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Grasper type scissors for endoscopic submucosal dissection of gastric epithelial neoplasia

World Journal of Gastroenterology 2013年第37期19卷 6221-6227页

作者： woo-Chul Chung Byung-wook Kim Chul-hyun Lim Tae-Ho Kim Jae-Myung Park Joon-Sung Kim Division of Gastroenterology Department of Internal MedicineSuwon St.Vincent’s HospitalThe Catholic University of Korea Division of Gastroenterology Department of Internal MedicineIncheon St.Mary’s HospitalThe Catholic University of Korea Division of Gastroenterology Department of Internal MedicineSeoul St.Mary’s HospitalThe Catholic University of Korea Division of Gastroenterology Department of Internal MedicineBucheon St.Mary’s HospitalThe Catholic University of Korea

AIM:To evaluate the efficacy and safety of grasper type scissors(GTS)for endoscopic submucosal dissection(ESD)of gastric epithelial ***:The study was performed by 4 endoscopists in 4 institutions affiliated to The Catholic University of *** was performed in 76 consecutive patients with gastric epithelial neoplasia by using the GTS(37 patients)or the hook knife plus coagrasper(HKC)(39 patients).The complete resection rate,complication rate,total time elapsed and elapsed time per square centimeter of the dissected specimen were analyzed between the GTS and HKC ***:The mean age of the GTS group was 62.3±11.4 years and mean age of the HKC group was 65.6±10.1 *** adenocarcinoma was found in32.4%in the GTS group and 33.3%in the HKC *** procedures were performed without interruption in every case in both *** en bloc resection rates of both groups were 100%.The total time elapsed during the procedure was 44.54±21.72 min in the GTS group and 43.77±21.84 min in the HKC group(P=0.88)and the time elapsed per square centimeter of the resected lesion was 7.53±6.35 min/cm2in the GTS group and 6.92±5.93 min/cm2in the HKC group(P=0.66).The overall complication rate was not significantly different between the two ***:GTS is a safe and effective device for ESD compared with *** can be performed with GTS alone,which can reduce the costs for ESD.

关键词： Gastric epithelial neoplasia Endoscopic submucosal dissection Grasper type scissors Hook knife Coagrasper

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Long-term treatment outcomes of clevudine in antiviral-naive patients with chronic hepatitis B

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World Journal of Gastroenterology 2012年第47期18卷 6943-6950页

作者： Suk Bae Kim Il Han Song Young Min Kim Ran Noh Ha Yan Kang Hyang Ie Lee Hyeon Yoong Yang An Na Kim Hee Bok Chae Sae Hwan Lee Hong Soo Kim Tae Hee Lee Young woo Kang Eaum Seok Lee Seok hyun Kim Byung Seok Lee Heon Young Lee Department of Internal Medicine Dankook University College of MedicineCheonan 330-715South Korea Department of Internal Medicine Eulji University College of MedicineDaejeon 302-779South Korea Department of Internal Medicine Chungbuk University College of MedicineCheongju 362-711South Korea Department of Internal Medicine Soonchunhyang University College of MedicineCheonan 330-090South Korea Department of Internal Medicine Konyang University College of MedicineDaejeon 371-718South Korea Department of Internal Medicine Chungnam University College of MedicineDaejeon 301-721South Korea

AIM:To evaluate the treatment outcomes of clevudine compared with entecavir in antiviral-naive patients with chronic hepatitis B(CHB).METHODS:We retrospectively analyzed the clinical data of CHB patients treated with clevudine 30 mg/d and compared their clinical outcomes with patients treated with entecavir 0.5 mg/*** biochemical response,as assessed by serum alanine aminotransferase(ALT) activity,virologic response,as assessed by serum hepatitis B virus DNA(HBV DNA) titer,serologic response,as assessed by hepatitis B e antigen(HBeAg) status,and virologic breakthrough with genotypic mutations were ***:Two-hundred and fifty-four patients [clevudine(n = 118) vs entecavir(n = 136)] were *** clevudine-treated patients,the cumulative rates of serum ALT normalization were 83.9% at week 48 and 91.5% at week 96(80.9% and 91.2% in the entecavir group,respectively),the mean titer changes in serum HBV DNA were-6.03 and-6.55 log 10 copies/mL(-6.35 and-6.86 log 10 copies/mL,respectively,in the entecavir group),and the cumulative non-detection rates of serum HBV DNA were 72.6% and 83.1%(74.4% and 83.8%,respectively,in the entecavir group).These results were similar to those of entecavir-treated *** cumulative rates of HBeAg seroconversion were 21.8% at week 48 and 25.0% at week 96 in patients treated with clevudine,which was similar to patients treated with entecavir(22.8% and 27.7%,respectively).The virologic breakthrough in the clevudine group occurred in 9(7.6%) patients at weeks 48 and 15(12.7%) patients at week 96,which primarily corresponded to genotypic mutations of rtM204I and/or *** was no virologic breakthrough in the entecavir ***:In antiviral-naive CHB patients,longterm treatment outcomes of clevudine were not inferior to those of entecavir,except for virologic breakthrough.

关键词： Chronic hepatitis B Hepatitis B virus Clevudine Entecavir Treatment outcomes

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Comparison of efficacy between adjuvant chemotherapy and chemoradiation therapy for pancreatic cancer: AJCC stage-based approach

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World Journal of Clinical Oncology 2020年第9期11卷 747-760页

作者： Min Su You Ji Kon Ryu Gunn Huh Jung Won Chun woo hyun Paik Sang Hyub Lee Yong-Tae Kim Internal Medicine and Liver Research Institute Seoul National University HospitalSeoul 110-744South Korea

BACKGROUND The adjuvant treatment for patients with resected pancreatic cancer(PC)is not yet *** the prognosis differs according to the American Joint Committee on Cancer(AJCC)stage,a tailored approach to establish more aggressive treatment plans in high-risk patients is ***,studies comparing the efficacy of adjuvant treatment modalities according to the AJCC stage are largely *** To compare the efficacy of chemotherapy and chemoradiation therapy according to AJCC 8th staging system in patients with PC who underwent surgical *** A total of 335 patients who underwent surgical resection and adjuvant treatment for PC were *** were divided into three groups:Chemoradiation therapy(CRT)group,systemic chemotherapy(SCT)group and combined treatment of chemoradiation plus chemotherapy therapy(CRT-SCT)*** primary outcomes were differences in overall survival(OS)between the three *** secondary outcomes were differences in recurrence-free survival,recurrence pattern and adverse events between the three *** Patients received CRT(n=65),SCT(n=62)and CRT-SCT(n=208).Overall median OS was 33.3 mo(95%confidence interval(CI):27.4-38.6).In patients with stage I/II,the median OS was 27.0 mo(95%CI:2.06-89.6)in the CRT group,35.8 mo(95%CI:26.9-NA)in the SCT group and 38.6 mo(95%CI:33.3-55.7)in the CRT SCT *** them,there was no significant difference in OS between the three *** 59 patients with stage III,median OS in the SCT group[19.0 mo(95%CI:12.6-NA)]and the CRT-SCT group[23.4 mo(95%CI:22.0-44.4)]was significantly longer than that in the CRT group[17.7 mo(95%CI:6.8-NA);P=0.011 and P<0.001,respectively].There were no significant differences in incidence of locoregional and distant recurrences between the three groups(P=0.158 and P=0.205,respectively).Incidences of grade 3 or higher hematologic adverse events were higher in the SCT and CRT-SCT groups than in the CRT *** SCT

关键词： Pancreatic cancer Adjuvant chemotherapy Radiotherapy Survival

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Cloning of Malate Synthase Gene from a Ophiostoma Fungus

Cloning of Malate Synthase Gene from a Ophiostoma Fungus

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The 7th Korea-China Joint Symposium for Mycology

作者： Min woo hyun Sang Do CHA Yeo Hong YUN Seoung Ryul SON Seong Hwan KIM Department of Microbiology Dankook University Department of Microbiology Dankook University Department of Microbiology Dankook University Department of Microbiology Dankook University Department of Microbiology Dankook University

＜正＞wood discoloration caused by Ophiostoma fungi results in economic loss in forest product industry. Melanin in Ophiostoma fungi is known to be responsible for discoloring damage in wood. To understand the role of carbon in melanin formation in sapstaining fungi, we have been working on the enzymes used for carbon metabolism. In this study we report cloning and

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Risk factors of organ failure in cholangitis with bacteriobilia

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World Journal of Gastroenterology 2015年第24期21卷 7506-7513页

作者： Jae Min Lee Sang Hyub Lee Kwang hyun Chung Jin Myung Park Ban Seok Lee woo hyun Paik Joo Kyung Park Ji Kon Ryu Yong-Tae Kim Departments of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul National University Hospital Department of Internal Medicine Gyeongsang National University College of Medicine Gyeongsang National University Hospital Department of Internal Medicine Kangwon National University School of Medicine Kangwon National University Hospital Department of Internal Medicine Inje University Ilsan Paik Hospital Department of Gastroenterology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine

AIM: To identify the risk factors for organ failure(OF) in cholangitis with ***: This study included 182 patients with acute cholangitis who underwent percutaneous transhepatic biliary drainage between January 2005 and April 2013. We conducted a retrospective analysis of comprehensive clinical and laboratory ***: There were 24 cases(13.2%) of OF and five deaths(2.7%). Bile culture was positive for microbial growth in 130 out of 138(94.2%) patients. In multivariate analysis of 130 patients with positivebile cultures, significant predictive factors for OF were the presence of extended-spectrum beta-lactamase(ESBL) organisms in blood cultures, pre-existing renal dysfunction, and choledocholithiasis as an etiology, with odds ratios of 15.376, 6.319, and 3.573, respectively. We developed a scoring system with a regression coefficient of each significant variable. The OF score was calculated using the following equation:(2.7 × ESBL organisms in blood cultures) +(1.8 × pre-existing renal dysfunction) +(1.3 × choledocholithiasis). This scoring system for predicting OF was highly specific(99.1%) and had a positive predictive value of 86.2%.CONCLUSION: ESBL organisms in blood cultures, preexisting renal dysfunction, and choledocholithiasis are risk factors for OF in cholangitis with bacteriobilia. The OF scoring system may aid clinicians to identify a poor prognosis group.

关键词： Acute cholangitis Bacteriobilia Bile culture Organ failure

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WNT5A drives interleukin-6-dependent epithelial-mesenchymal transition via the JAK/STAT pathway in keloid pathogenesis

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Burns & Trauma 2022年第1期10卷 200-215页

作者： Young In Lee Jung Eun Shim Jihee Kim Won Jai Lee Jae woo Kim Kee hyun Nam Ju Hee Lee Department of Dermatology Severance HospitalCutaneous Biology Research InstituteYonsei University College of MedicineSeoul 03722Korea Bioinformatics Collaboration Unit Yonsei University College of MedicineSeoul 03722Korea Department of Plastic and Reconstructive Surgery Severance HospitalYonsei University College of MedicineSeoul 03722Korea Scar Laser and Plastic Surgery Center Yonsei Cancer HospitalYonsei University College of MedicineSeoul 03722Korea Department of Biochemistry and Molecular Biology Chronic Intractable Disease for Systems Medicine Research CenterYonsei University College of MedicineSeoul 03722Korea Department of Surgery Severance HospitalYonsei University College of MedicineSeoulKorea

Background:Keloid scarring is a fibroproliferative disease caused by aberrant genetic activation with an unclear underlying *** predisposition,aberrant cellular responses to environmental factors,increased inflammatory cytokines and epithelial-mesenchymal transition(EMT)phenomena are known as major *** this study,we aimed to identify the molecular drivers that initiate keloid ***:Bulk tissue RNA sequencing analyses of keloid and normal tissues along with ex vivo and in vitro tests were performed to identify the contributing genes to keloid *** animal model of inflammatory keloid scarring was reproduced by replication of a skin fibrosis model with intradermal bleomycin injection in C57BL/6 ***:Gene set enrichment analysis revealed upregulation of Wnt family member 5A(WNT5A)expression and genes associated with EMT in keloid ***,human keloid tissues and the bleomycin-induced skin fibrosis animal model showed significantly increased expression ofWNT5A and EMT *** activation of the interleukin(IL)-6/Janus kinase(JAK)/signal transducer and activator of transcription(STAT)pathway and subsequent elevation of EMT markerswas also observed in keratinocytes co-cultured withWNT5A-activated fibroblasts or keloid ***,WNT5A silencing and the blockage of IL-6 secretion via neutralizing IL-6 antibody reversed hyperactivation of the STAT pathway and EMT markers in ***,STAT3 silencing significantly reduced the EMT-like phenotypes in both keratinocytes and IL-6-stimulated ***:Intercellular communication via the WNT5A and STAT pathways possibly underlies a partial mechanism of EMT-like phenomena in keloid ***-6 secreted from WNT5A-activated fibroblasts or keloid fibroblasts activates the JAK/STAT signaling pathway in adjacent keratinocytes which in turn express EMT markers.A better understanding of keloid development and the

关键词： Keloid Wnt family member 5A Interleukin-6 JAK/STAT pathway Epithelial-mesenchymal transition Scar Epithelial mesenchymal transition

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Healing of the nasal septal mucosa in an experimental rabbit model of mucosal injury

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2017年第1期3卷 -页

作者： Kyu Young Choi Sung woo Cho Jun-Jae Choi Yu-Lian Zhang Dae woo Kim Doo Hee Han hyun Jik Kim Dong-Young Kim Chae-Seo Rhee Tae-Bin Won Department of Otorhinolaryngology-Head and Neck Surgery Hallym University College of MedicineKangnam Sacred Heart HospitalSeoul07441South Korea Department of Otorhinolaryngology-Head and Neck Surgery Seoul National University College of MedicineSeoul National University HospitalSeoul03080South Korea

Objective:The aim of this study was to investigate the regeneration process of the nasal mucosa after a surgically created mucosal defect in the rabbit nasal septum,and to evaluate the effects of different ***:A 7 mm-diameter circular mucosal defect was made in the septum of forty New Zealand white *** rabbits were divided into four groups (ten rabbits in each group) according to the type of intervention;no treatment (control),silastic sheet (SS),hyaluronic acid (HA),and silastic sheet and hyaluronic acid (SS + HA) *** diameter of the defect,mucosal thickness,epithelial thickness,and ciliated cell count were evaluated every week for five ***:The average diameter of the defect in the control group were 5.1,3.65,1.2,0.75,and 0.05 mm at postoperative 1,2,3,4,and 5 *** the SS group,the diameter decreased to 4.35,2.1,0.35,0.15,and 0 mm at postoperative 1,2,3,4,and 5 weeks,respectively,in which the mean diameter of the postoperative week 2 was significantly smaller compared to control (3.65 mm vs.2.1 mm,P =0.039).For the HA group and SS + HA group,the diameter of the defect did not show a significant difference from the control group during the five *** mucosal thickness,epithelial thickness,and ciliated cell count of the regenerated mucosa were not significantly different among the ***:The regeneration process of the nasal septal mucosa was identified using a novel rabbit *** regeneration can be accelerated by applying silastic sheets.

关键词： Nasal septum Nasal mucosa Mucous membrane Hyaluronic acid Rabbits

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Clinical and pathological differences between serum immunoglobulin G4-positive and -negative type 1 autoimmune pancreatitis

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World Journal of Gastroenterology 2013年第25期19卷 4031-4038页

作者： woo hyun Paik Ji Kon Ryu Jin Myung Park Byeong Jun Song Joo Kyung Park Yong-Tae Kim Kyoungbun Lee Department of Internal Medicine Liver Research Institute Division of Gastroenterology Department of Internal Medicine Seoul National University College of Medicine Department of Pathology Seoul National University College of Medicine

AIM: To identify clinical and pathological differences between serum immunoglobulin G4 (IgG4)-positive (SIP) and IgG4-negative (SIN) type 1 autoimmune pancreatitis (AIP) in South Korea. METHODS: AIP was diagnosed by the international consensus diagnostic criteria. The medical records and pathology were retrospectively reviewed and IgG4-positive cells were counted in a high power field (HPF). Type I AIP was defined as a high serum level of IgG4or histological finding. SIN type 1 AIP was defined as a histological evidence of type 1 AIP and a normal serum IgG4 level. The clinical and pathological findings were compared between the two groups. The analysis was performed using Student's t test, Fischer's exact test and Mann-Whitney's U test. A P value of < 0.05 was considered statistically significant. As repeated com- parison was made, P values of less than 5% (P < 0.05) were considered significant. RESULTS: Twenty five patients with definite type 1 AIP (19 histologically and six serologically diagnosed cases) were enrolled. The mean tissue IgG4 concentrations were significantly higher in SIP than SIN group (40 cells per HPF vs 18 cells per HPF, P = 0.02). Among eight SIN patients, the tissue IgG4 concentrations were less than 15 cells per HPF in most of cases, except one. The sensitivity of serum IgG4 was 68% (17 SIP and eight SIN AIP). Other organ involvement was more frequent- ly associated with SIP than SIN AIP (59% vs 26%, P = 0.016). However, the relapse rate and diffuse swelling of the pancreas were not associated with serum IgG4 level. The concentrations of IgG4-positive cells per HPF were higher in SIP than SIN AIP (40 vs 18, P = 0.02). CONCLUSION: The sensitivity of serum IgG4 was 68% in type 1 AIP. High serum IgG4 level was associated with other organ involvement and tissue IgG4 concentration but did not affect the relapse rate in type 1 AIP.

关键词： Autoimmunity Chronic pancreatitis Immunoglobulin G4-related systemic disease Lymphoplas-macytic sclerosing pancreatitis Immunoglobulin G4

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Attenuated FOLFIRINOX in the salvage treatment of gemcitabine-refractory advanced pancreatic cancer: a phase II study

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Cancer Communications 2018年第1期38卷 344-351页

作者： Jung Hoon Kim Sang-Cheol Lee Sung Yong Oh Seo-Young Song Namsu Lee Eun Mi Nam Soonil Lee In Gyu Hwang Hyo Rak Lee Kyu Taek Lee Sang-Byung Bae Han Jo Kim Joung Soon Jang Do Hyoung Lim hyun woo Lee Seok Yun Kang Jung Hun Kang Department of Internal Medicine Institute of Health SciencesGyeongsang National University15 Jinju-daero 816beon-gilJinju 52727Republic of Korea Divsion of Hematology and Oncology Department of Internal MedicineSoonchunhyang University Hospital CheonanCheonan 31151Republic of Korea Department of Internal Medicine Dong-A University HospitalBusan 49201Republic of Korea Department of Internal Medicine Kangwon National University School of MedicineChuncheon 24289Republic of Korea Divsion of Hematology and Oncology Department of Internal MedicineSoonchunhyang University Hospital SeoulSeoul 04401Republic of Korea Department of Internal Medicine Ewha Womans UniversityCollege of MedicineSeoul 07985Republic of Korea Department of Internal Medicine Dankook University HospitalCheonan 31116Republic of Korea Department of Internal Medicine Chung-Ang UniversityCollege of MedicineSeoul 06973Republic of Korea Division of Hematology and Medical Oncology Department of Internal MedicineKorea Cancer HospitalSeoul 01812Republic of Korea Department of Hematology-Oncology Ajou University HospitalSuwon 16499Republic of Korea

Background:Combination therapy with oxaliplatin,irinotecan,fluorouracil,and leucovorin(FOLFIRINOX)chemotherapy drastically improves survival of advanced pancreatic cancer ***,the efficacy of FOLFIRINOX as a second-line treatment after gemcitabine failure has not been tested *** investigated the feasibility and safety of attenuated FOLFIRINOX in patients with gemcitabine-refractory advanced pancreatic ***:A multicenter phase II prospective open-label,single-arm study was conducted at 14 *** with histologically proven invasive ductal pancreatic adenocarcinoma,a measurable or evaluable lesion,Eastern Cooperative Oncology Group performance status 0 or 1,adequate organ function,and aged 19 years or older were *** FOLFIRINOX consisted of oxaliplatin 65 mg/m2,irinotecan 135 mg/m2,and leucovorin 400 mg/m2 injected intravenously on day 1 and 5-fluorouracil 2000 mg/m2 continuously infused intravenously over 46 h on days 1-2,repeated every 2 *** primary endpoint was progression-free survival from the initiation of *** endpoints were the objective response rate,disease control rate,overall survival,safety,and *** estimated overall survival and progression-free survival using the Kaplan-Meier ***:We enrolled 39 patients from 14 *** objective response rate was 10.3%,while the disease control rate was 64.1%.The 6-month and 1-year overall survival rates were 59.0%and 15.4%,*** progression-free survival and overall survival were 3.8 months(95%confidence interval[CI]1.5-6.0 months)and 8.5 months(95%CI 5.6-11.4 months),*** 3 or 4 adverse events were neutropenia(41.0%),nausea(10.3%),anorexia(10.3%),anemia(7.7%),mucositis(7.7%),pneumonia/pleural effusion(5.1%),and fatigue(5.1%).One treatment-related death attributable to septic shock ***:Attenuated FOLFIRINOX may be promising as a second-line therapy for gemcitabin

关键词： Attenuated FOLFIRINOX Second-line Pancreatic cancer Gemcitabine

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Lichen Planus Pigmentosus Inversus:Two Case Reports

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International Journal of Dermatology and Venereology 2022年第2期5卷 116-118页

作者： Se Hoon Lee Minah Cho Yu Jin Han Yu Ri woo Sang hyun Cho Jeong Deuk Lee Hei Sung Kim Department of Dermatology Incheon St.Mary’s HospitalThe Catholic University of KoreaSeoulSouth Korea Department of Biomedicine&Health Sciences The Catholic University of KoreaSeoulSouth Korea.

Introduction:Lichen planus pigmentosus inversus(LPPI)is a rare a rare variant of lichen planus characterized by hyperpigmented patches with predominating localization in intertriginous *** to its rarity,only a few LPPI cases are *** herein describe two rare cases of *** presentation:The two patients were all with a brownish macular lesion on the intertriginous area.A diagnosis of LPPI was made based on their clinical manifestations,dermoscopic features,and histopathologic features,which revealed an interface change,lichenoid infiltration,and pigmentary ***:LPPI is pruritic or asymptomatic,hyperpigmented macules and patches on the flexural *** axillae and flanks were the most commonly affected areas,followed by the groin and *** half of the female patients had inframammary fold *** shows higher female predominance than Lichen planus *** were fewer cases that lasted more than 3 years compared to ***:LPPI is a rare variant of lichen planus,with a locational characteristic and female ***,in the case of a pigmented disease occurring in the flexural folds,it should be placed in the differential diagnosis.

关键词： lichen planus pigmentosus lichen planus pigmentosus inversus

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