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OPTICAL MEASUREMENT OF PHOTOSENSITIZER CONCENTRATION IN VIVO

journal of Innovative Optical Health Sciences 2011年第2期4卷 97-111页

作者： MARTIN R.AUSTWICK jOSEPHINE H.WOODHAMS VADZIM CHALAU CHARLES A.MOSSE CAROLINE ELIOT LAURENCE LOVAT ALEXANDER j.MACROBERT irving j.bigio STEPHEN G.BOWN National Medical Laser Centre Charles Bell House 67-73 Riding House Street University College London London W1W 7EJUK Boston University BME44 Cummington Street BostonMA 02215USA

Most techniques for measuring tissue concentrations of drugs are invasive,time-consuming,and often require the removal of tissue or *** pharmacokinetics(OP)is a minimally invasive alternative giving an immediate *** of white light are directed at the tissue of interest using afiber optic *** light is detected by a secondfiber immediately adjacent to thefirst in the same probe(separation 1.7 mm).Using the photosensitizer disulfonated aluminium phthalocyanine(AlS_(2)Pc),OP measurements were made in phantoms and on the mouth,stomach,colon,skin,and liver of normal rats 1 and 24 h after intravenous AlS_(2)Pc ***_(2)Pc concentration was determined by calculating the area under the curve(AUC)in the spectral region around the peak drug absorption or measuring the height of the *** baseline interpolation removed the need for pre-drug,control optical *** measurements correlated well with values from alkali chemical extraction(CE)of the corresponding tissues,(R^(2)0.87=0.97).OP measurements in the mouth also correlated with CE of less accessible internal organs(R^(2)0.77-0.88).In phantoms,the lowest detectable concentration was 0.1μg/*** vivo,results were limited by the lower accuracy in the CE measurements but were almost certainly *** incidentalfinding was a 12-15nm red shifted component in the spectra observed 1 h after drug administration,suggesting partitioning of the drug in different microenvironment compartments,which could prove to be of considerable interest in future *** conclusion,OP shows promise for real-time measurement of concentrations of drugs with suitable absorption peaks.

关键词： Optical pharmacokinetics chemometrics photodynamic therapy noninvasive measurement

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Endoscopic ultrasound fine needle aspiration vs fine needle biopsy for pancreatic masses,subepithelial lesions,and lymph nodes

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World journal of Gastroenterology 2021年第26期27卷 4194-4207页

作者： irving Levine Arvind j Trindade Division of Gastroenterology Long Island Jewish Medical CenterZucker School of Medicine at Hofstra/NorthwellNorthwell Health SystemNew Hyde ParkNY 11040United States

Endoscopic ultrasound tissue acquisition,in the form of both fine needle aspiration(EUS-FNA)and fine needle biopsy(EUS-FNB),is utilized for pancreatic mass lesions,subepithelial lesions,and lymph node *** procedures are safe and yield high diagnostic *** its high diagnostic yield,EUS-FNA has potential limitations associated with cytological aspirations,including inability to determine histologic architecture,and a small quantitative sample for further immunohistochemical ***-FNB,with its larger core biopsy needle,was designed to overcome these potential ***,it remains unclear which technique should be used and for which *** trials are plagued by heterogeneity at every stage of comparison;including variable needles used,and different definitions of endpoints,which therefore limit ***,we present a review of prospective trials,systematic reviews,and meta-analyses on studies examining EUS-FNA vs *** comparative trials of EUS-FNA vs EUS-FNB primarily focus on pancreatic mass lesions,and yield conflicting results in terms of demonstrating the superiority of one ***,consistent among trials is the potential for diagnosis with fewer passes,and a larger quantity of sample achieved for next generation *** regard to subepithelial lesions and lymph node biopsy,fewer prospective trials exist,and larger prospective studies are *** on the available literature,we would recommend EUS-FNB for peri-hepatic lymph nodes.

关键词： Endoscopic ultrasound fine needle aspiration Endoscopic ultrasound fine needle biopsy Pancreatic lesions Subepithelial lesions Lymph node biopsy

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Post-ablation surveillance in Barrett's esophagus: A review of the literature

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World journal of Gastroenterology 2016年第17期22卷 4297-4306页

作者： Matthew W Stier Vani j Konda john Hart irving Waxman Department of Internal Medicine The University of Chicago Medicine Division of Gastroenterology Department of Medicine The University of Chicago Medicine Department of Pathology The University of Chicago Medicine

Barrett’s esophagus (BE) is a pre-malignant condition affecting up to 15% of patients with gastroesophageal reflux disease. Neoplastic Barrett’s mucosa is defined as harboring high grade dysplasia or intra-mucosal cancer, and carries a high risk of progression to esophageal adenocarcinoma. The rising incidence of Barrett’s lesions along with the high morbidity of surgical approaches has led to the development of numerous validated endoscopic techniques capable of eradicating neoplastic mucosa in a minimally invasive manner. While there has been widespread adoption of these techniques, less is known about optimal surveillance intervals in the post-therapy period. This is due in part to limitations in current surveillance methods, questions about durability of treatment response and the risk of subendothelial progression. As we are now able to achieve organ sparing eradication of superficial neoplasia in BE, we need to also then focus our attention on how best to manage these patients after eradication is achieved. Implementing optimal surveillance practices requires additional understanding of the biology of the disease, appreciation of the limits of current tools and treatments, and exploration of the role of adjunctive technologies. The aim of this article is to provide a comprehensive review of current literature surrounding post-ablation surveillance in neoplastic BE.

关键词： Barrett’ s esophagus Endotherapy Post-ablation surveillance Neoplastic Radiofrequency ablation Endoscopic mucosal resection

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The gardener's companion to medicinal plants

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作者： Simmonds Monique S. j. Howes Melanie-jayne irving jason

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Molecular dynamics reveal a novel kinase-substrate interface that regulates protein translation

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journal of Molecular Cell Biology 2014年第6期8卷 473-485页

作者： Ming S. Liu Die.Wang Hiroyuki Morimoto Howard C.H. Yim Aaron T. irving Bryan R.G. Williams Anthony j, Sadler Centre for Cancer Research MIMR-PHI Institute of Medical Research Melbourne VIC 3168 Australia CSIRO - Computational Informatics and Digital Productivity Flagship Private Bag 10 Clayton South VlC 3169 Australia Department of Anatomy School of Medicine University of Occupational and Environmental Health Kitakyushu Fukuoka 807-8555 Japan Department of Molecular and Translational Science Monash University Melbourne VlC 3168 Australia

A key control point in gene expression is the initiation of protein translation, with a universal stress response being constituted by in- hibitory phosphoryiation of the eukaryotic initiation factor 2α （el F2oL）. In humans, four kinases sense diverse physiological stresses to regulate elF2α to control cell differentiation, adaptation, and survival. Here we develop a computational molecular model of elF2α and one of its kinases, the protein kinase R, to simulate the dynamics of their interaction. Predictions generated by coarse-grained dynamics simulations suggest a novel mode of action. Experimentation substantiates these predictions, identifying a previously unrecognized interface in the protein complex, which is constituted by dynamic residues in both elF2α and its kinases that are crucial to regulate protein translation. These findings call for a reinterpretation of the current mechanism of action of the el F2α kinases and demonstrate the value of conducting computational analysis to evaluate protein function.

关键词： molecular dynamics eukaryotic initiation factor 2α(elF2oc) elF2α kinases protein kinase R (PKR) protein translation kinase activity

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Expression of human FUS protein in Drosophila leads to progressive neurodegeneration

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Protein & Cell 2011年第6期2卷 477-486页

作者： Yanbo Chen Mengxue Yang jianwen Deng Xiaoping Chen Ye Ye Li Zhu jianghong Liu Haihong Ye Yan Shen Yan Li Elizabeth j.Rao Kazuo Fushimi Xiaohong Zhou Eileen H.bigio Marsel Mesulam Qi Xu jane Y.Wu National Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Science and Peking Union Medical CollegeTsinghua UniversityBeijing 100730China State Key Laboratory of Brain and Cognitive Science Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Department of Neurology Center for Genetic MedicineLurie Cancer CenterNorthwestern University Feinberg School of Medicine303 E.Superior St.ChicagoIL 60611 USA The Cognitive Neurology&Alzheimer's Disease Center Northwestern University Feinberg School of Medicine303 E.Chicago Ave.ChicagoIL 60611USA Trumbull College Yale UniversityNew HavenCT 06511USA

Mutations in the Fused in sarcoma/Translated in liposarcoma gene(FUS/TLS,FUS)have been identified among patients with amyotrophic lateral sclerosis(ALS).FUS protein aggregation is a major pathological hallmark of FUS proteinopathy,a group of neurodegenerative diseases characterized by FUS-immunoreactive inclusion *** prepared transgenic Drosophila expressing either the wild type(Wt)or ALS-mutant human FUS protein(hFUS)using the UAS-Gal4 *** expressing Wt,R524S or P525L mutant FUS in photoreceptors,mushroom bodies(MBs)or motor neurons(MNs),transgenic flies show age-dependent progressive neural damages,including axonal loss in MB neurons,morphological changes and functional impairment in *** transgenic flies expressing the hFUS gene recapitulate key features of FUS proteinopathy,representing the first stable animal model for this group of devastating diseases.

关键词： frontotemporal lobar degeneration(FTLD) FUS proteinopathy animal model amyotrophic lateral sclerosis neurodegeneration

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Synthesis of N-(2-Hydroxy-1-Phenoxyacetyl)Prolyproline

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Wuhan University journal of Natural Sciences 1998年第2期3卷 217-220页

作者： Yang Dingqiao(Department of Chemistry,Huanggang Teachers College, Huanggang City, Hubei 436100,China)Grace B Borowitz,irving j Borowitz(Department of Chemistry,Ramapo College of New jersey, Mahwah,Nj 07430,USA) Huanggang Teachers College Department of Chemistry Huanggang City Hubei China Ramapo College of New jersey Department of Chemistry Mahwah USA (GRID:grid.418922.4) (ISNI:0000 0001 2108 5881)

Ionophores consist of molecules which surround and carry positive metal ions and other ions through biological membranes. One classe of ionophores which we have been developing contains dipeptides which are encouraged to become part of a ring because of possible hydrogen bond formation between the 2-hydroxy on the phenyl group and carboxyl group (COOH) of the final amide proline. Formation of a ring should increase the complexation ability of the ionophore. We report that the synthesis of N-(2-hydroxyl-1-phenoxyacetyl) prolyproline(1), a novel ionophore is prepared from activated 2-acetoxy phenoxyacetic acid (3a) and the appropriate dipeptide ester using coupling methods such as dicyclohexyl carbodiimide with hydroxyben-ztriazole or carbonyl diimidazole.

关键词： synthesis ionophore dipeptide

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负载型固体超强酸催化剂上的烷基化反应

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环境化学 2000年第2期19卷 103-109页

作者：陈建民 TierneyjW Wenderirving 复旦大学环境科学与工程系上海200433 美国匹兹堡大学化工与石油工程系 pa15601

本文利用Ｐｔ／ＳＯ＾２－４／ＺｒＯ２，Ｐｔ／ＷＯ３／ＺｒＯ２负载于大比表面Ａｌ２Ｏ３固体强酸催化剂，进行异丁烷和丁烯的烷基化反应。

关键词：固体强酸催化剂烷基化反应负载型

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巨晶及它们的寄主玄武岩中痕量元素丰度:对分配系数及巨晶成因的控制

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宝石和宝石学杂志(中英文) 1984年第1期 35-47页

作者： A.j.irving F.A.Frey 邱家骧

在我们致力于获取有关基性岩、高压下岩石形成的矿物/熔体痕量元素的分配信息过程中,我们测定了单斜辉石、斜方辉石、角闪石、云母、歪长石、磷灰石和锆石巨晶,以及它们的寄主玄武岩中稀土和其它痕量元素的丰度。通常由实验分配研究和斑... 详细信息

在我们致力于获取有关基性岩、高压下岩石形成的矿物/熔体痕量元素的分配信息过程中,我们测定了单斜辉石、斜方辉石、角闪石、云母、歪长石、磷灰石和锆石巨晶,以及它们的寄主玄武岩中稀土和其它痕量元素的丰度。通常由实验分配研究和斑晶/基质测定得到的矿物/熔体分配系数的范围,与巨晶/寄主岩的丰度比范围是一致的。我们的有关Hf、SC、Ta及Th分配数据可供多种估算之用。考虑到相平衡,主要元素的分配和同位素比率表明,在高压下(大概为10—25kb),大多数辉石及角闪石巨晶与它们的寄主岩浆是平衡的。相反,要与它们寄主玄武岩平衡形成云母、歪长石、磷灰石及锆石巨晶,则是不太可能的,而我们推断,它们是从更高程度演化的岩浆中析出的,并且经过混合变为现有的寄主岩浆。因此,巨晶/寄主岩的痕量元素丰度比,不应视为分配系数,而只能当作在高压岩石形成过程中,认识痕量元素分配的向导。有鉴于此,我们假定,巨晶/寄主岩痕量元素丰度数据所表明的,在高压分离过程中,玄武岩体系矿物/熔体的分配系数,与低压分离过程中有效的分配系数,并没有很明显的区别。

关键词：巨晶痕量元素 REE 微量元素碱性长石歪长石基性岩玄武岩元素丰度寄主分配系数

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变质沉积混合岩杂岩体中贫钾淡色体的成因

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国外花岗岩类地质与矿产 1995年第2期 1-9页

作者： D.L.Whitney A.j.irving 涂绍雄

在美国华盛顿州北喀斯喀特地区斯卡吉特混合岩杂岩体的交质沉积岩中已鉴别出两类层状淡色体。一类淡色体REE相对富集,其中含有小的(<0.8mm)富Fe石榴石、富Ti矿物(金红石和榍石),石(?)中含有富CO_2包裹体。这类淡色体的成因被认为是通过... 详细信息

在美国华盛顿州北喀斯喀特地区斯卡吉特混合岩杂岩体的交质沉积岩中已鉴别出两类层状淡色体。一类淡色体REE相对富集,其中含有小的(<0.8mm)富Fe石榴石、富Ti矿物(金红石和榍石),石(?)中含有富CO_2包裹体。这类淡色体的成因被认为是通过原地局部熔融形成,并伴随上角闪岩相交质过程中富水流体的流入。另一类淡色体REE相对亏损,不含石榴石和富Ti矿物,石英中仅含富H_2O流体包裹体,其成因被认为完全由亚固相线作用(如变质分异作用)形成。与变质沉积(含黑云母)源岩共生的贫K(英云闪长质-奥长花岗岩)淡色体可能是通过水饱和局部熔融或通过亚固相线作用形成。两种淡色体形成机制都可以在上角闪岩相区域交质作用过程中进行。在中地壳造山作用过程中,如果正在结晶的深成岩体充当为超变质作用所必需的富水流体的外部来源,则局部熔融可由同变质的岩浆活动触发。大规模的混合岩杂岩体例如斯卡吉特混合岩的形成可能至少部分地与高级变质过程中深成作用的接触效应有关。因此,尽管混合岩杂岩体在体积上是许多造山带的一部分,但它们本身并不代表大规模火成岩体原来的岩浆来源。

关键词：变质沉积混合岩杂岩体钾淡色体成因

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