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Stochastic simulation of successive waves of COViD-19 in the province of Barcelona

infectious Disease Modelling 2023年第1期8卷 145-158页

作者： M.Bosman A.Esteve L.Gabbanelli X.Jordan A.Lòpez-Gay M.Manera M.Martínez P.Masjuan Ll.M.Mir J.Paradells A.Pignatelli i.riu V.Vitagliano institut de Física d’Altes Energies(iFAE) The Barcelona Institute of Science and TechnologyBarcelonaSpain Centre d’Estudis Demogrèfics(CED-CERCA) BarcelonaSpain Serra Húnter Fellow Departament de Ciències Polítiques i SocialsUniversitat Pompeu FabraBarcelonaSpain i2CAT Foundation Edifici Nexus(Campus Nord UPC)BarcelonaSpain Departament de Geografia Universitat Autónoma de BarcelonaBellaterraSpain Serra Húnter Fellow Departament de FísicaUniversitat Autònoma de BarcelonaBellaterraSpain institucióCatalana de Recerca i Estudis Avançats(iCREA) BarcelonaSpain Departament de Física Universitat Autónoma de BarcelonaBellaterraSpain Departament d’Enginyeria Telemàtica Universitat Politècnica de CatalunyaBarcelonaSpain DiME University of GenovaVia all’Opera Pia 1516145GenovaItaly iNFN Sezione di Genovavia Dodecaneso 3316146GenoaItaly Department of Mathematics and Physics University of HullKingston upon HullHU67RXUK

Analytic compartmental models are currently used in mathematical epidemiology to forecast the COViD-19 pandemic evolution and explore the impact of mitigation strategies.in general,such models treat the population as a single entity,losing the social,cultural and economical specificities.We present a network model that uses socio-demographic datasets with the highest available granularity to predict the spread of COViD-19 in the province of Barcelona.The model is flexible enough to incorporate the effect of containment policies,such as lockdowns or the use of protective masks,and can be easily adapted to future epidemics.We follow a stochastic approach that combines a compartmental model with detailed individual microdata from the population census,including social determinants and age-dependent strata,and time-dependent mobility information.We show that our model reproduces the dynamical features of the disease across two waves and demonstrates its capability to become a powerful tool for simulating epidemic events.

关键词： COViD-19 modelling Parameter estimation Socio-demographic data intervention

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NAMPT在多发性骨髓瘤中的作用机制及其临床意义

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中国实验血液学杂志 2024年第1期32卷 138-145页

作者：王亚茹马艳萍山西医科大学第二医院血液内科山西太原030001

目的:探讨烟酰胺磷酸核糖转移酶(NAMPT)在多发性骨髓瘤中的作用机制及其临床价值。方法:采用RT-q PCR和Western blot方法检测多发性骨髓瘤细胞和正常骨髓单个核细胞中NAMPT的表达水平,同时通过细胞增殖与凋亡实验、小干扰RNA沉默、过表... 详细信息

目的:探讨烟酰胺磷酸核糖转移酶(NAMPT)在多发性骨髓瘤中的作用机制及其临床价值。方法:采用RT-q PCR和Western blot方法检测多发性骨髓瘤细胞和正常骨髓单个核细胞中NAMPT的表达水平,同时通过细胞增殖与凋亡实验、小干扰RNA沉默、过表达实验和染色质免疫共沉淀实验分析NAMPT的生物学功能。结果:多发性骨髓瘤细胞系(MM1R、MM1S、U266和RPMi-8226)中NAMPT m RNA和蛋白的表达水平较正常骨髓单个核细胞均显著升高(Pi-NC组相比,Si-NAMPT组转染24、48、72 h均显著抑制U266细胞增殖(P=0.006,PiRE1α-XBP1信号通路的转录调控。稳定敲除NAMPT或阻断iRE1α-XBP1通路可显著提高U266细胞对硼替佐米的敏感性。

关键词：多发性骨髓瘤烟酰胺磷酸核糖转移酶硼替佐米 X-盒结合蛋白1 肌醇需要酶1α

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Efficacy of standard therapy with synbiotic or without synbiotic to reduce Gardnerella vaginalis,Atopobium vaginae and Megaesphaera phylotypeⅠin pregnant women with bacterial vaginosis

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Asian pacific Journal of Reproduction 2020年第3期9卷 111-117页

作者： Deviana Soraya riu Efendi Lukas Firdaus Kasim Rizalinda Sjahril Department of Obstetrics and Gynecology Faculty of MedicineHasanuddin UniversityIndonesia Epidemiology Biostatistics&Occupational Health Medical FacultyHasanuddin UniversityIndonesia Department of Microbiology Medical FacultyHasanuddin UniversityIndonesia

Objective: To evaluate whether addition of symbiotic to clindamycin could reduce Gardnerella vaginalis,Atopobium vaginae,and Megasphaera phylotypeⅠin pregnant women with bacterial vaginosis.Methods: This randomized controlled trial(RSUP Dr.Wahidin Sudirohusodo Makassar clinical trial registry UH17010021)included 61 samples.The intervention group was given clindamycin and synbiotic while the control group was given clindamycin and placebo(without synbiotic).Wilcoxon test and hypothesis test of two independent samples were used to compare the treatment efficacy.Results: This study showed a significant difference in Nugent score before and after treatment in each group.But there was no difference in Nugent score between the intervention group and the control group after treatment or in Nugent scores reduction in both groups.The most common type of bacteria found was Megasphaera phylotypeⅠ.There were no significant differences in the three types(Gardnerella vaginalis,Atopobium vaginae,and Megasphaera phylotypeⅠ)of bacteria after treatment between both groups.Additionally,there was no difference in therapeutic effect between the intervention group and the control group.Conclusions: Clindamycin along with synbiotics is no more effective for treated bacterial vaginosis than clindamycin without synbiotics.Megaesphaera is the most commonly found bacteria,which cannot be eradicated with clindamycin.

关键词： Bacterial vaginosis Synbiotic Nugent score Amsel criteria

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh i. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa i.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced background.This paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS experiment.Two taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet pseudorapidity.Differences in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGiNG

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Narrow band imaging and white light endoscopy in the characterization of a polypectomy scar:A single-blind observational study

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World Journal of Gastroenterology 2018年第45期24卷 5179-5188页

作者： Fausto riu Pons Montserrat Andreu Javier Gimeno Beltran Marco Antonioálvarez-Gonzalez Agustín Seoane Urgorri Josep Maria Dedeu Luis Barranco Priego Xavier Bessa Gastroenterology Department Hospital del MarBarcelona 08003Spain iMiM(Hospital del Mar Medical Research institute) Barcelona 08003Spain Department of Medicine Autonomous University of BarcelonaBarcelona 08003Spain Pompeu Fabra University Barcelona 08003Spain Pathology Department Hospital del MarBarcelona 08003Spain.

AiM To assess the incremental benefit of narrow band imaging(NBi) and white light endoscopy(WLE), randomizing the initial technique for the detection of residual neoplasia at the polypectomy scar after an endoscopic piecemeal mucosal resection(EPMR).METHODS We conducted an observational study in an academic center to assess the incremental benefit of NBi and WLE randomly applied 1:1(NBi-WLE or WLE-NBi) in the follow-up of a post-EPMR scar by the same endoscopist.RESULTS A total of 112 EPMR scars were included. The median baseline polyp size was 20 mm(interquartile range: 14-30). At first review, NBi and WLE showed good sensitivity(85.0% vs 78.9%), specificity(77.1% vs 84.2%) and overall accuracy(80.0% vs 82.5%). NBi after WLE(WLE-NBi group) improved accuracy, but this difference was not statistically significant [area under the curve(AUC): 86.8% vs 81.6%, P = 0.15]. WLE after NBi(NBi-WLE group) did not improve accuracy(AUC: 81.4% vs 81.1%, P = 0.9). Overall, recurrence was found in 39/112(34.8%) lesions.CONCLUSiON Although no statistically significant differences were found between the two techniques at the first postEPMR assessment, the use of NBi after WLE may improve residual neoplasia detection. Nevertheless, biopsy is still required in the first scar review.

关键词： Colonoscopy Narrow band imaging Endoscopic mucosal resection

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Evaluation of an educational telephone intervention strategy to improve non-screening colonoscopy attendance:A randomized controlled trial

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World Journal of Gastroenterology 2020年第47期26卷 7568-7583页

作者： Agustin Seoane Xenia Font Juan C Perez Rocio Perez Carlos F Enriquez Miriam Parrilla Faust riu Josep M Dedeu Luis E Barranco Xavier Duran ines A ibanez Marco A Alvarez Digestive Department Endoscopy UnitHospital del MarParc de Salut MarBarcelona 08003Spain Colorectal Cancer Research Group IMIM(Hospital del Mar Medical Research Institute)Barcelona 08003Spain Department of Medicine Autonomous University of BarcelonaBarcelona 08003Spain Consulting Service on Methodology for Biomedical Research IMIM(Hospital del Mar Medical Research Institute)Barcelona 08003Spain

BACKGROUND Colonoscopy attendance is a key quality parameter in colorectal cancer population screening programmes.Within these programmes,educative interventions with bidirectional contact carried out by trained personnel have been proved to be an important tool for colonoscopy attendance improvement,and because of its huge clinical and economic impact,they have been widely implemented.However,outside of this population programmes,educative measures to improve colonoscopy attendance have been poorly studied and no navigation interventions are usually performed.AiM To investigate the clinical and economic impacts of an educational telephone intervention on colonoscopy attendance outside colorectal cancer screening programmes.METHODS This randomized controlled trial included consecutive patients referred to colonoscopy from primary care centres from November 2017 to May 2018.The intervention group(iG)received a telephone intervention,while the control group(CG)did not.Patients assigned to the iG received an educational telephone call 7 d before the colonoscopy appointment.The intervention was carried out by two nurses with deep endoscopic knowledge who were previously trained for a telephone educational intervention for colonoscopy.The impact on patient compliance with preparedness protocols related to bowel cleansing,antithrombotic management,and sedation scheduling was also evaluated.A second call was conducted to assess patient satisfaction.intention-to-treat(iTT)and perprotocol(PP)analyses were performed.RESULTS A total of 738 and 746 patients were finally included in the iG and CG respectively.Six hundred thirteen(83%)patients were contacted in the iG.The non-attendance rate was lower in the iG,both in the iTT analysis(iG 8.4%vs CG 14.3%,Pin the PP analysis(4.4%vs 14.3%,Pin a multivariable analysis,belonging to the control group increased the risk of nonattendance in both,the iTT analysis(OR 1.81,95%Ci:1.27 to 2.58,P=0.001)and the PP analysis(OR 3.56,95%Ci:2.25 to 5.64,P<0.001).There was als

关键词： Colonoscopy Quality improvement No-show patients Nursing education Patient compliance Telephone intervention

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改性稻壳生物炭对水溶液中甲基橙的吸附效果与机制

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环境科学 2019年第6期40卷 2783-2792页

作者：史月月单锐袁浩然中国科学院广州能源研究所广州510640 中国科学院可再生能源重点实验室广州510640 广东省新能源和可再生能源研究开发与应用重点实验室广州510640 中国科学技术大学纳米科技学院苏州215123

本文以废弃稻壳为原料,通过不同改性方法将其制成生物炭吸附剂,并用于水体中甲基橙(MO)的吸附.通过氮吸附、X射线衍射(XRD)、傅立叶转换红外光谱(FT-iR)、扫描电镜分析(SEM)、热重分析(TG)、透射电镜(TEM)和X射线光电子能谱(XPS)等技术... 详细信息

本文以废弃稻壳为原料,通过不同改性方法将其制成生物炭吸附剂,并用于水体中甲基橙(MO)的吸附.通过氮吸附、X射线衍射(XRD)、傅立叶转换红外光谱(FT-iR)、扫描电镜分析(SEM)、热重分析(TG)、透射电镜(TEM)和X射线光电子能谱(XPS)等技术分析了改性剂种类、浸渍比和热解温度对生物炭的物理化学性质及对MO吸附量的影响,发现热解温度为400℃,以ZnCl_2为改性剂,浸渍比为2∶1时制备的生物炭Z2RT400对MO的去除效果最好.以Z2RT400为吸附剂,探究吸附剂添加量、吸附时间、初始污染物浓度、溶液pH等对甲基橙吸附效果的影响,结果表明,饱和吸附时间为420 min,吸附反应的最佳pH为4,当吸附剂用量为10 mg,初始甲基橙浓度为2 000 mg·L^(-1)时,Z2RT400对MO的最大吸附量可达1 967. 72 mg·g^(-1);当吸附剂添加量为80 mg时,去除率最高可达99. 52%.此外,对吸附机制进行分析,发现吸附等温线数据符合Freundlich模型,吸附动力学数据符合拟二级动力学模型,说明吸附以化学吸附为主,物理吸附为辅.因此,废弃稻壳为原料改性制备的生物炭可作为高效的有机染料吸附剂,并应用于水体中污染物的治理.

关键词：改性氯化锌稻壳生物炭甲基橙(MO) 吸附

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欠发达地区农村社会养老保障的出路研究

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河南大学学报（社会科学版） 2008年第1期48卷 92-96页

作者：梅瑞江河南大学经济学院金融证券研究所河南开封475001

农村社会养老保险陷入清理、整顿的困境,特别是在欠发达地区农村这个问题更加突出。其原因一方面是因为社会养老保险制度产生在工业化的社会环境,而我国欠发达地区农村基本上仍处于工业化之前的自然经济状态;另一方面,社会养老保险的不... 详细信息

农村社会养老保险陷入清理、整顿的困境,特别是在欠发达地区农村这个问题更加突出。其原因一方面是因为社会养老保险制度产生在工业化的社会环境,而我国欠发达地区农村基本上仍处于工业化之前的自然经济状态;另一方面,社会养老保险的不同筹资模式所适应的社会经济条件在欠发达地区农村不具备。因此,我国欠发达地区农村解决养老问题,不应采用社会养老保险的方式,而应以建立适当的社会福利等制度来逐步解决。

关键词：欠发达农村养老保障

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恩拉霉素自微乳制剂的研制及质量评价

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中国药学杂志 2016年第14期51卷 1235-1240页

作者：陈浩陈敏刘蕊浙江工商大学杭州310018

目的研制恩拉霉素自微乳制剂,并进行质量评价。方法测定恩拉霉素在各辅料中的溶解度,通过三相配伍实验筛选自微乳化基质;以微乳粒径作为效应值,应用D-最优混料设计进行处方优化,并对优化后的恩拉霉素自微乳制剂进行稳定性、释放度及... 详细信息

目的研制恩拉霉素自微乳制剂,并进行质量评价。方法测定恩拉霉素在各辅料中的溶解度,通过三相配伍实验筛选自微乳化基质;以微乳粒径作为效应值,应用D-最优混料设计进行处方优化,并对优化后的恩拉霉素自微乳制剂进行稳定性、释放度及抑菌活性考察。结果恩拉霉素自微乳的最佳处方组成为20%油酸乙酯、40%聚氧乙烯氢化蓖麻油和40%丙二醇。1 g自微乳中较佳载药量20 mg,加水乳化后的平均粒径为（27.81±0.79）nm;体外溶出度10 min达90%以上,比原料药溶出度显著提高。在4-40℃循环条件下48 h,自微乳的粒径及载药量均无明显变化;自微乳化释药系统对恩拉霉素的抑菌活性没有影响。结论恩拉霉素自微乳质量稳定,可显著提高恩拉霉素的溶出度,有望改善恩拉霉素口服生物利用度。

关键词：恩拉霉素自微乳药物传递系统 D-最优混料设计质量评价

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杆塔结构设计规程变化对杆塔通用设计的影响研究

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建筑结构 2023年第10期53卷 21-25页

作者：房正刚李正李毅刚刘蕊中国电力科学研究院有限公司北京100055

简要介绍了《架空输电线路杆塔结构设计技术规程》(DL/T 5486—2020)修编的主要内容。就该技术规程中对输电杆塔设计有较大影响的主要规定差异与《架空输电线路杆塔结构设计技术规定》(DL/T 5154—2012)进行了比较分析。探究了《架空输... 详细信息

简要介绍了《架空输电线路杆塔结构设计技术规程》(DL/T 5486—2020)修编的主要内容。就该技术规程中对输电杆塔设计有较大影响的主要规定差异与《架空输电线路杆塔结构设计技术规定》(DL/T 5154—2012)进行了比较分析。探究了《架空输电线路杆塔结构设计技术规程》(DL/T 5486—2020)修编对35~750kV杆塔通用设计的影响,提出了杆塔通用设计的优化建议。

关键词：架空输电线路杆塔通用设计规程修编优化设计

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