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Acta Geologica Sinica(English Edition) 2011年第6期85卷 1351-1358页

作者： SUZUKI Shigeyuki SUN Ge Ulrich KNITTEL DANHARA Tohru IWANO hideki Department of Earth Sciences Okayama University Okayama 700-8530 Japan Key-Lab for Evolution of Past Life and Environment MEC Jilin University Changchun 130026 China Paleontological Institute of Shenyang Normal University Shenyang 110034 China Department of Geosciences National Taiwan University Taipei 106 China Clay andlnterface Mineralogy RWTHAaehen University Germany Kyoto Fission-Track Co. Ltd. 44-4 Minamitajiri-eho Omiya Kita-ku Kyoto 603-8832 Japan

The existence of the Cretaceous-Tertiary （K/T） boundary in the non-marine succession is expected at Jiayin in the Heilongjiang River area, China. Zircons from a tuff sample from the Baishantou Member of Wuyun Formation in Jiayin were analyzed by the laser ablation inductively coupled plasma mass spectrometry （LA-ICP-MS） U-Pb dating and fission-track dating methods. Ages of 64.1±0.7 Ma （U-Pb） and 61.7±1.8 Ma （fission-track dating） were obtained, which allow reevaluation of a previously reported late Maastrichian age for the tuff layer that was in conflict with the paleontological evidence. These results confirm the Danian age of the section in agreement with the paleontological evidence.

关键词： U-Pb dating fission-track dating Baishantou section K/T boundary Danian Heilongjiang River area

Cellular reprogramming and hepatocellular carcinoma development

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World Journal of Gastroenterology 2013年第47期19卷 8850-8860页

作者： Yun-Wen Zheng Yun-Zhong Nie hideki Taniguchi Department of Regenerative Medicine Graduate School of MedicineYokohama City UniversityKanazawa-kuYokohamaKanagawa 236-0004Japan Jiangsu University Hospital Advanced Medical Research Center Yokohama City UniversityYokohamaKanagawa 236-0004Japan

Hepatocellular carcinoma(HCC)is one of the most common cancers,and is also the leading cause of death *** have shown that cellular reprogramming contributes to chemotherapy and/or radiotherapy resistance and the recurrence of *** this article,we summarize and discuss the latest findings in the area of cellular reprogramming in *** aberrant expression of transcription factors OCT4,KLF4,SOX2,c-MYC,NANOG,and LIN28 have been also observed,and the expression of these transcription factors is associated with unfavorable clinical outcomes in *** indicate that cellular reprogramming may play a critical role in the occurrence and recurrence of *** reports have shown that DNA methylation,miRNAs,tumor microenvironment,and signaling pathways can induce the expression of stemness transcription factors,which leads to cellular reprogramming in ***,studies indicate that therapies based on cellular reprogramming could revolutionize HCC ***,a novel therapeutic concept is discussed:reprogramming control therapy.A potential reprogramming control therapy method could be developed based on the reprogramming demonstrated in HCC studies and applied at two opposing levels:differentiation and *** increasing understanding and control of cellular programming should facilitate the exploitation of this novel therapeutic concept and its application in clinical HCC treatment,which may represent a promising strategy in the future that is not restricted to liver cancer.

关键词： Reprogramming Hepatocellular carcinomas Cancer stem cells Transcription factor Therapeutics

Prophylactic managements of hepatitis B viral infection inliver transplantation

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World Journal of Gastroenterology 2016年第1期22卷 165-175页

作者： Takashi Onoe Hiroyuki Tahara Yuka Tanaka hideki Ohdan Division of Applied Immunobiology Institute for Clinical ResearchNational Hospital OrganizationKure Medical Center/Chugoku Cancer CenterHiroshima 737-0023Japan Gastroenterological and Transplant Surgery Applied Life SciencesInstitute of Biomedical and Health SciencesHiroshima UniversityHiroshima 734-8551Japan

Liver transplantation(LT)is a considerably effective treatment for patients with end-stage hepatitis B virus(HBV)-related liver ***,HBV infection often recurs after LT without *** the1990s,the treatment for preventing HBV reinfection after LT has greatly progressed with the introduction of hepatitis B immunoglobulin(HBIG)and nucleos(t)ide analogues(NAs),resulting in improved patient *** combination therapy consisting of high-dose HBIG and lamivudine is highly efficacious for preventing the recurrence of HBV infection after LT and became the standard prophylaxis for HBV ***,mainly due to the high cost of HBIG treatment,an alternative protocol for reducing the dose and duration of HBIG has been ***,combination therapy using low-dose HBIG and NAs is considered as the most efficacious and cost-effective prophylaxis for post-LT HBV ***,NA monotherapy and withdrawal of HBIG from combination therapy,along with the development of new,potent high genetic barrier NAs,have provided promising efficacy,especially for low-risk *** review summarizes the prophylactic protocol and their efficacy including prophylaxis of de novo HBV infection from anti-HBc antibody-positive *** addition,challenging approaches such as discontinuation of all prophylaxis and active immunity through hepatitis B vaccination are discussed.

关键词： Liver transplantation Hepatitis B infection prophylaxis nucleos(t)ide analogue anti-hepatitis Bimmunoglobulin

Expression of the Japanese oak silkworm Antheraea yamamai fibroin gene in the domesticated silkworm Bombyx mori

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Insect Science 2009年第6期16卷 465-473页

作者： Isao Kobayashi Katsura Kojima hideki Sezutsu Keiro Uchino Toshiki Tamura Transgenic Silkworm Research Center Silk Materials Research Unit National Institute of Agrobiological Sciences Ibaraki Japan

To understand the evolutionary conservation ofthe gene expression mechanism and secretion machinery between Antheraea and Bombyx fibroins, we introduced the genomic A. yamamai fibroin gene into the domesticated silkworm, B. mori. The spliced A. yamamai fibroin mRNA appeared only in the posterior region of the silk gland of the transgenic silkworm, suggesting that the functions of the fibroin promoter region and the splicing machinery are conserved between these two species. The A. yamarnai fibroin protein was detected in the lumen of the silk gland of the transgenic silkworm, albeit at lower levels compared with the B. mori-type fibroin. We found a strong degeneration of the posterior region of the silk gland of the transgenic silkworm. As a result, the cocoon shell weight was much lower in the transgenic silkworm than in the non-transgenic line. These results indicate that the promoter function and splicing machinery are well conserved between A. yamamai and B. mori but that the secretion mechanism of fibroin is diversified between the two.

关键词： Antheraea yamamai Bombyx mori evolution fibroin silk transgenic

Three-Dimensional Rainbow Schlieren Measurements in Underexpanded Sonic Jets from Axisymmetric Convergent Nozzles

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Journal of Thermal Science 2016年第1期25卷 78-83页

作者： Hirofumi TAKANO Daiyu KAMIKIHARA Daisuke ONO Shinichiro NAKAO hideki YAMAMOTO Yoshiaki MIYAZATO The University of Kitakyushu 1-1WakamatsuKitakyushuFukuoka808-0135Japan The University of Kitakyushu 1-1WakamatsuKitakyushuFukuoka808-0135Japan

The rainbow schlieren deflectometry has been combined with the computed tomography to obtain three-dimensional density fields of shock containing free jets and we call the method the schlieren CT. Experiments on the schlieren CT have been performed at a nozzle pressure ratio of 4.0 by using an axisymmetric convergent nozzle with an inner diameter of 10 mm at the exit where the nozzle was operated at an underexpanded condition. Multidirectional rainbow schlieren pictures of an underexpanded sonic jet can be acquired by rotating the nozzle about its longitudinal axis in equal angular intervals and the three-dimensional density fields are reconstructed by the schlieren CT. The validity of the schlieren CT is verified by a comparison with the density fields reconstructed by the Abel inversion method. As a result, it is found that excellent quantitative agreement is reached between the three-dimensional jet density fields reconstructed from both methods.

关键词： Rainbow schlieren Computer tomography Convergent nozzle Sonic jet

Bonding formation and gas absorption using Au/Pt/Ti layers for vacuum packaging

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Microsystems & Nanoengineering 2022年第1期8卷 139-147页

作者： Shingo Kariya Takashi Matsumae Yuichi Kurashima hideki Takagi Masanori Hayase Eiji Higurashi Graduate School of Science and Engineering Tokyo University of ScienceChiba 278-8510Japan Device Technology Research Institute National Institute of Advanced Industrial Science and TechnologyIbaraki 305-8564Japan

In this study,we developed a metal multilayer that can provide hermetic sealing after degassing the assemblies and absorbing the residual gases in the package.A package without a leak path was obtained by the direct bonding of the Au/Pt/Ti *** packaging,annealing at 450°C caused thermal diffusion of the Ti underlayer atoms to the inner surface,which led to absorption of the residual gas *** results indicated that a wafer coated with a Au/Pt/Ti layer can provide hermetic sealing and absorb residual gases,which can simplify vacuum packaging processes in the electronics industry.

关键词： vacuum absorption sealing

Potential application of high pressure carbon dioxide in treated wastewater and water disinfection:Recent overview and further trends

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Journal of Environmental Sciences 2015年第10期27卷 38-47页

作者： Huy Thanh Vo Tsuyoshi imai Truc Thanh Ho Thanh-Loc Thi Dang Son Anh Hoang Division of Urban Infrastructural Engineering Mien trung University of Civil Engineering Division of Environmental Science and Engineering Yamaguchi University

Recently emerging disadvantages in conventional disinfection have heightened the need for finding a new solution. Developments in the use of high pressure carbon dioxide for food preservation and sterilization have led to a renewed interest in its applicability in wastewater treatment and water disinfection. Pressurized CO2 is one of the most investigated methods of antibacterial treatment and has been used extensively for decades to inhibit pathogens in dried food and liquid products. This study reviews the literature concerning the utility of CO2 as a disinfecting agent, and the pathogen inactivation mechanism of CO2 treatment is evaluated based on all available research. In this paper, it will be argued that the successful application and high effectiveness of CO2 treatment in liquid foods open a potential opportunity for its use in wastewater treatment and water disinfection. The findings from models with different operating conditions（pressure, temperature, microorganism, water content, media …） suggest that most microorganisms are successfully inhibited under CO2 treatment. It will also be shown that the bacterial deaths under CO2 treatment can be explained by many different ***, the findings in this study can help to address the recently emerging problems in water disinfection, such as disinfection by-products（resulting from chlorination or ozone treatment）.

关键词： High pressure CO2 Inactivation effect Inactivation mechanism

A Straight-bladed Vertical Axis Wind Turbine with a Directed Guide Vane Row-Effect of Guide Vane Geometry on the Performance-

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Journal of Thermal Science 2009年第1期18卷 54-57页

作者： Manabu TAKAO hideki KUMA Takao MAEDA Yasunari KAMADA Michiaki OKI Atsushi MINODA Department of Mechanical Engineering Matsue National College of Technology Department of Mechanical Engineering Mie University

The objective of this study is to show the effect of guide vane geometry on the performance. In order to overcome the disadvantages of vertical axis wind turbine, a straight-bladed vertical axis wind turbine （S-VAWT） with a directed guide vane row has been proposed and tested by the authors. According to previous studies, it was clarified that the performance of the turbine can be improved by means of the directed guide vane row. However, the guide vane geometry of S-VAWT has not been optimized so far. In order to clarify the effect of guide vanegeometry, the effects of setting angle and gap between rotor blade and guide vane on power coefticlent and start- ing characteristic were investigated in the experiments. The experimental study of the proposed wind turbine was carried out by a wind tunnel. The wind tunnel with a diameter of 1.8m is open jet type. The wind velocity is 8 m/s in the experiments. The rotor has three straight blades with a profile of NACA0018 and a chord length of 100 mm, a diameter of 0.6 m and a blade height of 0.7 m. The guide vane row consists of 3 arc plates.

关键词： fluid machinery wind energy vertical axis wind turbine guide vane

Birth after intracytoplasmic sperm injection of ejaculated spermatozoa from a man with mosaic Klinefelter's syndrome

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Asian Journal of Andrology 2005年第2期7卷 217-220,页

作者： Takuya Akashi hideki Fuse Yasuo Kojima Mikiko Hayashi Sachiko Honda Department of Urology Faculty of MedicineToyama Medical and Pharmaceutical UniversityToyamaJapan Department of Obsterics and Gynecology Toyama Prefectural Central HospitalToyamaJapan Toyama Institute of Health ToyamaJapan

Aim:To report a birth after intracytoplasmic sperm injection (ICSI) of ejaculated spermatozoa from a man with mosaic Klinefelter's syndrome detected by fluorescence in situ hybridization (FISH) ***:A 35-year- old man with a normal appearance consulted our hospital because of sterility over a 5-year *** analysis showed low-incidence mosaic Klinefelter's *** FISH,96 % hyperploidy of the lymphocytes was *** examined the sex chromosome of the ejaculated *** FISH,we examined 200 ejacu- lated spermatozoa and no hyperploidy was ***:The 33-year-old female partner of the male patient underwent an uncomplicated controlled ovarian hyperstimulation sequence using a combined recombinant-follicle stimulating hormone (rec-FSH) + human menopausal gonadotrophin (hMG) protocol,following late luteal phase pituitary down *** culminated in the retrieval of seven oocytes,six of which were fertilized with ICSI. One ICSI attempt led to clinical pregnancy with a healthy baby ***:We report a male patient with low- incidence mosaic Klinefelter's syndrome whose ejaculated spermatozoa were identified as being haploid by FISH before ICSI,leading to the successful pregnancy of his wife and the birth of a healthy baby girl.

关键词： Klinefelter's syndrome intracytoplasmic sperm injection fluorescence in situ hybridization

Novel concept of endoscopic device delivery station system for rapid and tight attachment of polyglycolic acid sheet

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World Journal of Gastroenterology 2018年第2期24卷 211-215页

作者： Hirohito Mori hideki Kobara Noriko Nishiyama Tsutomu Masaki Departments of Gastroenterology and Neurology Kagawa University

AIM To evaluate appropriate and rapid polyglycolic acid sheet(PGAs) covering time using device delivery station system(DDSS).METHODS This pilot basic study was conducted to evaluate the potential of accurate and rapid PGAs delivery using DDSS. Three 11-month-old female Beagle dogs were used in this study. Two endoscopic submucosal dissections(ESDs) 4 cm in diameter were performed in lesser curvature of middle gastric body and greater curvature of antrum(total 6 ESDs performed). DDSS(3 cm length, 12 mm in outer diameter) has 2 chambers which 16 cm^2 large 2 PGAs were stored, and DDSS was attached post ESD ulcers, respectively. Beriplast P?(CSL Behring K.K., Tokyo, Japan)(combination of fibringlue and thrombin) was applied equally to the artificial ulcer, and tight attachment of 2 PGAs with DDSS were completed. The evaluation items were covering times, post ESD bleeding and perforation during *** The covering time of PGAs(defined as the duration from the beginning of endoscope insertion into the mouth to the end of the fibrin glue coating process) was 6.07(4.86-8.29) min. There was no postESD bleeding(1-7 d after ESD), and there was no perforation during *** DDSS was very useful for rapid delivering and tight attachment of PGAs, and has potentials of multipurpose delivery station system.

关键词： Post-endoscopic submucosal dissection ulcers Bleeding Polyglycolic acid sheet Rapidly delivery Tightly attachment