Nitric oxide: orchestrating hypoxia regulation through mitochondrial respiration and the endoplasmic reticulum stress response

作     者：Ian G. CHARLES Salvador MONCADA 

作者机构：UK University College London Wolfson Institute for Biomedical Research Gower Street The Cruciform Building WC1E 6BT 

出 版 物：《Cell Research》 (细胞研究(英文版))

年 卷 期：2005年第15卷第1期

页      面：63-65页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

主　　题：nitric oxide hypoxia mitochondria endoplasmic reticulum stress. 

摘      要：Mitochondria have long been considered to be the powerhouse of the living cell, generating energy in the form of the molecule ATP via the process of oxidative phosphorylation. In the past 20 years, it has been recognised that they also play an important role in the implementation of apoptosis, or programmed cell death. More recently it has become evident that mitochondria also participate in the orchestration of cellular defence *** physiological concentrations, the gaseous molecule nitric oxide (NO) inhibits the mitochondrial enzyme cytochrome c oxidase (complex IV) in competition with oxygen. This interaction underlies the mitochondrial actions of NO, which range from the physiologi- cal regulation of cell respiration, through mitochondrial signalling, to the development of “metabolic hypoxia – a situation in which, although oxygen is available, the cell is unable to utilise it.