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Chinese Journal of Chemical Physics 2011年第3期24卷 353-357,I0004页

作者： Ghulam Murtaza Rai Muhamlnad Azhar Iqbal Yongbingxu iain gordon will wenzhang 巴基斯坦旁遮普大学物理系拉合尔54590 英国约克大学电子部自旋电子学实验室约克YO105DD

We have investigated the doping behavior of rare earth element holmium （Ho3＋） in ZnO semiconductor. The structural, microstructure, and magnetic properties of Zn1-xHoxO （x=0.0, 0.04, and 0.05） thin films deposited on Si（100） substrate by thermal evaporation technique were studied. The ceramic targets were prepared by conventional solid state ceramic technique. The pallets used as target were final sintered at 900℃ in the presence of N2 atmosphere. The experimental results of X-ray diffraction （XRD） spectra, surface morphology, and magnetic properties show that the Ho3＋ doped ZnO thin films has a strong influence on the materials properties. The higher angle shift in peak position and most preferred （101） orientation were observed in XRD pattern. These spectra confirmed the substitution of Ho3＋ in ZnO lattice. The surface morphology and stoichiometry for both bulk and thin films were analyzed by scanning electron microscopy and energy dispersive spectroscopy. It was observed that grain size decreases with the increase of Ho3＋. Room temperature ferromagnetism was observed for Zn0.95Ho0.050 films. The ferromagnetism might be attributed to the substitution of Ho ions for Zn2＋ in ZnO lattices.

关键词： Diluted magnetic semiconductor Structural analysis Scanning electron mi- croscope Magnetic property

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn J.W.So Konstantin Feinberg Marina Manoraj Jenny Cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

Central pattern generation underlying Limulus rhythmic behavior patterns

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Current Zoology 2010年第5期56卷 537-549页

作者： gordon A.Wyse Department of Biology University of Massachusetts

Many behavioral activities of the horseshoe crab Limulus are rhythmic, and most of these are produced in large part by central pattern generators within the CNS. The chain of opisthosomal （‘abdominal＇） ganglia controls gill movements of ventilation and gill cleaning, and the prosomal ring of fused ganglia （brain and segmental ‘thoracic＇ ganglia） controls generation of feeding and locomotor movements of the legs. Both the opisthosomal CNS and the prosomal CNS can generate behaviorally ap- propriate patterns of motor output in isolation, without movements or sensory input. Preparations of the isolated opisthosomal CNS generate rhythmic output patterns of motor activity characterized as fictive ventilatory and gill cleaning rhythms. Moreover, CNS preparations also express longer-term patterns, such as intermittent ventilation or sequential bouts of ventilation and gill cleaning. Such longer-term patterns are commonly observed in intact animals. The isolated prosomal CNS does not spontaneously generate the activity patterns characteristic of walking, swimming, and feeding. However, perfusion of octopamine in the isolated prosomal CNS activates central pattern generators underlying rhythmic chewing movements, and injection of octopamine into in- tact Limulus promotes the chewing pattern of feeding, whether or not food is presented. Our understanding of the ability of neu-romodulators such as octopamine to elicit or alter central motor programs may help to clarify the central neural circuits of pattern generation that oroduce and coordinate these rhythmic behaviors

关键词： Limulus Rhythmic behavior Central nervous system Central pattern generator Feeding Respiration

Asymmetric variability between maximum and minimum temperatures in Northeastern Tibetan Plateau:Evidence from tree rings

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Science China Earth Sciences 2008年第1期51卷 41-55页

作者： Jacoby gordon Tree-Ring Laboratory Lamont-Doherty Earth Observatory Columbia University NY 10964 USA

Ecological systems in the headwaters of the Yellow River, characterized by hash natural environmental conditions, are very vulnerable to climatic change. In the most recent decades, this area greatly attracted the public's attention for its more and more deteriorating environmental conditions. Based on tree-ring samples from the Xiqing Mountain and A'nyêmagên Mountains at the headwaters of the Yellow River in the Northeastern Tibetan Plateau, we reconstructed the minimum temperatures in the winter half year over the last 425 years and the maximum temperatures in the summer half year over the past 700 years in this region. The variation of minimum temperature in the winter half year during the time span of 1578―1940 was a relatively stable trend, which was followed by an abrupt warming trend since 1941. However, there is no significant warming trend for the maximum temperature in the summer half year over the 20th century. The asymmetric variation patterns between the minimum and maximum temperatures were observed in this study over the past 425 years. During the past 425 years, there are similar variation patterns between the minimum and maximum temperatures; however, the minimum temperatures vary about 25 years earlier compared to the maximum temperatures. If such a trend of variation patterns between the minimum and maximum temperatures over the past 425 years continues in the future 30 years, the maximum temperature in this region will increase significantly.

关键词： Tibetan Plateau tree-ring minimum temperature maximum temperature asymmetric variability warming trend

Detection of alcoholic liver disease

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World Journal of Gastroenterology 2001年第3期7卷 297-302页

作者： Harriet gordon Consultant Physician and Gastroenterologist The Royal Hampshire County HospitalWinchesterHampshireUK

INTRODUCTIONAlcohol has been used in society over centuries and all over the world for its mood-lifting properties and taste. It is probably ,however ,the commonest drug of abuse world-wide and unfortunately causes considerable morbidity, mortality and social disruption .In 1990 the cost tl the USA was more than $ 100 billion and 100 000 lives.The relationship between alcohol and mankind is well documented from the earliest tines .

关键词： Biological Markers Humans Liver Diseases, Alcoholic

Unlearning Descartes:Sentient AI is a Political Problem

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Journal of Social Computing 2023年第3期4卷 193-204页

作者： gordon Hull the School of Data Science UNC CharlotteCharlotteNC 28223USA

The emergence of Large Language Models(LLMs)has renewed debate about whether Artificial Intelligence(AI)can be conscious or *** paper identifies two approaches to the topic and argues:(1)A“Cartesian”approach treats consciousness,sentience,and personhood as very similar terms,and treats language use as evidence that an entity is *** approach,which has been dominant in AI research,is primarily interested in what consciousness is,and whether an entity possesses it.(2)An alternative“Hobbesian”approach treats consciousness as a sociopolitical issue and is concerned with what the implications are for labeling something sentient or *** both enables a political disambiguation of language,consciousness,and personhood and allows regulation to proceed in the face of intractable problems in deciding if something“really is”sentient.(3)AI systems should not be treated as conscious,for at least two reasons:(a)treating the system as an origin point tends to mask competing interests in creating it,at the expense of the most vulnerable people involved;and(b)it will tend to hinder efforts at holding someone accountable for the behavior of the systems.A major objective of this paper is accordingly to encourage a shift in *** place of the Cartesian question-is AI sentient?-I propose that we confront the more Hobbesian one:Does it make sense to regulate developments in which AI systems behave as if they were sentient?

关键词： artificial intelligence Large Language Model consciousness sentience personhood Descartes Hobbes

Disruption of bone and skeletal muscle in severe burns

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Bone Research 2015年第1期3卷 6-10页

作者： gordon L Klein Department of Orthopaedic Surgery and Rehabilitation University of Texas Medical Branch and Shriners Hospitals for Children

Severe burn injury triggers the body＇s nonspecific adaptive responses to acute insult, including the systemic inflammatory and stress responses, as well as the sympathetic response to immobilization. These responses trigger inflammatory bone resorption followed by glucocorticoid-induced apoptosis of osteoblasts and probably osteocytes. Because these patients are catabolic, they suffer concomitant muscle wasting and negative nitrogen balance. The use of anabolic agents such as recombinant human growth hormone and oxandrolone results in improved bone mineral content and muscle strength after approximately I year. Use of bisphosphonates within the first 10 days of a severe burn completely blocks the resorptive bone loss and has the added advantage of appearing to preserve muscle protein from excessive breakdown. The mechanism for the protective effect on muscle is not currently known. However, if the effect of bisphosphonates on muscle can be confirmed, it raises the possibility that bone communicates with muscle.

关键词： bone Disruption of bone and skeletal muscle in severe burns

Visualisation techniques to support public interpretation of future climate change and land-use choices:a case study from N-E Scotland

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International Journal of Digital Earth 2016年第6期9卷 586-605页

作者： Chen Wang David Miller iain Brown Yang Jiang Marie Castellazzi Information and Computational Sciences The James Hutton InstituteAberdeenUK School of Computing Science and Digital Media Robert Gordon UniversityAberdeenUK

Mitigating and adapting to climate change includes a requirement to evaluate the role of future land uses in delivering robust integrated responses that are sensitive to local landscape *** practice,this emphasises the need for community engagement,planning and inclusive *** engagement may be potentially facilitated by the use of spatially explicit quantitative scenarios of landuse change in combination with interactive *** requires a coherent framework to integrate spatial data modelling,analytical capabilities and visualisation tools in a format that will also engage diverse public *** challenges were explored with a case study of virtual landscapes from N-E Scotland that was used to test preferences for scenarios of future land *** employed texture-based rendering rather than full photo-realistic rendering to facilitate interactivity and this provided additional scope for audiences to explore multiple future scenarios compared to the present *** voting in a virtual landscape theatre suggested preferences for visual diversity,good stewardship and perceived naturalness that should be considered in developing planned responses to *** investigation of preferences was conducted using interactive 3D features located within the *** findings are reviewed against objectives for inclusive engagement in the Digital Earth agenda and used to make further recommendations on the use of scenarios and visualisation *** particular,technical advances in user engagement need to be developed in conjunction with emerging good practice that addresses ethical,behavioural and inclusion issues so that the content is presented in as transparent and unbiased format as possible.

关键词： Landscape visualisation geographic information systems land-use scenarios public participation knowledge exchange

On embedding infinite cyclic covers in compact 3-manifolds

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Science China Mathematics 2017年第9期60卷 1575-1578页

作者： gordon Cameron McA. Department of Mathematics The University of Texas at AustinAustinTX 78712USA

We show that there are knots whose infinite cyclic covers do not embed in any compact 3-manifold,answering a question of Jiang et al.(2006).

关键词： knot infinite cyclic cover compact 3-manifold

Scale up of reactors for carbon dioxide reduction

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Frontiers of Chemical Science and Engineering 2023年第1期17卷 116-122页

作者： Andrew Nattestad Klaudia Wagner gordon G.Wallace Intelligent Polymer Research Institute and ARC Centre of Excellence for Electromaterials Science University of WollongongWollongong NSW 2522Australia School of Chemistry Monash UniversityClayton VIC 3800Australia

In recent times there has been a great deal of interest in the conversion of carbon dioxide into more useful chemical *** the other hand,the translation of these developments in electrochemical reduction of carbon dioxide from the laboratory bench to practical scale remains an underexplored *** we examine some of the major challenges,demonstrating some promising strategies towards such scale-up,including increased electrode area and stacking of electrode pairs in different *** observed that increasing the electrode area from 1 to 10 cm^(2) led to only a 4%drop in current density,with similarly small penalties realised when stacking sub-cells together.

关键词： CO_(2)reduction electrochemical cell electrosynthesis upscaling