rescue and recovery workers. This review discusses the breadth of effect of social support, as well as other elements, such as temporal factors, that may affect the effectiveness of social support in disaster responders.

关键词： Disaster responders Meta-analysis Post-disaster psychological outcomes Psychological distress Social support