检索结果-南通市图书馆

Selective toxicity of hydroxyl-rich carbon nanodots for cancer research

在线全文

学校读者我要写书评

暂无评论

Nano Research 2018年第4期11卷 2204-2216页

作者： Tak H. Kim Joseph P. Sirdaarta Qian Zhang Ehsan Eftekhari james st. John Derek Kennedy ian E. Cock Qin Li Queensland Micro and Nano Technology Center & School of Engineering Griffith University 170 Kessels Rd Nathan OLD 4111 Australia Aust.alian Rivers Inst.tute & School of Natural Sciences Griffith University 170 Kessels Rd Nathan QLD 4111 Australia Griffith Inst.tute for Drug Discovery Gfiffith University 46 Don Young Rd Nathan QLD 4111 Australia Menzies Health Inst.tute Queensland Griffith University Parkland Drive Southport QLD 4222 Australia

The toxicity of nanoparticles in a biological syst.m is an integration of effects arising from surface functionali~ particle size, ionic dissolution, etc. This complexity suggest. that generalization of a material＇s toxicity may be inappropriate. Moreover, from a medicinal point of view, toxicity can be used for treatment of malignant cells, such as cancer. In this st.d~ highly biocompatible carbon nanodots （gCDs） were synthesized by reacting citric acid and urea in glycerol, which resulted in abundant hydroxyl functional groups on the particle surface. gCDs show excitation-dependent photoluminescence but with bright green to yellow emission. Importantly, a series of toxicity assessments showed that as-synthesized gCDs possessed exceptional biocompatibilities to various biological entities including 18 bacteria species, Petunia axillaris seedlings, and Artemia franciscana nauplii. Furthermore, the particles were shown to have low to no toxic effects on human embryonic kidney （HEK-293）, breast.（MCF-7）, and oral squamous （CAL-27） carcinoma cell lines. Of particular interest. the gCDs displayed antiproliferative activities against.ovarian choriocarcinoma cells （JAr/Jeg-3 cell lines）, which may be further explored for cancer drug discovery.

关键词： carbon nanodots nanotoxicity fluorescence choriocarcinoma cells thioredoxin reductase

Improving cell transplantation by underst.nding and manipulating the phagocytic activity of peripheral glia

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第2期17卷 313-314页

作者： Lynn Nazareth james st.John Jenny Ekberg Menzies Health Inst.tute Queensland Griffith UniversitySouthportAustralia Clem Jones Centre for Neurobiology and st.m Cell Research Griffith UniversityNathanAustralia Griffith Inst.tute for Drug Discovery Griffith UniversityNathanAustralia

One of the key challenges in neuroscience is that the central nervous syst.m(CNS;the brain and spinal cord), is largely unable to regene rate after injury. One factor contributing to this lack of repair is the accumulation of cellular and myelin debris at the site of injury. The debris is not efficiently phagocytosed and can persist.for years after the initial injury, resulting in an inflammatory environment which inhibits axonal regrowth(Lutz and Barres, 2014).

关键词： debris contributing injury

Factors that modulate olfactory dysfunction

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第7期13卷 1151-1155页

作者： Kate Beecher james A.st.John Fatemeh Chehrehasa School of Biomedical Science Queensland University of Technology Inst.tute of Health and Biomedical Innovation Queensland University of Technology Clem Jones Centre for Neurobiology and st.m Cell Research Griffith Institute for Drug DiscoveryGriffith University Menzies Health Inst.tute Queensland Griffith University

The olfactory syst.m is one of a few areas in the nervous syst.m which is capable of regeneration throughout the *** sensory neurons reside in the nasal cavity are continuously replenished with new neurons arising from st.m *** factors such as aging,neurodegenerative diseases,head trauma,brain tumor extraction and infection cause olfactory dysfunction which significantly influences physical wellbeing,quality of life,mental health,nutritional st.tus,memory processes,identifying danger and is associated with increased ***,finding a treatment to improve olfactory dysfunction is *** research efforts in the field have shown some very promising new approaches to treat olfactory *** review explores the current st.dies that have addressed therapeutic approaches to improve olfactory neuron regeneration based on cell transplantation therapy,modulation of physiological olfactory dysfunction and drug treatments.

关键词： olfactory neuron regeneration anosmia loss of smell degeneration bulbectomy ensheathing cells growth factor epithelium receptor

The link between olfactory ensheathing cell survival and spinal cord injury repair: a commentary on common limitations of contemporary research

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第10期15卷 1848-1849页

作者： Ronak Reshamwala Megha Shah james st.John Jenny Ekberg Griffith Inst.tute for Drug Discovery Griffith UniversityBrisbaneQLDAustralia Menzies Health Inst.tute Queensland Griffith UniversitySouthportQLDAustraliaClem Jones Centre for Neurobiology and Stem Cell ResearchGriffith UniversityBrisbaneQLDAustralia

Olfactory ensheathing cells(OECs)are crucial players in the continuous regeneration of the olfactory nervous syst.m that occurs through out life and are thought to have unique growth-promoting *** this reason,OEC transplantation has been thoroughly explored for the potential to promote neural repair after both central and peripheral nervous syst.m *** st.dies have shown that OEC transplantation is safe and can promote recovery after spinal cord injury(SCI),both in animal models and in human clinical *** date,a variety of injury types and time-points after injury,as well as different delivery methods,have been *** have been encouraging(in rodent models including,for example,rest.ration of locomotion,breathing and climbing ability along with induction of axonal sprouting and some axonal regeneration)but highly variable(Barnett and Riddell,2007;Gomez et al.,2018).

关键词： injuries injury limitations

Neuron-fibrous scaffold interfaces in the peripheral nervous syst.m: a perspective on the st.uctural requirements

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第9期17卷 1893-1897页

作者： Sanaz Behtaj james A.st.John Jenny A.K.Ekberg Maksym Rybachuk Clem Jones Centre for Neurobiology and st.m Cell Research Griffith UniversityQueenslandAustralia Menzies Health Inst.tute Queensland Griffith UniversitySouthportAustralia Griffith Inst.tute for Drug Discovery NathanAustralia School of Engineering and Built Environment Griffith UniversityNathanAustralia Centre for Quantum Dynamics and Aust.alian Attosecond Science Facility Griffith UniversityNathanAustralia

The nerves of the peripheral nervous syst.m are not able to effectively regenerate in cases of severe neural *** can result in debilitating consequences,including morbidity and lifelong impairments affecting the quality of the patient’s *** findings in neural tissue engineering have opened promising avenues to apply fibrous tissue-engineered scaffolds to promote tissue regeneration and functional *** scaffolds,known as neural scaffolds,are able to improve neural regeneration by playing two major roles,namely,by being a carrier for transplanted peripheral nervous syst.m cells or biological cues and by providing st.uctural support to direct growing nerve fibers towards the target ***,successful implementation of scaffold-based therapeutic approaches calls for an appropriate design of the neural scaffold st.ucture that is capable of up-and down-regulation of neuron-scaffold interactions in the extracellular matrix *** review discusses the main challenges that need to be addressed to develop and apply fibrous tissue-engineered scaffolds in clinical *** describes some promising solutions that,so far,have shown to promote neural cell adhesion and growth and a potential to repair peripheral nervous syst.m injuries.

关键词： electrospun scaffold extracellular matrix nerve conduit neural tissue engineering physical lumen filler scaffold topography st.uctural support surface interaction

Reliable cell purification and determination of cell purity:crucial aspects of olfactory ensheathing cell transplantation for spinal cord repair

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第11期15卷 2016-2026页

作者： Ronak Reshamwala Megha Shah Lucy Belt Jenny A.K.Ekberg james A.st.John Griffith Inst.tute for Drug Discovery Griffith UniversityBrisbaneQLDAustralia Menzies Health Inst.tute Queensland Griffith UniversitySouthportQLDAustralia Clem Jones Centre for Neurobiology and st.m Cell Research Griffith UniversityBrisbaneQLDAustralia

Transplantation of olfactory ensheathing cells,the glia of the primary olfactory nervous syst.m,has been trialed for spinal cord injury repair with promising but variable outcomes in animals and *** ensheathing cells can be harvest.d either from the lamina propria beneath the neuroepithelium in the nasal cavity,or from the olfactory bulb in the *** these areas contain several other cell types,isolating and purifying olfactory ensheathing cells is a critical part of the *** is largely unknown how contaminating cells such as fibroblast.,other glial cell types and supporting cells affect olfactory ensheathing cell function post.transplantation;these cells may also cause unwanted *** is also,however,possible that the presence of some of the contaminant cells can improve ***,we reviewed the last.decade of olfactory ensheathing cell transplantation st.dies in rodents,with a focus on olfactory ensheathing cell *** analyzed how purification methods and resultant cell purity differed between olfactory mucosa-and olfactory bulb-derived cell *** analyzed how the st.dies reported on olfactory ensheathing cell purity and which criteria were used to define cells as olfactory ensheathing ***,we analyzed the correlation between cell purity and transplantation *** found that olfactory bulb-derived olfactory ensheathing cell preparations are typically purer than mucosa-derived *** concluded that there is an association between high olfactory ensheathing cell purity and favourable outcomes,but the lack of olfactory ensheathing cell-specific markers severely hampers the field.

关键词： antibody ast.ocyte fibroblast glia glial cell injury nerve neuron trauma surgery

Combined VEGF/PDGF improves olfactory regeneration after unilateral bulbectomy in mice

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第10期13卷 1820-1826页

作者： Kate Beecher Louise M.Hafner Jenny Ekberg james A.st.John Fatemeh Chehrehasa School of Biomedical Sciences Queensland University of Technology Clem Jones Centre for Neurobiology and st.m Cell Research Griffith Institute for Drug DiscoveryGriffith University Inst.tute of Health and Biomedical Innovation Queensland University of Technology Menzies Health Inst.tute Queensland Griffith University

The olfactory receptor neurons lining the nasal cavity have a remarkable capacity to regenerate throughout life. They are replenished continuously and their axons make new connections within the olfactory bulb. However, some factors such as head trauma and skull base surgery damage the olfactory nerve which lead to olfactory dysfunction. Losing the sense of smell has considerable effects on quality of life and life-expectancy. Therefore, there is a clear need to find a treatment for olfactory dysfunction. One such potential treatment is growth factor therapy which showed promising results in the spinal cord and brain injuries. The aim of the present st.dy was to invest.gate whether combined delivery of two growth factors, vascular endothelial growth factor and platelet-derived growth factor treatment can improve the olfactory neurons regeneration in mice. The degeneration of the olfactory neurons was induced by unilateral bulbectomy. The treatment group received 1.5 μg of the combined growth factors intranasally, while the control injured group received saline. Growth factor treatment significantly increased the number of immature neurons at 5 and 7 days post.injury and also the number of mature olfactory neurons at 10 and 14 days post.bulbectomy. Regenerating axons extended over a larger volume in the operated cavity in the treatment group compared to control group at 14 days post.bulbectomy. The growth factor treatment also significantly reduced ast.ocytic glia scar in the operated cavity. The results indicate that the combined delivery of the growth factors has the potential to improve olfactory dysfunction.

关键词： ast.ocytes olfactory bulb glial scar axon growth factors neuron

Interventional radiology in the management of malignant biliary obst.uction

在线全文

学校读者我要写书评

暂无评论

World Journal of Gast.ointest.nal Oncology 2010年第3期2卷 146-150页

作者： Cherian George Oliver Richard Byass james Edmund ian Cast Department of Radiology Hull and East Yorkshire NHS TrustCastle Hill HospitalCastle RoadCottinghamKingston-Upon-Hull

Malignant biliary obst.uction is commonly due to pancreatic carcinoma,cholangiocarcinoma and metast.tic disease which are often inoperable at presentation and carry a poor *** biliary drainage and st.nting provides a safe and effective method of palliation in such patients,thereby improving their quality of *** may also be an adjunct to surgical management by improving hepatic and,indirectly,renal function before resection of the tumor.

关键词： Biliary tract Biliary tract neoplasms Jaundice Cholangiography Carcinoma Pancreatic ductal

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

关于幼儿急腹痛、哭闹、激惹和喂养的问题

中国优生与遗传杂志 2006年第2期14卷 106-107页

作者： Alan Lucas B Chir MA ian st.james-roberts

有三种证据显示腹胀痛或哭闹与喂养方式有关：1．母乳喂养和配方奶喂养婴儿的差异。2．不同类型奶瓶喂养的影响。3．早期生长率的增长伴随哭闹持续时间的增加。

关键词：配方奶喂养哭闹急腹痛幼儿激惹喂养方式持续时间母乳喂腹胀痛同类型