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Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury

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World Journal of Gastroenterology 2016年第27期22卷 6192-6200页

作者： Natalia A Osna Wayne G Carter Murali Ganesan Irina A Kirpich Craig J Mc Clain Dennis R petersen Colin T Shearn Maria L Tomasi Kusum K Kharbanda Research Service Veterans Affairs Nebraska-Western Iowa Health Care System Omaha NE 68105 United States Department of Internal Medicine 982000 Nebraska Medical Center Omaha NE 68198 United States School of Medicine University of Nottingham Royal Derby Hospital Centre Derby DE22 3DT United Kingdom Division of Gastroenterology Hepatology and Nutrition Department of Medicine Department of Medicine and Pharmacology and Toxicology University of Louisville Louisville KY 40202 United States University of Colorado Denver School of Pharmacy Department of Pharmaceutical Sciences Aurora CO 80045 United States Division of Gastroenterology Department of Medicine Davis research building suite 2096/2035 Cedars-Sinai Medical Center Los Angeles CA 90048 United States Department of Biochemistry and Molecular Biology 985870 Nebraska Medical Center Omaha NE 68198 United States

It is likely that the majority of proteins will undergo post-translational modification, be it enzymatic or non-enzymatic. These modified protein(s) regulate activity, localization and interaction with other cellular molecules thereby maintaining cellular hemostasis. Alcohol exposure significantly alters several of these post-translational modifications leading to impairments of many essential physiological processes. Here, we present new insights into novel modifications following ethanol exposure and their role in the initiation and progression of liver injury. This critical review condenses the proceedings of a symposium at the European Society for the Biomedical Research on Alcoholism Meeting held September 12-15, 2015, in Valencia, Spain.

关键词： Alcohol Acetylation Liver Carbonylation methylation Dysfunction Methylation Glycosylation Phosphorylation Ubiquitination Sumoylation Betaine Post-translational protein modification

Clinical outcome after surgery on schwannomas in the extremities

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World Journal of Orthopedics 2021年第10期12卷 760-767页

作者： Andreas Saine Granlund Michala Skovlund Sørensen Claus Lindkær Jensen Birthe Højlund Bech Michael Mørk petersen Musculoskeletal Tumor Section Department of Orthopedic SurgeryCopenhagen University HospitalRigshospitaletCopenhagen 2100Denmark Department of Orthopedic Surgery Copenhagen University HospitalCopenhagen 2200Denmark Musculoskeletal Tumor Section Department of Orthopedic SurgeryUniversity of CopenhagenCopenhagen 2100Denmark Department of Radiology RigshospitaletUniversity of CopenhagenCopenhagen 2100Denmark

BACKGROUND Schwannoma is a benign,encapsulated and slowly growing tumor originating from Schwann cells and is rarely seen in the peripheral nerve *** symptoms are soreness,radiating pain and sensory loss combined with a soft tissue *** To evaluate pre-and postoperative symptoms in patients operated for schwannomas in the extremities and investigate the rate of malignant *** In this single center retrospective study design,all patients who had surgery for a benign schwannoma in the extremities from May 1997 to January 2018 were *** location of the tumor in the extremities was divided into five groups;forearm,arm,shoulder,thigh and leg including *** locations of the tumor in the nerves were also categorized as either;proximal,distal,minor or major *** the pre-and postoperative clinical evaluation,symptoms were classified as paresthesia,local pain,radiating pain,swelling,impairment of mobility/strength and asymptomatic tumors that were found incidentally(with magnetic resonance imaging).The patients were evaluated after surgery using the following categories:Asymptomatic or symptomatic patients(radiating and/or local pain)and those with *** follow up period was from the time of surgery until last examination of the particular *** logistic regression analysis was performed to identify independent prognostic factors for postoperative significant symptoms at *** We identified 858 cases from the institutional pathology *** excluded cases with duplicate diagnoses(n=407),pathology not including schwannomas(n=157),lesions involving the torso,spine and neck(n=150)leaving 144 patients for further *** this group 99 patients underwent surgery and there were five complications recorded:2 infections(treated with antibiotics)and 3 nerve palsies(2 involving the radial nerve and one involving the median nerve)that recovered *** the end of follow-up,1.4

关键词： Schwannoma Extremities Surgery Removal Symptoms Outcome

End-stage renal disease is associated with increased post endoscopic retrograde cholangiopancreatography adverse events in hospitalized patients

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World Journal of Gastroenterology 2018年第41期24卷 4691-4697页

作者： Tarek Sawas Fateh Bazerbachi Samir Haffar Won K Cho Michael J Levy John A Martin Bret T petersen Mark D Topazian Vinay Chandrasekhara Barham K Abu Dayyeh Division of Gastroenterology and Hepatology Mayo Clinic Department of Gastroenterology Digestive Center for Diagnosis and Treatment Division of Gastroenterology and Hepatology Georgetown University Medstar Washington Hospital Center

AIM To determine if end-stage renal disease (ESRD) is a risk factor for post endoscopic retrograde cholangio-pancreatography (ERCP) adverse events (AEs). METHODS We performed a retrospective cohort study using the Nationwide Inpatient Sample (NIS) 2011-2013. We identified adult patients who underwent ERCP using the International Classification of Diseases 9^(th) Revision (ICD-9-CM). Included patients were divided into three groups: ESRD, chronic kidney disease (CKD), and control. The primary outcome was post-ERCP AEs including pancreatitis, bleeding, and perforation determined based on specific ICD-9-CM codes. Secondary outcomes were length of hospital stay, in-hospital mortality, and admission cost. AEs and mortality were compared using multivariate logistic regression *** There were 492175 discharges that underwent ERCP during the 3 years. The ESRD and CKD groups contained 7347 and 39403 hospitalizations respectively, whereas the control group had 445424 hospitalizations. Post-ERCP pancreatitis (PEP) was significantly higher in the ESRD group (8.3%) compared to the control group (4.6%) with adjusted odd ratio (aOR) = 1.7 (95% CI: 1.4-2.1, ~aP < 0.001). ESRD was associated with significantly higher ERCP-related bleeding (5.1%) compared to the control group 1.5% (aOR = 1.86, 95%CI: 1.4-2.4, ~aP < 0.001). ESRD had increased hospital mortality 7.1% vs 1.15% in the control OR = 6.6 (95%CI: 5.3-8.2, ~aP < 0.001), longer hospital stay with adjusted mean difference (aMD) = 5.9 d (95% CI: 5.0-6.7 d, ~aP < 0.001) and higher hospitalization charges aMD = $+82064 (95%CI: $68221-$95906, ~aP < 0.001). CONCLUSION ESRD is a risk factor for post-ERCP AEs and is associated with higher hospital mortality. Careful selection and close monitoring is warranted to improve outcomes.

关键词： End-stage renal disease Nationwide Inpatient Sample Endoscopic retrograde cholangiopancreatography

The Adult Ventricular Septum;A Unique Portion of the Left and Right Ventricle

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Cardiovascular Innovations and Applications 2018年第B5期3卷 93-95页

作者： C.Richard Conti John W.petersen University of Florida Medical School GainesvilleFLUSA

The ventricular septum separates the right and left ventricles and thus is part of both *** is directed obliquely backward to the right,and curved with the convexity toward the right ventricle;it must be emphasized that the total cardiac septum has a complex,longitudinal twist and does not lie in any single *** upper and posterior part,is thin and fibrous,and is termed the membranous ventricular *** greater portion of the septum is thick and muscular and constitutes the muscular ventricular *** ventricular septum consists of two layers,a thin layer on the RV side and a thicker layer on the LV side[1].The major septal arteries tend to run between these two layers.

关键词： Adult Ventricular Septum Right Ventricle

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沉积物中趋磁细菌趋磁性优势的实验研究

第四纪研究 2014年第3期34卷 474-490页

作者：刘秀铭 Ramon Egli Nikolai Peterse 毛学刚 Nikolai petersen 福建师范大学地理研究所、福建省湿润亚热带山地生态重点实验室一省部共建国家重点实验室培育基地福州350007 Department of Environment and Geography Macquarie UniversitySydney NSW 2109Australia Zentralanstalt furMeteorologie und Geodynamik Hohe Warte 38A-1190WienAustria Institut fur Geophysik Ludwig-Maximilians-UniversitatTheresienstr.41D-80333 MunichGermany

趋磁细菌依靠其体内生物合成的磁小体颗粒沿地球磁场定向排列和游动,称为趋磁性。沿磁场的定向排列被认为可以使磁菌更有效地到达最佳生存环境,即趋磁性对磁菌的优势所在。目前对趋磁性优势的研究大多数集中在水环境或培养液环境下,而... 详细信息

趋磁细菌依靠其体内生物合成的磁小体颗粒沿地球磁场定向排列和游动,称为趋磁性。沿磁场的定向排列被认为可以使磁菌更有效地到达最佳生存环境,即趋磁性对磁菌的优势所在。目前对趋磁性优势的研究大多数集中在水环境或培养液环境下,而对于自然沉积物中趋磁性优势的理解还停留在假说阶段。越来越多的研究显示,磁菌在沉积物中的行为方式与水环境中所观测到的现象差别很大,因此,对趋磁性优势的研究也需要在沉积物环境中进行。本文我们通过对比在地磁场、近零磁场和反转磁场条件下两种磁菌:球菌和杆菌(Candidatus Magnetobacterium bavaricum)的时空变化,揭示在沉积物中趋磁性对趋磁细菌的作用。结果显示趋磁性对两种磁菌存在不同的作用,***在近零磁场条件下数量明显下降而在地磁场下又重新恢复,说明趋磁性优势对***的积极作用,然而球菌在近零磁磁场条件下的数量和分布与地磁场条件下相似,可能说明球菌在利用趋化性和行为方式上与***有很大不同。***在反转磁场条件下数量减少,而球菌则接近消失,说明球菌受极向趋磁性的影响比***大。两种磁菌因受沉积物环境和自身趋化性的影响在趋磁性上表现不同,可能***存在不同的趋磁性特点。本文实验结果说明对趋磁性的理解需要立足于复杂的沉积物环境。

关键词：趋磁细菌趋磁性优势沉积物环境 M bavaricum 球菌