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ABC/2 formula for"bedside"postoperative pneumocephalus volume measurement

chinese Neurosurgical Journal 2022年第4期8卷 284-291页

作者： David Yuen Chung Chan Eric Yuk Hong Cheung Ka Ho Hui Cecelia Mei Sze Leung Stephanie chi Ping Ng Wai Kit Mak George Kwok Chu wong Tat Ming Danny Chan Wai Sang Poon Division of Neurosurgery Department of SurgeryFaculty of MedicinePrince of Wales HospitalThe Chinese University of Hong KongHong KongSARChina

Background:Postoperative pneumocephalus is associated with a higher risk of recurrence of chronic subdural hematoma(cSDH).However,there is no verified simple way to measure the pneumocephalus volume at the bedside for daily clinical *** ABC/2 method was shown to be a simple and reliable technique to estimate volumes of intracranial lesions,such as intracranial *** study aims to evaluate the accuracy of the ABC/2 formula in estimating volumes of pneumocephalus,as compared to the gold standard with computer-assisted volumetric ***:A total of 141 postoperative computed tomographic(CT)brain scans of cSDH patients with burr-hole drainage were *** volume was measured independently by both the ABC/2 formula and the computer-assisted volumetric *** the computer-assisted measurement,the volume of the air was semiautomatically segmented and calculated by computer *** regression was used to determine the correlation between the ABC/2 method and computer-assisted ***:The postoperative pneumocephalus volume after bilateral burr-hole drainage was significantly larger than that of unilateral burr-hole drainage(29.34 ml versus 12.21 ml,p<0.001).The estimated volumes by the formula ABC/2 significantly correlated to the volumes as measured by the computer-assisted volumetric technique,with r=0.992(p<0.001).The Pearson correlation coefficient is very close to 1,which signifies a very strong positive correlation,and it is statistically ***:An excellent correlation is observed between the ABC/2 method and the computer-assisted *** study verified that the ABC/2 method is an accurate and simple"bedside"technique to estimate pneumocephalus volume.

关键词： ABC/2 Chronic subdural haematoma Burr-hole Pneumocephalus

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Transurethral resection of prostate for acute urinary retention is linked to shorter survival in younger men

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Asian Journal of Andrology 2019年第5期21卷 468-472页

作者： Jeremy Yuen-Chun Teoh chi-Kwok Chan Maggie Haitian Wang chi-Ho Leung Eddie Shu-Yin Chan Peter Ka-Fung chiu chi-Hang Yee Hon-Ming wong Simon See-Ming Hou chi-Fai Ng S.H.Ho Urology Centre Department of SurgeryPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina Division of Biostatistics JC School of Public Health and Primary CareThe Chinese University of Hong KongHong KongChina Division of Urology Department of SurgeryNorth District HospitalHong KongChina Division of Urology Department of SurgeryAlice Ho Miu Ling Nethersole HospitalHong KongChina

It is largely unknown whether lower urinary tract symptoms(LUTS)or acute retention of urine(AROU)is linked to shorter life expectancy in *** conducted a multicenter,retrospective database analysis of patients undergoing transurethral resection of prostate(TURP)to study their *** Cox regression analysis and Kaplan-Meier analysis with stratification to age and indication of TURP were *** further performed an age-and sex-matched survival analysis with the general population using data from the Census and Statistics Department of the Hong Kong Special Administrative Region(Hong Kong,china).From January 2002 to December 2012,3496 patients undergoing TURP were included in our study,with 1764 patients in the LUTS group and 1732 patients in the AROU *** age,ischemic heart disease,cerebrovascular accident,and AROU were risk factors of *** aged80 *** to the general population,younger patients in the LUTS group appeared to have better survival(80 years,survival was similar with the general population in both the LUTS and AROU *** conclusion,AROU at young age was associated with mortality,while early detection and management of LUTS may improve survival.

关键词： acute retention of urine lower urinary tract symptoms mortality transurethral resection of prostate

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Comparison of a Manual and an Automated Tracking Method for Tibetan Plateau Vortices

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Advances in Atmospheric Sciences 2018年第8期35卷 69-84页

作者： Julia CURIO Yongren CHEN Reinhard SchiEMANN Andrew G. TURNER Kai chi wong Kevin HODGES Yueqing LI NCAS-Climate University of Reading Reading RG6 6BB UK Department of Meteorology University of Reading Reading RG6 6BB UK Institute of Plateau Meteorology China Meteorological Administration Chengdu 610072 China Heavy Rain and Drought-Flood Disasters in Plateau and Basin Key Laboratory of Sichuan Province Chengdu 610072 China

Tibetan Plateau vortices （TPVs） are mesoscale cyclones originating over the Tibetan Plateau （TP） dnring the extended summer season （April-September）. Most TPVs stay on the TP, but a small number can move off the TP to the east. TPVs are known to be one of the main precipitation-bearing systems on the TP and moving-off TPVs have been associated with heavy precipitation and flooding downstream of the TP （e.g., in Sichuan province or over the Yangtze River Valley）. Identifying and tracking TPVs is difficult because of their comparatively small horizontal extent （400-800 kin） and the limited availability of soundings over the TP, which in turn constitutes a challenge for short-term predictions of TPV-related impacts and for the climatological study of TPVs. In this study, （i） manual tracking （MT） results using radiosonde data from a network over and downstream of the TP are compared with （ii） results obtained by an automated tracking （AT） algorithm applied to ERA-Interim data. Ten MT-TPV cases are selected based on method （i） and matched to and compared with the corresponding AT-TPVs identified with method （ii）. Conversely, ten AT-TPVs are selected and compared with the corresponding MT-TPVs. In general, the comparison shows good results in cases where the underlying data are in good agreement, but considerable differences are also seen in some cases and explained in terms of differences in the tracking methods, data availability/coverage and disagreement between sounding and ERA-Interim data. Recommendations are given for future efforts in TPV detection and tracking, including in an operational weather forecasting context.

关键词： Tibetan Plateau Vortices Yearbook of TPVs TRACK mesoscale cyclones manual tracking automated tracking

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Enhanced optical Kerr nonlinearity of MoS2 on silicon waveguides

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Photonics Research 2015年第5期3卷 206-209页

作者： Linghai Liu Ke Xu Xi Wan Jianbin Xu chi Yan wong Hon Ki Tsang Department of Electronic Engineering The Chinese University of Hong Kong Department of Electronic and Information Engineering Shenzhen Graduate SchoolHarbin Institute of Technology

A quasi-two-dimensional layer of MoS2 was placed on top of a silicon optical waveguide to form a MoS2–silicon hybrid structure. chirped pulse self-phase modulation measurements were carried out to determine the optica Kerr nonlinearity of the structure. The observed increase in the spectral broadening of the optical pulses in the MoS2–silicon waveguide compared with the silicon waveguides indicated that the third-order nonlinear effect in MoS2 is about 2 orders of magnitude larger than that in silicon. The measurements show that MoS2 has an effective optical Kerr coefficient of about 1.1 × 10-16m2∕W. This work reveals the potential application of MoS2 to enhance the nonlinearity of hybrid silicon optical devices.

关键词： Mo Enhanced optical Kerr nonlinearity of MoS2 on silicon waveguides mode

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LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson’s disease

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Translational Neurodegeneration 2022年第1期11卷 869-882页

作者： Shirley Yin-Yu Pang Rachel Cheuk Nam Lo Philip Wing-Lok Ho Hui-Fang Liu Eunice Eun Seo Chang chi-Ting Leung Yasine Malki Zoe Yuen-Kiu Choi Wing Yan wong Michelle Hiu-Wai Kung David Boyer Ramsden Shu-Leong Ho Division of Neurology Department of MedicineQueen Mary HospitalUniversity of Hong KongHong KongChina School of Biomedical Sciences Li Ka Shing Faculty of MedicineUniversity of Hong KongHong KongChina Institute of Metabolism and Systems Research University of BirminghamBirminghamUK.

Mutations in leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GBA) represent two most common genetic causes of Parkinson’s disease (PD). Both genes are important in the autophagic-lysosomal pathway (ALP), defects of which are associated with α-synuclein (α-syn) accumulation. LRRK2 regulates macroautophagy via activation of the mitogen activated protein kinase/extracellular signal regulated protein kinase (MAPK/ERK) kinase (MEK) and the calcium-dependent adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathways. Phosphorylation of Rab GTPases by LRRK2 regulates lysosomal homeostasis and endosomal trafficking. Mutant LRRK2 impairs chaperone-mediated autophagy, resulting in α-syn binding and oligomerization on lysosomal membranes. Mutations in GBA reduce glucocerebrosidase (GCase) activity, leading to glucosylceramide accumulation, α-syn aggregation and broad autophagic abnormalities. LRRK2 and GBA influence each other: GCase activity is reduced in LRRK2 mutant cells, and LRRK2 kinase inhibition can alter GCase activity in GBA mutant cells. Clinically, LRRK2 G2019S mutation seems to modify the effects of GBA mutation, resulting in milder symptoms than those resulting from GBA mutation alone. However, dual mutation carriers have an increased risk of PD and earlier age of onset compared with single mutation carriers, suggesting an additive deleterious effect on the initiation of PD pathogenic processes. Crosstalk between LRRK2 and GBA in PD exists, but its exact mechanism is unclear. Drugs that inhibit LRRK2 kinase or activate GCase are showing efficacy in pre-clinical models. Since LRRK2 kinase and GCase activities are also altered in idiopathic PD (iPD), it remains to be seen if these drugs will be useful in disease modification of iPD.

关键词： Parkinson’s disease Interaction LRRK2 GBA GCase Mutation Autophagy α-Synuclein

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Curriculum Adaptation in Special Schools for Students with Intellectual Disabilities(SID):A Case Study of Project Learning in One SID School in Hong Kong

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Frontiers of Education in china 2014年第2期9卷 250-273页

作者： ZHANG Jia-Wei wong Lam CHAN Tak-Hang chiU chi-Shing Hong Kong Institute of Educational Research The Chinese University of Hong KongHong KongChina

Using a qualitative case study approach,the authors analyzed the curriculum adaptation process for one project learning activity in School K,which is a SID school in the context of school-university *** sources of data were collected for triangulation,including interviews,documents and *** adaptation strategies in this study were analyzed from five perspectives:instructional goals,instructional content,instructional strategies,instructional settings,and student behavioral *** was found that curriculum adaptation efforts could help students with ID develop potential at their own level through project learning activates and teachers could also gain professional development during the university-school collaboration *** for future studies,enlarging the sample size,involving teachers’past orientations and motivations in the project learning process,and collecting quantitative data could all be taken into account.

关键词： special education students with intellectual disabilities(SID) curriculum adaptation project learning

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Late retroperitoneal recurrence of hepatocellular carcinoma 12 years after initial diagnosis

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World Journal of Gastroenterology 2010年第17期16卷 2187-2189页

作者： Tiffany Cho-Lam wong Ka-Fai To Simon See-Ming Hou Sidney Kam-Hung Yip chi-Fai Ng Department of Surgery Prince of Wales HospitalThe Chinese University of Hong Kong Department of Anatomical and Cellular Pathology The Chinese University of Hong Kong

Hepatocellular carcinoma (HCC) is an aggressive tumor with poor long-term ***,we present an unusual patient with a solitary recurrence of HCC in the right kidney 12 years after the initial *** illustrates the importan... 详细信息

关键词： Hepatocellular carcinoma Late recurrence Metastasis Retroperitoneal

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Progress and key challenges in catalytic combustion of lean methane

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Journal of Energy Chemistry 2022年第12期75卷 173-215,I0005页

作者： Xiangbo Feng Lei Jiang Danyang Li Shaopeng Tian Xing Zhu Hua Wang chi He Kongzhai Li Xi’an Key Laboratory of Advanced Photoelectronics Materials and Energy Conversion Device School of ScienceXijing UniversityXi’an 710123ShaanxiChina State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization Kunming University of Science and TechnologyKunming 650093YunnanChina Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming 650093YunnanChina State Key Laboratory of Multiphase Flow in Power Engineering School of Energy and Power EngineeringXi'an Jiaotong UniversityXi'an 710049ShaanxiChina National Engineering Laboratory for VOCs Pollution Control Material&Technology University of Chinese Academy of SciencesBeijing 101408China

As a primary type of clean energy,methane is also the second most important greenhouse gas after CO_(2)due to the high global warming *** quantities of lean methane(0.1–1.0 vol%)are emitted into the atmosphere without any treatment during coal mine,oil,and natural gas production,thus leading to energy loss and greenhouse *** general,it is challenging to utilize lean methane due to its low concentration and flow instability,while catalytic combustion is a vital pathway to realize an efficient utilization of lean methane owing to the reduced emissions of polluting gases(e.g.,NOxand CO)during the *** particular,to efficiently convert lean methane,it necessitates both the designs of highly active and stable heterogeneous catalysts that accelerate lean methane combustion at low temperatures and smart reactors that enable autothermal operation by optimizing heat *** this review,we discuss the in-depth development,challenges,and prospects of catalytic lean methane combustion technology in various configurations,with particular emphasis on heat management from the point of view of material design combined with reactor *** target is to describe a framework that can correlate the guiding principles among catalyst design,device innovation and system optimization,inspiring the development of groundbreaking combustion technology for the efficient utilization of lean methane.

关键词： Lean methane combustion Catalyst design Heat management Reactor optimization Catalytic mechanism

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The Hong Kong consensus recommendations on the diagnosis and management of pancreatic cystic lesions

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 715-735,I0019-I0020页

作者： Tan-To Cheung Yuk Tong Lee Raymond Shing-Yan Tang wong Hoi She Kai chi Cheng chin Cheung Cheung keith Wan Hang chiu Kenneth Siu Ho Chok Wing Sun Chow Tak Wing Lai Wai-Kay Seto Thomas Yau Department of Surgery Queen Mary HospitalThe University of Hong KongHong KongChina Gastroenterologist in private practice Hong KongChina Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina Department of Surgery Kwong Wah HospitalHong KongChina Department of Surgery Tuen Mun HospitalHong KongChina Department of Radiology&Imaging Queen Elizabeth HospitalHong KongChina Department of Medicine The University of Hong KongHong KongChina Department of Surgery Princess Margaret HospitalHong KongChina Department of Medicine School of Clinical MedicineThe University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina

Background:The finding of pancreatic cystic lesions(PCL)on incidental imaging is becoming increasingly *** studies report a prevalence of 2.2-44.7%depending on the population,imaging modality and indication for imaging,and the prevalence increases with *** with PCL are at risk of developing pancreatic cancer,a disease with a poor *** publication summarizes recommendations for the diagnosis and management of PCL and post-operative pancreatic exocrine insufficiency(PEI)from a group of local ***:Clinical evidence was consolidated from narrative reviews and consensus statements formulated during two online meetings in March *** expert panel included gastroenterologists,hepatobiliary surgeons,oncologists,radiologists,and ***:Patients with PCL require careful investigation and follow-up due to the risk of malignant transformation of these *** should undergo clinical investigation and pancreas-specific imaging to classify lesions and understand the risk profile of the *** indicated,patients should undergo pancreatectomy to excise *** pancreatectomy,patients are at risk of PEI,leading to gastrointestinal dysfunction and ***,such patients should be monitored for symptoms of PEI,and promptly treated with pancreatic enzyme replacement therapy(PERT).Patients with poor response to PERT may require increases in dose,addition of a proton pump inhibitor,and/or further investigation,including tests for pancreatic *** are also at risk of new-onset diabetes mellitus after pancreatectomy;they should be screened and treated with insulin if ***:These statements are an accurate summary of our approach to the diagnosis and management of patients with PCL and will be of assistance to clinicians treating these patients in a similar clinical landscape.

关键词： Pancreatic cystic lesions pancreatic endocrine insufficiency pancreatic enzyme replacement therapy

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Correction:Targeted prebiotics alter the obese gut microbiome in humans

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Signal Transduction and Targeted Therapy 2022年第2期7卷 597-597页

作者： Junjun She chi Chun wong Jun Yu Department of General Surgery The First Affiliated Hospital of Xi’an Jiaotong University Xi’an Shaanxi China Center for Gut Microbiome Research Med-X Institute The First Affiliated Hospital of Xi’an Jiao tong University Xi’an Shaanxi China Institute of Digestive Disease and Department of Medicine and Therapeutics State Key Laboratory of Digestive Disease Li Ka Shing Institute of Health Sciences The Chinese University of Hong Kong Hong Kong SAR China

In the original version of this article1 given name of first author Junjun She was supplied and published incorrectly as Junyun *** original article has been corrected.

关键词： Targeted corrected obese

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