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Protein and energy concentrations of meat meal and meat and bone meal fed to pigs based on in vitro assays

Animal Nutrition 2021年第1期7卷 252-257页

作者： hyunjun choi Chang Sik Won Beob Gyun Kim Department of Animal Science and Technology Konkuk UniversitySeoul 05029Republic of Korea

The objective of this study was to develop equations for estimating ileal digestible crude protein(CP)and metabolizable energy(ME)contents of meat meal(MM)and meat and bone meal(MBM)as feed in-gredients for pigs based on in vitro *** ingredients were 4 sources of MM and 3 sources of *** and CP contents of the ingredients ranged from 3.8%to 33.1%and 46.8%to 82.9%(as-is basis),*** vitro ileal disappearance(IVID)of CP was determined and ileal digestible CP content was calculated by multiplying CP content by IVID of *** vitro total tract disappearance(IVTTD)of dry matter(DM)was determined and ME was calculated using gross energy,CP contents,and IVTTD of *** IVID of CP and IVTTD of DM ranged from 77.2%to 88.7%and from 82.7%to 92.4%,*** ileal digestible CP and ME contents ranged from 37.8%to 73.5%DM and 2,405 to 3,905 kcal/kg DM,*** contents were negatively correlated(P<0.001)with CP(r=-0.99),in vitro ileal digestible CP(r=-0.97),gross energy(r-1.00),in vitro digestible energy(r=-0.97),and adjusted ME(r=-0.97).The most fitting equations for ileal digestible CP and adjusted ME were:ileal digestible CP(%DM)=11.91-0.90×Ash(%DM)+0.74×IVID of CP(%)(R2=0.99)and adjusted ME(kcal/kg DM)=130.85-50.90×ash(%DM)+47.06×IVTTD of DM(%)(R2=0.99).To validate the accuracy of the prediction equations for ME,mean bias and linear bias were determined using a regression *** ME values of MM and MBM were in a good agreement with data obtained from animal ex-periments based on a statistically insignificant bias in the *** conclusion,ME concentrations of MM and MBM as swine feed ingredients can be calculated using ash concentration and in vitro disap-pearance of dry matter.

关键词： Animal offal Energy In vitro disappearance method Protein

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Investigation of the nutritional and functional roles of a combinational use of xylanase and β-glucanase on intestinal health and growth of nursery pigs

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Journal of Animal Science and Biotechnology 2024年第5期15卷 1932-1950页

作者： hyunjun choi Yesid Garavito Duarte Guilherme A.M.Pasquali Sung Woo Kim Department of Animal Science North Carolina State University116 Polk HallCampus Box 7621RaleighNC 27695USA BASF SE Ludwigshafen 67056Germany

Background Xylanase andβ-glucanase combination(XG)hydrolyzes soluble non-starch polysaccharides that are anti-nutritional *** study aimed to evaluate the effects of increasing levels of XG on intestinal health and growth performance of nursery *** Forty pigs(6.5±0.4 kg)were assigned to 5 dietary treatments and fed for 35 d in 3 phases(11,9,and 15 d,respectively).Basal diets mainly included corn,soybean meal,and corn distiller's dried grains with solubles,contained phytase(750 FTU/kg),and were supplemented with 5 levels of XG at(1)0,(2)280 TXU/kg xylanase and 125 TGU/kgβ-glucanase,(3)560 and 250,(4)840 and 375,or(5)1,120 and 500,*** performance was *** d 35,all pigs were euthanized and jejunal mucosa,jejunal digesta,jejunal tissues,and ileal digesta were collected to determine the effects of increasing XG levels and XG intake on intestinal *** Increasing XG intake tended to quadratically decrease(P=0.059)viscosity of jejunal digesta(min:1.74 m Pa·s at 751/335(TXU/TGU)/kg).Increasing levels of XG quadratically decreased(P<0.05)Prevotellaceae(min:0.6%at 630/281(TXU/TGU)/kg)in the jejunal *** XG intake quadratically increased(P<0.05)Lactobacillaceae(max:40.3%at 608/271(TXU/TGU)/kg)in the jejunal *** XG intake quadratically decreased(P<0.05)Helicobacteraceae(min:1.6%at 560/250(TXU/TGU)/kg)in the jejunal *** levels of XG tended to linearly decrease(P=0.073)jejunal Ig G and tended to quadratically increase(P=0.085)jejunal villus height to crypt depth ratio(max:2.62 at 560/250(TXU/TGU)/kg).Increasing XG intake tended to linearly increase the apparent ileal digestibility of dry matter(P=0.087)and ether extract(P=0.065).Increasing XG intake linearly increased(P<0.05)average daily *** A combinational use of xylanase andβ-glucanase would hydrolyze the non-starch polysaccharides fractions,positively modulating the jejunal mucosa-associated *** intake of

关键词： Glucanase Growth performance Intestinal health Nursery pigs Xylanase

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A novel combined multi-battery dataset based approach for enhanced prediction accuracy of data driven prognostic models in capacity estimation of lithium ion batteries

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Energy and AI 2021年第3期5卷 141-149页

作者： Vijay Mohan Nagulapati hyunjun Lee DaWoon Jung SalaiSargunan S Paramanantham Boris Brigljevic Yunseok choi Hankwon Lim School of Energy and Chemical Engineering UNISTUlsanRepublic of Korea Xynergypower Corp Gyeonggi-doRepublic of Korea Department of Energy Engineering UNISTUlsanRepublic of Korea

To ensure smooth and reliable operations of battery systems,reliable prognosis with accurate prediction of State of Health of lithium ion batteries is of utmost ***,battery degradation is a complex challenge involving many electrochemical reactions at anode,separator,cathode and electrolyte/electrode ***,there is significant effect of the operating conditions on the battery *** machine learning tech-niques have been applied to estimate the capacity and State of Health of lithium ion batteries to ensure reliable operation and timely *** this paper,we study the Gaussian Process Regression(GPR)and Support Vector Machine(SVM)model-based approaches in estimating the capacity and State of Health of ***-tery capacity and State of Health estimations are carried out using GPR and SVM models and the predictions comparatively studied for accuracy based on RMSE *** prediction accuracy is further compared with re-spect to single sensor and multi sensor ***,a combined multi battery data set model is used to improve the prediction *** the data of multiple batteries with similar operating conditions for training a model resulted in higher prediction accuracy.

关键词： Capacity estimation State of health Gaussian process regression Support vector machine Lithium ion battery

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Alveolar macrophage phagocytosis-evading inhaled microgels incorporating nintedanib-PLGA nanoparticles and pirfenidone-liposomes for improved treatment of pulmonary fibrosis

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Bioactive Materials 2024年第3期33卷 262-278页

作者： Woo Tak Lee hyunjun Lee Juho Kim Yujin Jung Eojin choi Ji Hoon Jeong Jee-Heon Jeong Jung Heon Lee Yu Seok Youn School of Pharmacy Sungkyunkwan University2066 Seobu-roJangan-guSuwonGyeonggi-do16419Republic of Korea Department of Precision Medicine School of MedicineSungkyunkwan University2066 Seobu-roJangan-guSuwon16419Republic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan University2066 Seobu-roJangan-guSuwon16419Republic of Korea

Idiopathic pulmonary fibrosis(IPF)is a chronic inflammatory and fibrotic response-driven lung disease that is difficult to cure because it manifests excessive profibrotic cytokines(e.g.,TGF-β),activated myofibroblasts,and accumulated extracellular matrix(ECM).In an attempt to develop an inhalation formulation with enhanced antifibrotic efficacy,we sought to fabricate unique aerosolizable inhaled microgels(μGel)that contain nintedanib-poly(lactic-co-glycolic acid)(PLGA)nanoparticles(NPs;n-PN)and pirfenidone-liposomes(p-LP).The aero-μGel was~12μm,resisted phagocytosis by alveolar macrophages in vitro and in vivo,and protected inner-entrapped n-PN and *** n-PN/p-LP@aero-μGel caused enhanced/extended antifibrotic efficacy in a bleomycin-induced pulmonary fibrosis mouse presumably due to prolonged lung ***,the results obtained by intratracheal aerosol insufflation of our n-PN/p-LP@aero-μGel twice a week were much better than those by as many as seven doses of single or mixed applications of n-PN or *** antifibrotic/pharmacokinetic results for the n-PN/p-LP@aero-μGel included reduced fibrosis progression,restored lung physiological functions,deactivated myofibroblasts,inhibited TGF-βprogression,and suppressed ECM component production(collagen I andα-SMA)along with prolonged lung retention *** believe that our n-PN/p-LP@aero-μGel increased the local availability of both nintedanib and pirfenidone due to evasion of alveolar macrophage phagocytosis and prolonged lung retention with reduced systemic *** this approach,our inhalation formulation subsequently attenuated fibrosis progression and improved lung ***,these results hold profound implications in the therapeutic potential of our n-PN/p-LP@aero-μGel to serve as a clinically promising platform,providing significant advancements for improved treatment of many respiratory diseases including IFP.

关键词： Aerosolizable microgel Lung retention Extracellular matrix Pro-inflammatory cytokines Idiopathic pulmonary fibrosis

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微塑料过滤器|MICROPLASTIC FILTER PIPE

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设计 2021年第6期34卷 9-9页

作者： Doowon choi hyunjun Oh Gwanguk Namgung 大真大学

人类对海洋环境的负面影响巨大且情况各异,最严重的影响是塑料废物的分解,导致微塑料污染。该产品有潜力在污水排入海中前对其进行过滤,从而减少问题。经过家庭第一道过滤和下水道的第二道过滤,可以完全防止微塑料的排放。该设计获得202... 详细信息

人类对海洋环境的负面影响巨大且情况各异,最严重的影响是塑料废物的分解,导致微塑料污染。该产品有潜力在污水排入海中前对其进行过滤,从而减少问题。经过家庭第一道过滤和下水道的第二道过滤,可以完全防止微塑料的排放。该设计获得2020if设计新秀奖评委点评:该系统从源头解决微塑性污染问题。大量塑料从我们的家中直接进入大海,停止从源头排放微塑料远比试图从海洋中移除微塑料更为有效。

关键词：微塑料海洋环境过滤器微塑性下水道

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