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Erectile function and late-onset hypogonadism symptoms related to lower urinary tract symptom severity in elderly men

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Asian Journal of Andrology 2013年第6期15卷 785-789,I0008页

作者： Ozan Bozkurt Deniz Bolat Omer Demir oktay Ucer Ali Sahin Burak Ozcift Abdulkadir Pekta Tahir Turan Bilal H Gümü Ertan Cans Ahmet Bolukbasi Haluk Erol Adil Esenx Department of Urology Dokuz Eylul University Faculty of Medicine Izmir 35340 Turkey Division of Urology Doc. Dr. Yasar Eryilmaz Dogubayazit State Hospital Agri 04900 Turkey Department of Urology Celal Bayar University Manisa 45040 Turkey Department of Urology Sifa University Izmir 35230 Turkey Clinic of Urology Ataturk Training and Research Hospital Izmir 35965 Turkey Division of Urology Adiyaman 82. Yll State Hospital Adiyaman 02040 Turkey Department of Urology Pamukkale University Faculty of Medicine Denizli 20020 Turkey Clinic of Urology Tepecik Training and Research Hospital Izmir 35120 Turkey Department of Urology Adnan Menderes University Faculty of Medicine Aydin 09100 Turkey

The aim of this study was to evaluate the relationship between lower urinary tract symptoms （LUTSs）, erectile dysfunction （ED） and symptomatic late-onset hypogonadism （SLOH） in ageing men in the Aegean region of Turkey. Five hundred consecutive patients 〉40 years old who had been in a steady sexual relationship for the past 6 months and were admitted to one of six urology clinics were included in the study. Serum prostate-specific antigen and testosterone levels and urinary flow rates were measured. All patients filled out the international Prostate Symptom Score and Quality of Life （iPSS-QoL）, international index of Erectile Function （iiEF） and Aging Males＇ Symptoms （AMS） scale forms. Of the patients, 23.9% had mild LUTSs, 53.3% had moderate LUTSs and 22.8% had severe LUTSs. The total testosterone level did not differ between groups. Additionally, 69.6% had ED. The presence of impotence increased with increasing LUTS severity. Symptomatic late-onset hypogonadism （AMS 〉27） was observed in 71.2% of the patients. The prevalence of severe hypogonadism symptoms increased with the iPSS scores. A correlation analysis revealed that all three questionnaire scores were significantly correlated. in conclusion, LUTS severity is an age-independent risk factor for ED and SLOH. LUTS severity and SLOH symptoms appear to have a strong link that requires etiological and biological clarification in future studies.

关键词： ageing male erectile dysfunction lower urinary tract symptoms symptomatic late-onset hypogonadism symptom scores testosterone

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Alvarado, Eskelinen, Ohhmann and Raja isteri Pengiran Anak Saleha Appendicitis scores for diagnosis of acute appendicitis

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World Journal of Gastroenterology 2013年第47期19卷 9057-9062页

作者： Hasan Erdem Süleyman etinkünar Koray Das Enver Reyhan Cumhur Deger Mehmet Aziret Hilmi Bozkurt Seluk Uzun Selim Szen oktay rkrücü Department of General Surgery Adana Numune Training and Research HospitalAdana 01240Turkey

AiM:To assess the reliability and practical applicability of the widely used Alvarado,Eskelinen,Ohhmann and Raja isteri Pengiran Anak Saleha Appendicitis(RiPASA)scoring systems in patients with suspected acute ***:Patients admitted to our tertiary center due to suspected acute appendicitis constituted the study *** were divided into two *** group(Group A)consisted of patients who underwent appendectomy and were histopathologically diagnosed with acute appendicitis,and non-appendicitis group(Group N-A)consisted of patients who underwent negative appendectomy and were diagnosed with pathologies other than appendicitis and patients that were followed *** operative findings for the patients,the additional analyses from follow up of the patients and the results of those analyses were recorded using the follow-up ***:One hundred and thirteen patients with suspected acute appendicitis were included in the *** the 113 patients(62 males,51 females),the mean age was 30.2±10.1(range 18-67)*** the 113patients,94 patients underwent surgery,while the rest were followed *** the 94 patients,77patients were histopathologically diagnosed with acute *** study showed a sensitivity level of81%for the Alvarado system when a cut-off value of 6.5was used,a sensitivity level of 83.1%for the Ohmann system when a cut-off value of 13.75 was used,a sensitivity level of 80.5%for the Eskelinen system when a cut-off value of 63.72 was used,and a sensitivity level of 83.1%for the RiPASA system when a cut-off value of 10.25 was ***:The Ohmann and RiPASA scoring systems had the highest specificity for the diagnosis of acute appendicitis.

关键词： Acute appendicitis Alvarado Eskelinen Ohhmann Raja isteri Pengiran Anak Saleha Appendicitis

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Mitigation of indomethacin-induced gastric mucosal lesions by a potent specific type V phosphodiesterase inhibitor

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World Journal of Gastroenterology 2009年第40期15卷 5091-5096页

作者： Kemal Karakaya Volkan Hanci Sibel Bektas Murat Can Hamdi B Ucan Ali Ugur Emre Oge Tasc1lar is1l Ozkocak Turan Mustafa Comert oktay irkorucu Guldeniz Karadeniz Cakmak Department of General Surgery Zonguldak Karaelmas UniversityMedical Faculty Department of Anesthe-siology Zonguldak Karaelmas UniversityMedical Faculty Department of Pathology Zonguldak Karaelmas UniversityMedical Faculty Department of Biochemistry Zonguldak Karaelmas UniversityMedical Faculty

AiM: To investigate the gastroprotective effect of vardenafil against indomethacin-induced gastric damage. METHODS: Forty-eight female Wistar albino rats were randomly divided into 6 groups. Group 1 received saline only. Group 2 (indomethacin) received indomethacin. Rats in group 3 and 4 were pretreated with different doses of famotidine. Group 5 and 6 were pretreated with different doses of vardenafil. Rats in groups 3 to 6 received 25 mg/kg indomethacin 30 min after pretreatment. The animals were sacrificed 6 h later and their stomachs were opened. Gastric lesions were counted and measured. The stomach of each animal was divided in two parts for histopathological examinations and nitric oxide (NO) and malondialdehyde (MDA) assays, respectively. RESULTS: There were no gastric mucosal lesion in the saline group but all rats in the indomethacin group had gastric mucosal ulcerations (ulcer count; 6.25 ± 3.49, and mean ulcer area; 21.00 ± 12.35). Ulcer counts werediminished with famotidine 5 mg/kg (4.12 ± 2.47, P > 0.05), 20 mg/kg (2.37 ± 4.43, P il 2 mg/kg (4.37 ± 3.06), and vardenafil 10 mg/kg (1.25 ± 1.38, P indomethacin group. Gastric mucosal lesion areas were diminished with famotidine 5 mg/kg (8.62 ± 2.97, P idine 20 mg/kg (0.94 ± 2.06, P il 2 mg/kg (6.62 ± 5.87, P il 10 mg/kg (0.75 ± 0.88, P indomethacin group. MDA levels were signif icantly higher in indometh-acin group (28.48 ± 14.51), compared to the famotidine 5 mg/kg (6,21 ± 1.88, P idine 20 mg/kg (5.88 ± 1.60. P il 2 mg/kg (15.87 ± 3.93, P il 10 mg/kg (10.97 ± 4.50, P ion in gastric tissues of the fa-motidine groups were significantly increased (P increases in the vardenafil groups were not statistically significant. Histopathology revealed dimin-ished gastric damage for pretreatment groups co

关键词： Vardenafil Gastric ulceration indomethacin Gastroprotection Rats

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Clinical evaluation of submucosal colonic lipomas: Decision making

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World Journal of Gastroenterology 2006年第31期12卷 5075-5077页

作者： Oge Tascilar Güldeniz Karadeniz Cakmak Banu Dogan Gün Bülent Hamdi U(?)an Hakan Balbaloglu Ali Cesur Ali Ugur Emre Mustafa Comert Lütfü oktay Erdem Selim Aydemir Department of SurgeryZonguldak Karaelmas University School of MedicineKozlu-ZonguldakTurkey Department of pathologyZonguldak Karaelmas University School of MedicineKozlu-ZonguldakTurkey Department of RadiologyZonguldak Karaelmas University School of MedicineKozlu-ZonguldakTurkey Department of GastroenterologyZonguldak Karaelmas University School of MedicineKozlu-ZonguldakTurkey

Even lipomas are the most common mesenchymal benign tumors of the gastrointestinal tract, symptomatic colonic presentation is rare. Herein, we evaluated four patients suffering from various size of colonic lipomas and... 详细信息

关键词： Colon Lipoma Complication Management

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Neural cell adhesion molecule-180 expression as a prognostic criterion in colorectal carcinoma:Feasible or not?

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World Journal of Gastroenterology 2007年第41期13卷 5476-5480页

作者： Oge Tascilar Gldeniz Karadeniz Cakmak ishak Ozel Tekin Ali Ugur Emre Bulent Hamdi Ucan oktay irkorucu Kemal Karakaya Mesut Gl Hseyin Blent Engin Mustafa Comert Department of Surgery Zonguldak Karaelmas UniversityThe School of MedicineKozlu-Zonguldak 67600Turkey Department of immunology Zonguldak Karaelmas UniversityThe School of MedicineKozlu-Zonguldak 67600Turkey Department of Medical Oncology Zonguldak Karaelmas UniversityThe School of MedicineKozlu-Zonguldak 67600Turkey

AiM： To evaluate the frequency of neural cell adhesion molecule （NCAM）-180 expression in fresh tumor tissue samples and to discuss the prognostic value of NCAM-180 in routine clinical practice.METHODS： Twenty-six patients （16 men, 10 women） with colorectal cancer were included in the study. Fresh tumor tissue samples and macroscopically healthy proximal margins of each specimen were subjected to flow-cytometric analysis for NCAM-180 expression.RESULTS： Flow-cytometric analysis determined NCAM-180 expression in whole tissue samples of macroscopically healthy colorectal tissues. However, NCAM-180 expression was positive in only one case （3.84%） with well-differentiated Stage Ⅱ disease who experienced no active disease at 30 months follow-up. CONCLUSiON： As a consequence of the limited number of cases in our series, it might not be possible to make a generalisation, nevertheless the routine use of NCAM-180 expression as a prognostic marker for colorectal carcinoma seems to be unfeasible and not cost-effective in clinical practice due to its very low incidence.

关键词： Neural cell adhesion molecule-180 Colorectal cancer Prognosis Flow-cytometry

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Photoluminescence Compounds ZnGa2Se4and ZnGa2Se4: Eu2+

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Journal of Modern Physics 2012年第8期3卷 827-830页

作者： oktay Tagiyev Saida Asadullayeva Gurban Eyyubov Ulvi Kasumov Kenan Tagiyev institute of Chemistry Azerbaijan NAS AZ 1143 33 H. Javid ave. Baku Azerbaijan institute of Physics of Azerbaijan NAS AZ-1143 33 H. Javid ave. Baku Azerbaijan

Photoluminescence (PL) spectra measurements have been carried out in the ternary chalcopyrite semiconductor compounds ZnGa2Se42Se4: Eu2+ using single-wavelength excitation of a Hg lamp with λ = 365 and 375 nm. Measurements were performed at the temperature range of (120 ~ 220 K) and (110 ~ 230 K) for ZnGa2Se4 and ZnGa2Se4:Eu2+, respectively. No PL was observed for both crystals at the temperatures higher than 220 K (ZnGa2Se4) and 230 K (ZnGa2Se4:Eu2+). At temperatures lower than ~220 K and ~230 K one and three lines were observed for ZnGa2Se4 and ZnGa2Se4: Eu at 591 nm and 566, 591, 646 nm, respectively. 566 nm line was assigned as due of the 4f65d→ 4f7 (8S7/2) transition of Eu2+ ions, whereas the rest two lines were attributed to the donor-acceptor recombination pairs. Probability of non-radiation transfers (A = 108 ~109 s-1), energy of optical phonons (hω= 25 ~ 30 meV), Huan Rice parameter (S = 8 ~ 10), energy of thermal quenching (△E = 0.02 ~ 0.06 eV) were determined from the tem-perature dependences of the full width at half maximum (FWHM = Г(T)).

关键词： Ternary Chalcopyrite Photoluminescence Rare-Earth Elements

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Protective effects of erythropoietin against acute lung injury in a rat model of acute necrotizing pancreatitis

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World Journal of Gastroenterology 2007年第46期13卷 6172-6182页

作者： Oge Tascilar Güldeniz Karadeniz Cakmak ishak Ozel Tekin Ali Ugur Emre Bulent Hamdi Ucan Burak Bahadir Serefden Acikgoz oktay irkorucu Kemal Karakaya Hakan Balbaloglu Gürkan Kertis Handan Ankarali Mustafa Comert Department of Surgery Zonguldak Karaelmas UniversitySchool of MedicineKozlu-Zonguldak 67600Turkey Department of immunology Zonguldak Karaelmas UniversitySchool of MedicineKozlu-Zonguldak 67600Turkey Department of Pathology Zonguldak Karaelmas UniversityThe School of MedicineKozlu-Zonguldak 67600Turkey Department of Biochemistry Zonguldak Karaelmas UniversitySchool of MedicineKozlu-Zonguldak 67600Turkey Department of Biostatistics Zonguldak Karaelmas UniversitySchool of MedicineKozlu-Zonguldak 67600Turkey

AiM： TO investigate the effect of exogenous erythro- poietin （EPO） administration on acute lung injury （ALi） in an experimental model of sodium taurodeoxycholate- induced acute necrotizing pancreatitis （ANP）. METHODS： Forty-seven male Wistar albino rats were randomly divided into 7 groups： sham group （n = 5）, 3 ANP groups （n = 7 each） and 3 EPO groups （n = 7 each）. ANP was induced by retrograde infusion of 5% sodium taurodeoxycholate into the common bile duct. Rats in EPO groups received 1000 U/kg intramuscular EPO immediately after induction of ANP. Rats in ANP groups were given 1 mL normal saline instead. All animals were sacrificed at postoperative 24 h, 48 h and 72 h. Serum arnilase, iL-2, iL-6 and lung tissue malondialdehyde （MDA） were measured. Pleural effusion volume and lung/body weight （LW/BW） ratios were calculated. Tissue levels of TNF-a, iL-2 and iL-6 were screened immunohistochemically. Additionally, ox-LDL accumulation was assessed with immune-fluorescent staining. Histopathological alterations in the lungs were also ***： The mean pleural effusion volume, calculated LW/BW ratio, serum iL-6 and lung tissue MDA levels were significantly lower in EPO groups than in ANP groups. No statistically significant difference was observed in either serum or tissue values of iL-2 among the groups. The level of tumor necrosis factor-（~ （TNF-（~） and iL-6 and accumulation of ox-LDL were evident in the lung tissues of ANP groups when compared to EPO groups, particularly at 72 h. Histopathological evaluation confirmed the improvement in lung injury parameters a^er exogenous EPO administration, particularly at 48 h and 72 h. CONCLUSiON： EPO administration leads to a significant decrease in ALi parameters by inhibiting polymorphonuclear leukocyte （PMNL） accumulation, decreasing the levels of proinflammatory cytokines in circulation, preserving microvascular endothelial cell integrity and reducing oxidative stress-associated lipid peroxidation and therefore, can

关键词： Erythropoietin Acute pancreatitis Acute lunginjury Acute respiratory distress syndrome Cytokine

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女性肿瘤患者生育力保存：美国临床肿瘤协会临床实践指南更新

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中国实用妇科与产科杂志 2018年第9期34卷 1028-1029页

作者：杨孝明范琼王玉东 oktay K Harvey BE Partridge AH 上海交通大学医学院附属国际和平妇幼保健院上海200233

近年来,得益于肿瘤治疗领域的进展,越来越多的肿瘤患者可达到长期生存,但大部分肿瘤治疗可导致性腺功能减退甚至丧失生育功能。因此,生育力保存的问题变得越来越重要。美国临床肿瘤协会（ASCO）最先于2006年发表了关于生育力保存的基于... 详细信息

近年来,得益于肿瘤治疗领域的进展,越来越多的肿瘤患者可达到长期生存,但大部分肿瘤治疗可导致性腺功能减退甚至丧失生育功能。因此,生育力保存的问题变得越来越重要。美国临床肿瘤协会（ASCO）最先于2006年发表了关于生育力保存的基于循证医学基础的临床实践指南,2013年予以更新。2018年发表了最新的指南。本文对该指南关于女性肿瘤患者生育力保存的部分进行概括汇总。

关键词：生殖器肿瘤,雌性生育力保存指南

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土耳其东部的地震减灾工作和灾害管理对策

土耳其东部的地震减灾工作和灾害管理对策

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作者： oktay Ergunay 土耳其安卡拉灾害事务办公室

引言地震是土耳其的主要灾害。20世纪中土耳其的地震曾夺去7000多人的生命,并破坏350000座建筑物。据当时官方绘制的土耳其地震灾害区划图和1985年的人口统计数字,占国土总面积97%的地区和95%的人口都处在不同的地震带上。国家合成灾害...

引言地震是土耳其的主要灾害。20世纪中土耳其的地震曾夺去7000多人的生命,并破坏350000座建筑物。据当时官方绘制的土耳其地震灾害区划图和1985年的人口统计数字,占国土总面积97%的地区和95%的人口都处在不同的地震带上。国家合成灾害图认定的最可能遭受损失的区域和城市表明,由强烈地震造成损失的具有最高危险的地区都在土耳其东部。根据对过去地震造成破坏的统计验证,土耳其东部要比土耳其西部的死亡率高出70%,建筑物毁坏率高200%。土耳其之所以比别的地方更易于遭受地震袭击,是因为这一地区的建筑物都是由物主按照传统的结构自建为主,建筑材料也多是用易于遭受破坏的碎石-石头,并由泥灰浆砌筑成

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土耳其东部的地震减灾工作和灾害管理对策

土耳其东部的地震减灾工作和灾害管理对策

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作者： oktay Ergunay 土耳其安卡拉灾害事务办公室

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