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Current and future applications of in vitro magnetic resonance spectroscopy in hepatobiliary disease

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World Journal of Gastroenterology 2006年第30期12卷 4773-4783页

作者： i jane cox Amar Sharif Jeremy FL Cobbold Howard C Thomas Simon D Taylor-Robinson imaging Sciences Department Division of Clinical Sciences Imperial College London Hammersmith Hospital Campus Du Cane Road London W12 OHS United Kingdom Department of Medicine Division of Medi-cine Imperial College London St Mary's Campus London W2 United Kingdom

原子磁性的回声光谱学允许细胞的生物化学和新陈代谢的学习，在整个身体在活体内并且在更高的磁场力量在试管内。因为这种技术非侵略、非选择，磁性的回声光谱学方法论广泛地在生物化学和药被使用了。房间，身体液体和纸巾的在试管内磁... 详细信息

原子磁性的回声光谱学允许细胞的生物化学和新陈代谢的学习，在整个身体在活体内并且在更高的磁场力量在试管内。因为这种技术非侵略、非选择，磁性的回声光谱学方法论广泛地在生物化学和药被使用了。房间，身体液体和纸巾的在试管内磁性的回声光谱学研究在医药生物化学被使用了调查 pathophysiological 过程，更最近，这种技术被医生使用了决定疾病畸形在活体内。这个加亮的话题说明在试管内的潜力在学习肝胆管系统的磁性的回声光谱学。在恶意、非恶意的肝疾病和胆汁作文的学习的磁性的回声光谱学学习的在试管内质子和磷的角色被讨论，特别地与关联词在活体内的参考整个身体的磁性的回声光谱学应用。在摘要，磁性的回声光谱学技术能在到内在的 pathophysiological 过程的疾病严厉和指针上提供非侵略的生物化学的信息。磁性的回声光谱学为疾病简历标记，以及估计的治疗学的反应作为一个屏蔽工具保持潜在的诺言。

关键词：肝胆疾病磁共振成像代谢障碍治疗

Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study

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World Journal of Gastroenterology 2016年第16期22卷 4191-4200页

作者： i jane cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson institute of Hepatology London Foundation for Liver Research Department of Chemistry University College London Division of Digestive Diseases Department of Surgery and Cancer Imperial College London Department of Hepatology Bangabandhu Sheikh Mujib Medical University Department of Medical Sciences Toshiba General Hospital

AiM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P ignificant differences in age(P ight(P index(P inical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P in was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA),

关键词： Urinary metabolic profiling Hepatocellular carcinoma Nuclear magnetic resonance spectroscopy Hepatit

Hepatocellular carcinoma: Review of disease and tumor biomarkers

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World Journal of Hepatology 2016年第10期8卷 471-484页

作者： Jin Un Kim Mohamed i F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes i jane cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson Division of Digestive Health Department of Surgery and Cancer Imperial College London Division of Computational Medicine Department of Surgery and Cancer Imperial College London the Foundation for Liver Research Institute of Hepatology MRC Gambia

Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. international guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. in addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest.

关键词： Hepatocellular carcinoma Biomarker Metabonomics Warburg hypothesis Serum Plasma Urine

Scaffold protein MAPK8iP2 expression is a robust prognostic factor in prostate cancer associated with AR signaling activity

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Asian Journal of Andrology 2023年第2期25卷 198-207页

作者： Jian Huang Wang Liu Bi-Yun Lin Jean C Li jane Lu Ben-Yi Li Center for Pathological Diagnosis and Research The Affiliated Hospital of Guangdong Medical UniversityZhanjiang 524001China Department of Urology The University of Kansas Medical CenterKansas CityKS 66160USA

Mitogen-activated protein kinase-8-interacting protein 2(MAPK8iP2)is a scaffold protein that modulates MAPK signal *** MAPK pathways were heavily implicated in prostate cancer progression,the regulation of MAPK8iP2 expression in prostate cancer is not yet *** assessed MAPK8iP2 gene expression in prostate cancer related to disease progression and patient survival ***8iP2 expression was analyzed using multiple genome-wide gene expression datasets derived from The Cancer Genome Atlas(TCGA)RNA-sequence project and complementary DNA(cDNA)*** cox regressions and log-rank tests were used to analyze the overall survival outcome and progression-free ***8iP2 protein expression was evaluated using the immunohistochemistry *** quantitative PCR and Western blot methods analyzed androgen-stimulated MAPK8iP2 expression in LNCaP *** primary prostate cancer tissues,MAPK8iP2 mRNA expression levels were significantly higher than those in the case-matched benign prostatic *** MAPK8iP2 expression was strongly correlated with late tumor stages,lymph node invasion,residual tumors after surgery,higher Gleason scores,and preoperational serum prostate-specific antigen(PSA)***8iP2 upregulation was significantly associated with worse overall survival outcomes and progression-free *** castration-resistant prostate cancers,MAPK8iP2 expression strongly correlated with androgen receptor(AR)signaling *** cell culture-based experiments,MAPK8iP2 expression was stimulated by androgens in AR-positive prostate cancer ***,MAPK8iP2 expression was blocked by AR antagonists only in androgen-sensitive LNCaP but not castration-resistant C4-2B and 22RV1 *** results indicate that MAPK8iP2 is a robust prognostic factor and therapeutic biomarker for prostate *** potential role of MAPK8iP2 in the castration-resistant progression is under further investigation.

关键词： cell cycle regulation disease progression mitogen-activated protein kinase-8-interacting protein 2 patient survival prostate cancer

Adjuvant chemotherapy for intrahepatic cholangiocarcinoma: approaching clinical practice consensus?

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Hepatobiliary Surgery and Nutrition 2020年第5期9卷 577-586,I0001页

作者： Ariella M.Altman Scott Kizy Schelomo Marmor jane Y.C.Hui Todd M.Tuttle Eric H.Jensen Jason W.Denbo Department of Surgery University of MinnesotaMinneapolisMNUSA Department of Gastrointestinal Oncology H.Lee Moffitt Cancer CenterTampaFLUSA

Background:intrahepatic cholangiocarcinoma(iCC)is rare with limited evidence-based *** retrospective study evaluates the use of chemotherapy in patients with resected ***:The Surveillance Epidemiology and End Results(SEER)program database was used to identify patients with resected *** were stratified by date of diagnosis(2000-2004,2005-2009,2010-2014),T,and N *** logistic regression models identified predictors of chemotherapy ***-Meier and cox proportional hazard models were used to identify survival ***:One thousand and two hundred twenty-three patients met inclusion *** utilization increased over time(33%to 41%,P≤0.05).Chemotherapy use increased in lymph node(LN)positive patients[32%to 60%in 2010-2014;(P≤0.05)and T3/T4 disease(40%to 60%in 2010-2014;P≤0.01)],but not in patients with LN negative or T1/T2 *** positivity was associated with utilization of chemotherapy in 2005-2009 and *** survival increased from 32 to 41 months(P≤0.05).in LN positive patients,chemotherapy was associated with a decreased hazard ratio of death(P≤0.05)and T3/T4 disease was associated with an increased hazard ratio of death(P≤0.05).Conclusions:Adjuvant chemotherapy use in iCC has *** LN positive or patients with T3/T4 tumors are receiving chemotherapy,which may explain the improvement in overall survival.

关键词： Cholangiocarcinoma adjuvant chemotherapy survival lymph node(LN) surgical procedures

Allogeneic and autologous stem cell transplantation with busulfan, cyclophosphamide, and etoposide conditioning therapy for relapsed/refractory non-Hodgkin lymphoma

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Modern Chemotherapy 2013年第4期2卷 57-65页

作者： Neelima Vidula Andrew M. Evens irene B. Helenowski Borko Jovanovic jane N. Winter Jayesh Mehta Seema Singhal Stephanie F. Williams Olga Frankfurt Jessica K. Altman Joanne Monreal Leo i. Gordon Department of Preventive Medicine Northwestern University Chicago USA Division of Hematology-Oncology Northwestern University Chicago USA Division of Hematology-Oncology Northwestern University Chicago USA Division of Hematology-Oncology The University of Massachusetts Medical School Worcester USA Division of Hematology-Oncology University of California San Francisco USA

The optimal stem cell transplantation (SCT) conditioning therapy for relapsed/refractory non-Hodgkin lymphoma (NHL) is not clearly defined. in a retrospective analysis, we examined 25 patients with “high risk” relapsed/refractory NHL who received busulfan, cyclophosphamide, and etoposide (Bu/Cy/VP16) conditioning with autologous or allogeneic SCT. The majority of patients had aggressive histology and 52% had primary refractory NHL. Furthermore, 48% of patients had chemotherapy-resistant disease at the time of SCT. Fifty-six percent of patients underwent allogeneic SCT, while 44% had autologous SCT. The median engraftment time for neutrophils and platelets was 13.5 and 14 days, respectively. The 100-day treatment-related mortality (TRM) was 16%, while the 2-year non-relapse mortality (NRM) rate was also 16%. At a median follow-up of 15 months, the estimated 2-year disease-free survival (DFS) rate was 64% (95% confidence interval (Ci): 36%-82%) and the estimated 2-year overall survival (OS) was 69% (95% Ci: 40%-86%). Furthermore, the 2-year disease-specific survival (DSS) rate was 73% (95% Ci: 40%-90%). Using cox proportional hazard modeling, the international Prognostic index at time of relapse predicted DFS and OS. Altogether, Bu/Cy/VP16 was associated with early TRM;however, late toxicities (including NRM) were uncommon resulting in relatively good survival rates in a high-risk relapsed/refractory NHL population.

关键词： Stem Cell Transplantation Busulfan Cyclophosphamide Etoposide Non-Hodgkin Lymphoma

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前列腺素E_2合成酶与类风湿关节炎

中国药物与临床 2002年第4期2卷 225-227页

作者：郭素堂孙俊宁 Leslie jane crofford 山西省肿瘤研究所免疫室 030013 山西省肿瘤研究所细胞室 030013 DepartmentofinternalMedicine

目的　研究膜相关前列腺素E2 合成酶 (membrane associatedprostagladinE2 synthase ,mPGES)与类风湿关节炎的关系。方法　用反转录聚合酶链反应 (RT PCR) ,酶联免疫吸附测定法 (ELiSA)等方法分析环氧化酶 2(cyclooxygenase 2 ,cox 2 ) ... 详细信息

目的　研究膜相关前列腺素E2 合成酶 (membrane associatedprostagladinE2 synthase ,mPGES)与类风湿关节炎的关系。方法　用反转录聚合酶链反应 (RT PCR) ,酶联免疫吸附测定法 (ELiSA)等方法分析环氧化酶 2(cyclooxygenase 2 ,cox 2 ) ,mPGES基因转录和表达以及前列腺素E2 (PGE2 )合成。结果　白细胞介素 (iL) 1β可诱导滑膜成纤维细胞cox 2 ,mPGES转录水平升高 ,主要的炎性介质PGE2 合成增加。cox 2抑制剂NS 398和mPGES抑制剂MK 886可降低iL 1β诱导的PGE2 合成增加。提示cox 2、mPGES、PGE2 三者密切相关。丝裂原激活蛋白激酶(MAPK)抑止剂PD和SB可降低iL 1β诱导的滑膜成纤维细胞cox 2 ,mPGES转录水平。

关键词：基因转录环氧化酶-2 RA 反转录聚合酶链反应酶联免疫吸附法前列腺素E2合成酶类风湿关节炎

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儿童扩张型心肌病的发病率、病因及预后

美国医学会杂志（中文版） 2007年第4期26卷 217-225页

作者： Jeffrey A. Towbin April M. Lowe Steven D. Colan Lynn A. Sleeper E. John Orav Sarah Clunie jane Messere Gerald F. cox Paul R. Lurie Daphne Hsu Charles Canter James D. Wilkinson Steven E. Lipshultz 康俊萍（译）马长生（校） Texas Children＇s Hospital Baylor College of Medicine Houston New England Research institutes Watertown Mass Children＇s Hospital Brigham and Women＇s Hospital Harvard Medical School Boston Mass Genzyrne Corp Cambridge Mass Albany Medical College Albany NY Columbia University New York NY Washington University School of Medicine Saint Louis Mo Department of Pediatrics University of Miami Miller School of Medicine Miami Fla 不详

背景：扩张型心肌病（dilated cardiomyopathy，DCM）是儿童心肌病最常见的类型，也是小儿心脏移植最常见的原因。但是，目前尚不清楚儿童DCM的流行病学特点和临床过程。目的：详细描述儿童DCM的发病率、病因、预后及相关危险因素。设... 详细信息

背景：扩张型心肌病（dilated cardiomyopathy，DCM）是儿童心肌病最常见的类型，也是小儿心脏移植最常见的原因。但是，目前尚不清楚儿童DCM的流行病学特点和临床过程。目的：详细描述儿童DCM的发病率、病因、预后及相关危险因素。设计及地点：本项以人群为基础的前瞻性纵向队列研究入选1996年1月至2003年2月在89个儿科心脏中心诊断为DCM的儿童以及1990年1月至1995年12月在北美大型三级治疗中心诊断的患儿。参试者：共入选1426例来自美国和加拿大的18岁以下DCM患儿。通过严格的超声心动图和／或病理学标准来诊断原发性DCM。因内分泌、免疫、药物中毒及其他原因患病者除外。主要观测指标：每年每10万儿童的发病率、死亡率和心脏移植率。结果：18岁以下儿童DCM每年的总发病率为0．57／10万，男孩的年发病率高于女孩（分别为0．66／10万和0．47／10万；P〈0．001），黑人的年发病率高于白人（分别为0．98／10万和0．46／10万；P〈0．001），婴儿（〈1岁）的年发病率高于儿童（分别为4．40／10万和0．34／10万；P〈0．001）。绝大部分属特发性，最常见的病因为心肌炎（46％）和神经肌肉性疾病（26％）。1年和5年死亡／移植率分别为31％和46％。死亡／移植的独立危险因素包括患儿诊断DCM时年龄较大、伴有充血性心力衰竭、左室收缩期Z评分较低以及DCM的病因（P均〈0．001）。结论：儿童DCM有其多样性。患儿预后主要取决于病因、年龄和心力衰竭状况。人种、性别和年龄对发病率有一定影响。大部分患儿无明确病因，限制了特异性治疗。

关键词：儿童扩张型心肌病总发病率病因预后充血性心力衰竭神经肌肉性疾病心脏移植流行病学特点

各年龄段成年人的高血压：当前社区人群的预后和控制

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美国医学会杂志（中文版） 2006年第3期25卷 156-161页

作者： Donald M．Lloyd-Jones jane C．Evans Daniel Levy 康俊萍（译）马长生（校） Department of Preventive Medicine Feinberg School of MedicineNorthwestem UniversityChicagoill the National Heart Lungand Blood Instnute’s Framingham Heart StudyFraminghamMass 不详

背景：对于80岁以上的人群，目前有关高血压的治疗和控制率以及高血压相关危险性的数据很少。目的：明确老年高血压患者各级别血压的患病率、高血压的治疗率和控制率以及心血管危险因素。设计、地点及参试者：社区队列研究，数据收集于2... 详细信息

背景：对于80岁以上的人群，目前有关高血压的治疗和控制率以及高血压相关危险性的数据很少。目的：明确老年高血压患者各级别血压的患病率、高血压的治疗率和控制率以及心血管危险因素。设计、地点及参试者：社区队列研究，数据收集于20世纪90年代进入Framinghanl心脏研究的全部检查。根据年龄将入选者集中分层：60岁以下、60～79岁和〉t80岁。共5296例入选者，检查14458人次，其中高血压7135人次（治疗4919例）。主要观测指标：比较各年龄段人群高血压的患病率、治疗率和控制率。6年随访期间发生心血管疾病的危险性，采用cox比例风险回归的多变量校正风险比（hazardratios，HRs）和95％可信区间（confidenceintervals，Cis）评估。结果：高血压的患病率和药物治疗率随着年龄增加而升高，但是在老年女性控制率（收缩压〈140mmHg，舒张压〈90mmHg）显著降低。〈60岁、60～79岁和t〉80岁组男性的控制率分别为38％、36％和38％（P=0．30）；女性的控制率分别为38％、28％和23％（P〈0．001）。随着年龄增加，与血压分级升高相关的心血管疾病的相对危险性没有下降，而绝对危险性显著升高。在〉t80岁的参试者，正常血压组（对照组）主要心血管事件的发生率为9．5％，高血压前期、1级高血压以及2级或治疗的高血压组的发生率分别为19．8％（HR，1．9；95％Ci，0．9～3．9）、20．3％（HR，1．8；95％Ci，0．8～3．7）和24．7％（HR，2．4；95％Ci，1．2～4．6）。结论：相对于目前的国家指南，在社区人群血压的控制率较低，特别是在老年女性高血压患者。短期心血管疾病危险性很高表明，对于老年高血压患者应加大安全有效降低危险性的力度。

关键词：老年高血压患者社区人群各年龄段控制率心血管危险因素成年人 80岁以上 20世纪90年代心血管疾病预后