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Efficacy of Essential Trace Elements Supplementation on Mineral Composition,Sperm Characteristics,Antioxidant Status,and Genotoxicity in Testis of Tebuconazole-treated Rats

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Biomedical and Environmental Sciences 2020年第10期33卷 760-770页

作者： Hajer ben SAAD Fatma ben ABDALLAH Intidhar BKHAIRIA Ons BOUDAWARA Moncef NASRI Ahmed HAKIM ibtissem ben AMARA Laboratory of Enzyme engineering and Microbiology National Engineering School in SfaxUniversity of SfaxB.P.11733038 SfaxTunisia Laboratory of Human Molecular Genetics Faculty of Medicine ofSfaxUniversity of SfaxTunisia Laboratory of Anatomopathology CHU Habib BourguibaUniversity of Sfax3029 SfaxTunisia Laboratory of Pharmacology Faculty of Medicine3029 SfaxUniversity of SfaxTunisia

Objective This research was performed to evaluate the effect of tebuconazole(TBZ)on reproductive organs of male rats and to assess the protective role of combined essential trace elements in alleviating the detrimental effect of TBZ on male reproductive *** For this purpose,48 rats were exposed to 100 mg/kg TBZ,TBZ supplemented with zinc(Zn),selenium(Se),copper(Cu),and iron(Fe),TBZ+(Se+Zn);TBZ+Cu;or TBZ+*** experiment was conducted for 30 consecutive *** TBZ caused a significant perturbation in mineral levels and reduction in reproductive organs weights,plasma testosterone level,and testicular antioxidant enzyme *** TBZ-treated group also showed a significant increase in sperm abnormalities(count,motility,and viability percent),plasma follicle-stimulating hormone and luteinizing hormone concentrations,lipid peroxidation,protein oxidation,and severe DNA degradation in comparison with the ***,TBZ caused testis ***,treatment with trace elements,in combination or alone,improved the reproductive organ weights,sperm characteristics,TBZ-induced toxicity,and histopathological modifications in *** TBZ exerts significant harmful effects on male reproductive *** concurrent administration of trace elements reduces testis dysfunction,fertility,and toxicity induced by TBZ.

关键词： Zinc Selenium Iron Copper Testicular toxicity

Dimethoate Induced Oxidative Damage and Histopathological Changes in lung of Adult rats:Modulatory Effects of Selenium and/or Vitamin E

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Biomedical and Environmental Sciences 2012年第3期25卷 340-351页

作者： ibtissem ben AMARA Nejla SOUDANI Afef TROUDI Ahmed HAKIM Khaled Mounir ZEGHAL Tahia BOUDAWARA Najiba ZEGHAL Animal Physiology Laboratory Faculty of ScienceBP11713000 SfaxUniversity of SfaxTunisia Laboratory of Pharmacology Faculty of Medicine3029 SfaxUniversity of Sfax Tunisi Anatomopathology Laboratory CHU Habib Bourguiba 3029 SfaxUniversity of SfaxTunisia

Objective To determine the efficiency of selenium and/or vitamin E to alleviate lung oxidative damage induced by dimethoate, an organophosphorus compound. Methods Adult Wistar rats were exposed during 30 days either to dimethoate （0.2 g/L of drinking water）, dimethoate＋selenium （0.5 mg/kg of diet）, dimethoate＋vitamin E （100 mg/kg of diet）, or dimethoate＋selenium＋vitamin E. Results Exposure to dimethoate caused oxidative stress in lung evidenced by an increase of malondialdehyde, protein carbonyl groups and advanced oxidation protein products. An increase in glutathione peroxidase, superoxide dismutase, catalase and a decrease in acetylcholinesterase and butyrylcholinesterase activities, glutathione, non-protein thiols and vitamins C levels were observed. Histopathological changes in lung tissue were noted as emphysema, hemorrhages and hemosiderin deposits. Co-administration of selenium or vitamin E to the diet of dimethoate treated rats ameliorated the biochemical parameters as well as histological impairments. The joint effect of these elements was more powerful in antagonizing dimethoate-induced lung oxidative damage. Conclusion We concluded that selenium and vitamin E ameliorated the toxic effects of this pesticide in lung tissue suggesting their role as potential antioxidants.

关键词： Dimethoate Selenium Vitamin E Rats Lung Antioxidant status Histopathological studies

A Comparative Study of Different Drying Processes for a Deformable Saturated Porous Medium

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Fluid Dynamics & Materials Processing 2023年第6期19卷 1339-1348页

作者： Nour El Houda ben Mustaphaa ibtissem Boumnijel M.El-Ganaoui Daoued Mihoubi Laboratory of Wind Energy Management and Waste Energy Recovery Research and Technology Center of EnergyHammam-LifTunisia Laboratory of Studies and Research on Wood Material(LERMAB) University of LorraineLongwyFrance National Engineering School of Monastir University of MonastirMonastirTunisia

Drying of a deformable saturated porous medium based on convective tempering is a novel method that can enhance energy efficiency and the quality of the dried product *** this experimental investigation,the performances of this specific technique are compared with those of a standard stationary drying process in terms of deformation,drying kinetics,moisture redistribution,and energy *** particular,the response of a deformable saturated porous medium(Kaolin)is *** results are critically discussed pointing out advantages and drawbacks.

关键词： Convective drying tempering convective drying energy consumption Kaolin

Potassium Bromate-induced Changes in the Adult Mouse Cerebellum Are Ameliorated by Vanillin

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Biomedical and Environmental Sciences 2018年第2期31卷 115-125页

作者： Hajer ben Saad Dorra Driss Imen Jaballi Hanen Ghozzi Ons Boudawara Michael Droguet Christian Magne Monsef Nasri Khaled Mounir Zeghal Ahmed Hakim ibtissem ben Amara Laboratory of Pharmacology University of SfaxFaculty of Medicine3029 SfaxTunisia Laboratory of Enzyme engineering and Microbiology National Engineering School in SfaxUniversity of SfaxB.P.11733038 SfaxTunisia Centre of Biotechnology of Sfax P.O.Box 11773018 SfaxTunisia Anatomopathology Laboratory University of SfaxHabib Bourguiba Hospital3029 SfaxTunisia EA 4324 ORPHY Faculty of MedicineUniversity of Brest29238 Brest CedexFrance EA 2219 Geoarchitecture University of BrestUFR Sciences&Techniques29238 Brest Cedex 3France

Objective The current study aimed to elucidate the effect of vanillin on behavioral changes, oxidative stress, and histopathological changes induced by potassium bromate （KBrO3）, an environmental pollutant, in the cerebellum of adult *** The animals were divided into four groups： group 1 served as a control, group 2 received KBrO3, group 3 received KBrO3 and vanillin, and group 4 received only vanillin. We then measured behavioral changes, oxidative stress, and molecular and histological changes in the *** We observed significant behavioral changes in KBrO3-exposed mice. When investigating redox homeostasis in the cerebellum, we found that mice treated with KBrO3 had increased lipid peroxidation and protein oxidation in the cerebellum. These effects were accompanied by decreased Na＋-K＋ and Mg2＋ ATPase activity and antioxidant enzyme gene expression when compared to the control group. Additionally, there was a significant increase in cytokine gene expression in KBrO3-treated mice. Microscopy revealed that KBrO3 intoxication resulted in numerous degenerative changes in the cerebellum that were substantially ameliorated by vanillin supplementation. Co-administration of vanillin blocked the biochemical and molecular anomalies induced by *** Our results demonstrate that vanillin is a potential therapeutic agent for oxidative stress associated with neurodegenerative diseases.

关键词： Cerebellum Behavior Potassium bromate Vanillin ATPases Genes expression

Complete pathologic response after chemoradiotherapy in a patient with rectal squamous cell carcinoma： a case report

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Cancer Biology & Medicine 2017年第4期14卷 414-417页

作者： Zaied Sonia Daldoul Amira Bhiri Hanene Ammar Nouha Khechine Wiem Toumi Omar Abbes ibtissem ben Salem Amina Njima Manel Mhabrech Houda Department of Medical Oncology Fattouma Bourguiba University Hospital of Monastir Monastir 5000 Tunisia Department of Surgery Fattouma Bourguiba University Hospital of Monastir Monastir 5000 Tunisia Department of Radiology El Omrane University Hospital of Monastir Monastir 5000 Tunisia Department of Pathological Anatomy Fattouma Bourguiba University Hospital of Monastir Monastir 5000 Tunisia

Squamous cell carcinoma(SCC)of the rectum is a rare disease.A 59-year-old man presented with SCC of the middle rectum located 10 cm from the *** stage of the tumor was revealed to be T3N+*** patient received a combined treatment with cisplatin and fluorouracil in concomitance with external radiation *** then underwent an anterior resection of the *** postoperative histopathological findings classified the tumor as yp T0N0 with cancer-free margins and lymph *** of SCC remains very challenging,and the acquisition of more consistent data is needed.

关键词： Squamous cell carcinoma rectal neoplasm surgery colonoscopy

A Novel 3-D Nano-assembly Bacteria Based Biosensor for Enhanced Detection of Heavy Metal Pollutants

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Journal of Environmental Science and Engineering(A) 2012年第7期1卷 924-935页

作者： Mina Souiri ibtissem Gammoudi Laurence Mora Hafedh ben Ouada Thierry Jouenne Nicole Jaffrezic-Renault Corinne Dejous Ali Othmane Anthony C. Duncan Biophysic Laboratory LIMA Faculty of Medicine of Monastir University of Monastir Monastir 5019 Tunisia Department of Bioengineering of Cardiovascular Polymers Galilee Institute Villetaneuse 93430 France Laboratory of the Interfaces of the Advanced Materials Faculty of Sciences of Monastir Monastir 5000 Tunisia Proteomic Platform Faculty of Sciences of Rouen Mont Saint A ignan Cedex 76821 France Analytical Sciences Laboratory Claude Bernard Lyon 1 University Villeurbanne Cedex 69622 France University of Bordeaux Talence 33405 France

Nowadays, at a time of growing concern for sustainable development and compliance with environmental standards and legislation, the detection of heavy metal contaminants in environmental matrices represents a difficult but important task. The current major limitation lies in the poor detection limits of the targeted pollutant＇s trace concentrations by the available conventional techniques. In order to elaborate a novel ＂living＂ self assembled electrochemical 3-D biosensor, the authors propose a new concept to overcome this shortcoming. The advantages of the properties of polyelectrolyte-functionalized NBs （nanobeads） are combined along with the use of non covalently strongly bound micro-organisms. The designed 3-D biosensor is all the more promising as it has showed a significantly improved sensitivity. In fact, the detection limits of the tested heavy metals （cadmium and mercury） were as low as 1.0 × 10^-12 mol.L-1 and six to seven orders of magnitude lower than those provided by conventional 2-D biosensors. Furthermore, it is potentially applicable to a wide range of bioreceptor-pollutant detection systems.

关键词： Biosensor nanobeads PEM heavy metals E. coli EIS (electrochemical impedance spectroscopy).