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Thermal Management of Electrified Propulsion System for Low-Carbon Vehicles

Automotive Innovation 2020年第4期3卷 299-316页

作者： Bo Li Huang Kuo Xuehui Wang Yiyi Chen Yangang Wang David Gerada Sean Worall ian stone Yuying Yan Faculty of Engineering University of NottinghamNottingham NG72RDUK Dynex Semiconductor Limited Doddington RoadLincoln LN63LFUK GKN Driveline Ltd Pentagon SAbingdon OX143PZUK

An overview of current thermal challenges in transport electrification is introduced in order to underpin the research developments and trends of recent thermal management techniques.Currently,explorations of intelligent thermal management and control strategies prevail among car manufacturers in the context of climate change and global warming impacts.Therefore,major cutting-edge systematic approaches in electrified powertrain are summarized in the first place.In particular,the important role of heating,ventilation and air-condition system(HVAC)is emphasised.The trends in developing efficient HVAC system for future electrified powertrain are analysed.Then electric machine efficiency is under spotlight which could be improved by introducing new thermal management techniques and strengthening the efforts of driveline integrations.The demanded integration efforts are expected to provide better value per volume,or more power output/torque per unit with smaller form factor.Driven by demands,major thermal issues of high-power density machines are raised including the comprehensive understanding of thermal path,and multiphysics challenges are addressed whilst embedding power electronic semiconductors,non-isotropic electromagnetic materials and thermal insulation materials.Last but not least,the present review has listed several typical cooling techniques such as liquid cooling jacket,impingement/spray cooling and immersion cooling that could be applied to facilitate the development of integrated electric machine,and a mechanic-electric-thermal holistic approach is suggested at early design phase.Conclusively,a brief summary of the emerging new cooling techniques is presented and the keys to a successful integration are concluded.

关键词： Thermal management Electrified powertrain Efficient cooling and heating Electric machine and control High power electronics

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TMEM63B regulates postnatal development of cochlear sensory epithelia via thyroid hormone signaling

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Journal of Genetics and Genomics 2024年第6期51卷 673-676页

作者： Chang Ye Tian-Zi Zhang Yan-Yu Zang Yun stone Shi Guoqiang Wan State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study Model Animal Research CenterMedical SchoolNanjing UniversityNanjingJiangsu 210032China Guangdong Institute of Intelligence Science and Technology ZhuhaiGuangdong 519031China

Sound transmission occurs in the cochlea,a complex and ingenious subdivision in the inner ear.The structure of the cochlea develops structurally and functionally by the time before two postnatal weeks(the time of hearing onset)in mice(Geal-Dor et al.,1993).Greater epithelial ridge(GER,also known as Kolliker's organ)is a transient cochlear structure containing a group of columnar epithelial supporting cells surrounding the inner hair cells(IHCs).

关键词： cochlear al. supporting

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A spotlight on dosage and subject selection for effective neuroprotection: exploring the central role of mitochondria

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Neural Regeneration Research 2025年第4期20卷 1081-1082页

作者： John Mitrofanis Jonathan stone Michael R.Hamblin Pierre Magistretti Alim-Louis Benabid Glen Jeffery Fonds Clinatec UniversitéGrenoble AlpesGrenobleFrance School of Medical Science University of SydneySydneyAustralia Faculty of Health Sciences University of JohannesburgJohannesburgSouth Africa King Abdullah University of Science and Technology ThuwalSaudi Arabia Institute of Ophthalmology University College LondonLondonUK

Neurons are notoriously vulnerable cell types.Even the slightest change in their internal and/or external environments will cause much distress and dysfunction,leading often to their death.A range of pathological conditions,including stroke,head trauma,and neurodegenerative disease,can generate stress in neurons,affecting their survival and proper function.In most neural pathologies,mitochondria become dysfunctional and this plays a pivotal role in the process of cell death.The challenge over the last few decades has been to develop effective interventions that improve neuronal homeostasis under pathological conditions.Such interventions,often referred to as disease-modifying or neuroprotective,have,however,proved frustratingly elusive,at both preclinical and,in particular,clinical levels.In this perspective,we highlight two factors that we feel are key to the development of effective neuroprotective treatments.These are:firstly,the choice of dose of intervention and method of application,and secondly,the selection of subjects,whether they be patients or the animal model.

关键词： protective dosage distress

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雾里看花的AI时代

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商业周刊（中文版） 2024年第8期 4-6页

作者： Brad stone Rachel Metz 易语(译) 不详

●从技术、经济到动力,这一新兴产业还有许多有待梳理的方方面面旧金山初创公司AtmoInc.的25名员工有一万条理由感到志志。这家已经成立四年的公司从气象传感器中获取大气数据,使用人工智能(AI)进行天气预测,并将预测结果出售给美国空... 详细信息

●从技术、经济到动力,这一新兴产业还有许多有待梳理的方方面面旧金山初创公司AtmoInc.的25名员工有一万条理由感到志志。这家已经成立四年的公司从气象传感器中获取大气数据,使用人工智能(AI)进行天气预测,并将预测结果出售给美国空军和菲律宾政府等对之有需求的客户。Atmo表示,其AI生成的预测比超级计算机处理大量数据后作出的预测更加准确,使用成本也低得多,而且还能从以往的错误中吸取教训。

关键词：初创公司新兴产业气象传感器菲律宾政府超级计算机天气预测美国空军 AI

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美国富豪对特朗普热情高涨

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商业周刊（中文版） 2024年第6期 4-5页

作者： Brad stone 易语(译) 不详

乔·拜登(Joe Biden)与唐纳德·特朗普(Donald Trump)在2024年美国总统大选中的再度对决,给人的感觉或许是早该退休的两个老家伙之间以自由世界未来为赌注的一场令人乏味的复赛。不过这一次,有些东西感觉有点不一样,而且很难解释。特朗... 详细信息

乔·拜登(Joe Biden)与唐纳德·特朗普(Donald Trump)在2024年美国总统大选中的再度对决,给人的感觉或许是早该退休的两个老家伙之间以自由世界未来为赌注的一场令人乏味的复赛。不过这一次,有些东西感觉有点不一样,而且很难解释。特朗普最明显的支持者不再是来自红州那些戴着印有MAGA标识的帽子、在集会上挥舞着“抽干沼泽”标语的愤怒蓝领工人,反倒变成了国内一些最成功的商界精英,他们不断在网上发帖表达心中的不满,大力秤击移民问题和乌克兰战争,并不断对拜登的表现和老迈提出质疑。

关键词：美国总统大选特朗普商界精英乌克兰提出质疑

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Clinical high risk for psychosis provides new opportunities for schizophrenia intervention strategies

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General Psychiatry 2022年第2期35卷 73-75页

作者： Jijun Wang William S stone Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China Department of Psychiatry Beth Israel Deaconess Medical Health CenterHarvard Medical SchoolBostonMassachusettsUSA

Schizophrenia is a chronic lifelong illness that is associated with huge healthcare burdens for society and healthcare systems,and even more so for ill individuals and their families.It is characterised clinically by problems in multiple domains,including cognition,motivation,thinking,brain function,social functioning,and mood.Many of these difficulties precede the formal diagnosisof schizophreniaor a related disorder such as schizoaffective disorder.Psychosis usually develops in adolescence or early adulthood,after many of these clinical problems have already started,and eventually leads to the formal diagnosis of the illness.

关键词： motivation such formal

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Real-world challenges for multi-agent reinforcement learning ingrid-interactive buildings

能源与人工智能(英文)

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能源与人工智能(英文) 2022年第4期10卷 161-170页

作者： Kingsley Nweye Bo Liu Peter stone Zoltan Nagy Intelligent Environments Laboratory Department of CivilArchitectural and Environmental EngineeringThe University of Texas at Austin301 E.Dean Keeton St.ECJ 4.200Austin78712-1700TXUSA Department of Computer Science The University of Texas at Austin2317 SpeedwayGDC 2.302Austin78712-1700TXUSA

Building upon prior research that highlighted the need for standardizing environments for building controlresearch, and inspired by recently introduced challenges for real life reinforcement learning (RL) control, herewe propose a non-exhaustive set of nine real world challenges for RL control in grid-interactive buildings(GIBs). We argue that research in this area should be expressed in this framework in addition to providing astandardized environment for repeatability. Advanced controllers such as model predictive control (MPC) andRL control have both advantages and disadvantages that prevent them from being implemented in real worldproblems. Comparisons between the two are rare, and often biased. By focusing on the challenges, we caninvestigate the performance of the controllers under a variety of situations and generate a fair comparison.

关键词： Grid-interactive buildings Benchmarking Reinforcement learning

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The code of light:do neurons generate light to communicate and repair?

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Neural Regeneration Research 2022年第6期17卷 1251-1252页

作者： Cecile Moro Ann Liebert Catherine Hamilton Nicolas Pasqual Glen Jeffery Jonathan stone John Mitrofanis Universite Grenoble Alpes CEALETIClinatecGrenobleFrance Department of Anatomy University of SydneySydneyAustralia Vie Integrative GrenobleFrance Institute of Ophthalmology University College LondonLondonUK Department of Physiology University of SydneySydneyAustralia

A great challenge in neuroscience has been to understand how neurons communicate.The neuroanatomists of the 19th Century could see neurons stretching processes to contact other neurons,but could not see the detail of the contact.Many thought that neurons formed a syncytium,with continuity of membranes from one to the next.Over the ensuing two hundred years or so,we have come to understand that the circuity of the brain is not formed by a syncytium of neurons;rather,individual neurons communicate with each other with a range of biological signals.Neurons are highly active cells,with their activity being electrical and their communication being either chemical,electrical or gaseous.

关键词： communicate stretching electrical

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Unfolded protein response in myelin disorders

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Neural Regeneration Research 2020年第4期15卷 636-645页

作者： Wensheng Lin Sarrabeth stone Department of Neuroscience University of MinnesotaMinneapolisMNUSA Institute for Translational Neuroscience University of MinnesotaMinneapolisMNUSA

Activation of the unfolded protein response in response to endoplasmic reticulum stress preserves cell viability and function under stressful conditions.Nevertheless,persistent,unresolvable activation of the unfolded protein response can trigger apoptosis to eliminate stressed cells.Recent studies show that the unfolded protein response plays an important role in the pathogenesis of various disorders of myelin,including multiples sclerosis,Charcot-Marie-Tooth disease,Pelizaeus-Merzbacher disease,vanishing white matter disease,spinal cord injury,tuberous sclerosis complex,and hypoxia-induced perinatal white matter injury.In this review we summarize the current literature on the unfolded protein response and the evidence for its role in the pathogenesis of myelin disorders.

关键词： axon ER multiples sclerosis myelin oligodendrocyte Schwann cell spinal cord injury UPR

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Neuroplastin in Ca^(2+)signal regulation and plasticity of glutamatergic synapses

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Neural Regeneration Research 2023年第8期18卷 1705-1706页

作者： Ayse Malci Xiao Lin Yun stone Shi Rodrigo Herrera-Molina Center for Neuroscience Research Children’s National Medical CenterWashingtonDCUSA Guangdong Institute of Intelligence Science and Technology ZhuhaiGuangdong ProvinceChina Combinatorial Combinatorial NeuroImaging Leibniz Institute for NeurobiologyMagdeburgGermany Centro Integrativo de Biología y Química Aplicada Universidad Bernardo O’HigginsSantiagoChile

The main function of neurons is information transmission in the form of action potentials.To fulfill this duty,neurons are connected functionally with each other via synapses,the microscopic structures where specialized molecular machinery is strategically placed to release and receive neurotransmitters and to generate and extinguish calcium(Ca^(2+))signals.These synaptic molecular components are highly dynamic and they influence each other to confer structural and functional adaptability(plasticity)to neuronal communication(Biederer et al.,2017).

关键词： plasticity specialized structural

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