Dietary vitamin D intake and vitamin D related genetic polymorphisms are not associated with gastric cancer in a hospital-based case-control study in Korea

作     者：Sang-Yong Eom Dong-Hyuk Yim Dae-Hoon Kim Hyo-Yung Yun Young-Jin Song Sei-Jin Youn Taisun Hyun Joo-Seung Park Byung Sik Kim Yong-Dae Kim Heon Kim 

作者机构：Departments of Preventive Medicine and Medical Research InstituteCollege of Medicine Departments of Preventive Medicine and SurgeryCollege of Medicine Departments of Preventive Medicine and Internal MedicineCollege of Medicine Dartment of Food and NutritionChungbuk National UniversityCheongju 28644Korea Department of SurgeryCollege of MedicineEulji UniversityDaejon 301746Korea Department of SurgeryAsan Medical CenterCollege of MedicineUlsan UniversitySeoul 138736Korea 

出 版 物：《The Journal of Biomedical Research》 (生物医学研究杂志（英文版）)

年 卷 期：2018年第32卷第4期

页      面：257-263页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Research Foundation of Korea Grant funded by the Korean Government(Ministry of Education,Science and Technology)[NRF-355-2010-1-E00026 and 2012R1-A1A2044765] 

主　　题：gastric cancer vitamin D vitamin D receptor gene-environment interaction 

摘      要：There have been few studies on the association between vitamin D levels and gastric cancer in Asian populations,but no studies have been performed on the interactions between vitamin D intake and polymorphisms in the vitamin D *** effects of vitamin D intake,vitamin D related genetic polymorphisms,and their association with the incidence of gastric cancer were investigated in a hospital case-control study,including 715 pairs of newly diagnosed gastric cancer patients and controls matched for age and *** between vitamin D intake and plasma vitamin D concentrations were also assessed in a subset of *** statistically significant difference was observed in the dietary intake of vitamin D between the patients and controls,nor were there any evident associations between vitamin D intake and risk of gastric cancer in multivariate *** D intake significantly correlated with the circulating 25-hydroxyvitamin D levels,but not with the active form of the vitamin,1,25-dihydroxyvitamin *** were no statistically significant interactions between vitamin D intake,and VDR or TXNIP *** study suggests that dietary vitamin D intake is not associated with gastric cancer risk,and the genetic polymorphisms of vitamin D-related genes do not modulate the effect of vitamin D with respect to gastric carcinogenesis.