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inhibiting SHP2 reduces glycolysis, promotes microglia. M1 pola.iza.ion, a.d a.levia.es seconda.y infla.ma.ion following spina. cord injury in a.mouse model

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Neura. Regenera.ion Resea.ch 2025年第3期20卷 858-872页

作者： Xintia. Ding chun chen Heng Zha. Bin Da. Lei Ye Ta. Song Shua. Hua.g Jia.Wa.g Ta. You Depa.tment of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Depa.tment of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the seconda.y infla.ma.ory response, which is pa.tly media.ed by microglia. is a.key focus in the trea.ment of spina. cord injury. Src homology 2-conta.ning protein tyrosine phospha.a.e 2(SHP2), encoded by PTPN11, is widely expressed in the huma. body a.d pla.s a.role in infla.ma.ion through va.ious mecha.isms. Therefore, SHP2 is considered a.potentia. ta.get for the trea.ment of infla.ma.ion-rela.ed disea.es. However, its role in seconda.y infla.ma.ion a.ter spina. cord injury rema.ns unclea.. in this study, SHP2 wa. found to be a.unda.tly expressed in microglia.a. the site of spina. cord injury. inhibition of SHP2 expression using siRNa.a.d SHP2 inhibitors a.tenua.ed the microglia. infla.ma.ory response in a. in vitro lipopolysa.cha.ide-induced model of infla.ma.ion. Nota.ly, a.ter trea.ment with SHP2 inhibitors, mice with spina. cord injury exhibited significa.tly improved hind limb locomotor function a.d reduced residua. urine volume in the bla.der. Subsequent in vitro experiments showed tha., in microglia.stimula.ed with lipopolysa.cha.ide, inhibiting SHP2 expression promoted M2 pola.iza.ion a.d inhibited M1 pola.iza.ion. Fina.ly, a.co-culture experiment wa. conducted to a.sess the effect of microglia.trea.ed with SHP2 inhibitors on neurona. cells. The results demonstra.ed tha. infla.ma.ory fa.tors produced by microglia.promoted neurona. a.optosis, while inhibiting SHP2 expression mitiga.ed these effects. Collectively, our findings suggest tha. SHP2 enha.ces seconda.y infla.ma.ion a.d neurona. da.a.e subsequent to spina. cord injury by modula.ing microglia. phenotype. Therefore, inhibiting SHP2 a.levia.es the infla.ma.ory response in mice with spina. cord injury a.d promotes functiona. recovery postinjury.

关键词： a.optosis glycolysis infla.ma.ory response microglia neurons pola.iza.ion spina. cord injury Src homology 2-conta.ning protein tyrosine phospha.a.e 2

Single-cell tra.scriptomic profiling revea.s ZEB1-media.ed regula.ion in microglia. subtypes a.d the impa.t of exercise on neuroinfla.ma.ory responses

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Tra.itiona. Medicine Resea.ch 2025年第2期10卷 55-64页

作者： Jin-Fa.g Wu Yi-Sheng chen Yu-chun Xie Depa.tment of Reha.ilita.ion Medicine Jiangsu Province Geriatric HospitalNanjing 210024China Fujia. Key La.ora.ory of Toxica.t a.d Drug Toxicology Medical CollegeNingde Normal UniversityNingde 352100China Centra. La.ora.ory Jiangsu Province Geriatric HospitalNanjing 210024China

Ba.kground:This study a.ms to identify distinct cellula. subtypes within bra.n tissue using single-cell tra.scriptomic a.a.ysis,focusing on specific bioma.kers tha. differentia.e cell types a.d the effects of tra.itiona. a.d exercise ***:Four sa.ples were a.a.yzed:older control(OC),older exercise(OE),younger control(YC),a.d younger exercise(YE).Single-cell RNa.sequencing wa. used to distinguish cellula. subtypes through their bioma.ker *** visua.iza.ion included violin a.d t-SNE plots to illustra.e bioma.ker expression a.ross cell clusters such a. oligodendrocytes,microglia.a.d ***,BV2 cells were exposed to a.yloid-beta.fra.ments to simula.e a.zheimer’s disea.e,a.sessing the impa.t of exercise-induced cellula. ***:Distinct cellula. subtypes were identified:oligodendrocytes(MBP,St18),microglia.Dock8),a.d a.trocytes(a.p4,Gpc5).Sa.ple OE wa. predomina.tly oligodendrocytes,while YE ha. more a.trocytes,inhibitory neurons,a.d Ca.a.-Retzius *** showed a.significa.t presence of Olfm3+ga.glion ***1 gene knockout revea.ed cha.ges in SMa. fa.ily gene expression,which regula.e *** stress levels were a.so ***:This profiling enha.ces our understa.ding of bra.n cellula. functions a.d intera.tions,potentia.ly informing ta.geted thera.ies in neurologica. *** ma. influence bra.n cell immune responses a.d cell dea.h pa.hwa.s by regula.ing specific gene expressions,offering new insights for trea.ing neuroinfla.ma.ion a.d degenera.ion.

关键词： single-cell tra.scriptomics bra.n tissue cellula. subtypes bioma.ker expression neurona. diversity

Ca.a.ytic a.roposelective synthesis of indolyl quina.olinones bea.ing N-N/C-C dia.es

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Science China.Chemistry 2025年

作者： Ning-Yi Wa.g Shuo Ga. Zhu-Di Shu Bei-Bei cheng chun Ma.Yu-chen Zha.g Feng Shi Resea.ch Center of Chira. Functiona. Heterocycles School of Chemistry and Materials Science Jiangsu Normal University School of Petrochemica. Engineering Changzhou University School of Chemistry a.d Chemica. Engineering Henan Normal University

The first ca.a.ytic a.roposelective synthesis of indole deriva.ives bea.ing N-N/C-C dia.es ha. been esta.lished by the stra.egy of de novo ring forma.ion. By this stra.egy, va.ious indolyl quina.olinones bea.ing vicina. N-N/C-C dia.es were synthesized in high yields with overa.l good dia.tereoselectivities a.d excellent ena.tioselectivities via.chira. phosphoric a.id-ca.a.yzed onepot a.ymmetric forma. (5+1) cycloa.dition/oxida.ion rea.tion. Moreover, such indolyl quina.olinones bea.ing vicina. N-N/CC dia.es ha.e good configura.iona. sta.ility a.d could be converted into new chira. liga.ds with a.plica.ions in a.ymmetric ca.a.ysis. Therefore, this work not only offered a.new member for the fa.ily of dia.ia. a.ropisomers, but a.so provided a.powerful stra.egy for ca.a.ytic a.ymmetric synthesis of a.ropisomers bea.ing N-N/C-C dia.es.

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identifica.ion of a.dua. functiona. betulinic a.id a.a.og for the trea.ment of osteoa.thritis by phenotypic screening

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Science China.Life Sciences 2025年第1期 300-302页

作者： Ze-Min Lin Ma. Xia.g Wen-Hui Wei Shu-Hui Fa. Li chen Jie Wa.g Xia.-Qia. Ya.g chun-Ha. Ya.g Shi-Jun He Jia.-Ping Zuo La.ora.ory of immunopha.ma.ology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pha.ma.y University of Chinese Academy of Sciences School of Pha.ma.y Nanjing University of Chinese Medicine Sta.e Key La.ora.ory of Drug Resea.ch Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences innova.ion Resea.ch institute of Tra.itiona. Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science a.d Technology Shanghai University of Traditional Chinese Medicine

Dea. Editor, Phenotypic drug discovery, which observes compound effects on physiology,ha. given wa. to ta.geting specific molecules, but ha. revived by using modern methods to find drugs ba.ed on thera.eutic outcomes in disea.e models(Vincent et a.., 2022). Osteoa.thritis(Oa. is a.preva.ent chronic joint disorder, prima.ily a.fecting knee joints, with osteocla.t a.tiva.ion due to low-gra.e infla.ma.ion resulting in increa.ed bone resorption a.d structura. cha.ges in the joint(Ka.z et a..,2021).

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a.va.ces in ethnopha.ma.ology,phytochemistry a.d pha.ma.ology of Erigerontis Herba.a.d its Chinese medicine prescriptions

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Tra.itiona. Medicine Resea.ch 2025年第1期10卷 44-61页

作者： Ya.g Zhou Yua.-Ya. Hua.g Ding-Yue Sha.g Ying chen Meng Tia. cheng-Yu Jin Xin Lu Bing-chun Ya. Ha.-Qing Pa.g institute of Tra.sla.iona. Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jia.gsu Key La.ora.ory of integra.ed Tra.itiona. Chinese a.d Western Medicine for Prevention a.d Trea.ment of Senile Disea.es Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China Sta.e Key La.ora.ory for Chemistry a.d Molecula. Engineering of Medicina. Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba.EH),the dried whole pla.t of Erigeron brevisca.us,is well-known for circula.ing blood,a.tiva.ing meridia.s to a.levia.e pa.n,expelling wind,a.d clea.ing a.a. *** ha. been extensively utilized in southern China.for the trea.ment of stroke hemiplegia.chest stuffiness a.d pa.ns,rheuma.ic a.thra.gia.hea.a.he,a.d *** review focuses on the bota.y,ethnopha.ma.ology,phytochemistry,pha.ma.ology a.d toxicity of EH a.d its rela.ed prescriptions to offer new insights for prospective resea.ch of *** informa.ion a.out EH wa. retrieved from a.cient records a.d books,PubMed,China.Na.iona. Knowledge infra.tructure,Chinese Pha.ma.opoeia.Web of Science,Doctora. a.d Ma.ter’s Theses,a.d va.ious electronic *** is a.member of Composita. fa.ily a.d is ma.nly grown in southern *** Chinese medicine records tha. EH ha. the effects of circula.ing blood a.d removing blood sta.is,expelling wind,a.d removing cold,a. well a. relieving rigidity of muscle a.d relieving *** now,nea.ly 200 ingredients ha.e been cha.a.terized from EH,including fla.onoids,ca.feoyls,a.oma.ic a.ids,couma.ins,penta.yclic terpenoids,vola.ile oil a.d other *** extra.ts,EH rela.ed prescriptions(Dengzha. Xixin injection,Dengzha. Shengma. ca.sules,etc.)or compounds(scutella.in,scutella.ein,etc.)possessed obvious thera.eutic effects of ischemic stroke,cerebra. hemorrha.e,myoca.dia. infa.ction,a.zheimer’s disea.e,dia.etes a.d its complica.ions,ga.tric ca.cer,bone,a.d joint degenera.ive ***,the ma.or a.tive compound of EH,ha. been used a. a.qua.ity *** no obvious toxicity of EH ha. been *** to its tra.itiona. a.plica.ions,ethnopha.ma.ology,phytochemistry,pha.ma.ology,a.d toxicity,EH wa. a.plied a. a.va.ua.le herb for clinica. a.plica.ion in food a.d medicine *** severa. compounds ha.e been shown to possess diverse biologica. a.tivities,the underlying mecha.isms of their a.tions rema.n *** fully exploi

关键词： Erigeron brevisca.us tra.itiona. a.plica.ions ethnopha.ma.ology phytochemistry pha.ma.ology

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高品质学校的内涵结构、建设困境与突破路径

教学与管理 2025年第1期 19-23页

作者：邓纯臻隆平陈书忠重庆师范大学生命科学学院重庆401331 四川省攀枝花市第七高级中学校四川攀枝花617005 重庆市育才中学校重庆400050

高品质学校的创建既是区域教育高质量发展的基本组成,也是助推教育强国、人才强国建设的实践基础。综合来看,学校内部维度的高品质是一种过程取向以及主观层面的高品质,外部维度的高品质是一种结果取向以及客观层面的高品质,高品质学校... 详细信息

高品质学校的创建既是区域教育高质量发展的基本组成,也是助推教育强国、人才强国建设的实践基础。综合来看,学校内部维度的高品质是一种过程取向以及主观层面的高品质,外部维度的高品质是一种结果取向以及客观层面的高品质,高品质学校包括学生、教师、管理者以及课程、课堂、课题六个核心的动力要素。当前,高品质学校的建设依然在前沿理论、本地生源、教育资源以及师资队伍等方面存在一些阻碍,对此,建议从学校文化、优质资源、课程体系、师资队伍、管评系统等五个维度探寻突破路径,以期找到高品质学校的创新之路、高品质之路。

关键词：教育高质量发展高品质学校中小学管理学校治理

Experimenta. a.d a.a.ytica. study on design performa.ce of full-sca.e viscoela.tic da.pers

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Ea.thqua.e Engineering a.d Engineering Vibra.ion 2018年第4期17卷 693-706页

作者： Shia.g-Jung Wa.g i-chen Chiu chung-Ha. Yu Kuo-chun Cha.g Depa.tment of Civil a.d Construction Engineering Taiwan University of Science and Technology Taipei Chinese Taipei Depa.tment of Civil Engineering Taiwan University (NTU) Taipei Chinese Taipei Center for Resea.ch on Ea.thqua.e Engineering (NCREE) Taipei Chinese Taipei

Viscoela.tic（VE） da.pers, with their stiffness a.d energy dissipa.ion ca.a.ilities, ha.e been widely used in civil engineering for mitiga.ing wind-induced vibra.ion a.d seismic responses of structures, thus enha.cing the comfort of residents a.d servicea.ility of equipment inside. in pa.t releva.t resea.ch, most a.a.ytica. models for cha.a.terizing the mecha.ica. beha.ior of VE da.pers were verified by compa.ing their predictions with performa.ce test results from sma.l-sca.e specimens, which might not a.equa.ely or conserva.ively represent the a.tua. beha.ior of full-sca.e da.pers, especia.ly with rega.d to the a.bient tempera.ure, tempera.ure rise, a.d hea. convection effects. Thus, in this study, by using a.high-performa.ce testing fa.ility with a.tempera.ure control system, full-sca.e VE da.pers were dyna.ica.ly tested with different displa.ement a.plitudes, excita.ion frequencies, a.d a.bient tempera.ures. By compa.ing the a.a.ytica. predictions with the experimenta. results, it is demonstra.ed tha. a.opting the fra.tiona. deriva.ive method together with considering the effects of excita.ion frequencies, a.bient tempera.ures, tempera.ure rises, softening, a.d ha.dening, ca. reproduce the design performa.ce of full-sca.e VE da.pers very well.

关键词： viscoela.tic da.per full-sca.e designperforma.ce dyna.ic test fra.tiona. deriva.ive model

PEDOT:Funda.enta.s a.d its Na.ocomposites for Energy Stora.e

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Chinese Journa. of Polymer Science 2020年第5期38卷 435-448,I0005页

作者： Hong-Wu chen chun Li Depa.tment of Chemistry Ministry of Education Key Laboratory ofBioorganic Phosphorous Chemistry and Chemical BiologyTsinghua UniversityBeijing 100084China

PEDOT,or poly(3,4-ethylenedioxythiophene),is a.ong the most successful conducting polymer products beca.se of its sta.le conductivity,colloida. processa.ility,a.d rich a.sembly *** the very first pa.ents on PEDOT filed in 1988,the ma.eria. ha. been widely explored for deca.es in ma.y *** this review,a.comprehensive summa.y on the synthesis,processing a.d post-trea.ment of PEDOT will be presented for the sa.e of the discussion on PEDOT a.d its na.ocomposites for energy *** wha. PEDOT lends itself to the electrode ma.eria.s is of importa.ce to the ra.iona. design of energy stora.e devices tha. ma.imize the rea.-world *** on these discussions,a.roa.ma. for the development of PEDOT a. promising multifunctiona. electrode component is presented.

关键词： PEDOT Energy stora.e Na.oma.eria.s Ca.a.itor Ba.tery

Eigensta.e properties of the disordered Bose-Hubba.d cha.n

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Frontiers of physics 2024年第4期19卷 57-72页

作者： Jie chen chun chen Xia.qun Wa.g Key La.ora.ory of a.tificia. Structures a.d Qua.tum Control(Ministry of Educa.ion) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China School of Physics Zhejiang UniversityHangzhou 310058China Colla.ora.ive innova.ion Center of a.va.ced Microstructures Nanjing UniversityNanjing 210093China

Ma.y-body loca.iza.ion(MBL)of a.disordered intera.ting boson system in one dimension is studied numerica.ly a. the filling fa.tion *** von Neuma.n enta.glement entropy Svn is commonly used to detect the MBL pha.e tra.sition but rema.ns cha.lenging to be directly *** on the U(1)symmetry from the pa.ticle number conserva.ion,Svn ca. be decomposed into the pa.ticle number entropy S_(n) a.d the configura.ion entropy *** light of the tendency tha. the eigensta.e's S_(c) nea.s zero in the loca.ized pha.e,we introduce a.qua.tity describing the devia.ion of S from the idea. therma.iza.ion distribution;finite-size sca.ing a.a.ysis illustra.es tha. it sha.es the sa.e pha.e tra.sition point with Sv but displa.s the better critica. *** observa.ion hints tha. the pha.e tra.sition to MBL might la.gely be determined by S a.d its fluctua.ions Nota.ly,the recent experiments[***,et a..,Science 364,256(2019);***,et a..,***.19,481(2023)]demonstra.ed tha. this devia.ion ca. potentia.ly be mea.ured through the Sn ***,our investiga.ions revea. tha. the therma.ized sta.es prima.ily occupy the low-energy section of the spectrum,a. indica.ed by mea.ures of loca.iza.ion length,ga. ra.io,a.d energy density *** low-energy spectrum of the Bose model closely resembles the entire spectrum of the Fermi(or spin XXZ)model,a.commoda.ing a.tra.sition from the therma.ized to the loca.ized ***,owing to the bosonic sta.istics,the high-energy spectrum of the model a.lows the forma.ion of distinct clusters of bosons in the ra.dom potentia. *** a.a.yze the resulting eigensta.e properties a.d briefly summa.ize the a.socia.ed *** distinguish between the pha.e regions a. the low a.d high energies,a.probing qua.tity ba.ed on the structure of S_(VN) is a.so *** work highlights the importa.ce of symmetry combined with enta.glement in the study of *** this rega.d,for the disordered Heisenberg XXZ

关键词： enta.glement entropy decomposition U(1)symmetry therma.iza.ion-to-loca.iza.ion tra.sition