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Exploiting fly models to investigate rare human neurological disorders

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Neural Regeneration Research 2025年第1期20卷 21-28页

作者： Tomomi Tanaka hyung-Lok Chung Department of Neurology Houston Methodist Research InstituteHoustonTXUSA Department of Neurology Weill Cornell Medical CollegeNew YorkNYUSA

Rare neurological diseases,while individually are rare,collectively impact millions globally,leading to diverse and often severe neurological *** attributed to genetic mutations that disrupt protein function or structure,understanding their genetic basis is crucial for accurate diagnosis and targeted *** investigate the underlying pathogenesis of these conditions,researchers often use non-mammalian model organisms,such as Drosophila(fruit flies),which is valued for their genetic manipulability,cost-efficiency,and preservation of genes and biological functions across evolutionary *** tools available in Drosophila,including CRISPR-Cas9,offer a means to manipulate gene expression,allowing for a deep exploration of the genetic underpinnings of rare neurological *** boasts a versatile genetic toolkit,rapid generation turnover,and ease of large-scale experimentation,making it an invaluable resource for identifying potential drug *** can expose flies carrying disease-associated mutations to various compounds,rapidly pinpointing promising therapeutic agents for further investigation in mammalian models and,ultimately,clinical *** this comprehensive review,we explore rare neurological diseases where fly research has significantly contributed to our understanding of their genetic basis,pathophysiology,and potential therapeutic *** discuss rare diseases associated with both neuron-expressed and glial-expressed *** cases include mutations in CDK19 resulting in epilepsy and developmental delay,mutations in TIAM1 leading to a neurodevelopmental disorder with seizures and language delay,and mutations in IRF2BPL causing seizures,a neurodevelopmental disorder with regression,loss of speech,and abnormal *** we explore mutations in EMC1 related to cerebellar atrophy,visual impairment,psychomotor retardation,and gain-of-function mutations in ACOX1 causing Mitchell ***-of-fun

关键词： ACOX1 Drosophila melanogaster glia lipid metabolism model organisms neuroinflammation neurologic disorders neuron rare disease VLCFA

Fibrinogen’s potential role in connecting cerebrovascular abnormalities with glymphatic dysfunction in Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 203-204页

作者： Vishal Singh Arnab Choudhury hyung Jin Ahn Department of Pharmacology Physiology and NeurosciencesRutgers-New Jersey Medical SchoolNewarkNJUSA Brain Health Institute Rutgers UniversityPiscatawayNJUSA

Alzheimer’s disease(AD)stands out as the primary manifestation of age-related dementia,portraying a chronic neurodegenerative disorder distinguished by the accumulation of fibrillar amyloid-β(Aβ)plaques and neurofibrillary tangles of hyperphosphorylated ***,from a clinical standpoint,AD presents itself as a complex condition with a spectrum of dysfunctions rather than a singular pathological *** often-overlooked aspect of the disease is the presence of extensive cerebrovascular abnormalities,given that the majority of AD patients experience altered cerebral blood flow,damaged vasculature,increased microinfarcts and *** models of AD further support this observation,showing cerebrovascular dysfunction such as impaired cerebral blood flow and altered cerebrovascular reactivity(Tataryn et al.,2021;Gareau et al.,2023).

关键词： cerebrovascular dysfunction Alzheimer

Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： do-Hun Lee Dan Cao Younghye Moon Chen Chen Nai-Kui Liu Xiao-Ming Xu Wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

Increased risk of colorectal cancer in young males with higher cardiovascular risk:A nationwide population-based cohort study

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 69-80页

作者： Ji Hyun Song Su-Yeon Choi Young Sun Kim Sun Young Yang Kyung-do Han Internal Medicine and Healthcare Research Institute Seoul National University Hospital Healthcare System Gangnam CenterSeoul 06236South Korea Internal Medicine Seoul National University HospitalSeoul National University College of MedicineSeoul 06236South Korea Department of Statistics and Actuarial Science Soongsil UniversitySeoul 06978South Korea

BACKGROUND Although the link between cardiovascular disease(CVD)and various cancers is well-established,the relationship between CVD risk and colorectal cancer(CRC)remains *** To elucidate the relationship between CVD risk scores and CRC *** In this population-based cohort study,participants from the 2009 National Health Checkup were followed-up until *** cardiovascular(CV)risk score was calculated as the sum of risk factors(age,family history of coronary artery disease,hypertension,smoking status,and high-density lipoprotein levels)with high-density lipoprotein(≥60 mg/dL)reducing the risk score by *** primary outcome was incidence of newly diagnosed *** Among 2526628 individuals,30329 developed CRC during a mean follow-up of 10.1 *** by CV risk scores(0,1,2,and≥3).CRC risk increased with higher CV risk scores after adjusting for covariates[(hazard ratio=1.155,95%confidence interval:1.107-1.205)in risk score≥3,P<0.001].This association individuals not using ***,even in participants without diabetes,a higher CV risk was associated with an increased CRC *** Increased CV risk scores were significantly associated with higher CRC risk,especially among males,younger populations,and non-statin ***,males with a higher CV risk score,even at a younger age,are recommended to control their risk factors and undergo individualized CRC screening.

关键词： Colorectal cancer Cardiovascular disease Cohort study Age Gender

Investigation on cost-effective composites for CO_(2) adsorption from post-gasification residue and metal organic framework

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Journal of Environmental Sciences 2025年第2期148卷 174-187页

作者： Hong Nam Nguyen Thu Phuong Nguyen Phuong Thu Le Quang Minh Tran Thi Hai do Trung Dung Nguyen Phuong Lan Tran-Nguyen Toshiki Tsubota Thi Mai Thanh Dinh University of Science and Technology of Hanoi Vietnam Academy of Science and Technology18 Hoang Quoc VietCau GiayHanoi 100000Vietnam Institute for Tropical Technology Vietnam Academy of Science and Technology18 Hoang Quoc VietCau GiayHanoi 100000Vietnam Faculty of Basic Science Hanoi University of Mining and Geology18 Pho VienDuc ThangNam Tu LiemHanoi 100000Vietnam Faculty of Physical and Chemical Engineering Le Quy Don Technical University236 Hoang Quoc VietBac Tu LiemHanoi 100000Vietnam Department of Mechanical Engineering Can Tho University3/2 streetCan Tho City 94000Vietnam Department of Engineering Graduate School of EngineeringKyushu Institute of Technology1-1 SensuichoTobata-kuKitakyushuFukuoka 804-8550Japan

Cost-effective CO_(2) adsorbents are gaining increasing attention as viable solutions for mitigating climate *** this study,composites were synthesized by electrochemically combining the post-gasification residue of Macadamia nut shell with copper benzene-1,3,5-tricarboxylate(CuBTC).Among the different composites synthesized,the ratio of 1:1 between biochar and CuBTC(B 1:1)demonstrated the highest CO_(2) adsorption *** controlled laboratory conditions(0°C,1 bar,without the influence of ambient moisture or CO_(2) diffusion limitations),B 1:1 achieved a CO_(2) adsorption capacity of 9.8 mmol/g,while under industrial-like conditions(25℃,1 bar,taking into account the impact of ambient moisture and CO_(2) diffusion limitations within a bed of adsorbent),it reached 6.2 mmol/*** values surpassed those reported for various advanced CO_(2) adsorbents investigated in previous *** superior performance of the B 1:1 composite can be attributed to the optimization of the number of active sites,porosity,and the preservation of the full physical and chemical surface properties of both ***,the composite exhibited a notable CO_(2)/N_(2) selectivity and improved stability under moisture *** favorable characteristics make B 1:1 a promising candidate for industrial applications.

关键词： Biochar-based composites CO_(2)adsorption CuBTC Metal organic framework Post-gasification residue

Refractory lipoatrophy treated with autologous whole blood injection:A case report

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World Journal of Clinical Cases 2025年第2期13卷 33-38页

作者： Wonnam Kim Jun Su Park En hyung Kim Department of Pharmacology School of Korean MedicinePusan National UniversityYangsan 50612GyeongnamSouth Korea Department of Dermatology College of MedicineChungbuk National UniversityCheongju 28644ChungbukSouth Korea Department of Dermatology Chungbuk National University HospitalCheongju 28644ChungbukSouth Korea

BACKGROUND Intramuscular corticosteroid injection may cause adverse effects such as dermal and/or subcutaneous atrophy,alopecia,hypopigmentation,and *** cutaneous atrophy can spontaneously resolve,several treatment options have been suggested for this *** SUMMARY In this paper,we report a case of corticosteroid injection induced lipoatrophy treated with autologous whole blood(AWB)injection,as the condition had been unresponsive to fractional laser therapy.A 29-year-old female patient visited the dermatology clinic complaining of skin depression on her right buttock area,which had appeared six months *** had been only subtle improvement at the margins after fractional CO_(2) laser treatment;therefore,after obtaining informed consent from the patient,AWB treatment was *** month after the first AWB injection,the size and depth of the lesion had noticeably improved,and a slight improvement was also observed in *** Close observation is the initial treatment of choice for steroid induced skin atrophy;however,for patients in need of immediate cosmetic improvement,AWB injection may be a safe and cost-effective alternative.

关键词： Atrophy Corticosteroid Subcutaneous fat Autologous whole blood injection Laser therapy Case report

Flexible thermocells for utilization of body heat

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Nano Research 2014年第4期7卷 443-452页

作者： Hyeongwook Im hyung Geun Moon Jeong Seok Lee In Young Chung Tae June Kang Yong hyup Kim School of Mechanical and Aerospace Engineering Seoul National University Seoul 151-742 Republic of Korea Department of Electronics and Communications Engineering Kwangwook University Seou1139-701 Republic of Korea Department of Nanofusion Technology Pusan National University Busan 609-735 Republic of Korea

Plastic thermo-electrochemical ceils （thermocells） involving aqueous potassium ferricyanide/ferrocyanide electrolyte have been investigated as an alternative to conventional thermoelectrics for thermal energy harvesting. Plastic thermocells that consist of all pliable materials such as polyethylene terephthalate （PET）, fabrics, and wires are flexible enough to be wearable on the human body and to be wrapped around cylindrical shapes. The performance of the thermocells is enhanced by incorporating carbon nanotubes into activated carbon textiles, due to improved charge transfer at the interface. In cold weather conditions （a surrounding temperature of 5 ℃）, the thermocell generates a short-circuit current density of 0.39 A/m2 and maximum power density of 0.46 mW/m2 from body heat （temperature of 36℃）. For practical use, we have shown that the thermocell charges up a capacitor when worn on a T-shirt by a person. We also have demonstrated that the electrical energy generated from waste pipe heat using a serial array of the thermocells and voltage converters can power a typical commercial light emitting diode （LED）.

关键词： wearable thermocell body heat waste heat recovery carbon nanotubes activated carbon textile porous electrode

Biomass growth characteristics of 13-year-old Pinus densiflora *** *** a post-fire plantation on different contour conditions in Samcheuk,Korea

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Journal of Mountain Science 2016年第7期13卷 1238-1244页

作者： Lee Ju-Hyoung Lee do-hyung Kim do-Hyun Park Jin-Hwa KimJae-Hee Department of Forest Resources Yeungnam UniversityGyeongsan 712-749Republic of Korea Useful Plant Resources Center Korea National ArboretumYangpgeong-gun 12519Republic of Korea Korea Forest Welfare Institute Therapy-ro 209Bonghyeon-myeonYeongju-siGyeongsangbuk-doRepublic of Korea Department of forest genetic resources National Institute of Forest Science57HoegiroDongdaemun-guSeoul 02455Republic of Korea

We used preliminary data to estimate the growth volume of artificially reforested Pinus densiflora in a post-fire area on three different contour conditions. We compared the growth of P. densiflora on a south-facing slope(Ssth), north-facing slope(Snth) and ridge area(Ridge), using 7 trees selected from each stand aspect. The tree height, diameter and growth volume were measured and the dry weight of each plant part were compared and analyzed. The results revealed that the total dry weight was highest on Ssth(5992.3 g), followed by Snth(4833.2 g) and lowest on Ridge(3160.1 g). The height growth was highest on Snth(285.8 cm), followed by Ssth(274.5 cm) and lowest on Ridge(211.5 cm). The diameter growth was greatest on Ssth(7.37 cm), followed by Snth(7.10 cm) and lowest on Ridge(5.72 cm). The volume growth was highest on Ssth(4257.7 cm3), followed by Snth(3750.7 cm3) and lowest on Ridge(2093.7 cm3). Therefore, we should consider and include the concept of slope orientation together with differences in habitat environments in afforestation projects when creating artificial forests with P. densiflora. These study results can serve as important preliminary data for future establishment of artificial forest of P. densiflora in a post-fire plantation.

关键词： Pinus densiflora Growth characteristics Contour conditions Planted stand Post-fire plantation

Technical Proposal for the Recovery of Iron Tailings in Dams in the Context of a Circular Economy

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Journal of Geoscience and Environment Protection 2025年第1期13卷 387-396页

作者： Vidal Félix Navarro Torres Geraldo Aparecido do Vale Eduardo da Rosa Aquino Instituto Tecnolgico Vale-Minerao Ouro Preto Brazil Vale S.A. Parauapebas Brazil

The objective of this study is to present a tailings recovery project in a dam located in northern Brazil;the tailings in this dam have high concentrations of iron. The sustainable recovery of mineral resources can be achieved using the dredging method. The methodology used was based on two drilling projects conducted in 2001 and 2010;these projects contained samples with information on the chemical composition and particle size fractions. The dredging system was designed to operate with four cutter suction dredgers. For operation, factors such as productivity, pumping distance and material flow were considered. The material contained in the dam was estimated using the natural neighborhood interpolation method;this resulted in approximately 192 million tons of tailings, with an average iron content of 63.37%. Based on these data, a 13-year mining plan was prepared, with the potential to maximize the use of the tailings and reduce the environmental impacts, thus contributing to a circular economy.

关键词： Tailings Dredging Iron Content Circular Economy