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Impairment of ghrelin synthesis in Helicobacter pyloricolonized stomach:New clues for the pathogenesis of ***-related gastric inflammation

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World Journal of Gastroenterology 2014年第3期20卷 639-646页

作者： Omero Alessandro Paoluzi Giovanna Del Vecchio blanco Roberta Caruso Ivan Monteleone Giovanni Monteleone Francesco Pallone Department of Systems Medicine University of Rome "Tor Vergata"

Ghrelin,the ligand of growth hormone secretagogue receptor 1a,takes part in several functions of the digestive system,including regulation of appetite,energy homeostasis,gastric acid secretion and *** has also immunoregulatory properties and is supposed to inhibit some inflammatory pathways that can mediate gastric ***,ghrelin synthesis is reduced in the gastric mucosa of patients with Helicobacter pylori(***)infection,a worldwide condition inducing a T helper(Th)1/Th17 cell responsedriven gastritis,which may evolve towards gastric atrophy and *** this article,we review the available data on the expression of ghrelin in *** infection and discuss how the defective ghrelin synthesis may contribute to sustain the ongoing inflammatory response in this disease.

关键词： Gastritis Ghrelin Helicobacter pylori T helper 1 cells

砂土中桥梁高桩承台基础的抗震延性能力参数分析

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土木工程学报 2018年第5期51卷 112-121页

作者：王晓伟 Guillermo blanco 叶爱君赫中营同济大学土木工程防灾国家重点实验室上海200092 西班牙马德里MC2结构设计公司西班牙马德里28016 河南大学河南开封475001

尽管现行的各国抗震规范对桩基础优先按照能力保护构件进行设计,但以往震害和相关分析表明,桩基础进入非线性对于桥梁的抗震性能并非一定不利。基于此出发点,本文采用Pushover方法对2×3高桩承台基础的延性能力进行了参数分析,探究其延... 详细信息

尽管现行的各国抗震规范对桩基础优先按照能力保护构件进行设计,但以往震害和相关分析表明,桩基础进入非线性对于桥梁的抗震性能并非一定不利。基于此出发点,本文采用Pushover方法对2×3高桩承台基础的延性能力进行了参数分析,探究其延性抗震的潜力。数值模型通过某高桩承台基础的拟静力试验进行了验证。参数分析考虑了桩基础、上部结构和土体三方面参数变化的影响,包括桩径、配筋率、配箍率、恒载轴压比、承台底附加弯矩、自由段长度和土体相对密实度。提出了基于不同性能状态的高桩承台基础延性能力指标:"易修位移延性系数"和"极限位移延性系数",揭示了指标随各参数的变化规律;结果表明,易修、极限位移延性系数基本符合对数正态分布,中位值分别为2.66、3.82,延性能力可观;另外,建立了位移延性系数和截面曲率延性系数的定量关系。

关键词：高桩承台基础有限元方法拟静力试验 Pushover 延性能力

Injection of bone marrow mesenchymal stem cells by intravenous or intraperitoneal routes is a viable alternative to spinal cord injury treatment in mice

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Neural Regeneration Research 2018年第6期13卷 1046-1053页

作者： Bruna dos Santos Ramalho FernANDa Martins de Almeida Conrado Mendonca Sales Silmara de Lima Ana Maria blanco Martinez Laboratorio de Neurodegeneracao e Reparo Departamento de Patologia - Faculdade de Medicina HUCFF Universidade Federal do Rio de Janeiro Rio de laneiro Brazil

In spite of advances in surgical care and rehabilitation, the consequences of spinal cord injury （SCI） are still challenging. Several experimental therapeutic strategies have been studied in the SCI field, and recent advances have led to the development of therapies that may act on the inhibitory microenvironment. Assorted lineages of stem cells are considered a good treatment for SCI. This study investigated the effect of systemic transplantation of mesenchymal stem cells （MSCs） in a compressive SCI model. Here we present results of the intraperitoneal route, which has not been used previously for MSC administration after compressive SCI. We used adult female C57BL/6 mice that underwent laminectomy at the T9 level, followed by spinal cord compression for 1 minute with a 30-g vascular clip. The animals were divided into five groups： sham （anesthesia and laminectomy but without compression injury induction）, MSC i.p. （intraperitoneal injection of 8×10^5 MSCs in 500 μL of DMEM at 7 days after SCI）, MSC i.v. （intravenous injection of 8 × 10^5 MSCs in 500μL of DMEM at 7 days after SCI）, DMEM i.p. （intraperitoneal injection of 500μL of DMEM at 7 days after SCI）, DMEM i.v. （intravenous injection of 500 μL of DMEM at 7 days after SCI）. The effects of MSCs transplantation in white matter sparing were analyzed by luxol fast blue staining. The number of preserved fibers was counted in semithin sections stained with toluidine blue and the presence of trophic factors was analyzed by immunohistochemistry. In addition, we analyzed the locomotor performance with Basso Mouse Scale and Global Mobility Test. Our results showed white matter preservation and a larger number of preserved fibers in the MSC groups than in the DMEM groups. Furthermore, the MSC groups had higher levels of trophic factors （brain-derived neurotrophic factor, nerve growth factor, neurotrophin-3 and neurotrophin-4） in the spinal cord and improved locomotor performance. Our results indicate that injection of MSC

关键词： spinal cord injury mesenchymal stem cells intravenous route intraperitoneal route functional recovery systemic transplantation neural regeneration

Platelet aggregation is affected by nitrosothiols in patients with chronic hepatitis: In vivo and in vitro studies

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World Journal of Gastroenterology 2007年第27期13卷 3677-3683页

作者： A Federico A Filippelli M Falciani C Tuccillo A Tiso A Floreani R Naccarato F Rossi C Del Vecchio blanco C Loguercio Inter-University Research Centre on Foods Nutrition and Gastrointestinal Tract Gastroenterology School 2nd University of Naples Italy Department of Experimental Medicine 2nd University of Naples Italy Department of Surgical and Gastroenterological Sciences University of Padua Italy

AIM: To investigate the relationship among the number of platelets and plasma levels of S-nitrosothiols (S-NO), nitrite, total non-protein SH (NPSH), glutathione (GSH), cysteine (CYS), malondialdehyde (MDA), 4-hydroxininenal (4HNE), tumor necrosis factor-alpha (TNFα) and interleukin (IL)-6 in patients with chronic hepatitis C (CH).METHODS: In vitro the aggregation of platelets derived from controls and CH patients was evaluated before and after the addition of adenosine diphosphate (ADP) and collagen, both in basal conditions and after incubation with nitrosoglutathione (GSNO). RESULTS: In vivo , S-NO plasma levels increased significantly in CH patients and they were significantly directly correlated with platelet numbers. Patients with platelet counts 150 000/μL. In vitro, the ADP and collagen aggregation time was increased in platelets from patients and not from controls; in addition, platelets from CH patients but not from controls also showed a latency time after exposure to collagen. CONCLUSION: The incubation of platelets with GSNO improved the percentage aggregation and abolished the latency time.

关键词： Liver disease Function of platelets Hepatitis C Oxidative stress Anti-aggregant

Past,present and future of preserving and restoring function in the visual system:removing galectin-3 as a promising treatment

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Neural Regeneration Research 2017年第1期12卷 58-59页

作者： Silmara de Lima Henrique Rocha Mendonca Camila Oliveira Goulart Ana M.blanco Martinez Laboratories for Neuroscience Research in Neurosurgery and F.M.Kirby Neurobiology Center Children's Hospital BostonDepartmentsof Surgery and Ophthalmology and Program in NeuroscienceHarvard Medical SchoolBostonMAUSA Laboratorio de Neurodegeneracao e Reparo-Departamento de Patologia-Faculdade de Medicina-HUCFF-UFRJ-Rio de Janeiro-RJ Brazil Polo Universitairio Macae UFRJMacaeRJBrazil

Great advances in retinal ganglion cells survival（RGCs）,optic nerve preservation and regeneration have been made in the past ***,we know that RGCs are capable of regenerating the full length of the optic nerve,cross... 详细信息

关键词： RGCs preserving regeneration preservation galectin removing optic capable ganglion microglia

Author Correction to: SARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells

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Cellular & Molecular Immunology 2022年第8期19卷 965-966页

作者： Daniel Perez-Zsolt Jordana Muñoz-Basagoiti Jordi Rodon Marc Elosua-Bayes Dàlia Raïch-Regué Cristina Risco Martin Sachse Maria Pino Sanjeev Gumber Mirko Paiardini Jakub Chojnacki Itziar Erkizia Xabier Muñiz-Trabudua Ester Ballana Eva Riveira-Muñoz Marc Noguera-Julian Roger Paredes Benjamin Trinité Ferran Tarrés-Freixas Ignacio blanco Victor Guallar Jorge Carrillo Juliàblanco Amalio Telenti Holger Heyn Joaquim Segalés Bonaventura Clotet Javier Martinez-Picado Júlia Vergara-Alert Nuria Izquierdo-Useros IrsiCaixa AIDS Research Institute 08916 Badalona Spain Germans Trias i Pujol Research Institute (IGTP) Can Ruti Campus 08916 Badalona Spain University of Vic—Central University of Catalonia (UVic-UCC) Vic 08500 Spain Catalan Institution for Research and Advanced Studies (ICREA) 08010 Barcelona Spain IRTA Centre de Recerca en Sanitat Animal (CReSA IRTA-UAB) Campus de la UAB 08193 Bellaterra (Cerdanyola del Vallès) Spain CNAG-CRG Centre for Genomic Regulation (CRG) Barcelona Institute of Science and Technology (BIST) 08028 Barcelona Spain Universitat Pompeu Fabra (UPF) Barcelona Spain Centro Nacional de Biotecnología CSIC 28049 Madrid Spain Division of Microbiology and Immunology Yerkes National Primate Research Center Emory University Atlanta GA USA Department of Pathology and Laboratory Medicine School of Medicine Emory University Atlanta GA USA Division of Pathology Yerkes National Primate Research Center Emory University Atlanta GA USA Barcelona Supercomputing Center (BSC) 08034 Barcelona Spain Department of Integrative Structural and Computational Biology Scripps Research La Jolla CA 92037 USA UAB CReSA (IRTA-UAB) Campus de la UAB 08193 Bellaterra (Cerdanyola del Vallès) Spain Departament de Sanitat i Anatomia Animals Facultat de Veterinària UAB 08193 Bellaterra (Cerdanyola del Vallès) Spain

Correction to:Cellular&Molecular Immunology https://***/10.1038/s41423-021-00794-6,published online 15 November 2021 In the version of this correspondence initially published,one of the SARS-CoV-2 variants used in Fig.1B,which was originally described in the article as the SARS-CoV-2 variant‘B.1.***.248.2 Gamma’,is actually the‘P.2 Zeta’SARS-CoV-2 variant of *** GISAID accession ID EPI_ISL_1831696 provided is correct。

关键词： interaction media initially

Using old liver grafts for liver transplantation: Where are the limits?

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World Journal of Gastroenterology 2014年第31期20卷 10691-10702页

作者： Carlos Jiménez-Romero Oscar Caso Maestro Félix Cambra Molero iago Justo Alonso Cristina Alegre Torrado Alejandro Manrique Municio Jorge Calvo Pulido Carmelo Loinaz Segurola Enrique Moreno González Service of General and Digestive Surgery and Abdominal Organ Transplantation "Doce de Octubre" University Hospital

The scarcity of ideal liver grafts for orthotopic liver transplantation (OLT) has led transplant teams to investigate other sources of grafts in order to augment the donor liver pool. One way to get more liver grafts is to use marginal donors, a not well-defined group which includes mainly donors > 60 years, donors with hypernatremia or macrosteatosis > 30%, donors with hepatitis C virus or hepatitis B virus positive serologies, cold ischemia time > 12 h, non-heart-beating donors, and grafts from split-livers or living-related donations. Perhaps the most practical and frequent measure to increase the liver pool, and thus to reduce waiting list mortality, is to use older livers. In the past years the results of OLT with old livers have improved, mainly due to better selection and maintenance of donors, improvements in surgical techniques in donors and recipients, and intra- and post-OLT management. At the present time, sexagenarian livers are generally accepted, but there still exists some controversy regarding the use of septuagenarian and octogenarian liver grafts. The aim of this paper is to briefly review the aging process of the liver and reported experiences using old livers for OLT. Fundamentally, the series of septuagenarian and octogenarian livers will be addressed to see if there is a limit to using these aged grafts.

关键词： Old liver donors Liver transplantation Aging liver Liver graft Liver disease Aging Donor management Septuagenarian donors Octogenarian donors

四开关逆变器供电永磁同步电机直接转矩控制系统转矩脉动抑制

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中国电机工程学报 2007年第21期27卷 47-52页

作者：孙丹何宗元 Ivonne Yznaga blanco 贺益康浙江大学电气工程学院浙江省杭州市310027

永磁同步电机直接转矩控制(PMSM DTC)系统的转矩脉动问题一直被广泛关注,特别是在四开关逆变器供电系统中,由于可用电压矢量减少,转矩脉动更加严重。空间矢量调制(SVM)是一种常用的消除电力谐波的调制技术,更可用于电机控制中转矩脉动... 详细信息

永磁同步电机直接转矩控制(PMSM DTC)系统的转矩脉动问题一直被广泛关注,特别是在四开关逆变器供电系统中,由于可用电压矢量减少,转矩脉动更加严重。空间矢量调制(SVM)是一种常用的消除电力谐波的调制技术,更可用于电机控制中转矩脉动的削减。该文针对四开关逆变器供电PMSM DTC系统的特殊性,采用了一种新型SVM方法,分析了等效零矢量模拟技术,将传统SVPWM调制中的劈零思想引入到空间矢量的合成上。仿真及实验结果验证了该新型SVM DTC方法大大减小了转矩脉动,且仍保持了DTC系统固有的快速转矩动态响应。

关键词：永磁同步电机直接转矩控制四开关逆变器容错运行空间矢量调制

Development of a vehicle-track interaction model to predict the vibratory benefits of rail grinding in the time domain

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Journal of Modern Transportation 2015年第3期23卷 189-201页

作者： Julia Irene Real Clara Zamorano José Luis Velarte Antonio Enrique blanco University Institute for Multidisciplinary Mathematics Polytechnic University of Valencia Foundation for the Research and Engineering in Railways

Imperfections in the wheel-rail contact are one of the main sources of generation of railway vibrations. Consequently, it is essential to take expensive corrective maintenance measures, the results of which may be unknown. In order to assess the effectiveness of these measures, this paper develops a vehicle-track interaction model in the time domain of a curved track with presence of rail corrugation on the inner rail. To characterize the behavior of the track, a numerical finite element model is developed using ANSYS software, while the behavior of the vehicle is characterized by a unidirectional model of two masses developed with VAMPIRE PRO software. The overloads obtained with the dynamic model are applied to the numerical model and then, the vibrational response of the track is obtained. Results are validated with real data and used to assess the effectiveness of rail grinding in the reduction of wheel-rail forces and the vibration generation phenomenon.

关键词： Corrugation · Dynamic overloads · Finiteelement method · Vibrations