检索结果-南通市图书馆

Journal of Diabetes Mellitus 2012年第2期2卷 170-178页

作者： Takahiro Hata Takeshi Ohta Yukihito ishii Tomohiko Sasase Takayuki Yamaguchi Yasuko Mera katsuhiro Miyajima Gimpei Tanoue Eimei Sato Mutsuyoshi Matsushita Japan Tobacco inc. Central Pharmaceutical Research Institute Osaka Japan Japan Tobacco inc. Central Pharmaceutical Research Institute Toxicology Research Laboratories Hadano Japan Laboratory of Animal Reproduction Graduate School of Agricultural Science Tohoku University Sendai Japan

Nutritional regulation plays a critical role to reduce the incidence or progression of diabetes mellitus. in this study, we investigated the effects of a high-fat diet on Spontaneously Diabetic Torii Leprfa (SDT fatty) rats, a novel model for obese type 2 diabetes. The SDT fatty rats were divided into two dietary groups, which were fed a high-fat diet or a standard diet for 18 weeks, from 6 to 24 weeks of age. The calorie intake in the high-fat diet (HF) group was reduced after 10 weeks of age and the group inhibited an incidence of diabetes. interestingly, the HF induced an increase of serum glucagon-like peptide-1 (GLP-1) levels in SDT fatty rats with refeeding. Fat tissue weights in the HF group increased, but the visceral fat/subcutaneous fat (V/S) ratio decreased. Moreover, histopathological observations revealed an improvement of the pancreatic abnormalities and fatty liver in the HF group. in conclusion, a preventive effect on diabetes in rats fed a high-fat diet has a relation with an increase in incretin hormone, and it might be advantageous for prevention of incidence or progression of diabetes to develop functional foods inducing an increase in incretin hormone.

关键词： Glucagon-Like Peptide-1 High Fat Diets SDT Fatty Rats

Submucosal hematoma is a highly suggestive finding for amyloid light-chain amyloidosis:Two case reports

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Endoscopy 2012年第9期4卷 434-437页

作者： Shinji Yoshii.katsuhiro Mabe Katsuhiko Nosho Hiroyuki Yamamoto Hiroshi Yasui Hiroyuki Okuda Akira Suzuki Masahiro Fujita Toshihiro Sato Department of Gastroenterology Keiyukai Sapporo HospitalSapporo 003-0027Japan Third Department of internal Medicine Hokkaido University Graduate School of MedicineSapporo 060-8648Japan First Department of internal Medicine Sapporo Medical University School of MedicineSapporo 060-8556Japan Department of Medical Oncology Keiyukai Sapporo HospitalSapporo 003-0027Japan Department of Pathology KKR Sapporo Medical CenterSapporo 062-0931Japan Keiyukai institute of Clinical Pathology Sapporo 003-0027Japan

The clinical and endoscopic features of amyloid lightchain(AL) amyloidosis are diverse and mimic various other ***,few reports on submucosal hematomas of the gastrointestinal(Gi) tract are available in the ***,we report two cases of AL amyloidosis presenting as submucosal hematomas in the absence of clinical disease elsewhere in the *** 2 cases were referred to our hospital because of *** endoscopic findings in both cases were similar in submucosal hematoma ***,the clinical courses *** the first case,there was no evidence of systemic amyloidosis and the disease was conservatively *** the second case,the disease progressed to systemic amyloidosis and the patient died within a short *** conclude that the endoscopic detection of a submucosal hematoma in the setting of Gi bleeding should raise suspicion of AL *** to a hematologist should be done immediately for treatment while the involvement is limited to the Gi tract.

关键词： Amyloid light-chain amyloidosis Submucosal hematoma Gastrointestinal bleeding Colonoscopy

Female spontaneously diabetic Torii fatty rats develop nonalcoholic steatohepatitis-like hepatic lesions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第30期21卷 9067-9078页

作者： Yukihito ishii Yu Motohashi Makoto Muramatsu Yoshiaki Katsuda katsuhiro Miyajima Tomohiko Sasase Takahisa Yamada Tohru Matsui Shinichi Kume Takeshi Ohta Japan Tobacco inc. Central Pharmaceutical Research Institute Japan Tobacco inc. Central Pharmaceutical Research InstituteToxicology Research Laboratories Niigata University Graduate School of Science and Technology Kyoto University Graduate School of Agriculture

AiM:To investigate the histological features of the liver in spontaneously diabetic Torii(SDT) fatty rats compared with age-matched Sprague-Dawley(SD) ***:Female SDT Leprfa(SDT fatty) rats and age-matched SD rats were fed ad libitum. Body weight and biochemical parameters,such as serum glucose,triglyceride(TG),total cholesterol(TC),alanine aminotransferase(ALT) and aspartate aminotransferase(AST) levels as well as fatty acid and TG accumulation in the liver were evaluated at 8 wk of age in the nonfasting state and at 8-wk intervals from 8 to 40 wk of age. Histopathological examinations of the liver were performed using hematoxylin and eosin and Sirius Red staining as well as double staining for ED-1 and toluidine blue. The expression of genes involved in TG synthesis,inflammation,and fibrosis was examined in the ***:SDT fatty rats showed significantly increased body weight compared with SD rats. Serum glucose,TG,and TC levels were significantly higher in SDT fatty rats compared with SD rats. The serum AST and ALT levels in SDT fatty rats were significantly elevated at 8 wk of age compared with the levels in SD rats. Hepatic TG content was marked in SDT fatty rats from 8 to 32 wk of age. Histopathologically,severe hepatosteatosis accompanied by inflammation was observed at 8 wk of age,and fibrosis started to occur at 32 wk of age. Furthermore,Sirius Red and ED-1 staining were increased in the liver at 32 wk of age. Hepatic gene expression related to TG synthesis,inflammation and fibrosis tended to increase in SDT fatty rats compared with SD rats,and the gene expression related to TG secretion was decreased in SDT fatty rats compared with SD rats. CONCLUSiON:Female SDT fatty rats have the potential to become an important animal model of nonalcoholic steatohepatitis with type 2 diabetes and obesity.

关键词： Nonalcoholic steatohepatitis Spontaneouslydiabetic Torii fatty rat Fibrosis Fatty liver Metabolicsyndrome

The Analysis Time Reduction using Fast Gas Chromatography-Mass Spectrometry （Fast-GC/ MS） and Diagnostic Software for inherited Metabolic diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Analysis Time Reduction using Fast Gas Chromatography-Ma...

第五届亚太地区新生儿筛查学术交流会

作者： Shuichi Kawana katsuhiro Nakagawa Takashi Yamamoto Yuki Hashi Qin Ya Ping Zhou Hai Xia Masahiko Kimura Seiji Yamaguchi SHiMADZU CORPORATiON No.1 Nishinokyo-Kuwabaracho Nakagyo-ku Kyoto 604-8511 Japan SHiMADZU CORPORATiON No.1 Nishinokyo-Kuwabaracho Nakagyo-ku Kyoto 604-8511 Japan SHiMADZU SYSTEM DEVELOPMENT CORPORATiON 2-11 Sanjyo Boh-Cho Nishinokyo Nakagyo- ku Kyoto 604-8435 JAPAN SHiMADZU （HONGKONG） LiMiTED 14F No.16Chao Yang Men Wai Street Beijing China SHiMADZU （HONGKONG） LiMiTED 14F No.16Chao Yang Men Wai Street Beijing China SHiMADZU （HONGKONG） LiMiTED 14F No.16Chao Yang Men Wai Street Beijing China Shimane University Faculty of Medicine 89-1 En-ya-cho Izumo Shimane 693-8501 JAPAN Shimane University Faculty of Medicine 89-1 En-ya-cho Izumo Shimane 693-8501 JAPAN

＜正＞The tandem MS is usually used for the screening of inherited disorders because of shorter analysis time. To obtain more accurate quantity information in close inspection and evaluation of curative effect the gas chromatography - mass spectrometer （GC/MS） method is used. it usually takes one hour to analyse the extract that is treated from the urine sample. The reduction of analysis time has been required to improve the analytical productivity. Fast GC/MS can dramatically reduce the analysis run time without sacrificing the analytical performance. Narrow bore （＜0.1 mm i.D.） capillary columns can shorten the analysis time without loss in the separation efficiency.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

SiOxNy薄膜结构对气体阻隔性的影响

中国印刷与包装研究 2011年第2期3卷 73-75页

作者： Daisuke Yonekura katsuhiro Fujikawa Ri- ichi Murakami 桑利军(编译) Department of Mechanical Engineering The University of Tokushima 2-1 Minami-josanjimaTokushima 770-8506 Japan 不详

在聚合物表面沉积一层薄膜可以有效阻止氧气和水蒸气的渗透,目前比较常用的阻隔膜为氧化铝薄膜和氧化硅薄膜。氧化铝薄膜具有很好的气体阻隔性能,被广泛应用于食品包装;氧化硅薄膜也是比较流行的透明包装阻隔材料。近年来随着包装业的发... 详细信息

在聚合物表面沉积一层薄膜可以有效阻止氧气和水蒸气的渗透,目前比较常用的阻隔膜为氧化铝薄膜和氧化硅薄膜。氧化铝薄膜具有很好的气体阻隔性能,被广泛应用于食品包装;氧化硅薄膜也是比较流行的透明包装阻隔材料。近年来随着包装业的发展,对包装品阻隔性的要求越来越高,如要求更长的货架期。然而,目前所应用的氧化物阻隔膜已很难达到这一更高的要求。经研究发现,相对于氧化硅薄膜,类金刚石（DLC）是非常有前景的阻隔材料,特别是氮氧化硅（SiOxNy）薄膜,可以提供更高的阻隔性能。

关键词：气体膜结构食品包装氧化铝薄膜水蒸气聚合物包装业

A prospective randomized trial of lafutidine vs rabeprazole on post-ESD gastric ulcers

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Endoscopy 2010年第1期2卷 36-40页

作者： Tomohiko Richard Ohya Hiroki Endo Kei Kawagoe Tatsuro Yanagawa katsuhiro Hanawa Ken Ohata Masako Asayama Kantaro Hisatomi Takuma Teratani Toshiaki Gunji Hajime Sato Nobuyuki Matsuhashi Department of Gastroenterology Kanto Medical CenterNTT East5-9-22 Higashi-gotandaShinagawa-kuTokyo 141-8625Japan Department of Public Health Graduate School of MedicineUniversity of TokyoTokyo 108-0075Japan

AiM:To compare the effects of rabeprazole and lafutidine on post-endoscopic submucosal dissection(ESD) gastric ***:Patients with gastric tumors indicated for ESD were prospectively *** ESD,all patients were treated with intravenous omeprazole for the first 3 *** were then randomly assigned to oral lafutidine or *** size,ulcer size reduction rate,and ulcer stage were evaluated 4 wk *** of complication was monitored throughout the 4-wk ***:Sixty five patients were enrolled in the study,and 60 patients were subjected to the final *** the lafutidine group(30 lesions in 29 patients),initial and 4-wk post-ESD ulcer sizes were 33.3 ± 9.2 and 10.5 ± 4.8 mm,*** the rabeprazole group(34 lesions in 31 patients),the values were 34.7 ± 11.3 and 11.8 ± 6.7 mm,*** size reduction rates in lafutidine and rabeprazole groups were 32.3% and 33.5%,respectively(P=0.974).Ulcer stage 4 wk post-ESD did not differ significantly between the two groups(P=0.868).Two cases in the rabeprazole group and no cases in the lafutidine group developed ulcer bleeding during the oral dose period,although the difference of bleeding rate between the two groups was not statistically significant(P=0.157).CONCLUSiON:Lafutidine and rabeprazole have equivalent therapeutic effects on post-ESD gastric ulcers.

关键词： Cytoprotection Endoscopic submucosal dissection Gastric ulcer Histamine H2 receptor antagonists Lafutidine Proton pump inhibitors Rabeprazole

Current state of practice for colonic diverticular bleeding in 37 hospitals in Japan: A multicenter questionnaire study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Endoscopy 2016年第20期8卷 785-794页

作者： Ryota Niikura Naoyoshi Nagata Hisashi Doyama Ryosuke Ota Naoki ishii.katsuhiro Mabe Tsutomu Nishida Takuto Hikichi Kazuki Sumiyama Jun Nishikawa Toshio Uraoka Shu Kiyotoki Mitsuhiro Fujishiro Kazuhiko Koike

AiMTo clarify the current state of practice for colonic diverticular bleeding (CDB) in Japan. METHODSWe conducted multicenter questionnaire surveys of the practice for CDB including clinical settings (8 questions), diagnoses (8 questions), treatments (7 questions), and outcomes (4 questions) in 37 hospitals across Japan. The answers were compared between hospitals with high and low number of inpatient beds to investigate which factor influenced the answers. RESULTSEndoscopists at all 37 hospitals answered the questions, and the mean number of endoscopists at these hospitals was 12.7. Of all the hospitals, computed tomography was performed before colonoscopy in 67% of the hospitals. The rate of bowel preparation was 46.0%. Early colonoscopy was performed within 24 h in 43.2% of the hospitals. Of the hospitals, 83.8% performed clipping as first-line endoscopic therapy. More than half of the hospitals experienced less than 20% rebleeding events after endoscopic hemostasis. No significant difference was observed in the annual number of patients hospitalized for CDB between high- (≥ 700 beds) and low-volume hospitals. More emergency visits (P = 0.012) and endoscopists (P = 0.015), and less frequent participation of nursing staff in early colonoscopy (P = 0.045) were observed in the high-volume hospitals. CONCLUSiONSome practices unique to Japan were found, such as performing computed tomography before colonoscopy, no bowel preparation, and clipping as first-line therapy. Although, the number of staff differed, the practices for CDB were common irrespective of hospital size.

关键词： Colonic diverticular hemorrhage Lower gastrointestinal bleeding Computed tomography Endoscopy Bowel preparation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

高频脑电振荡:临床研究综述

癫痫杂志 2018年第6期4卷 545-557页

作者： Birgit Frauscher Fabrice Bartolomei.katsuhiro Kobayashi 陆璐张乐慕洁

现代脑电图(EEG)技术的进步增强了对经典伯杰频段外,包含重要信息的脑电信号的识别。在癫痫领域,近十年的相关研究主要集中在发作间期>80 Hz的高频振荡(High frequency oscillations, HFOs)。HFOs大型临床应用始于癫痫手术术前的评估,... 详细信息

现代脑电图(EEG)技术的进步增强了对经典伯杰频段外,包含重要信息的脑电信号的识别。在癫痫领域,近十年的相关研究主要集中在发作间期>80 Hz的高频振荡(High frequency oscillations, HFOs)。HFOs大型临床应用始于癫痫手术术前的评估,近来也开始用于评估癫痫严重程度和监测抗癫痫疗效。该综述总结了HFOs在癫痫临床应用的证据,重点介绍了最新的进展。近期大量文献强调了HFOs与术后癫痫预后关系,一篇近期的Meta分析证实术后癫痫未发作患者HFOs切除率高于术后发作患者,利用术后EEG中的残留HFOs比术前HFOs率对癫痫手术预后预测更准确。文章深入讨论了区分生理性和癫痫性HFOs的尝试,这可能进一步加强HFOs的特异度。如睡眠结构分析表明,在痫灶内外对HFOs的偶联有差异。同时,越来越多的证据表明,HFOs可用于对评估疾病活动度和利用非侵入性EEG和脑磁图(MEG)等检查中评估治疗效果。鉴于儿童EEG中HFOs比例高,这一技术在患儿中有良好的前景。在婴儿痉挛症中经促肾上腺皮质激素治疗后HFOs比例下降。在Rolandic区棘波时出现HFOs与发作频率相关。耗时的人工评估是过去HFOs临床应用的障碍,目前这一问题可由可靠的计算机算法解决。过去十年,HFOs研究有了长足进展,利用非侵入性手段检测HFOs已在大量患者中得到应用。期待未来有多中心、大样本量研究获取长程监测资料,为这一领域提供更多信息。

关键词：头皮脑电图生物标记手术预后癫痫发作睡眠

多育赛多孢菌性鼻窦炎1例——致病菌的鉴定和体外抗真菌药物敏感性研究

在线全文

学校读者我要写书评

暂无评论

中国真菌学杂志 2010年第1期5卷 1-4页

作者：帕丽达.阿布利孜 Takashi Yaguchi 罗德梅惠艳 katsuhiro Kamei Kazuko Nishimura 新疆医科大学第一附属医院皮肤科乌鲁木齐830053 日本国立千叶大学真菌医学研究中心

目的报告国内首例多育赛多孢菌致鼻窦炎,并探讨致病菌的鉴定及其对抗真菌药物体外敏感性。方法取患者左侧上颌窦分泌物进行真菌培养和形态学鉴定,分离菌株β-球蛋白、rDNAiTS序列分析确切鉴定,对分离菌进行7种抗真菌药体外药敏试验。结... 详细信息

目的报告国内首例多育赛多孢菌致鼻窦炎,并探讨致病菌的鉴定及其对抗真菌药物体外敏感性。方法取患者左侧上颌窦分泌物进行真菌培养和形态学鉴定,分离菌株β-球蛋白、rDNAiTS序列分析确切鉴定,对分离菌进行7种抗真菌药体外药敏试验。结果根据菌株的形态学特点和基因序列结果鉴定为多育赛多孢菌。体外药敏试验显示该菌对7种抗真菌药物耐药。结论多育赛多孢菌所致的真菌病较少见,其确切鉴定靠形态学特征和基因分析。该菌株对多种抗真菌药物耐药。

关键词：多育赛多孢菌鼻窦炎致病菌鉴定体外药物敏感性

在线全文

学校读者我要写书评

暂无评论

考虑随机阴影影响的光伏阵列失配运行特性

电工技术学报 2010年第6期25卷 104-109页

作者：卞海红徐青山高山雪田和人一柳胜宏东南大学风力发电研究中心南京210096 爱知工业大学电力及电子系

目前为了减少功率失配损失,一般太阳能模组串联时都配置旁路二极管以提供一个能量散逸的途径;而在并联运行前,还将配置阻断二极管以防止功率逆向传送。本文基于上述新配置条件重点考察了随机阴影导致的光伏阵列运行失配特性,并比较了不... 详细信息

目前为了减少功率失配损失,一般太阳能模组串联时都配置旁路二极管以提供一个能量散逸的途径;而在并联运行前,还将配置阻断二极管以防止功率逆向传送。本文基于上述新配置条件重点考察了随机阴影导致的光伏阵列运行失配特性,并比较了不同串并联模式下的阵列抗失配能力。研究结果表明:由于多辐射强度导致功率曲线多峰走向的趋势,常规单调MPPT算法可能因只检测到伪极大值点而失效;其次,局部辐射强度导致的"门槛效应",即局部阴影的变化并不一定对全局功率输出有影响;最后,为了相对提高输出功率,提出全阵列设计时应优先考虑并联的建议。

关键词：光伏阵列旁路二极管阻断二极管辐射强度最大功率点