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Breathing adapted radiation therapy for leukemia relapse in the breast: A case report

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World Journal of Clinical Oncology 2019年第11期10卷 369-374页

作者： Omer Sager Ferrat Dincoglan Selcuk Demiral Bora uysal Hakan Gamsiz Fatih Ozcan Onurhan Colak Yelda Elcim Bahar Dirican Murat Beyzadeoglu Department of Radiation Oncology Gulhane Medical Faculty University of Health SciencesAnkara

BACKGROUND infiltration of the breast by leukemic cells is uncommon but may manifest as an oncological emergency requiring prompt *** relapse of T-cell acute lymphoblastic leukemia(T-ALL)within the breast is exceedingly rare and there is paucity of data in the literature regarding this *** consensus exists on management of isolated extramedullary breast relapses of ***,we report a case of isolated extramedullary breast relapse of T-ALL treated with breathing adapted radiation therapy(BART)using the active breathing control(ABC)*** SUMMARY The patient was a 33-year-old female with diagnosis of *** received intensive systemic chemotherapy that resulted in complete remission of her disease,and then underwent allogeneic hematopoietic stem cell *** a 15 mo period without symptoms and signs of progression,the patient presented with palpable masses in both *** complained from severe pain and swelling of the *** workup showed bilateral breast lesions,and diagnosis of breast infiltration by leukemic cells was confirmed after immunohistopathological *** patient suffering from severe pain,discomfort,and swelling of both breasts due to leukemic infiltration was referred to the Radiation Oncology Department for symptomatic *** breast irradiation was delivered to both breasts of the patient with BART using the ABC *** patient had complete resolution of her symptoms after treatment with *** BART with the ABC system resulted in complete resolution of the patient’s symptoms due to leukemic infiltration of both breasts with *** contemporary treatment technique should be preferred for radiotherapeutic management of patients with leukemic infiltration of the breasts to achieve effective symptomatic palliation.

关键词： T-cell acute lymphoblastic leukemia Breast relapse Breathing adapted radiation therapy Active breathing control Case report

Concise review of stereotactic irradiation for pediatric glial neoplasms:Current concepts and future directions

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World Journal of Methodology 2021年第3期11卷 61-74页

作者： Omer Sager Ferrat Dincoglan Selcuk Demiral Bora uysal Hakan Gamsiz Onurhan Colak Fatih Ozcan Esin Gundem Yelda Elcim Bahar Dirican Murat Beyzadeoglu Department of Radiation Oncology Gulhane Medical FacultyUniversity of Health SciencesAnkara 06018Turkey

Brain tumors,which are among the most common solid tumors in childhood,remain a leading cause of cancer-related mortality in pediatric ***,which may be broadly categorized as low grade glioma and high grade glioma,account for the majority of brain tumors in *** management,surgery,radiation therapy(RT),chemotherapy,targeted therapy or combinations of these modalities may be used for management of pediatric *** patient,tumor and treatment-related characteristics including age,lesion size,grade,location,phenotypic and genotypic features,symptomatology,predicted outcomes and toxicity profile of available therapeutic options should be considered in decision making for optimal *** of pediatric gliomas poses a formidable challenge to the physicians due to concerns about treatment induced *** effects of therapy may include neurological deficits,hemiparesis,dysphagia,ataxia,spasticity,endocrine sequelae,neurocognitive and communication impairment,deterioration in quality of life,adverse socioeconomic consequences,and secondary ***,improved understanding of molecular pathology and technological advancements may pave the way for progress in management of pediatric glial *** management with close collaboration of disciplines including pediatric oncology,surgery,and radiation oncology is warranted to achieve optimal therapeutic *** the context of RT,stereotactic irradiation is a viable treatment modality for several central nervous system disorders and brain *** the importance of minimizing adverse effects of irradiation,radiosurgery has attracted great attention for clinical applications in both adults and *** applications offer great potential for improving the toxicity profile of radiation delivery by focused and precise targeting of well-defined tumors under stereotactic immobilization and image ***,we provide

关键词： Radiosurgery Stereotactic irradiation Stereotactic radiosurgery Pediatric glioma Gamma knife Linear accelerator

Subduction initiation for the Formation of High-Cr Chromitites in the Kop Ophiolite, NE Turkey

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Acta Geologica Sinica(English Edition) 2016年第S1期90卷 253-页

作者： ZHANG Pengfei ibrahim uysal ZHOU Meifu SU Benxun Erdi AVCi Department of Earth Sciences the University of Hong Kong Department of Geological Engineering Karadeniz Technical University State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics Chinese Academy of Sciences

The Kop ophiolite in NE Turkey,representing a forearc fragment of Neo-Tethys ocean,mainly consists of a paleoMoho transition zone(MTZ)and a harzburgitic upper mantle *** Kop MTZ locally contains cumulate

关键词： NE Turkey high REE Subduction initiation for the Formation of High-Cr Chromitites in the Kop Ophiolite Cr

Concise review of radiosurgery for contemporary management of pilocytic astrocytomas in children and adults

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World Journal of Experimental Medicine 2022年第3期12卷 36-43页

作者： Omer Sager Ferrat Dincoglan Selcuk Demiral Bora uysal Hakan Gamsiz Esra Gumustepe Fatih Ozcan Onurhan Colak Ahmet Tarik Gursoy Cemal Ugur Dursun Ahmet Oguz Tugcu Galip Dogukan Dogru Rukiyye Arslan Yelda Elcim Esin Gundem Bahar Dirican Murat Beyzadeoglu Department of Radiation Oncology Gulhane Medical FacultyUniversity of Health SciencesAnkara 0090Turkey

Pilocytic astrocytoma(PA)may be seen in both adults and children as a distinct histologic and biologic subset of low-grade *** is the principal treatment for the management of PAs;however,selected patients may benefit from irradiation particularly in the setting of inoperability,incomplete resection,or recurrent *** conventionally fractionated radiation therapy has been traditionally utilized for radiotherapeutic management,stereotactic irradiation strategies have been introduced more recently to improve the toxicity profile of radiation delivery without compromising tumor *** may be suitable for radiosurgical management due to their typical appearance as well circumscribed *** and precise targeting of these well-defined lesions under stereotactic immobilization and image guidance may offer great potential for achieving an improved therapeutic ratio by virtue of radiosurgical *** the high conformality along with steep dose gradients around the target volume allowing for reduced normal tissue exposure,radiosurgery may be considered a viable modality of radiotherapeutic *** advantage of radiosurgery may be the completion of therapy in a usually shorter overall treatment time,which may be particularly well suited for children with requirement of anesthesia during *** studies have addressed the utility of radiosurgery particularly as an adjuvant or salvage treatment modality for ***,despite the growing body of evidence supporting the use of radiosurgery,there is need for a high level of evidence to dictate treatment decisions and establish its optimal role in the management of ***,we provide a concise review of radiosurgery for PA in light of the literature.

关键词： Pilocytic astrocytoma Radiosurgery Stereotactic irradiation Low-grade glioma Radiation oncology Children

Adaptive radiation therapy of breast cancer by repeated imaging during irradiation

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World Journal of Radiology 2020年第5期12卷 68-75页

作者： Omer Sager Ferrat Dincoglan Selcuk Demiral Bora uysal Hakan Gamsiz Fatih Ozcan Onurhan Colak Yelda Elcim Esin Gundem Bahar Dirican Murat Beyzadeoglu Department of Radiation Oncology Gulhane Medical FacultyUniversity of Health SciencesEtlikAnkara 06018Turkey

Breast cancer is the most frequent cancer among females and also a leading cause of cancer related mortality worldwide.A multimodality treatment approach may be utilized for optimal management of patients with combinations of surgery,radiation therapy(RT)and systemic *** composes an integral part of breast conserving treatment,and is typically used after breast conserving surgery to improve local *** years have witnessed significant improvements in the discipline of radiation oncology which allow for more focused and precise treatment *** radiation therapy(ART)is among the most important RT techniques which may be utilized for redesigning of treatment plans to account for dynamic changes in tumor size and anatomy during the course of *** the context of breast cancer,ART may serve as an excellent tool for patients receiving breast irradiation followed by a sequential boost to the tumor *** benefits of ART include more precise boost localization and potential for improved normal tissue sparing with adapted boost target volumes particularly in the setting of seroma reduction during the course of ***,we provide a concise review of ART for breast cancer in light of the literature.

关键词： Breast cancer Adaptive radiation therapy Tumor bed boost Computed tomography imaging Replanning

Quantitative Methods in Human Resource Management

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Journal of Modern Accounting and Auditing 2019年第7期15卷 367-370页

作者： Gurhan uysal Ondokuz Mayis University Samsun Turkey

This study searches for possibility of quantitative models in human resources management (HRM). Quantitative methods turn thinking into model structure. Coefficients and symbols represent variables of HRM. Markov Analysis, linear functions, logaritma, and Pisagor Models are explored in this study as a quantitative method. Thus, HR managers use these models to solve HR-related issues. Aim is fastness and effectiveness in management of HR. The study concludes that quantitative methods exist in HRM.

关键词： HR quantitative methods Markov Pisagor Limit Theorems

3rd Definition of SHRM: HR Systems Approach

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Management Studies 2019年第5期7卷 496-501页

作者： Gurhan uysal Ondokuz Mayis University SamsunTurkey

First definition of SHRM is made by Devanna, Tichy and Fonbrum (1981, 1984). it is Michigan model. 1st definition relates HRM with strategic management. i.e., HRM affects firm-level strategies. Second definition is made by Wright and McMahan (1992). it relates HRM with performance. There exists direct relations between HRM and firm performance. innovation capability of human resources provides of linear relation between HR and performance. HR make innovations, and it increases firm performance. This is linear relations in American HRM (HR (innovation)→ performance). This study makes 3rd definition in SHRM. it relates performance with HR systems. Accordingly, HR applies HR systems in organizations that increases employee’s individual performance. and individual performance has impact on firm performance. in 3rd definition there is relation between HR system and performance through individual performance. Moderator is individual performance.

关键词： SHRM 3rd definition HR systems individual performance firm performance

Fifth Definition for Strategic HRM:HRM involvement

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Journal of Modern Accounting and Auditing 2023年第2期19卷 31-35页

作者： Gürhan uysal Ondokuz Mayıs University SamsunTurkey

This study aims to contribute to development of SHRM *** personnel management and human resource management are in practice by firms,however,firms do not apply strategic HRM *** are four definitions of SHRM so *** study presents a new approach for the development of the *** is HRM *** involvement is related to appointment of managers and board of *** board of directors appoints managers in firms,HR must be member of board of *** managers achieve firm performance(market share and profit),and Board of Directors appoints ***,HRM manager must be involved with board of directors to affect *** study uses semantic content analysis and systematic review methods as a research *** conclude,organizations may apply strategic HRM through strategic HR Directors at top level,appointment of C-level Executives and HRM involvement.

关键词： Strategic HRM HRM involvement board of directors appointment of managers

从地幔橄榄岩和豆荚状铬铁矿分析土耳其Kizildag蛇绿岩的构造环境

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从地幔橄榄岩和豆荚状铬铁矿分析土耳其Kizildag蛇绿岩的构造环境