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Flavonoid Myricetin as Potent Anticancer Agent: A Possibility towards Development of Potential Anticancer Nutraceuticals

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Chinese Journal of Integrative Medicine 2024年第1期30卷 75-84页

作者： Anchal Trivedi Adria Hasan Rumana Ahmad Sahabjada Siddiqui Aditi Srivastava aparna Misra Snober S.Mir Department of Biochemistry Era's Lucknow Medical College&HospitalEra UniversityLucknow(226003)India Molecular Cell Biology Laboratory Integral Information and Research Centre-4(IIRC-4)Department of BioengineeringFaculty of EngineeringIntegral UniversityLucknow(226026)India Department of Biotechnology Era's Lucknow Medical College&HospitalEra UniversityLucknow(226003)India Department of Biosciences Faculty of ScienceIntegral UniversityLucknow(226026)India

Good nutrition plays a crucial role in maintaining a balanced lifestyle. The beneficial effects of nutrition have been found to counteract nutritional disturbances with the expanded use of nutraceuticals to treat and manage cardiovascular diseases, cancer, and other developmental defects over the last decade. Flavonoids are found abundantly in plant-derived foods such as fruits, vegetables, tea, cocoa, and wine. Fruits and vegetables contain phytochemicals like flavonoids, phenolics, alkaloids, saponins, and terpenoids. Flavonoids can act as anti-inflammatory, anti-allergic, anti-microbial(antibacterial, antifungal, and antiviral) antioxidant, anti-cancer, and anti-diarrheal agents. Flavonoids are also reported to upregulate apoptotic activity in several cancers such as hepatic, pancreatic, breast, esophageal, and colon. Myricetin is a flavonol which is naturally present in fruits and vegetables and has shown possible nutraceutical value. Myricetin has been portrayed as a potent nutraceutical that may protect against cancer. The focus of the present review is to present an updated account of studies demonstrating the anticancer potential of myricetin and the molecular mechanisms involved therein. A better understanding of the molecular mechanism(s) underlying its anticancer activity would eventually help in its development as a novel anticancer nutraceutical having minimal side effects.

关键词： myricetin flavonoids anticancer nutraceuticals Chinese medicine Ayurveda complementary and alternative medicine

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Optoelectronic and thermoelectric properties of spinel chalcogenides HgLa2X4（X=S and Se）:A first-principles study

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Journal of Rare Earths 2024年第10期42卷 1927-1936页

作者： aparna Dixit Inas A.Ahmed Jisha Annie Abraham Zeinhom M.El-Bahy Mumtaz Manzoor Sajad Ahmad Dar Ramesh Sharma Department of Basic Science and Humanities Pranveer Singh Institute of Technology Department of Chemistry Faculty of ScienceKing Khalid University Department of Physics National Defence Academy Department of Chemistry Faculty of ScienceAl-Azhar University Institute of Physics Slovak Academy of Sciences Department of Physics Motilal Vigyan Mahavidyalya College Department of Applied Science Feroze Gandhi Institute of Engineering and Technology

We investigated spinel chalcogenides HgLa2（S/Se）4by using density function theory,and scrutinized the structural,optical,electrical,mechanical and thermoelectric transport characteristics of HgLa2（S/Se）4spinel *** enthalpy of formation,energy of cohesion,and energy volume optimum plots were used to obtain the stability as well as the perfect ground state of these *** ductility of these materials was the best illustrated with the help of Poisson's and Pugh's *** band gap results were obtained using Trans and Blaha modified Becke-Johanson potential（TB-mBJ）.Both the materials present semi-conducting nature with direct band gap equal to 1.449 and 0.892 eV respectively for HgLa2S4and *** were also made for optical characteristics with the values of dielectric function,absorption coefficient,optical conductivity,reflectivity,and refractive *** to the findings,both of these materials are suitable for infrared optoelectronic *** materials were found to have promising optoelectronic and thermoelectric applications after their optical properties and transport aspects were *** tiny levels of temperature conductivities,substantial am ounts of power conductivities,the figure of merit（more than unity）,as well as Seebecs coefficients all point to the potential use of both the materials in thermoelectric power generators.

关键词： Density functional theory Direct band gap Optoelectronic Power factor Semiconductors Thermoelectric

The AI Paradox: Mapping the Unintended Disruptions in IT and Beyond

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International Journal of Communications, Network and System Sciences 2024年第7期17卷 105-112页

作者： aparna Gadhi Chinna Manikanta Bandaru Olatunde Abiona Department of Computer Information Systems Indiana University Northwest Gary IN USA

In the realm of Artificial Intelligence (AI), there exists a complex landscape where promises of efficiency and innovation clash with unforeseen disruptions across Information Technology (IT) and broader societal realms. This paper sets out on a journey to explore the intricate paradoxes inherent in AI, focusing on the unintended consequences that ripple through IT and beyond. Through a thorough examination of literature and analysis of related works, this study aims to shed light on the complexities surrounding the AI paradox. It delves into how this paradox appears in various domains, such as algorithmic biases, job displacement, ethical dilemmas, and privacy concerns. By mapping out these unintended disruptions, this research seeks to offer a nuanced understanding of the challenges brought forth by AI-driven transformations. Ultimately, its goal is to pave the way for the responsible development and deployment of AI, fostering a harmonious integration of technological progress with societal values and priorities.

关键词： Artificial Intelligence AI Paradox Unintended Disruptions Information Technology Ethical Dilemmas Privacy Concerns Job Displacement Algorithmic Biases

Cyber Resilience through Real-Time Threat Analysis in Information Security

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International Journal of Communications, Network and System Sciences 2024年第4期17卷 51-67页

作者： aparna Gadhi Ragha Madhavi Gondu Hitendra Chaudhary Olatunde Abiona Department of Computer Information Systems Indiana University Northwest Gary IN USA

This paper examines how cybersecurity is developing and how it relates to more conventional information security. Although information security and cyber security are sometimes used synonymously, this study contends that they are not the same. The concept of cyber security is explored, which goes beyond protecting information resources to include a wider variety of assets, including people [1]. Protecting information assets is the main goal of traditional information security, with consideration to the human element and how people fit into the security process. On the other hand, cyber security adds a new level of complexity, as people might unintentionally contribute to or become targets of cyberattacks. This aspect presents moral questions since it is becoming more widely accepted that society has a duty to protect weaker members of society, including children [1]. The study emphasizes how important cyber security is on a larger scale, with many countries creating plans and laws to counteract cyberattacks. Nevertheless, a lot of these sources frequently neglect to define the differences or the relationship between information security and cyber security [1]. The paper focus on differentiating between cybersecurity and information security on a larger scale. The study also highlights other areas of cybersecurity which includes defending people, social norms, and vital infrastructure from threats that arise from online in addition to information and technology protection. It contends that ethical issues and the human factor are becoming more and more important in protecting assets in the digital age, and that cyber security is a paradigm shift in this regard [1].

关键词： Cybersecurity Information Security Network Security Cyber Resilience Real-Time Threat Analysis Cyber Threats Cyberattacks Threat Intelligence Machine Learning Artificial Intelligence Threat Detection Threat Mitigation Risk Assessment Vulnerability Management Incident Response Security Orchestration Automation Threat Landscape Cyber-Physical Systems Critical Infrastructure Data Protection Privacy Compliance Regulations Policy Ethics Cybercrime Threat Actors Threat Modeling Security Architecture

Variable frequency deep brain stimulation of subthalamic nucleus to improve freezing of gait in Parkinson's disease

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National Science Review 2024年第06期 102-104页

作者： Fumin Jia aparna Wagle Shukla Wei Hu Yu Ma Jianguo Zhang Leonardo Almeida Chris Kao Yi Guo Shizhong Zhang Yingqun Tao Zhipei Ling Xin Xu Zhiquan Yang Fan-gang Meng Xinhua Wan Hesheng Liu Peter E.Konard Luming Li National Engineering Laboratory for Neuromodulation Tsinghua University University of Florida Center for Movement Disorders and Neurorestoration Tsinghua University Yuquan Hospital Beijing Tiantan Hospital Capital Medical University School of Medicine Vanderbilt University Peking Union Medical College Hospital ZhuJiang Hospital of Southern Medical University The General Hospital of Shenyang Military Chinese PLA General Hospital Xiangya Hospital Central South University Beijing Neurosurgical Institute Capital Medical University Athinoula A. Martinos Center for Biomedical Imaging Harvard Medical School Precision Medicine & Healthcare Research Center Tsinghua-Berkeley Shenzhen Institute Man-Machine-Environment Engineering Institute School of Aerospace EngineeringTsinghua University Center of Epilepsy Beijing Institute for Brain Disorders

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a welle-stablished therapy for patients with Parkinson’s disease (PD) presenting with medication refractory tremors, motor fluctuations and dyskinesias induced by dopaminergic medications [1]. However,traditional high-frequency stimulation(HFS) does not effectively control axial symptoms such as gait dysfunction,postural instability and freezing of gait(FOG)[2,3].

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Xception-Fractalnet:Hybrid Deep Learning Based Multi-Class Classification of Alzheimer’s Disease

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Computers, Materials & Continua 2023年第3期74卷 6909-6932页

作者： Mudiyala aparna Battula Srinivasa Rao School of Computer Science and Engineering VIT-AP UniversityAndhra Pradesh522237India

Neurological disorders such as Alzheimer’s disease(AD)are very challenging to treat due to their sensitivity,technical challenges during surgery,and high *** complexity of the brain structures makes it difficult to distinguish between the various brain tissues and categorize AD using conventional classification ***,conventional approaches take a lot of time and might not always be ***,a suitable classification framework with brain imaging may produce more accurate findings for early diagnosis of *** in this paper,an effective hybrid Xception and Fractalnet-based deep learning framework are implemented to classify the stages of AD into five ***,a network based on Unet++is built to segment the tissues of the ***,using the segmented tissue components as input,the Xception-based deep learning technique is employed to extract high-level ***,the optimized Fractalnet framework is used to categorize the disease condition using the acquired *** proposed strategy is tested on the Alzheimer’s Disease Neuroimaging Initiative(ADNI)dataset that accurately segments brain tissues with a 98.45%of dice similarity coefficient(DSC).Additionally,for themulticlass classification of AD,the suggested technique obtains an accuracy of 99.06%.Moreover,ANOVA statistical analysis is also used to evaluate if the groups are significant or *** findings show that the suggested model outperforms various stateof-the-art methods in terms of several performance metrics.

关键词： Fractalnet deep learning xception unet++ alzheimer’s disease magnetic resonance imaging

Injectable hydrogels of newly designed brush biopolymers as sustained drug-delivery vehicle for melanoma treatment

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Signal Transduction and Targeted Therapy 2021年第3期6卷 925-937页

作者： aparna Shukla Akhand Pratap Singh Pralay Maiti School of Materials Science and Technology Indian Institute of Technology(BHU)Varanasi 221005India

Novel biocompatible and brush copolymers have been developed for cancer treatment using its controlled drug-release *** graft on linear dextrin has been synthesized to control the hydrophilic-hydrophobic balance for regulated drug *** properties of the graft copolymers have been tuned through graft *** prepared grafts are thermally stable and mechanically *** injectable hydrogel has been developed by embedding the drug-loaded brush copolymers in methyl cellulose to better control the release for a prolonged period,importantly by keeping the drug release at a constant *** studies indicate the biocompatible nature of the brush copolymers whose controlled and slow release of drug exhibit significant cytotoxic effects on cancer *** of drug tagged contrast agent indicates greater transport of biologically active material inside cell as observed through cellular uptake *** vivo studies on melanoma mice exhibit the real efficacy of the controlled drug release from the injectable hydrogel with significant melanoma suppression without any side effects as opposed to severe toxic effects observed in conventional *** application method of drug-loaded hydrogel just beneath the tumor makes this system incredibly effective through ***,brush copolymer injectable hydrogel is a promising vehicle for control release of drug for cancer treatment in future.

关键词： density. release hydrogel

Optical characterization of nano-sized organic carbon particles emitted from a small gasoline engine

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Particuology 2013年第3期11卷 249-255页

作者： Bireswar Paul Amitava Datta aparna Datta Abhijit Saha Department of Power Engineering Jadavpur University UGC-DAE Consortium for Scientific Research

The nano-sized organic carbon （NOC） particles emitted from a small gasoline engine were characterized using various ex situ optical techniques to assess their hazardous impact. The exhaust gas was sampled iso-kinetically by a quartz probe and passed through de-ionized water to gather the hydrophilic car- bonaceous particulates as hydrosol. The hydrodynamic diameter of the particles ranged between 1.7 and 3.6 nm at no load, with a mean diameter of 2.4 nm. The particle size in the engine exhaust was found to increase at higher loads, which is attributed to coagulation of the particles. The chemical structure of the particles was analyzed using UV-vis and infra-red spectroscopy. Both the band gap energy and oscillator strength data evaluated from the UV-vis absorbance showed that the NOC particles contained polyaromatic hydrocarbon structures with three to five aromatic rings. Infra-red spectroscopy analysis further confirmed the presence of aliphatic and carbonyl functionalities in the aromatic structures of the particles. The fine size of the particles, their high number concentration for the type of the engine under study and their structural features, make the particles extremely hazardous for environment and health.

关键词： Gasoline engine Combustion Emission Carbon nano-particle Characterization

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Visual Object Tracking Based on Modified LeNet-5 and RCCF

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Computer Systems Science & Engineering 2023年第7期46卷 1127-1139页

作者： aparna Gullapelly Barnali Gupta Banik Department of Computer Science and Engineering Koneru Lakshmaiah Education FoundationDeemed to be UniversityHyderabad500075TelanganaIndia

The field of object tracking has recently made significant ***,the performance results in both deep learning and correlation filters,based trackers achieved effective tracking ***,there are still some difficulties with object tracking for example illumination and deformation(DEF).The precision and accuracy of tracking algorithms suffer from the effects of such *** this situation,finding a solution is *** research proposes a new tracking algorithm to handle this *** features are extracted by using Modified LeNet-5,and the precision and accuracy are improved by developing the Real-Time Cross-modality Correlation Filtering method(RCCF).In Modified LeNet-5,the visual tracking performance is improved by adjusting the number and size of the convolution kernels in the pooling and convolution *** high-level,middle-level,and handcraft features are extracted from the modified LeNet-5 *** handcraft features are used to determine the specific location of the target because the handcraft features contain more spatial information regarding the visual *** LeNet features are more suitable for a target appearance change in object *** experiments were conducted by the Object Tracking Benchmarking(OTB)databases like OTB50 and *** experimental results reveal that the proposed tracker outperforms other state-of-the-art trackers under different *** experimental simulation is carried out in *** overall success rate and precision of the proposed algorithm are 93.8%and 92.5%.The average running frame rate reaches 42 frames per second,which can meet the real-time requirements.

关键词： Object tracking correlation filters feature extraction experimental results semantic information