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Acute kidney injury due to intravenous detergent poisoning:A case report

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World Journal of Clinical Cases 2022年第6期10卷 2036-2044页

作者： sungbin park hyun-Sik Ryu Jae-Kwang Lee sung-Soo park Sun-Jung Kwon Won-Min Hwang sung-Ro Yun Moon-Hyang park Yohan park Department of Internal Medicine Division of NephrologyKonyang University HospitalCollege of MedicineDaejeon 35365South Korea Department of Emergency Medicine Konyang University HospitalCollege of MedicineDaejeon 35365South Korea Department of Internal Medicine Division of Respiratory and Critical Care MedicineKonyang University HospitalCollege of MedicineDaejeon 35365South Korea Department of Pathology Konyang University HospitalCollege of MedicineDaejeon 35365South Korea

BACKGROUND Detergent poisoning mostly occurs through oral ingestion(>85%),ocular exposure(<15%),or dermal exposure(<8%).Reports of detergent poisoning through an intravenous injection are extremely *** addition,there are very few cases of renal toxicity directly caused by ***,we report a unique case of acute kidney injury caused by detergent poisoning through an accidental intravenous *** SUMMARY A 61-year-old man was intravenously injected with 20 mL of detergent by another patient in the same room of a local *** surfactant and calcium carbonate accounted for the largest proportion of the *** patient complained of vascular pain,chest discomfort,and nausea,and was transferred to our *** hospitalization,the patient’s serum creatinine level increased to 5.42 mg/dL,and his daily urine output decreased to approximately 300 *** biopsy findings noted that the glomeruli were relatively intact;however,diffuse acute tubular injury was *** edema was also noted,and the patient underwent a total of four hemodiafiltration ***,the patient’s urine output gradually increased whereas the serum creatinine level *** patient was discharged in a stable status without any *** Detergents appear to directly cause renal tubular injury by systemic *** treating a patient with detergent poisoning,physicians should be aware that the renal function may also *** addition,timely renal replacement therapy may help improve the patient’s prognosis.

关键词： Detergents Poisoning Intravenous injection Acute kidney injury Acute tubular injury Case report

Comparative studies on the binding site of anesthetics to GABA a receptors using in silico docking methods

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BIOCELL 2023年第7期47卷 1661-1673页

作者： SEUNGhyun AHN JUNG-YEON LEE JIHA sung hyun JOO KIM SEYEON park Department of Applied Chemistry Dongduk Women’s UniversitySeoul02748Korea Division of Applied Chemistry and Cosmetic Science Dongduk Women’s UniversitySeoul02748Korea Department of Anesthesiology and Pain Medicine Anesthesia and Pain Research InstituteYonsei University College of MedicineSeoul03722Korea

Although the GABAA receptor(GABAAR)has been proposed as the main action site for sevoflurane,isoflurane,halothane,enflurane,propofol,and benzodiazepines(BZDs),binding of these anesthetics with high-resolution structures of the GABAAR have been rarely examined by comparative docking ***,various combinations of ligands on more GABAARs with various subtypes need to be analyzed to understand the elaborate action mechanism of GABAARs better because some GABAA ligands showed specificity toward the distinct subtypes of the ***:We performed in silico docking analysis to compare the binding modes of sevoflurane,isoflurane,halothane,enflurane,propofol,and BZDs to the GABAAR based on one of the most recently provided 3D *** performed the docking analysis and the affinity-based ranking of the binding ***:Our docking studies revealed that isoflurane,halothane,and enflurane docked in an extracellular domain(ECD)on GABAARs,in contrast to ***:Our results supported a multi-site mechanism for the allosteric modulation of *** was bound to the pore or favored various subsites in the transmembrane domain(TMD).Our result confirmed that different chemically related BZD ligands interact via distinct binding modes rather than by using a common binding mode,as previously suggested.

关键词： GABAAR In silico docking Multi-binding site Anesthetics

Flux Optimization During Tapping in BOF Process

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Journal of Iron and Steel Research International 2011年第S2期18卷 148-152页

作者： hyun-Seo park sung-Mo SEO Ji-Tae KWON Joo CHOI Steelmaking Research Group POSCO Technical Research Laboratories 699 Gumho-dong Gwangyang-si Jeonnam 545-090 Korea Technology development team plate rolling department Gwangyang Steelworks POSCO Gumho-dong Gwangyang-si Jeonnam 545-711 Korea

An integrated Plate Mill has started it’s operation on July 7, 2010 in Gwangyang Steelworks, POSCO. The production capability is about 2.5 million tons per year and the main stream consists of Blast Furnace, Hot metal pretreatment (KR), Converter, Bubbling Station, RH/VTD and Continuous Casting. Particularly, it is possible to control sulfur concentration at excellent level in BOF without any further treatment in LF or VTD, which is attained by unique KR process and scrap usage strategy in BOF. In this paper, desulfurization efficiency and steel cleanliness was introduced by optimizing flux amount during tapping in BOF process. In addition, the effect of the flux addition on the refractory of ladle was investigated based on EPMA analyses with the viewpoint of phase diagram. The cleanliness of each sample was examined using optical emission spectrometry and oxygen nitrogen determinator.

关键词： plate mill steel cleanliness flux tapping

Effects of vagus nerve preservation and vagotomy on peptide YY and body weight after subtotal gastrectomy

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World Journal of Gastroenterology 2012年第30期18卷 4044-4050页

作者： hyung Hun Kim Moo In park Sang Ho Lee hyun Yong Hwang sung Eun Kim Seun Ja park Won Moon Departments of Internal Medicine Kosin University College of MedicineBusan 602-702South Korea Departments of Surgery Kosin University College of MedicineBusan 602-702South Korea Departments of Laboratory Medicine Kosin University College of MedicineBusan 602-702South Korea

AIM:To investigate the relationship between the function of vagus nerve and peptide YY 3-36 and ghrelin levels after subtotal ***:We enrolled a total of 16 patients who underwent subtotal gastrectomy due to gastric *** surgeries were performed by a single skilled *** measured peptide YY 3-36,ghrelin,leptin,insulin,growth hormone levels,and body weight immediately before and one month after ***:Vagus nerve preservation group showed less body weight loss and less increase of peptide YY 3-36 compared with vagotomy group(-5.56 ± 2.24 kg vs-7.85 ± 1.57 kg,P = 0.037 and 0.06 ± 0.08 ng/mL vs 0.19 ± 0.12 ng/mL,P = 0.021,respectively).Moreover,patients with body weight loss of less than 10% exhibited reduced elevation of peptide YY 3-36 level,typically less than 20% [6(66.7%) vs 0(0.0%),P = 0.011,odd ratio = 3.333,95% confidence interval(1.293,8.591)].CONCLUSION:Vagus nerve preservation contributes to the maintenance of body weight after gastrectomy,and this phenomenon may be related to the suppressed activity of peptide YY 3-36.

关键词： Peptide YY Ghrelin Vagotomy Gastrectomy Body weight

Thermoresponsive Al^(3+)-crosslinked poly(N-isopropylacrylamide)/alginate composite for green recovery of lithium from Li-spiked seawater

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Green Energy & Environment 2022年第2期7卷 334-344页

作者： sung Ho park Sang Joon Lee Department of Mechanical Engineering Pohang University of Science and Technology(POSTECH)Pohang790-784South Korea

With the rapid increase in the demand for lithium as an energy-critical element,the recovery of Li+ions from seawater is a worldwide challenging ***,we propose a new facile and fast selective recovery approach of Li+using an Al^(3+)-crosslinked poly(N-isopropylacrylamide)(PNIPAAm)/alginate(Alg)(PNP/Alg(Al)) *** in situ TEM images indicate that Alg-Al^(3+)coordination is reorganized via the rearrangement of PNIPAAm and Alg networks,as the temperature *** reorganization eventually leads to the formation of polycrystalline *** in situ FTIR results exhibit that PNP/Alg(Al) composite has peculiar phase transitions,which includes a retrogressive phase change from hydrophobic to *** synergetic effect of the strong repulsion force of Al^(3+) ions and the attractive force of negatively charged polymeric chains enables the efficient adsorption of Li+ions with a low affinity from Li-spiked seawater.7.3% of Li+ions are recovered from Li-spiked seawater although the concentration of Li-spiked seawater is very *** addition,Li+ions can be extracted from PNP/Alg(Al) composite with the use of a small thermal *** proposed thermoresponsive IPN gel provides a strong potential in practical applications for Li+recovery as an innovative energy-material strategy.

关键词： structure seawater lithium

Synchronous quintuple primary gastrointestinal tract malignancies: Case report

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World Journal of Gastroenterology 2017年第1期23卷 173-177页

作者： Soo-Hong Kim Byung-Soo park hyun sung Kim Jae Hun Kim Department of Surgery Pusan National University Yangsan Hospital Department of Surgery Pusan National University Hospital

Multiple primary malignancy is defined as two or more malignancies detected in an individual person. In particular, synchronous quintuple primary malignancy is extremely rare. A 52-year-old male with anal pain and intermittent blood-tinged stool was diagnosed with malignancies in the stomach, jejunum, ascending colon, transverse colon and rectum. He underwent a subtotal gastrectomy, segmental resection of the jejunum and total protocolectomy with end ileostomy. The postoperative pathologic findings were moderate differentiated gastric adenocarcinoma (pT1bN0M0, pStageIA), combined adenocarcinoma and neuroendocrine carcinoma of the jejunum (pT3N0M0, pStageIIA), three mucinous adenocarcinoma of the ascending colon (pT3N0M0, pStageIIA), transverse colon (pT1N0M0, pStageI) and rectum (pT3N1aM0, pStageIIIB). The tumors did not lack MLH-1 and MSH-2 expression, as the markers (bat26, D5S346, bat25, D2S123) suggest MSI-H presence. Adjuvant chemoradiotherapy was started according to regimen, FOLFOX 4 for advanced rectal cancer. Six years post-operation, the patient is currently attending regular follow-ups without recurrence or metastasis.

关键词： Small bowel neoplasm Stomach neoplasm Synchronous quintuple primary cancer Colon neoplasm

Cholecystoduodenal fistula presenting with upper gastrointestinal bleeding: A case report

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World Journal of Clinical Cases 2021年第2期9卷 410-415页

作者： Jin Myung park Chang Don Kang Ji hyun Kim Sang Hoon Lee Seung-Joo Nam sung Chul park sung JoonLee Seungkoo Lee Department of Internal Medicine Kangwon National University School of MedicineChuncheon 24289Kangwon DoSouth Korea Department of Gastroenterology Kangwon National University HospitalChuncheon 24289Kangwon DoSouth Korea Anatomy and Pathology Kangwon National University School of MedicineChuncheon 200947Kangwon DoSouth Korea Department of Pathology Kangwon National University HospitalChuncheon 24289Kangwon DoSouth Korea

BACKGROUND Cholecystoduodenal fistula is a rare complication of *** are usually non-specific and often indistinguishable from those of etiologic diseases,but it rarely presents as severe gastrointestinal *** associated with cholecystoduodenal fistula usually requires surgery because significant bleeding from the cystic artery is unlikely to be resolved by conservative management or endoscopic *** SUMMARY We report a case of cholecystoduodenal fistula that presented with hematemesis which was diagnosed by endoscopy and computed *** hemostasis could not be achieved,but surgical treatment was ***,we have presented a literature *** Cholecystoduodenal fistula should be considered as differential diagnosis when a patient with history of gallstone disease presents with gastrointestinal bleeding.

关键词： Biliary fistula Hematemesis Cholecystitis Gallstones Cholecystectomy Case report

Change in renal function after sodium phosphate preparation for screening colonoscopy

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World Journal of Gastroenterology 2010年第16期16卷 2010-2016页

作者： Dong Choon Seol sung Noh Hong Jeong Hwan Kim In Kyung sung hyung Seok park Jung hyun Lee Chan Sup Shim Department of Internal Medicine Konkuk University School of Medicine Department of Health Promotion Healthcare CenterKonkuk University Medical Center Healthcare Center Konkuk University Medical CenterDepartment of Internal MedicineKonkuk University School of MedicineMedical Immunology CenterInstitute of Biomedical Science and Technology Department of Internal Medicine Konkuk University School of MedicineMedical Immunology CenterInstitute of Biomedical Science and Technology

AIM:To investigate the changes in renal function at 12-24 mo in patients following sodium phosphate(NaP) preparation for screening ***:We carried out a retrospective study on the results from patients who received health check-up services as part of an employer-provided wellness program performed between August 2006 and May 2008 and who were followed up for 12-24 *** to screening colonoscopy,224 patients underwent bowel cleansing with NaP(NaP group) and 113 patients with polyethylene glycol(PEG group).The control group comprised 672 age-matched *** compared the changes in the creatinine levels and the glomerular filtration rates(GFRs) from baseline to 12-24 mo between the NaP,PEG,and control groups using two-way repeated measured analysis of *** addition,multivariate linear regression analysis was performed to assess the risk factors for a decreased ***:The baseline mean serum creatinine level in the NaP,PEG,and control groups was 1.12 ± 0.15,1.12 ± 0.16,and 1.12 ± 0.15 mg/dL,which increased to 1.15 ± 0.15,1.15 ± 0.18,and 1.15 ± 0.15 mg/dL,respectively,after 12-24 *** baseline mean GFR in the NaP,PEG,and control groups was 69.0 ± 7.7,68.9 ± 8.0,and 69.6 ± 6.7 mL/min per 1.73 m2,which decreased to 66.5 ± 7.8,66.5 ± 8.3,and 67.4 ± 6.4 mL/min per 1.73 m2,respectively,after 12-24 *** changes in serum creatinine levels and GFRs were not significantly between the NaP,PEG,and control groups(P = 0.992 and P = 0.233,respectively).Using multivariate linear regression analysis,only the baseline GFR was associated with the change in GFR(P < 0.001).Indeed,the bowel preparations were not associated with the change in GFR(P = 0.297).CONCLUSION:NaP bowel preparation in subjects with normal renal function was not associated with renal injury,and NaP can thus be used safely for screening colonoscopy.

关键词： Sodium phosphate Polyethylene glycol Purgatives Colonoscopy Creatinine Glomerular filtration rate

Small sphincterotomy combined with endoscopic papillary large balloon dilation versus sphincterotomy

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World Journal of Gastroenterology 2009年第34期15卷 4298-4304页

作者： hyun Gun Kim Young Koog Cheon Young Deok Cho Jong Ho Moon Do hyun park Tae Hoon Lee hyun Jong Choi Sang-Heum park Joon Seong Lee Moon sung Lee Institute for Digestive Research Digestive Disease Center Soonchunhyang University College of Medicine

AIM： To compare small sphincterotomy combined with endoscopic papillary large balloon dilation （SES ＋ ELBD） and endoscopic sphincterotomy （EST） for large bile duct stones. METHODS： We compared prospectively SES ＋ ELBD （group A, n = 27） with conventional EST （group B, n = 28） for the treatment of large bile duct stones （≥ 15 mm）. When the stone could not be removed with a normal basket, mechanical lithotripsy was performed. We compared the rates of complete stone removal with one session and application of mechanical lithotripsy. RESULTS： No significant differences were observed in the mean largest stone size （A： 20.8 mm, B： 21.3 mm）, bile duct diameter （A： 21.4 turn, B： 20.5 ram）, number of stones （A： 2.2, B： 2.3）, or procedure time （A： 18 min, B： 19 rain） between the two groups. The rates of complete stone removal with one session was 85% in group A and 86% in group B （P = 0.473）. Mechanical lithotripsy was required for stone removal in nine of 27 patients （33%） in group A and nine of 28 patients （32%, P = 0.527） in group ***： SES ＋ ELBD did not show significant benefits compared to conventional EST, especially for the removal of large （≥ 15 mm） bile duct stones.

关键词： Sphincterotomy Endoscopic Balloon dilatation Cholelithiasis Lithotripsy