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Fitness consequences of altering floral circadian oscillations for Nicotiana attenuata

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Journal of Integrative Plant Biology 2017年第3期59卷 180-189页

作者： Felipe Yon Danny Kessler Youngsung Joo Lucas Cortes Llorca Sang-Gyu Kim ian t. Baldwin Department of Molecular Ecology Max Planck Institute for Chemical Ecology Hans-Knoll-Straβe 8 D-07745 Jena Germany Center for Genome Engineering Institute for Basic Science Yuseong-gu 34047 Daeieon South Korea

Ecological interactions between flowers and pollinators are all about timing. Flower opening/closing and scent emissions are largely synchronized with pollinator activity, and a circadian clock regulates these rhythms. However, whether the circadian clock increases a plant＇s reproductive success by regulating these floral rhythms remains untested. Flowers of Nicotiana attenuata, a wild tobacco, diurnally and rhythmically open, emit scent and move vertically through a 140° arc to interact with nocturnal hawkmoths. We tethered flowers to evaluate the importanceof flower positions for Manduca flower position dramatically sexta-mediated pollinations; nfluenced pollination. We examined the pollination success of phase-shifted flowers, silenced in circadian clock genes, NaZtL, NaLHY, and NatOCI, by RNAi. Circadian rhythms in N. attenuata flowers are responsible for altered seed set from outcrossed pollen.

关键词： Yonggen Lou Zhejiang University China

Nitric oxide regulation of plant metabolism

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Molecular Plant 2022年第2期15卷 228-242页

作者： Kapuganti Jagadis Gupta Vemula Chandra Kaladhar teresa B.Fitzpatrick Alisdair R.Fernie ian Max Møller Gary J.Loake National Institute of Plant Genome Research Aruna Asaf Ali MargNew DelhiDelhi 110067 India Vitamins and Environmental Stress Responses in Plants Department of Botany and Plant BiologyUniversity of GenevaGeneva 1211 Switzerland Max-Planck-Institute of Molecular Plant Physiology Am Mühlenberg 1Potsdam-Golm 14476 Germany Department of Molecular Biology and Genetics Aarhus UniversityForsøgsvej 14200 SlagelseDenmark Institute of Molecular Plant Sciences School of Biological SciencesUniversity of EdinburghEdinburgh EH93BFUK

Nitric oxide(NO)has emerged as an important signal molecule in plants,having myriad roles in plant *** addition,NO also orchestrates both biotic and abiotic stress responses,during which intensive cellular metabolic reprogramming *** to these responses is the location of NO biosynthetic and scavenging pathways in diverse cellular compartments,enabling plants to effectively organize signal transduction *** regulates plant metabolism and,in turn,metabolic pathways reciprocally regu-late NO accumulation and ***,these diverse cellular processes are inextricably *** re-view addresses the numerous redox pathways,located in the various subcellular compartments that pro-duce NO,in addition to the mechanisms underpinning NO *** focus on how this molecular dance is integrated into the metabolic state of the *** this context,a reciprocal relationship be-tween NO accumulation and metabolite production is often *** also showcase cellular pathways,including those associated with nitrate reduction,that provide evidence for this integration of NO function and ***,we discuss the potential importance of the biochemical reactions governing NO levels in determining plant responses to a changing environment.

关键词： hypoxi amitochondria metabolism nitric oxide S-nitrosylation pyridoxine reactive nitrogen species reactive oxygen species

Machine Learning Models of Plastic Flow Based on Representation theory

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Computer Modeling in Engineering & Sciences 2018年第12期117卷 309-342页

作者： R.E.jones J.A.templeton C.M.Sanders J.t.Ostien Sandia National Laboratories P.O.Box 969LivermoreCA 94551USA.

We use machine learning(ML)to infer stress and plastic flow rules using data from representative polycrystalline *** particular,we use so-called deep(multilayer)neural networks(NN)to represent the two response *** ML process does not choose appropriate inputs or outputs,rather it is trained on selected inputs and ***,its discrimination of features is crucially connected to the chosen inputoutput ***,we draw upon classical constitutive modeling to select inputs and enforce well-accepted symmetries and other *** the context of the results of numerous simulations,we discuss the design,stability and accuracy of constitutive NNs trained on typical experimental *** these developments,we enable rapid model building in real-time with experiments,and guide data collection and feature discovery.

关键词： Machine learning constitutive modeling plasticity invariance.

Mass transfer of an organophosphate flame retardant between product source and dust in direct contact

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Emerging Contaminants 2017年第3期3卷 115-120页

作者： Ioannis Liagkouridis Borislav Lazarov Georgios Giovanoulis ian t.Cousins Department of Environmental Science and Analytical Chemistry(ACES) Stockholm UniversitySE 10691StockholmSweden Environmental Risk and Health Unit VITOBoeretang 2002400MolBelgium IVL Swedish Environmental Research Institute P.O.Box21060SE 10031StockholmSweden

Organophosphate flame retardants(OPFRs)are a group of semi-volatile organic compounds(SVOCs)and among the most abundant contaminants *** indoor presence has been associated with potential health risks however there is limited understanding as to how they are released from indoor *** study uses an emission micro-chamber to explore one of the currently understudied chemical migration pathways;direct transfer between a source material and settled dust in contact with the source.A tris(2-chloroisopropyl)phosphate(tCIPP)-treated insulation board is used as the source *** and substantial transfer was observed after only 8 h of source-dust contact,resulting in 80 times higher concentrations in dust compared to pre-experiment *** time points at 24 h and 7 d showed similarly high average dust levels and the tCIPP in the dust and air in the chamber was calculated to be close to thermodynamic *** was concluded that tCIPP was effectively transferred from the insulation board to the dust on its surface and the surrounding air via gas-phase *** a real room,a gradient of tCIPP concentrations in air above the surface of a product could result in higher concentrations in dust sitting on the product than dust in the rest of the room.

关键词： OPFRs Source-to-dust transfer Indoor dust tCIPP Micro-chamber Air-dust equilibrium

Presentation of hepatocellular antigens

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Cellular & Molecular Immunology 2016年第3期13卷 293-300页

作者： Arash Grakoui ian Nicholas Crispe Division of Infectious Diseases Department of Medicine Emory University School of Medicine and Yerkes National Primate Research Center Atlantal GAUSA Department of Pathology University of Washington Seattle WA USA.

the liver is an organ in which antigen-specific t-cell responses manifest a bias toward immune tolerance. this is clearly seen in the rejection of allogeneic liver transplants, and multiple other phenomena suggest that this effect is more general. these include tolerance toward antigens introduced via the portal vein, immune failure to several hepatotropic viruses, the lack of natural liverstage immunity to malaria parasites, and the frequent metastasis of cancers to the liver. Here we review the mechanisms by which t cells engage with hepatocellular antigens, the context in which such encounters occur, and the mechanisms that act to suppress a full t-cell response. While many mechanisms play a role, we will argue that two important processes are the constraints on the cross-presentation of hepatocellular antigens, and the induction of negative feedback inhibition driven by interferons. the constant exposure of the liver to microbial products from the intestine may drive innate immunity, rendering the local environment unfavorable for specific t-cell responses through this mechanism. Nevertheless, tolerance toward hepatocellular antigens is not monolithic and under specific circumstances allows both effective immunity and immunopathology.

关键词： liver hepatocytes immunity tolerance

Melanosis of the vulva: A long-term follow-up from Brisbane, Australia

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Open Journal of Obstetrics and Gynecology 2012年第3期2卷 247-249页

作者： ian S. C. jones Women’s and Newborn Services Royal Brisbane and Women’s Hospital Brisbane and University of Queensland Herston Australia

Object: to determine if vulvar melanosis progressed to melanoma over a period of 20 years or more. Methods: In 2010 the hospital records from the Royal Brisbane Hospital Vulvar Clinic between 1976 and 1988 were reviewed and cross checked with the state wide Queensland Centre for Gynaecological Cancer (QCGC) data base to determine if any patient had been lost to follow up and subsequently developed a vulvar melanoma. Data collected were stored and analysed using the computer software Statistical Package for the Social Sciences (SPSS) 11.0. Results: None of the 12 patients developed vulval melanoma in the years up to 2010. Conclusion: In this small group, followed for more than 20 years, melanosis was not a precursor of melanoma. One patient, who attended the Vulvar Clinic but was not included in this melanosis study, was found to have co-existing melanosis well away from her melanoma in situ and malignant melanoma at presentation. It was not possible to determine if these findings represented a progression of the benign to malignant. Biopsy of abnormal hyper pigmented vulvar skin is recommended. Current knowledge suggests that vulvar melanosis is a benign condition but to be on the safe side follow up of all hyper pigmented vulval lesions to detect early malignant change is recommended.

关键词： Vulva Pigmented Epithelial Disorders Features Follow-Up Malignancy

Influences on the study of Vulvar Anatomy and Disease

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Open Journal of Obstetrics and Gynecology 2012年第3期2卷 223-226页

作者： ian S. C. jones Women’s and Newborn Services Royal Brisbane and Women’s Hospital Brisbane and University of Queensland Herston Australia

the study of Gynaecology over the years has been influenced by the culture and social attitudes of society to the body as a whole and to the genital organs in particular. Variations in these attitudes between different cultures and at different times have influenced the subsequent rate of progress in the study of the vulva and its diseases.

关键词： Vulvar Cancer Attitudes Communication Scientific Developments

the influence of curing conditions on the mechanical properties and leaching of inorganic polymers made of fayalitic slag

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Frontiers of Chemical Science and Engineering 2017年第3期11卷 317-327页

作者： Remus I. Iacobescu Valerie Cappuyns tinne Geens Lubica Kriskova Silviana Onisei Peter t. jones Yiannis Pontikes KU Leuven Department of Materials Engineering 3001 Leuven Belgium KU Leuven Department of Earth and Environmental Sciences 3001 Leuven Belgium KU Leuven Faculty of Economics and Business 1000 Brussels Belgium KU Leuven Department of Healthcare and Technology 3001 Leuven Belgium

this study reports on the impact of the curing conditions on the mechanical properties and leaching of inorganic polymer （IP） mortars made from a water quenched fayalitic slag. three similar IP mortars were produced by mixing together slag, aggregate and activating solution, and cured in three different environments for 28 d： a） at 20℃ and relative humidity （RH） - 50% （t20RH50）, b） at 20℃and RH≥90% （t20RH90） and c） at 60℃ and RH - 20% （t60RH20）. Compressive strength （EN 196-1） varied between 19 MPa （t20RH50） and 31 MPa （t20RH90）. this was found to be attributed to the cracks formed upon curing. Geochemical modelling and two leaching tests were performed, the EA NEN 7375 tank test, and the BS EN 12457-1 single batch test. Results show that Cu, Ni, Pb, Zn andAs leaching occurred even at high pH, which varied between 10 and 11 in the tank test＇s leachates and between 12 and 12.5 in the single batch＇s leachates. Leaching values obtained were below the requirements for non-shaped materials of Flemish legislation for As, Cu and Ni in the single batch test.

关键词： inorganic polymer geochemical leaching modelling heavy metals recycling non-ferrous fayalitic slag curing

A review of conditions altering the permanent appearance of the vulva

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Open Journal of Obstetrics and Gynecology 2012年第4期2卷 382-384页

作者： ian S. C. jones Women’s and Newborn Services Royal Brisbane and Women’s Hospital Herston Australia

this article is aimed at providing information on variations in the clinical appearance of the vulva. the appearance of the vulva can be altered by reversible or permanent conditions both of which may result in minor or major changes. Reversible conditions include those associated with infections or acute trauma which results in distortion of the vulva. Some permanent changes are caused by life threatening conditions which are present at birth whereas others develop more slowly or as the result of a deliberate act either traditional female surgery or surgery performed by a registered medical practitioner. to the inexperienced practitioner changes from the normal vulvar appearance can be confusing. the aim of this article is to highlight and categorise changes that can affect the appearance of the vulva. Whatever the presentation the importance of obtaining a detailed history and performing an appropriate, sensitive and thorough examination can not be over emphasised.

关键词： Vulvar Appearance Congenital traumatic Cultural Iatrogenic