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Detection of Epstein-Barr Virus in Nasopharyngeal Carcinoma in Sudanese by <i>in Situ</i>Hybridization

Journal of Cancer Therapy 2014年第6期5卷 517-522页

作者： Ameera A. m. Adam Nazik E. Abdullah Lamyaa A. m. El Hassan Elwaleed m. Elamin muntaser E. Ibrahim Ahmed m. El Hassan Department of molecular Biology Institute of Endemic Diseases University of Khartoum Khartoum Sudan Department of Surgery Faculty of Medicine University of Khartoum Khartoum Sudan Faculty of medical Laboratory Sciences Alzaeim Alazhari University Khartoum Sudan School of medicine Ahfad University for Women Omdurman Higher Specialization in Histopathology Khartoum Sudan

Objectives: The aim of this study is to detect Epstein-Barr virus (EBV) in nasopharyngeal carcinoma (NPC) biopsies of Sudanese patients using EBV-encoded RNA (EBER) in Situ hybridization (EBER-ish). Study Design: This is a descriptive cross-sectional study conducted at the National Center for ENT diseases and Head and Neck Surgery and the Institute of Endemic Diseases, University of Khartoum, Khartoum City, Sudan. Subjects and methods: Biopsies from 43 patients with nasopharyngeal carcinoma were examined for the presence of Epstein-Barr virus using EBER-ish. Ten normal samples were used to assess the presence of the virus in non cancer tissues. Results: Fifty three samples were examined for the presence of the virus by EBER-ish, 43 biopsies were NPC and ten were normal. Histologically the cases were, 20 (46.5%), 20 (46.5%) and 3 (7%) of the biopsies were classified as WHO types II, III and mixed type II and III, respectively;there were no cases of type I NPC. All nasopharyngeal carcinoma biopsies (100%) were positive for EBER1 in almost all carcinoma cells with focal and intense dark-blue staining limited to the nucleus;no hybridization was observed in the cytoplasm. No hybridization was observed in all ten non cancer tissues. Conclusion: All NPC cells are clearly EBV-infected. The virus is located in the nucleus of the tumour cells. The presence of Epstein-Barr virus in normal nasopharyngeal epithelia is not a common event. Objectives: The aim of this study is to detect Epstein-Barr virus (EBV) in nasopharyngeal carcinoma (NPC) biopsies of Sudanese patients using EBV-encoded RNA (EBER) in Situ hybridization (EBER-ish). Study Design: This is a descriptive cross-sectional study conducted at the National Center for ENT diseases and Head and Neck Surgery and the Institute of Endemic Diseases, University of Khartoum, Khartoum City, Sudan. Subjects and methods: Biopsies from 43 patients with nasopharyngeal carcinoma were examined for the presence of Epstein-Barr virus us

关键词： EBV NPC Sudan ish EBER

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Ultra-Dense Networking Architectures and Technologies for 5G

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ZTE Communications 2018年第2期16卷 1-2页

作者： victor c.m.leung zhang haijun the University of Brit⁃ish Columbia(UBS) Canada the Royal Soci⁃ety of Canada the Canadian Academy of Engineering and the Engineering Institute of Canada IEEE University of Science and Technology Beijing China Department of Electrical and Computer Engineering the University of British Columbia(UBC)Canada

With the continuous enrichment of mobile communication application scenarios in the future, the traditional macro-cellular-based mobile communication network architecture will be difficult to meet the explosive growth... 详细信息

关键词： In Ultra-Dense Networking Architectures and Technologies for 5G

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对低收入家庭喘息婴幼儿进行随机多方面干预的短期影响

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世界核心医学期刊文摘（儿科学分册） 2005年第5期1卷 40-41页

作者： Klinnert m. D. Liu A. H. Pearson m. R. 虎小毅 Natl. Jew ish med. and Res. Center 1400 Jackson St Denver CO 80206 United StatesDr.

Objective: To present an interim analysis of the effect of a home-based inter vention with low-income caregivers ofwheezing infants at risk for childhood ast hma on mediating variables. method: Infants aged 9 to 24 months with 3 or more p hysician-documented wheezing episodes were randomly assigned to environmental s upport intervention (ES) (n = 90) or control (n = 91) groups. Nurse home visitor s intervened for 1 year to decrease allergen and environmental tobacco smoke exp osure and improve symptom perception and management. Assessments at baseline and 12 months included allergens in house dust, infant urinary cotinine levels, car egivers’symptom reports, quality of life, illness management, and quality of ca regiving. medical records were coded for hospitalizations, emergency department visits, and corticosteroid bursts. Results: Within the ES group, cockroach aller gen levels were significantly reduced and there was a trend toward reduction in dog dander levels. Among infants with detectable urinary cotinine, levels were s ignificantly reduced in the ES group. Caregiver psychological resources modified the impact, and low-resource ES caregivers were the most strongly affected. As thma knowledge and provider collaboration improved significantly in the ES group . Neither reports of infant symptoms nor emergency department visits or hospital izations showed positive intervention effects. Number of corticosteroid bursts f or infants was significantly higher for the ES group. Conclusions: The Childhood Asthma Prevention Study intervention was effective in reducing several environm ental exposures and improving illness management. However, even with an intensiv e home-based intervention, we failed to reduce respiratory symptoms or medical use in the ES group relative to the control group, illustrating the difficulty o f changing the course of early asthma development among low-income infants.

关键词：喘息症状短期影响监护者狗毛医疗记录急诊科预知性内科医生皮质类固醇生存质量

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婴儿系统性透明变性病的毛细血管形态发生基因-2突变:对1例中国台湾婴儿超微结构的研究和突变分析

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世界核心医学期刊文摘（皮肤病学分册） 2005年第7期1卷 45-46页

作者： Lee J.Y.-Y. Tsai Y.-m. 王琼 Department of Dermatology College of Medicine Natl. Cheng Kung University Hospital Tainan TaiwanChina

Infantile systemic hyalinosis (ish) is a very rare infantile stiff-skin syndrome characterized by extensive deposits of hyaline material in various organs, especially the skin and gingiva. Recent studies identified pathogenic mutations in the capillary morphogenesis gene 2 (CmG2) in both ish and juvenile hyaline fibromatosis (JHF). Capillary morphogenesis protein- 2 is an integrin- like cell surface receptor for laminins and type IV collagen, and may play a key role in cell- matrix or cell- cell interactions. We report a case of ish in a 13- month- old Taiwan Residents girl who manifested progressive joint contractures, recurrent chest infections, chronic diarrhoea with severe hypoalbuminemia and ascites, gum hypertrophy, and violaceous papules and nodules over the occipital area, neck, lumbosacral and anogenital areas since birth. Skin biopsy revealed a thickened and hyalinized papillary dermis. Electron microscopy showed abundant extracellular fibrillogranular material and active fibroblasts with conspicuous Golgi complex filled with fibrillar material. mutation analysis identified a homozygous 1073- 1074insC mutation of CmG2 which had been reported in four other families and may represent a mutation hot spot.

关键词：超微结构突变分析透明变性形态发生基因丘疹结节真皮乳头层粘连蛋白纤维瘤病中国台湾成纤维细胞

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Global Cardiovascular Risk of the HIV Positive Patients Receiving Antiretroviral Therapy in Brazzaville

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World Journal of Cardiovascular Diseases 2019年第8期9卷 553-561页

作者： Stéphane méo Ikama Franck Ekoba-Otende Jospin makani Amélia Bokilo Bienvenu Ossibi-Ibara Louis Igor Ondze-Kafata Bertrand Fikhaem Ellenga-mbolla Thierry Raoul Gombet Suzy Gisèle Kimbally-Kaky Department of Cardiology Brazzaville University Hospital Center Brazzaville Congo National Centre of Blood Transfusion Brazzaville Congo Department of Infectious Diseases Brazzaville University Hospital Center Brazzaville Congo

A cross-sectional, descriptive and analytical study was conducted from January to August 2015 at the Brazzaville Ambulatory Treatment Center and at?the National Blood Transfusion Center. The objective was to contribute to improving?the care of people living with HIV under antiretroviral therapy by assessing their global cardiovascular risk (CVR). The variables studied focused on the epidemiological, clinical and biological aspects. The global CVR was assessed?by the Framingham and WHO/ish scores. There were 135 HIV-positive subjects,?including 64 treated patients and 71 untreated HIV+ subjects. The subjects were divided into 83 men (61.5%) and 52 women (38.5%), with an average age of 42.6 ± 2.9 old years. The subjects were single people (62.2%), of a secondary educational level (63.7%), and civil servants (32.6%). The main risk factors found were dyslipidaemia (60%), obesity (36%), smoking (12.6%), hypertension (5.9%), diabetes (0.7%). The metabolic syndrome was found in seven cases (11.3%). The global CVR according to the score of Framingham, initially moderated at 17.2%, and mean at 1.5% within treated patients, was mean at 9.4% and high at 1.6% of the subjects respectively at the sixth month of treatment (p CVR under antiretroviral therapy. Preventive actions are highly recommended.

关键词： HIV Infection Antiretroviral Therapy metabolic Disorders Global Cardiovascular Risk Congo

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残胃中EB病毒相关性胃癌:新生和异时残胃癌

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世界核心医学期刊文摘（胃肠病学分册） 2005年第11期1卷 54-55页

作者： Kaizaki Y. Hosokawa O. Sakurai S. Fukayama m. 李宏宇 Department of Pathology Fukui Prefectural Hospital 2- 8- 1 Yotsui Fukui 910- 8526 Japan

Background: The remnant stomach corresponds to the gastric cardia, but is exposed to a completely different environment. The present study was performed to investigate the role of Epstein- Barr virus (EBV) infection in patients with gastric remnant carcinoma (GRC).methods: Clinicopatho logical features,gastritis, and infection by EBV were investigated in patients with two types of GRC: GRC occurring at an interval of 10 years or longer between operations (de novo GRC group) and GRC occurring within 10 years after the initial operation for gastric carcinoma (metachronous GRC group). Results: EBV involvement in the de novo GRC group (23% ) was not significantly different from that in the cardia of non-remnant carcinomas (controls; 18% ). EBV involvement showed greater correlations inmale patients (18/63; 28% ), and in those with gastritis cystica polyposa (GCP; 13/41; 31% ), and those with an interval of 20 years or longer (15/50; 30% ) than with the other parameters. multivariate analysis showed a significant correlation between GCP and EBV infection. Histologically, hyperplasia or mild atrophy, and mild lymphocytic infiltration were observed in 56% and 67% of non-neoplastic mucosa of EBV- associated GRC, respectively. In the metachronous GRC group, EBV-enco-ded mRNA in situ hybridization (EBER-ish) of 27 pairs of primary gastric carcinomas (GCs) and metachronous GRCs indicated that only six EBV(? )metachronous GRCs were derived from EBV (? ) GC. Conclusions: Epstein-Barr virus infection, together with long-standing inflammation, which causes GCP, may facilitate the development of de novo GRC. Close follow-up of patients treated with distal gastrectomy for EBV associated GC is necessary to detect metachronous GRC.

关键词：残胃癌 EB病毒原发性胃癌远端胃切除临床病理学持续炎症组织学检查胃囊于术时间组

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慢性和发作性偏头痛患者的皮质抑制减少和所表示的疾病谱

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世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 17-18页

作者： Aurora S.K. Barrodale P. Chronicle E.P. mulleners W.m. 江山 Swed ish Headache Institute 1101 Madison St. Seattle WA 98104 United States Dr.

Background.- The pathophysiological relationship between episodic migraine a nd chronic migraine is not fully understood. We aimed to examine transcranial ma gnetic stimulation (TmS) indices of cortical excitability in patients with episo dic migraine (Em) and probable chronic migraine (PCm), and matched controls. met hods.- Cortical excitability was assessed at baseline with two well- establish ed methods: phosphene thresholds (PT) and magnetic suppression of perceptual acc uracy (mSPA)- profiles. Five Em patients, five PCm patients, and five normal co ntrols participated in the main study. In addition, two patients were reassessed after 30 days of treatment with topiramate. Results.- Both PT and mPSA measure s were consistent in indicating a continuum of excitability across the three gro ups: PCm patients had the highest excitability, followed by Em, then controls. I n the two treated patients mPSA profiles appeared to normalize at a 100 mg dosag e. Conclusions.- Patients with PCm appear to be characterized by very high cort ical excitability. This may contribute to their greatly increased attack frequen cy. TmS- based methods will be important for future research examining the evol ution of chronic migraine from episodic migraine over time.

关键词：偏头痛患者托吡酯经颅磁刺激病理生理学测量结果

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血压分类、高血压亚型与代谢综合征

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世界核心医学期刊文摘（心脏病学分册） 2007年第2期3卷 53-54页

作者： Franklin S.S. Barboza m.G. Pio J.R. Wong N.D. 何燕萍 Heart Disease Prevention Program C240 Medical SciencesUniversity of California Irvine IrvineCA92697 United States.Dr.

背景:血压升高是代谢综合征(metS)的表现之一,然而,各血压分类和高血压亚型与代谢综合征患病可能之间的关系尚未确定。方法:在1999—2002年国家健康和营养状况调查中选择了5968例年龄≥18岁、未经抗高血压治疗的受试者(加权为124700000... 详细信息

背景:血压升高是代谢综合征(metS)的表现之一,然而,各血压分类和高血压亚型与代谢综合征患病可能之间的关系尚未确定。方法:在1999—2002年国家健康和营养状况调查中选择了5968例年龄≥18岁、未经抗高血压治疗的受试者(加权为124700000)进行横断面研究,确定不同血压分类组的metS(依据NCEP标准)患病可能性。根据JNC-VI血压分类,非高血压情况被分为理想血压、正常血压和高正常血压。

关键词：代谢综合征抗高血压治疗横断面研究国家健康营养状况总胆固醇水平

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HPV E6/E7 mRNA原位杂交诊断宫颈低级别鳞状上皮内病变

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临床与实验病理学杂志 2018年第11期34卷 1199-1199页

作者：解建军张仁亚 mills A m Coppock J D Willis B C 青岛市城阳区人民医院病理科城阳266109 济宁医学院附属医院病理科济宁272029

宫颈低级别鳞状上皮内病变(LSIL)[亦称宫颈上皮内瘤变,1级(CIN1)]可带来相当大的诊断挑战,并且与观察者之间重复性较差和过诊断有关。此外,一些辅助性检测项目,如p16免疫组化检查在解析LSIL与正常/反应性鳞状上皮病变的差异作用不大。... 详细信息

宫颈低级别鳞状上皮内病变(LSIL)[亦称宫颈上皮内瘤变,1级(CIN1)]可带来相当大的诊断挑战,并且与观察者之间重复性较差和过诊断有关。此外,一些辅助性检测项目,如p16免疫组化检查在解析LSIL与正常/反应性鳞状上皮病变的差异作用不大。人类乳头状瘤病毒(HPV)RNA原位杂交(ish)检测在LSIL的诊断中可能是一种较好的辅助诊断方法,但目前这方面尚没有较大宗病例的研究。

关键词： mRNA原位杂交宫颈上皮内瘤变鳞状上皮内病变诊断方法低级别 HPV 人类乳头状瘤病毒 E7

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采用不同导管和技术的去肾交感神经术治疗单纯收缩期高血压:一项随机试验结果

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中华高血压杂志 2019年第7期27卷 699-699页

作者： Fengler K Rommel KP Lapusca R Blazek S Besler C Hartung P von Roeder m Kresoja KP Desch S Thiele H Lurz P 赵狄练桂丽不详

目前认为单纯收缩期高血压(isolated systolic hypertension,ish)患者经去肾交感神经术(renal sympathetic denervation,RDN)后血压降低。此结论绝大多数来自单极射频导管消融的研究。但采用新的RDN的数据有限。研究者采用比较3种不同RD... 详细信息

目前认为单纯收缩期高血压(isolated systolic hypertension,ish)患者经去肾交感神经术(renal sympathetic denervation,RDN)后血压降低。此结论绝大多数来自单极射频导管消融的研究。但采用新的RDN的数据有限。研究者采用比较3种不同RDN方法的RADIOSOUND-HTN(采用不同RDN导管与技术治疗顽固性高血压患者的三臂随机试验)数据,探讨ish与RDN反应的可能交互作用。

关键词：单纯收缩期高血压射频导管消融随机试验 hypertension 治疗经术交感高血压患者

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