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The code of light:do neurons generate light to communicate and repair?

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Neural Regeneration Research 2022年第6期17卷 1251-1252页

作者： Cecile Moro Ann Liebert Catherine Hamilton Nicolas Pasqual Glen Jeffery Jonathan stone John Mitrofanis Universite Grenoble Alpes CEALETIClinatecGrenobleFrance Department of Anatomy University of SydneySydneyAustralia Vie Integrative GrenobleFrance Institute of Ophthalmology University College LondonLondonUK Department of Physiology University of SydneySydneyAustralia

A great challenge in neuroscience has been to understand how neurons *** neuroanatomists of the 19th Century could see neurons stretching processes to contact other neurons,but could not see the detail of the *** thought that neurons formed a syncytium,with continuity of membranes from one to the *** the ensuing two hundred years or so,we have come to understand that the circuity of the brain is not formed by a syncytium of neurons;rather,individual neurons communicate with each other with a range of biological *** are highly active cells,with their activity being electrical and their communication being either chemical,electrical or gaseous.

关键词： communicate stretching electrical

Rationale and Design of a Randomized Controlled Trial of Bivalirudin with a Prolonged High-Dose Infusion Versus Heparin Monotherapy During Primary Percutaneous Coronary Intervention in Patients with Acute ST-Segment Elevation Myocardial Infarction:The BRIGHT-4 Trial

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Cardiology Discovery 2022年第4期2卷 226-230页

作者： Zhenyang Liang Yi Li Gregg W.stone Yaling Han Cardiovascular Research Institute and Department of Cardiology General Hospital of Northern Theater CommandShenyang 110016China Zena and Michael A.Wiener Cardiovascular Institute Icahn School of Medicine at Mount SinaiNew YorkNew York 10029-5674USA

Intravenous anticoagulant therapy is critical to prevent ischemic events without increasing the risk of bleeding in patients with ST-segment elevation myocardial infarction(STEMI)undergoing primary percutaneous coronary intervention(PPCI).Heparin and bivalirudin are the most commonly used adjunctive anticoagulant agents during ***,the superiority of the 2 most optimal regimens with these agents in patients undergoing PPCI remains *** BivaliRudin with prolonged high-dose Infusion durinG PPCI versus Heparin Trial 4(BRIGHT-4)is a large-scale,prospective,multicenter,active-control,parallel-group,open-label,randomized trial designed to test whether bivalirudin with a post-PCI high-dose infusion is superior to heparin monotherapy in STEMI patients undergoing PPCI.A total of 6000 patients will be enrolled and randomly assigned to receive bivalirudin or heparin in a 1:1 *** allocated to the bivalirudin group will be treated with a high-dose bivalirudin infusion(1.75 mg/(kg·h))after PCI for 2 to 4 *** the heparin group,the use of glycoprotein IIb/IIIa inhibitors will be reserved for the development of procedural thrombotic *** efficacy and safety of bivalirudin will be evaluated at 30 days,6 months,and 12 months after the *** primary endpoint is a composite of all-cause death or Bleeding Academic Research Consortium(BARC)types 3 to 5 bleeding at 30 days after *** BRIGHT-4 study protocol has received approval from the ethics committee of General Hospital of Northern Theater Command(Shenyang,China).The procedures set out in this protocol are in accordance with the principles of the Declaration of Helsinki and Good Clinical Practice *** results will be published following the Consolidated Standards of Reporting Trials statement in a peer-reviewed scientific journal(Trial registration number:NCT03822975).

关键词： Heparin Bivalirudin ST-segment elevation myocardial infarction Primary percutaneous coronary intervention

Unfolded protein response in myelin disorders

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Neural Regeneration Research 2020年第4期15卷 636-645页

作者： Wensheng Lin Sarrabeth stone Department of Neuroscience University of MinnesotaMinneapolisMNUSA Institute for Translational Neuroscience University of MinnesotaMinneapolisMNUSA

Activation of the unfolded protein response in response to endoplasmic reticulum stress preserves cell viability and function under stressful ***,persistent,unresolvable activation of the unfolded protein response can trigger apoptosis to eliminate stressed *** studies show that the unfolded protein response plays an important role in the pathogenesis of various disorders of myelin,including multiples sclerosis,Charcot-Marie-Tooth disease,Pelizaeus-Merzbacher disease,vanishing white matter disease,spinal cord injury,tuberous sclerosis complex,and hypoxia-induced perinatal white matter *** this review we summarize the current literature on the unfolded protein response and the evidence for its role in the pathogenesis of myelin disorders.

关键词： axon ER multiples sclerosis myelin oligodendrocyte Schwann cell spinal cord injury UPR

Observations of Dominant Behaviors and Habits of an Effective Leader

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Observations of Dominant Behaviors and Habits of an Effectiv...

Professor Donald stone: Experiencing China

作者： Ron Drew stone Center for Performance and ROI

Leadership behavior is at the center of organization *** dedicate significant resources to develop leaders so that work teams will achieve organization *** abound about the traits, characteristics and behaviors that make for the best *** team members and others who work closely with leaders are in a good position to know the answers, I asked these employees what type of leader and which leader behaviors influence them to do the work and stay connected with the *** research identified numerous behaviors and habits that facilitate communication, trust, respect, working relationships, and positive *** findings are arranged in two guides, each with an array of *** guide is for building leadership character and the other is for influencing connection *** guides are beneficial to leaders as they engage their team to achieve organization goals.A leadership workshop is forthcoming that focuses on applying the guides along with tools for leaders to connect with teams and achieve individual and organization performance goals.

关键词： Connections Respect Trust Leader Behavior Habits Willingness Character Compassion Performance

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国际人才交流 2018年第12期 62-64页

作者： Donald stone

In2006,afterhavingdevotednearlyfortyyearstoteaching English literature at the City University of New York, as well asHarvardUniversity(asvisitingprofessor)andNewYork University (as adjunct professor), I had the good fortune to be invited to teach in the English Department at Peking ***,IhavetaughttheundergraduateEnglishnovelscourse(JaneAustentoJamesJoyce)

关键词：英语小说课程研究教学方法

The Status of Acupuncture and Oriental Medicine in the United States

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Chinese Journal of Integrative Medicine 2014年第4期20卷 243-249页

作者： Jennifer A.M.stone Department of Radiation Oncology Indiana University School of Medicine

Since its first mention in U.S. media in the early 1970s, the practiceof acupuncture and Oriental medicine （AOM） has grown in stature from a fringe,counter-culture movement to a valid, evidenced-based treatment option for *** the last 40 years, AOM schools and colleges have been accredited by the *** of Education, offering both masters and doctoral degree programs. Todate, forty-seven states and the District of Columbia license or certify acupuncturistsbased on competency proven through state examination or professional certificationby the National Certification Commission for Acupuncture and Oriental Medicine（NCCAOM）. As acceptance of AOM in the U.S. has increased through both theassurance of psychometrically sound certification and the education of the Americanpublic on this topic, many challenges have emerged. Problems such as theunderemployment of AOM clinicians, methodological hurdles for the investigation of mechanisms, and efficacyof acupuncture and other AOM treatment techniques have been observed. Investigative challenges also includegaps in research training as well as a dearth of the basic resources needed to conduct randomized controlledtrials （RCTs）. As AOM research has sought integration into the Western research model, problems have beenidentified in the design of AOMRCTs, and strategies for their resolution through methods such as translationalresearch have been examined. Incorporating these strategies as well as efficacy, effectiveness, and qualitativemeasures will strengthen the evidence base and thus provide clinical decision makers with more tools that canbe used to design patient treatment regimens.

关键词： acupuncture Oriental medicine status research United States challenges

Cover Crops as Affecting Soil Chemical and Physical Properties and Development of Upland Rice and Soybean Cultivated in Rotation

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Rice science 2018年第6期25卷 340-349页

作者： Adriano Stephan NASCENTE Luis Fernando stone Embrapa Arroz e Feij(CNPAF) Rodovia GO-462km 12 Zona RuralCP.17975375-000Santo Antoio de GoiasGOBrasil

Cover crops can provide changes in soil chemical and physical properties, which could allow a sustainable development of soybean and upland rice rotation in Brazilian Cerrado. The objective of this study was to determine the effects of cover crops(cultivated in the offseason) in the soybean-upland rice rotation(cultivated in the summer season) on the soil chemical and physical properties, yield components and grain yield of the cash crops. The experimental design was a randomized block design in factorial scheme 4 × 2 with six replications. Treatments were composed by four cover crops: fallow, millet(Pennisetum glaucum) + Crotalaria ochroleuca, millet + pigeon pea(Cajanus cajans), and millet + pigeon pea + Urochola ruziziensis in the offseason with one or two cycles of cover crops, with rice(Oryza sativa)or soybean(Glycine max) in the summer season. Cover crops alone provided no changes in soil chemical properties. However, the rotation cover crops/cash crops/cover crops/cash crops reduced p H, Al and H + Al and increased Ca, Mg, K and Fe contents in the soil. The cover crops millet + pigeon pea and millet + pigeon pea + U. ruziziensis improved soil physical properties in relation to fallow,especially in the 0–0.10 m soil layer. In spite of the improvement of the soil physical properties after two years of rotation with cover crops and cash crops, the soil physical quality was still below the recommended level, showing values of macroporosity, S index and soil aeration capacity lower than 0.10 m3/m3, 0.035 and 0.34, respectively. Upland rice production was higher under mixtures of cover crops than under fallow, mainly because of soil physical changes done by these mixtures of cover *** grain yield was similar under all cover crops tested, but was higher after the rotation cover crops/upland rice/cover crops than after only one cycle of cover crops.

关键词： crop rotation no-tillage system sustainable agriculture tropical agriculture rice soybean

An inexpensive underwater mine countermeasures simulator with real-time 3D after action review

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Defence Technology（防务技术） 2016年第5期12卷 367-379页

作者： Robert stone Timothy SNELL Neil COOKE Human Interface Technologies Team University of Birmingham UK University of Birmingham UK

This paper presents the results of a concept capability demonstration pilot study, the aim of which was to investigate how inexpensive gaming software and hardware technologies could be exploited in the development and evaluation of a simulator prototype for training Royal Navy mine clearance divers, specifically focusing on the detection and accurate reporting of the location and condition of underwater ordnance. The simulator was constructed using the Blender open source 3D modelling toolkit and game engine, and featured not only an interactive 3D editor for underwater scenario generation by instructors, but also a real-time, 3D After Action Review(AAR) system for formative assessment and *** simulated scenarios and AAR architecture were based on early human factors observations and briefings conducted at the UK's Defence Diving School(DDS), an organisation that provides basic military diving training for all Royal Navy and Army(Royal Engineers) divers. An experimental pilot study was undertaken to determine whether or not basic navigational and mine detection components of diver performance could be improved as a result of exposing participants to the AAR system, delivered between simulated diving scenarios. The results suggest that the provision of AAR was accompanied by significant performance improvements in the positive identification of simulated underwater ordnance(in contrast to non-ordnance objects) and on participants' description of their location, their immediate in-water or seabed context and their structural condition. Only marginal improvements were found with participants' navigational performance in terms of their deviation accuracies from a pre-programmed expert search path. Overall, this project contributes to the growing corpus of evidence supporting the development of simulators that demonstrate the value of exploiting open source gaming software and the significance of adopting established games design techniques in delivering highly

关键词： Simulation Virtual reality Diver training Ordnance disposal Mine clearance

Role of nuclear factor κB in multiple sclerosis and experimental autoimmune encephalomyelitis

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Neural Regeneration Research 2018年第9期13卷 1507-1515页

作者： Yuan Yue Sarrabeth stone Wensheng Lin Department of Neuroscience University of Minnesota Institute for Translational Neuroscience University of Minnesota

The transcription factor nuclear factor κB（NF-κB） plays major roles in inflammatory diseases through regulation of inflammation and cell *** sclerosis（MS） is a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system（CNS）.It has been shown that NF-κB is activated in multiple cell types in the CNS of MS patients,including T cells,microglia/macrophages,astrocytes,oligodendrocytes,and ***,data from animal model studies,particularly studies of experimental autoimmune encephalomyelitis,have suggested that NF-κB activation in these individual cell types has distinct effects on the development of *** this review,we will cover the current literature on NF-κB and the evidence for its role in the development of MS and its animal model experimental autoimmune encephalomyelitis.

关键词： multiple sclerosis experimental autoimmune encephalomyelitis nuclear-factor κB T cell macrophage microglia astrocyte oligodendrocyte neuron