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Impacts of Coagulation Pretreatment on MF Filtration and a Comparative Study of Different Membrane Module Types

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Journal of Ocean University of China 2006年第4期5卷 295-299页

作者： LIU Oi-feng Kim Seung-hyun yun Jong-sup Moon Seong-yong Department of Civil Engineering Kyungnam University Masan 631701 Korea Water Environment ＆ Remediation Research Center Korea Institute of Science and Technology Seoul 136971 Korea

Changes in the regulatory requirements and the forthcoming Disinfectant/Disinfection By-Products （D/DBP） Rule will require that drinking water treatment facilities be operated to achieve maximum removals of particles and disinfectant tolerant microorganisms as well as natural organic matter （NOM）. For drinking water production, the use of membrane filtration processes such as microfiltration and ultrafiltration （MF/UF） alone to satisfy the turbidity, particle and microorganism removal a requirement of the surface water treatment regulation （SWTR） is not enough. MF/UF treatment processes can achieve only nominal （10 percent） removal of disinfection by-products （DBP） precursors （James, et al., 1995）. On the other hand, too fast fouling can make the filtration processes more difficult to carry on. To solve these problems, many authors have been interested in installing coagulation pretreatment before membrane filtration to improve membrane performance. However, previous studies reported conflicting results. Some supported the effectiveness of coagulation pretreatment, while others contended that coagulation aggravated membrane performance. This research aims to identify the effects of coagulation pretreatment on membrane filtration through a pilot study using PVDF membrane in combination with analyzing the rationale of coagulation. Another objective of this research was to evaluate the different impacts on membrane performance of using different membrane modules （the submerged module and pressured module）. The results showed that coagulation pretreatment greatly improved the membrane performance, extending the filtration time as well as reducing the permeated organic level, and that the submerged module is much more efficient than the pressured module.

关键词： coagulation pretreatment rationale fouling submerged module pressured module

Expression of Genes Affecting Skin Coloration and Sugar Accumulation in Apple Fruits at Ripening Stages in High Temperatures

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World Journal of Engineering and Technology 2015年第3期3卷 7-12页

作者： Seon Ae Kim Soon Young Ahn hyun Hee Han In Chang Son Hae Keun yun Department of Horticulture and Life Science Yeungnam University Gyeongsan South Korea National Institute of Horticultural & Herbal Science Wanju South Korea

High temperature is one of the most important environmental factors that affect the successful cultivation of apple (Malus × domestica Borkh). The expression of genes related with anthocyanin synthesis and sugar accumulation by high temperature treatment was investigated in the fruits of “Fuji” apple at different developmental stages in different temperature conditions through real- time PCR. In the initial ripening stages in fruits, there was high expression of genes associated with fruit ripening, flavonoid compound accumulation, and coloration in high temperatures. Expression of phenylalanine ammonia-lyase, chalcone synthase, flavone 3-hydrogenase, and malate dehydrogenase genes increased gradually in initial ripening stages, while sharply reduced at 24 hr after treatment. In addition, there was no significant difference in the expression of all temperature treatments in late ripening stages. In the further work, investigation of expression levels of various genes could be conducted in the level of transcriptomes from fruits at the early stages to get meaningful information of ripening metabolism in apples in high temperatures.

关键词： Anthocyanin Apple High Temperature Skin Coloration Sugar Content

Dietary vitamin D intake and vitamin D related genetic polymorphisms are not associated with gastric cancer in a hospital-based case-control study in Korea

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The Journal of Biomedical Research 2018年第4期32卷 257-263页

作者： Sang-Yong Eom Dong-Hyuk Yim Dae-Hoon Kim Hyo-yung yun Young-Jin Song Sei-Jin Youn Taisun hyun Joo-Seung Park Byung Sik Kim Yong-Dae Kim Heon Kim Departments of Preventive Medicine and Medical Research Institute College of Medicine Departments of Preventive Medicine and Surgery College of Medicine Departments of Preventive Medicine and Internal Medicine College of Medicine Dartment of Food and Nutrition Chungbuk National UniversityCheongju 28644Korea Department of Surgery College of MedicineEulji UniversityDaejon 301746Korea Department of Surgery Asan Medical CenterCollege of MedicineUlsan UniversitySeoul 138736Korea

There have been few studies on the association between vitamin D levels and gastric cancer in Asian populations,but no studies have been performed on the interactions between vitamin D intake and polymorphisms in the vitamin D *** effects of vitamin D intake,vitamin D related genetic polymorphisms,and their association with the incidence of gastric cancer were investigated in a hospital case-control study,including 715 pairs of newly diagnosed gastric cancer patients and controls matched for age and *** between vitamin D intake and plasma vitamin D concentrations were also assessed in a subset of *** statistically significant difference was observed in the dietary intake of vitamin D between the patients and controls,nor were there any evident associations between vitamin D intake and risk of gastric cancer in multivariate *** D intake significantly correlated with the circulating 25-hydroxyvitamin D levels,but not with the active form of the vitamin,1,25-dihydroxyvitamin *** were no statistically significant interactions between vitamin D intake,and VDR or TXNIP *** study suggests that dietary vitamin D intake is not associated with gastric cancer risk,and the genetic polymorphisms of vitamin D-related genes do not modulate the effect of vitamin D with respect to gastric carcinogenesis.

关键词： gastric cancer vitamin D vitamin D receptor gene-environment interaction

Risk of gastric cancer is associated with PRKAA1 gene polymorphisms in Koreans

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World Journal of Gastroenterology 2014年第26期20卷 8592-8598页

作者： Yong-Dae Kim Dong-Hyuk Yim Sang-Yong Eom Sun In Moon Hyo-yung yun Young-Jin Song Sei-Jin Youn Taisun hyun Joo-Seung Park Byung Sik Kim Jong-Young Lee Hee Kwan Won Heon Kim Department of Preventive Medicine College of MedicineChungbuk National University Department of Surgery College of MedicineChungbuk National University Department of Internal Medicine College of MedicineChungbuk National University Department of Food and Nutrition Chungbuk National University Department of Surgery College of MedicineEulji University Department of Surgery Asan Medical CenterCollege of MedicineUlsan University Center for Genome Science National Institute of Health Department of Internal Medicine Division of Endocrinology and MetabolismSchool of MedicineKonyang University

AIM: To evaluate the association between genetic polymorphisms of the gene encoding AMP-activated protein kinase (PRKAA1) and the risk of gastric cancer.

关键词： AMP-activated protein kinase Gastric cancer PRKAA1 Single nucleotide polymorphism Case-control study

Mechanical properties and flame retardancy of surface modified magnesium oxysulfate(5Mg(OH)_(2)·MgSO_(4)·3H_(2)O)whisker for polypropylene composites

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Journal of Materiomics 2018年第2期4卷 149-156页

作者： Eui-Su Kim Ye Chan Kim Jungwoo Park Youngjun Kim Sung-Hoon Kim Kwang Jin Kim Jonghwan Suhr Youngkwan Lee Seong Hoon Lee Dae-Sik Kim Soo-hyun Kim Ju-Ho yun In-Kyung Park Jae-Do Nam School of Chemical Engineering Department of Polymer Science and EngineeringSungkyunkwan UniversitySuwon16410Republic of Korea Department of Mechanical Engineering University of NevadaLas Vegas4505 S.Maryland ParkwayLas VegasNV89154United States Department of Energy Science Sungkyunkwan UniversitySuwon16410Republic of Korea Perceived Materials Research Team Hyundai Motor Group18280HwaseongRepublic of Korea Korea Institute of Science and Technology Seoul02792Republic of Korea Korea Automotive Technology Institute Cheonan31214Republic of Korea

Magnesium oxysulfate(MOS)whisker is considered as a promising inorganic material recently attracting a great attention for being used as a reinforcing filler for polymer composites due to high aspect ratio and extremely-low bulk *** this study,the MOS was treated with 3-methacryloyloxypropyl-trimethoxy silane(MPS)via sol-gel condensation reactions,which successfully allowed melt mixing with polypropylene(PP)up to 30 wt%of *** tensile strength at yield and modulus of the MOS/PP composites were substantially increased by 50.8%and 362%,respectively,when compared with the pristine *** a novel finding,the flame retardancy of MOS was proved by identifying water evolution at elevated temperatures giving out 9 wt%of water in 250-320℃and 14 wt%in 350-420℃in two *** work demonstrated that the MOS could be an excellent filler for PP not only increasing the mechanical properties in a great extent but also imposing flame retarding capability.

关键词： Magnesium oxysulfate Surface modification Mechanical properties Flame retardant

ITGA1 polymorphisms and haplotypes are associated with gastric cancer risk in a Korean population

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World Journal of Gastroenterology 2013年第35期19卷 5870-5876页

作者： Dong-Hyuk Yim Yan-Wei Zhang Sang-Yong Eom Sun In Moon Hyo-yung yun Young-Jin Song Sei-Jin Youn Taisun hyun Joo-Seung Park Byung Sik Kim Jong-Young Lee Yong-Dae Kim Heon Kim Department of Preventive Medicine and Medical Research Institute College of Medicine Chungbuk National University Center for Disease Control and Prevention Department of Surgery College of Medicine Chungbuk National University Department of Internal Medicine College of MedicineChungbuk National University Department of Food and Nutrition Chungbuk National University Department of Surgery College of MedicineEulji University Department of Surgery Asan Medical Center College of Medicine Ulsan University Center for Genome Science National Institute of Health

AIM:To evaluate the association between the geneticpolymorphisms and haplotypes of the ITGA1 gene and the risk of gastric ***:The study subjects were 477 age-and sex-matched case-control *** was performed for 15 single nucleotide polymorphisms(SNPs)in *** associations between gastric cancer and these SNPs and haplotypes were analyzed with multivariate conditional logistic regression *** testing corrections were carried out following methodology for controlling the false discovery ***-based association tests were performed using the versatile gene-based association study(VEGAS)***:In the codominant model,the ORs for SNPs rs2432143(1.517;95%CI:1.144-2.011)and rs2447867(1.258;95%CI:1.051-1.505)were statistically *** the dominant model,polymorphisms of rs1862610 and rs2447867 were found to be significant risk factors,with ORs of 1.337(95%CI:1.029-1.737)and 1.412(95%CI:1.061-1.881),*** the recessive model,only the rs2432143 polymorphism was significant(OR=1.559,95%CI:1.150-2.114).The C-C type of ITGA1 haplotype block 2 was a significant protective factor against gastric cancer in the both codominant model(OR=0.602,95%CI:0.212-0.709,P=0.021)and the dominant model(OR=0.653,95%CI:0.483-0.884).The ITGA1 gene showed a significant gene-based association with gastric cancer in the VEGAS *** the dominant model,the A-T type of ITGA1 haplotype block 2 was a significant risk factor(OR=1.341,95%CI:1.034-1.741).SNP rs2447867 might be related to the severity of gastric epithelial injury due to inflammation and,thus,to the risk of developing gastric ***:ITGA1 gene SNPs rs1862610,rs2432143,and rs2447867 and the ITGA1 haplotype block that includes SNPs rs1862610 and rs2432143 were significantly associated with gastric cancer.

关键词： Integrin ITGA1 Gastric cancer Polymorphism Haplotype

Catalpa bignonioides extract improves exercise performance through regulation of growth and metabolism in skeletal muscles

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Asian Pacific Journal of Tropical Biomedicine 2024年第2期14卷 47-54页

作者： Hoibin Jeong Dong-joo Lee Sung-Pil Kwon SeonJu Park Song-Rae Kim Seung hyun Kim Jae-Il Park Deug-chan Lee Kyung-Min Choi WonWoo Lee Ji-Won Park Bohyun yun Su-Hyeon Cho Kil-Nam Kim Seoul Center Korea Basic Science InstituteSeoul 02841Republic of Korea Chuncheon Center Korea Basic Science InstituteChuncheon 24341Republic of Korea Research&Development Center Chungdam CDC JNPharm LLC.Chuncheon 24341Republic of Korea Department of Biomedical Technology Kangwon National UniversityChuncheon 24341Republic of Korea Yonsei Institute of Pharmaceutical Sciences College of PharmacyYonsei UniversityIncheon 21983Republic of Korea Gwangju Center Korea Basic Science InstituteGwangju 61751Republic of Korea Honam National Institute of Biological Resources 99Gohadoan-gilMokpo-siJeollanam-do58762Republic of Korea Department of Bio-analysis Science University of Science&TechnologyDaejeon34113Republic of Korea

Objective:To evaluate the effects of Catalpa bignonioides fruit extract on the promotion of muscle growth and muscular capacity in vitro and in ***:Cell viability was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** proliferation was assessed using a 5-bromo-2’-deoxyuridine(BrdU)assay *** blot analysis was performed to determine the protein expressions of related *** effects of Catalpa bignonioides extract were investigated in mice using the treadmill exhaustion test and whole-limb grip strength *** composition analysis was performed using high-performance liquid chromatography(HPLC).Results:Catalpa bignonioides extract increased the proliferation of C2C12 mouse myoblasts by activating the Akt/mTOR signaling *** also induced metabolic changes,increasing the number of mitochondria and glucose metabolism by phosphorylating adenosine monophosphate-activated protein *** an in vivo study,the extract-treated mice showed improved motor abilities,such as muscular endurance and grip ***,HPLC analysis showed that vanillic acid may be the main component of the Catalpa bignonioides extract that enhanced muscle ***:Catalpa bignonioides improves exercise performance through regulation of growth and metabolism in skeletal muscles,suggesting its potential as an effective natural agent for improving muscular strength.

关键词： Catalpa bignonioides Skeletal muscle Cell proliferation Mitochondria Energy metabolism C2C12

The Anti-Inflammatory Effect of Cheongseoikki-Tang Ethanol Extract on Allergic Reactions Mediated by Bone Marrow-Derived Mast Cells

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Chinese Journal of Integrative Medicine 2013年第5期19卷 380-386页

作者： Joon-Ho Keum Ok-Hwa Kang Sung-Bae Kim Su-hyun Mun yun-Soo Seo Ma-Ryong Kim Jung-Rae Rho Young-Seob Lee Chung-Berm Park Young-Guk Kim Yong-II Kim sin-Hee Han Dong-Yeul Kwon College of Pharmacy and Wonkwang Oriental Medicines Research Institute Wonkwang UniversityJeonbuk(570-749)Republic of Korea Department of Oceanography Kunsan National UniversityKunsan(573-701)Republic of Korea National Institute of Horticultural & Herbal Science RDAEumsung(369-873)Republic of Korea

Objective： Cheongseoikki-tang （CIT, Korean）, also called Qingshu Yiqi decoction（清署益气汤）and Seisho-ekki-to （Japanese）, is well known as an effective traditional combination of herbs for treating cardiovascular diseases. This study was to research its effects on bone marrow-derived mast cell （BMMC）-mediated allergy and inflammation mechanisms. Methods： In this study, the biological effect of Cheongseoikki-tang ethanol extract （CITE） was evaluated, focusing on its effects on the production of allergic mediators by phorbol 12-myfistate 13-acetate （PMA） plus calcium ionophore A23187 （A23187）-stimulated BMMCs. These allergic mediators included intedeukin-6 （IL-6）, prostaglandin D2 （PGD2）, leukotfiene （34 （LTC4）, and β-hexosaminidase （13-hex）. Results： Our data revealed that CITE inhibited the production of IL-6, PGD2,/TC4, and 15-hex induced by PMA plus A23187 （P〈0.05）. Conclusion： These findings indicate that CITE has the potential for use in the treatment of allergy.

关键词： Cheongseoikki-tang ethanol extract bone marrow-derived mast cell allergy interleukin-6 prostaglandin D2 leukotriene C4

Delayed hippocampal neuronal death in young gerbil following transient global cerebral ischemia is related to higher and longer-term expression of p63 in the ischemic hippocampus

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Neural Regeneration Research 2015年第6期10卷 944-950页

作者： Eun Joo Bae Bai Hui Chen Bing Chun Yan Bich Na Shin Jeong Hwi Cho In Hye Kim Ji Hyeon Ahn Jae Chul Lee hyun-Jin Tae Seongkweon Hong Dong Won Kim Jun Hwi Cho yun Lyul Lee Moo-Ho Won Joon Ha Park Department of Pediatrics Chuncheon Sacred Heart HospitalCollege of MedicineHallym University Department of Physiology College of MedicineInstitute of Neurodegeneration and NeuroregenerationHallym University Institute of Integrative Traditional & Western Medicine Medical CollegeYangzhou University Department of Neurobiology School of MedicineKangwon National University Department of Biomedical Science and Research Institute for Bioscience and Biotechnology Hallym University Department of Surgery School of MedicineKangwon National University Department of Emergency Medicine Chuncheon Sacred Heart HospitalCollege of MedicineHallym University Department of Emergency Medicine School of MedicineKangwon National University

The tumor suppressor p63 is one of p53 family members and plays a vital role as a regulator of neuronal apoptosis in the development of the nervous system. However, the role of p63 in mature neuronal death has not been addressed yet. In this study, we first compared ischemia-induced effects on p63 expression in the hippocampal regions （CA1-3） between the young and adult gerbils subjected to 5 minutes of transient global cerebral ischemia. Neuronal death in the hippocampal CA1 region of young gerbils was significantly slow compared with that in the adult gerbils after transient global cerebral ischemia, p63 immunoreactivity in the hippocampal CA1 pyramidal neurons in the sham-operated young group was significantly low compared with that in the sham-operated adult group, p63 immunoreactivity was apparently changed in ischemic hippocampal CA1 pyramidal neurons in both ischemia-operated young and adult groups. In the ischemia-operated adult groups, p63 immunoreactivity in the hippocampal CA1 pyramidal neurons was significantly decreased at 4 days post-ischemia; however, p63 immunoreactivity in the ischemia-operated young group was significantly higher than that in the ischemia-operated adult group. At 7 days post-ischemia, p63 immunoreactivity was decreased in the hippocampal CA1 pyramidal neurons in both ischemia-operated young and adult groups. Change patterns of p63 level in the hippocampal CA1 region of adult and young gerbils after ischemic damage were similar to those observed in the immunohistochemical results. These findings indicate that higher and longer-term expression of p63 in the hippocampal CA1 region of the young gerbils after ischemia/reperfusion may be related to more delayed neuronal death compared to that in the adults.

关键词： p53 tumor suppressor gene family cerebral ischemia/reperfusion pyramidal neurons CA1 region delayed neuronal death immunohistochemistry western blotting neural regeneration