Healing of the nasal septal mucosa in an experimental rabbit model of mucosal injury

作     者：Kyu Young Choi Sung Woo Cho Jun-Jae Choi Yu-Lian Zhang Dae Woo Kim Doo Hee Han Hyun Jik Kim Dong-Young Kim Chae-Seo Rhee Tae-Bin Won 

作者机构：Department of Otorhinolaryngology-Head and Neck SurgeryHallym University College of MedicineKangnam Sacred Heart HospitalSeoul07441South Korea Department of Otorhinolaryngology-Head and Neck SurgerySeoul National University College of MedicineSeoul National University HospitalSeoul03080South Korea 

出 版 物：《World Journal of Otorhinolaryngology-Head and Neck Surgery》 (世界耳鼻咽喉头颈外科杂志（英文）)

年 卷 期：2017年第3卷第1期

页      面：-页

学科分类：1003[医学-口腔医学] 1002[医学-临床医学] 

基　　金：Seoul National University Hospital  SNUH  (30-2012-0180) 

主　　题：Nasal septum Nasal mucosa Mucous membrane Hyaluronic acid Rabbits 

摘      要：Objective:The aim of this study was to investigate the regeneration process of the nasal mucosa after a surgically created mucosal defect in the rabbit nasal septum,and to evaluate the effects of different ***:A 7 mm-diameter circular mucosal defect was made in the septum of forty New Zealand white *** rabbits were divided into four groups (ten rabbits in each group) according to the type of intervention;no treatment (control),silastic sheet (SS),hyaluronic acid (HA),and silastic sheet and hyaluronic acid (SS + HA) *** diameter of the defect,mucosal thickness,epithelial thickness,and ciliated cell count were evaluated every week for five ***:The average diameter of the defect in the control group were 5.1,3.65,1.2,0.75,and 0.05 mm at postoperative 1,2,3,4,and 5 *** the SS group,the diameter decreased to 4.35,2.1,0.35,0.15,and 0 mm at postoperative 1,2,3,4,and 5 weeks,respectively,in which the mean diameter of the postoperative week 2 was significantly smaller compared to control (3.65 mm vs.2.1 mm,P =0.039).For the HA group and SS + HA group,the diameter of the defect did not show a significant difference from the control group during the five *** mucosal thickness,epithelial thickness,and ciliated cell count of the regenerated mucosa were not significantly different among the ***:The regeneration process of the nasal septal mucosa was identified using a novel rabbit *** regeneration can be accelerated by applying silastic sheets.