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Very-high-frequency probes for atomic force microscopy with silicon optomechanics

Microsystems & Nanoengineering 2022年第2期8卷 35-48页

作者： L.Schwab P.E.Allain N.Mauran X.Dollat L.Mazenq D.Lagrange M.Gély S.Hentz G.Jourdan i.favero B.Legrand Laboratoire d'Analyse et d'Architecture des Systemes Universite de ToulouseCNRS UPR 800131031 ToulouseFrance Laboratoire Materiaux et Phenomenes Quantiques Universite de ParisCNRS UMR 716275013 ParisFrance Universite Grenoble Alpes CEALETIMinatec Campus38000 GrenobleFrance

Atomic force microscopy(AFM)has been consistently supporting nanosciences and nanotechnologies for over 30 years and is used in many fields from condensed matter physics to *** enables the measurement of very weak forces at the nanoscale,thus elucidating the interactions at play in fundamental ***,we leverage the combined benefits of micro/nanoelectromechanical systems and cavity optomechanics to fabricate a sensor for dynamic mode AFM at a frequency above 100 *** frequency is two decades above the fastest commercial AFM probes,suggesting an opportunity for measuring forces at timescales unexplored thus *** fabrication is achieved using very-large-scale integration technologies derived from photonic silicon *** probe's optomechanical ring cavity is coupled to a 1.55 pm laser light and features a 130 MHz mechanical resonance mode with a quality factor of 900 in air.A limit of detection in the displacement of 3×10^(-16)m/VHz is obtained,enabling the detection of the Brownian motion of the probe and paving the way for force sensing experiments in the dynamic mode with a working vibration amplitude in the picometer *** inserted in a custom AFM instrument embodiment,this optomechanical sensor demonstrates the capacity to perform force-distance measurements and to maintain a constant interaction strength between the tip and sample,an essential requirement for AFM *** indeed show a stable closed-loop operation with a setpoint of 4 nN/nm for an unprecedented subpicometer vibration amplitude,where the tip-sample interaction is mediated by a stretched water meniscus.

关键词： cavity maintain instrument

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Physical insights into trapping effects on vertical GaN-on-Si trench MOSFETs from TCAD

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Journal of Semiconductors 2024年第3期45卷 45-52页

作者： NicolòZagni Manuel Fregolent Andrea Del Fiol Davide favero Francesco Bergamin Giovanni Verzellesi Carlo De Santi Gaudenzio Meneghesso Enrico Zanoni Christian Huber Matteo Meneghini Paolo Pavan Department of Engineering“Enzo Ferrari” University of Modena and Reggio EmiliaModena 41125Italy Department of information Engineering University of PadovaPadova 35131Italy Department of Sciences and Methods for Engineering(DiSMi) University of Modena and Reggio EmiliaReggio Emilia 42122Italy EN&TECH Center University of Modena and Reggio EmiliaReggio Emilia 42122Italy Advanced Technologies and Micro Systems Department Robert Bosch GmbHRenningen 71272Germany

Vertical GaN power MOSFET is a novel technology that offers great potential for power switching *** still in an early development phase,vertical GaN devices are yet to be fully optimized and require careful studies to foster their *** this work,we report on the physical insights into device performance improvements obtained during the development of vertical GaN-on-Si trench MOSFETs(TMOS’s)provided by TCAD simulations,enhancing the dependability of the adopted process optimization ***,two different TMOS devices are compared in terms of transfer-curve hysteresis(H)and subthreshold slope(SS),showing a≈75%H reduction along with a≈30%SS *** allow attributing the achieved improvements to a decrease in the border and interface traps,respectively.A sensitivity analysis is also carried out,allowing to quantify the additional trap density reduction required to minimize both figures of merit.

关键词： vertical GaN trench MOSFET SiO_(2) interface traps border traps hysteresis BTi

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Lesson from the neuromuscular junction:role of pattern and timing of nerve activity in synaptic development

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Neural Regeneration Research 2015年第5期10卷 686-688页

作者： Morgana favero Alberto Cangiano Giuseppe Busetto Department of Neurological and Movement Sciences Section of Physiology and PsychologyUniversity of Verona National institute of Neuroscience

The anatomical plan of adult muscle innervation is relatively simple： a given muscle comprises several motor units, each constituted by one motor neuron and the muscle fibers that it innervates; moreover, every muscle fiber is innervated by only one axonal terminal. in other words, motor units have separate, although intermingled, territories of inner- vation （Figure 1D）. in striking contrast, the anatomical organization is different at birth, when every muscle fiber is innervated by several nerve terminals belonging to different motor neurons, a condition known as ＂polyneuronal inner- vation＂, with the consequence that motor units have larger and overlapped territories of innervation （Figure 1A）（Tapia and Lichtman, 2012）. Soon after birth, redundant nerve ter- minals are progressively eliminated in a couple of weeks in rodents, and muscle fibers acquire their mature mononeu- ronal innervation. The same process occurs again in the adult muscle during reinnervation after nerve damage, when a transient period of polyneuronal innervation involves a good fraction of the fibers （Rich and Lichtman, 1989;

关键词： Lesson from the neuromuscular junction

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The Use of Secondary Grape Biomass in Beef Cattle Nutrition on Carcass Characteristics, Quality and Shelf Life of Meat

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Food and Nutrition Sciences 2024年第6期15卷 447-469页

作者： Vitor L. Molosse Guilherme L. Deolindo Rafael V. P. Lago Bruna Klein Claiton A. Zotti Marcelo Vedovato Marcylene V. da Silveira Priscila M. Copetti Maria R. C. Schetinger Juscivete F. favero Eliana L. Fiorentin Aleksandro S. da Silva Universidade do Estado de Santa Catarina (UDESC) Chapec Brazil Department of Animal Science UDESC Chapec Brazil Department of Animal Science Universidade do Oeste de Santa Catarina Xanxere Brazil Dean Lee Research and Extension Center Louisiana State University Alexandria LA USA Department of Biochemistry Universidade Federal de Santa Maria Santa Maria Brazil Department of Medicina Veterinria UNOCHAPEC Chapec Brasil

We determined whether the inclusion of 100 g/kg dry matter of grape pomace silage (GPS) and grape pomace bran (GPB) as substitutes for other traditional fiber sources in the diet of steers (Charolais x Nellore) would improve carcass characteristics, meat quality and composition, and shelf life. Twenty-four animals (248 ± 19.32 kg of initial body weight) were fed a high concentrate diet for 121 days. Carcass characteristics were measured, and the longissimus dorsi muscle was analyzed for fatty acid (FA) profile and composition. The meat was sliced and stored in air-permeable packages for 10 days. On each sampling day (d 1, 3, 7, and 10), oxidative stability, bacterial load, lipid and protein oxidation, and staining were analyzed. The experimental diets influenced the pH of cold carcasses only. The GPS group had a higher pH than the control. The GPS and GPB groups showed improved oxidant status (i.e., lower lipid peroxidation and concentrations of reactive oxygen species were in the meat of both groups than in control). On the first day of storage, the antioxidant enzyme glutathione S-transferase activity was more significant in the meat of the GPS and GPB groups than in the control. The bacterial loads in the meat were attenuated by GPS inclusion;there were lower total coliform counts and a trend toward lower counts for enterobacteria in the control group. The diets altered the FA profile of the meat;i.e., the GPB diet allowed for a more significant amount of the n-6 omegas in the meat, while the GPS diet showed a tendency for a more significant amount of n-6 and 9 omegas. Both diets (GPS and GPB) increased the amounts of long-chain FAs. The GPS diet decreased saturated FA levels. We conclude that the dietary treatments GPS and GPB are a promising alternative to maintain meat quality standards throughout in real-world retail conditions. These treatments gave rise to an improvement in the nutritional value of the meat due to the more significant amounts of FAs that im

关键词： Animal Nutrition Antioxidant Biomass Grape Meat Quality Microbiology Residue

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The Land-Use Consequences of Woody Biomass with More Stringent Climate Mitigation Scenarios

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Journal of Environmental Protection 2017年第1期8卷 61-73页

作者： Alice favero Robert Mendelsohn Georgia institute of Technology Atlanta GA USA Yale School of Forestry and Environmental Studies New Haven CT USA

integrated assessment models increasingly rely on biomass for energy with ever more stringent mitigation policies. The stringency of mitigation will therefore have large effects on land use. As discussed in the literature, crop bio-energy will lead to substantial pressure to increase deforestation. This paper consequently explores using woody biomass for bioenergy. The paper combines the iAM WiTCH with a global dynamic forestry model GTM to determine the optimal size of the woody biomass market, the effects on the timber market, and the resulting forestland under two alternative mitigation strategies. This paper predicts that moving from a moderate to a stringent mitigation policy would increase the demand for woody biomass from 3.7 to 5.2 billion m3/yr, increasing forestland by 1049 to 1890 million ha, and shrinking farmland by 748 to 1550 million ha. The stringency of mitigation will therefore have large effects on land use.

关键词： Climate Change Forestry BECCS Land Use integrated Assessment Model

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Micro-Structured Fiber interferometer as Sensitive Temperature Sensor

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Photonic Sensors 2013年第3期3卷 208-213页

作者： F. C. favero M. BECKER, R. SPiTTEL M. ROTHHARDT J. KOBELKE H. BARTELT institute of Photonic Technology (iPHT) Albert-Einstein-Strafle-9 07745 Jena Germany

We report on a fast and sensitive temperature sensor using a micro-structured or photonic crystal fiber interferometer with a high germanium doped fiber core. The wavelength sensitivity for temperature variation was as high as △λ/△T= 78 pm/℃ up to 500℃, which was 6 times more sensitive than the fiber Bragg grating temperature sensitivity of △λ/△TT= 13pm/℃ at 1550nm. The sensor device was investigated conceming the sensitivity characteristics and response time.

关键词： Micro-structured optical fiber fiber interferometer fiber temperature sensor

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Resective surgery for liver tumor: a multivariate analysis of causes and risk factors linked to postoperative complications

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Hepatobiliary & Pancreatic Diseases international 2006年第4期5卷 526-533页

作者： Enrico Benzoni Dario Lorenzin Umberto Baccarani Gian Luigi Adani Alessandro favero Alessandro Cojutti Fabrizio Bresadola Alessandro Uzzau Department of Surgery University of Udine School of Medicine Udine Italy

BACKGROUND: in spite of accurate selection of patients eligible for resection, and although advances in surgical techniques and perioperative management have greatly contributed to reducing the rate of perioperative deaths, stress must be placed on reducing the postoperative complication rates reported to be still as high as 50%. This study was designed to analyze the causes and foreseeable risk factors linked to postoperative morbidity on the grounds of data derived from a single-center surgical population. METHODS: From September 1989 to March 2005, 287 consecutive patients, affected either with HCC or liver metastasis, had liver resection at our department. Among the HCC series we recorded 98 patients (73.2%) in Child- Pugh class A, 32 (23.8%) in class B and 4 in class C (3%). in 104 colorectal metastases, 71% were due to colon cancer, 25% rectal, 3% sigmoid, and 1% anorectal. in 49 non-colorectal metastases, 22.4% were derived from breast cancer, 63.2% gastrointestinal tumors (excluding colon) and 14.4% other cancers. We performed 80 wedge resections, 77 bisegmentectomies and/or left lobectomies, 74 segmentectomies, 22 major hepatectomies, 20 left hepatectomies, and 14 trisegmentectomies. RESULTS: The in-hospital mortality rate in this series was 4.5%, and the morbidity rate was 47.7%, because of pleural effusion (30%), hepatic abscess (25%), hepatic insufficiency (19%), ascites (10%), hemoperitoneum (10%), or biliary fistula (6%). The variables associated with the technical aspects of the surgical procedure thatwere responsible for the complications were: a Pringle maneuver length more than 20 minutes (P=0.001); the type of liver resection procedure, including major hepatectomy (P=0.02), left hepatectomy (P=0.04), trisegmentectomy (P=0.04), bisegmentectomy and/or left lobectomy (P=0,04); and a blood transfusion of more than 600 ml (P=0.04). CONCLUSiON: The evaluation of causes and foreseeable risk factors linked to postoperative morbidity during the planning of

关键词： carcinoma, hepatocellular liver metastases liver resection postoperative complications biliary leakage pleural effusion impaired liver function

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南极Gerlache海峡海鸟的取食集群及食性(英文)

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动物学报 2007年第3期53卷 425-430页

作者： Marco favero Néstor Bubén CORiA Universidad Nacional de Mar del Plata Facultad Ciencias Exactas y Naturales Departamento de Biología instituto Antártico Argentino División Biología

1997年12月至1998年2月,我们对南极半岛席尔瓦角善于飞翔海鸟与企鹅的取食关联性进行了研究,同时调查了取食集团中主要鸟种的食性。发现每个取食集团中有35.6-37.0只善于飞翔的海鸟,其中几乎都有纹颊企鹅群(Pygoscelis antarctica),黑背... 详细信息

1997年12月至1998年2月,我们对南极半岛席尔瓦角善于飞翔海鸟与企鹅的取食关联性进行了研究,同时调查了取食集团中主要鸟种的食性。发现每个取食集团中有35.6-37.0只善于飞翔的海鸟,其中几乎都有纹颊企鹅群(Pygoscelis antarctica),黑背鸥(Larus dominicanus)、灰贼鸥(Catharacta maccormicki)、花斑鹱(Daptioncapensis)和巨鹱(Macronectes giganteus)是各集团中最常见的鸟类。各取样单元内有相关性的种数随季节变化而减少,一些种类的减少与特定的物候期有关。南极磷虾(Euphausia superba)是绝大部分飞翔海鸟的主要食物,研究发现黑背鸥与纹颊企鹅所捕食的南极磷虾的大小最为接近。飞翔海鸟的觅食行为表明:在海面上短时停留的飞翔海鸟也能够成功捕捉到磷虾,这可能与磷虾躲避企鹅的捕食有关。

关键词：取食集群促进作用水下捕食者磷虾

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Tuning the second-harmonic generation in AlGaAs nanodimers via non-radiative state optimization [invited]

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Photonics Research 2018年第5期6卷 I0031-I0037页

作者： DAViDE Rocco VALERiO F.GiLi LAViNiA GHiRARDiNi LUCA CARLETTi iVAN favero ANDREA LOCATELLi GiUSEPPE MARiNO DRAGOMiR N.NESHEV MiCHELE CELEBRANO MARCO FiNAZZi GiUSEPPE LEO COSTANTiNO DE ANGELiS Department of information Engineering University of BresciaVia Branze 3&Brescia 25123Italy Materiaux et Phenomenes Quantiques Universite Paris DiderotCNRS UMR 716210 rue A.Domon et L.Duquet75013 ParisFrance Department of Physics Politecnico di MilanoPiazza Leonardo Da Vinci 32Milano 20133Italy National institute of Optics(iNO) Via Branze 45Brescia 25123Italy Nonlinear Physics Centre Research School of Physics and EngineeringThe Australian National UniversityCanberraACT 2601Australia

Dielectric nanocavities are emerging as a versatile and powerful tool for the linear and nonlinear manipulation of light at the nanoscale. in this work, we exploit the effective coupling of electric and toroidal modes in AiGaAs nanodimers to locally enhance both electric and magnetic fields while minimizing the optical scattering, thereby optimizing their second-harmonic generation efficiency with respect to the case of a single isolated nanodisk. We also demonstrate that proper near-field coupling can provide fitrther degrees of freedom to control the polari- zation state and the radiation diagram of the second-harmonic field.

关键词： Tuning the second-harmonic generation AiGaAs nanodimers via non-radiative state optimization

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Taxifolin stability: in silico prediction and in vitro degradation with HPLC-UV/UPLCe ESi-MS monitoring

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Journal of Pharmaceutical Analysis 2021年第2期11卷 232-240页

作者： Fernanda Cristina Stenger Moura Carmem Lúciados Santos Machado favero Reisdorfer Paula Angelica Garcia Couto Maurizio Ricci Valdir Cechinel-Filho Tiago J.Bonomini Louis P.Sandjo Tania Mari Belle Bresolin Pharmaceutical Sciences Graduate Program School of Health SciencesCourse of PharmacyUniversidade do Vale do ItajaíItajaíSC88302-202Brazil Laboratory of Research and Development of Drugs Pharmaceutical Sciences Graduate ProgramSchool of Health SciencesCourse of PharmacyUniversidade Federal do PampaUruguaianaRS97500-970Brazil Department of Pharmaceutical Science Universita degli Studi di PerugiaPerugiaPG06123Italy Chemistry Department Universidade Federal de Santa CatarinaTrindadeFlorian opolisSC88040-900Brazil

Taxifolin has a plethora of therapeutic activities and is currently isolated from the stem bark of the tree Larix gmelinni(Dahurian larch). it is a flavonoid of high commercial interest for its use in supplements or in antioxidant-rich functional foods. However, its poor stability and low bioavailability hinder the use of flavonoid in nutritional or pharmaceutical formulations. in this work, taxifolin isolated from the seeds of Mimusops balata, was evaluated by in silico stability prediction studies and in vitro forced degradation studies(acid and alkaline hydrolysis, oxidation, visible/UV radiation, dry/humid heating) monitored by high performance liquid chromatography with ultraviolet detection(HPLC-UV) and ultrahigh performance liquid chromatography-electrospray ionization-mass spectrometry(UPLC-ESi-MS). The in silico stability prediction studies indicated the most susceptible regions in the molecule to nucleophilic and electrophilic attacks, as well as the sites susceptible to oxidation. The in vitro forced degradation tests were in agreement with the in silico stability prediction, indicating that taxifolin is extremely unstable(class 1) under alkaline hydrolysis. in addition, taxifolin thermal degradation was increased by *** the other hand, with respect to photosensitivity, taxifolin can be classified as class 4(stable).Moreover, the alkaline degradation products were characterized by UPLC-ESi-MS/MS as dimers of taxifolin. These results enabled an understanding of the intrinsic lability of taxifolin, contributing to the development of stability-indicating methods, and of appropriate drug release systems, with the aims of preserving its stability and improving its bioavailability.

关键词： Dihydroquercetin in silico stability prediction Forced degradation

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