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Bone-targeted lipoplex-loaded three-dimensional bioprinting bilayer scaffold enhanced bone regeneration

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Regenerative Biomaterials 2024年第4期3卷 138-148页

作者： Woo-Jin Kim Jeong-hyun ryu Ji Won Kim Ki-Tae Kim Hye-Rim Shin Heein Yoon hyun-Mo Ryoo Young-Dan Cho Department of Molecular Genetics School of Dentistry and Dental Research InstituteSeoul National UniversitySeoul03080Republic of Korea Department of Periodontology School of Dentistry and Dental Research InstituteSeoul National University and Seoul National University Dental HospitalSeoul03080Republic of Korea

Clinical bone-morphogenetic protein 2(BMP2)treatment for bone regeneration,often resulting in complications like soft tissue inflammation and ectopic ossification due to high dosages and non-specific delivery systems,necessitates research into improved biomaterials for better BMP2 stability and *** tackle this challenge,we introduced a groundbreaking bone-targeted,lipoplex-loaded,three-dimensional bioprinted bilayer scaffold,termed the polycaprolactone-bioink-nanoparticle(PBN)scaffold,aimed at boosting bone *** encapsulated BMP2 within the fibroin nanoparticle based lipoplex(Fibroplex)and functionalized it with DSS6 for bone tissue-specific targeting.3D printing technology enables customized,porous PCL scaffolds for bone healing and soft tissue growth,with a two-step bioprinting process creating a cellular lattice structure and a bioink grid using gelatin-alginate hydrogel and DSS6-Fibroplex,shown to support effective nutrient exchange and cell growth at specific pore *** PBN scaffold is predicted through in silico analysis to exhibit biased BMP2 release between bone and soft tissue,a finding validated by in vitro osteogenic differentiation *** PBN scaffold was evaluated for critical calvarial defects,focusing on sustained BMP2 delivery,prevention of soft tissue cell infiltration and controlled fiber membrane pore size in *** PBN scaffold demonstrated a more than eight times longer BMP2 release time than that of the collagen sponge,promoting osteogenic differentiation and bone regeneration in a calvarial defect *** findings suggest that the PBN scaffold enhanced the local concentration of BMP2 in bone defects through sustained release and improved the spatial arrangement of bone formation,thereby reducing the risk of heterotopic ossification.

关键词： 3D bioprinting bone-targeting lipoplex BMP2 bone regeneration

Protein Arginine Methyltransferase 1 Ablation in Motor Neurons Causes mitochondrial Dysfunction Leading to Age-related Motor Neuron Degeneration with Muscle Loss

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Research 2024年第1期2023卷 637-649页

作者： hyun-Kyung So Hyebeen Kim Jinwoo Lee Chang-Lim You Chae-Eun Yun Hyeon-Ju Jeong Eun-Ju Jin Yunju Jo Dongryeol ryu Gyu-Un Bae Jong-Sun Kang Department of Molecular Cell Biology Sungkyunkwan University School of MedicineSuwonKorea Single Cell Network Research Center Sungkyunkwan University School of MedicineSuwonKorea Research Institute of Aging-Related Diseases AniMusCureInc.SuwonKorea Drug Information Research Institute Muscle Physiome Research CenterCollege of PharmacySookmyung Women’s UniversitySeoulKorea

Neuromuscular dysfunction is tightly associated with muscle wasting that occurs with age or due to degenerative ***,the molecular mechanisms underlying neuromuscular dysfunction are currently *** studies have proposed important roles of Protein arginine methyltransferase 1(Prmt1)in muscle stem cell function and muscle *** the current study,we set out to determine the role of Prmt1 in neuromuscular function by generating mice with motor neuron-specific ablation of Prmt1(mnKO)using *** exhibited age-related motor neuron degeneration and neuromuscular dysfunction leading to premature muscle loss and ***1 deficiency also impaired motor function recovery and muscle reinnervation after sciatic nerve *** transcriptome analysis of aged mnKO lumbar spinal cords revealed alterations in genes related to inflammation,cell death,oxidative stress,and ***,mnKO lumbar spinal cords of sciatic nerve injury model or aged mice exhibited elevated cellular stress response in motor ***,Prmt1 inhibition in motor neurons elicited mitochondrial *** findings demonstrate that Prmt1 ablation in motor neurons causes agerelated motor neuron degeneration attributing to muscle ***,Prmt1 is a potential target for the prevention or intervention of sarcopenia and neuromuscular dysfunction related to aging.

关键词： degeneration impaired prevention

Positive regulation of cell proliferation by the miR-1290-EHHADH axis in hepatocellular carcinoma

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Cancer Communications 2024年第6期44卷 705-709页

作者： Jinkwon Lee Gyeonghwa Kim Tae-Su Han Eunsun Jung Taesang Son Kwangho Kim Kiyoon Kwon Yuna Roh Tae Young ryu In Hwan Tae Yunsang Kang Byungheon Lee Yu Rim Lee Soo Young Park Won Young Tak Dae-Soo Kim mi-Young Son Keun Hur hyun-Soo Cho Stem Cell Convergence Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeonRepublic of Korea Department of Bioscience Korea University of Science and TechnologyDaejeonRepublic of Korea Department of Biochemistry and Cell Biology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Biological Science Sungkyunkwan UniversitySuwonRepublic of Korea Department of Internal Medicine School of MedicineKyungpook National University HospitalDaeguRepublic of Korea Department of Biomedical Convergence Science and Technology School of ConvergenceKyungpook National UniversityDaeguRepublic of Korea

Hepatocellular carcinoma(HCC)is the second most common cancer and the third leading cause of cancer-related death worldwide[1].Recently,HCC incidence and mortality rates have further increased due to changes in the global social environment and dietary habits[2].HCC is treated by surgical resection or combination chemotherapy,but the overall survival rate of HCC patients has not improved,and the recurrence rate is still high due to strong invasiveness and resistance to chemotherapy[3].

关键词： chemotherapy mortality cancer

Light-Material Interactions Using Laser and Flash Sources for Energy Conversion and Storage Applications

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Nano-micro Letters 2024年第12期16卷 468-514页

作者： Jung Hwan Park Srinivas Pattipaka Geon-Tae Hwang minok Park Yu mi Woo Young Bin Kim Han Eol Lee Chang Kyu Jeong Tiandong Zhang Yuho min Kwi-Il Park Keon Jae Lee Jungho ryu Department of Mechanical Engineering(Department of Aeronautics Mechanical and Electronic Convergence Engineering)Kumoh National Institute of Technology61Daehak-RoGumiGyeongbuk 39177Republic of Korea Department of Materials Science and Engineering Pukyong National University45Yongso-RoNam-GuBusan 48513Republic of Korea Energy Technologies Area Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-RoYuseong-GuDaejeon 34141Republic of Korea Division of Advanced Materials Engineering Jeonbuk National UniversityJeonju 54896JeonbukRepublic of Korea School of Electrical and Electronic Engineering Harbin University of Science and TechnologyHarbin 150080People’s Republic of China Key Laboratory of Engineering Dielectrics and Its Application Ministry of EducationHarbin University of Science and TechnologyHarbin 150080People’s Republic of China Department of Materials Science and Metallurgical Engineering Kyungpook National University80 Daehak-RoBuk-GuDaegu 41566Republic of Korea School of Materials Science and Engineering Yeungnam UniversityDaehak-RoGyeongsan-Si 38541Gyeongsangbuk-doRepublic of Korea

This review provides a comprehensive overview of the progress in light-material interactions(Lmis),focusing on lasers and flash lights for energy conversion and storage *** discuss intricate Lmi parameters such as light sources,interaction time,and fluence to elucidate their importance in material *** addition,this study covers various light-induced photothermal and photochemical processes ranging from melting,crystallization,and ablation to doping and synthesis,which are essential for developing energy materials and ***,we present extensive energy conversion and storage applications demonstrated by Lmi technologies,including energy harvesters,sensors,capacitors,and *** the several challenges associated with Lmis,such as complex mechanisms,and high-degrees of freedom,we believe that substantial contributions and potential for the commercialization of future energy systems can be achieved by advancing optical technologies through comprehensive academic research and multidisciplinary collaborations.

关键词： Light Light-material interaction Nanomaterials Energy conversion and storage devices

SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2702-2715页

作者： Hye Jin Shin Wooseong Lee Keun Bon Ku Gun Young Yoon hyun-Woo Moon Chonsaeng Kim mi-Hwa Kim Yoon-Sun Yi Sangmi Jun Bum-Tae Kim Jong-Won Oh Aleem Siddiqui Seong-Jun Kim Department of Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea Gyeongnam Biohealth Research Center Gyeongnam Branch InstituteKorea Institute of ToxicologyJinju 52834Republic of Korea Center for Research Equipment Korea Basic Science InstituteCheongjuChungcheongbuk-do 28119Republic of Korea Department of Biotechnology Yonsei UniversitySeoul 03722Republic of Korea Division of Infectious Diseases School of MedicineUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Present address:Department of microbiology Chungnam National University School of MedicineDaejeon 35015Republic of Korea

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a‘highly transmissible respiratory pathogen,leading to severe multiorgan ***,knowledge regarding SARS-CoV-2-induced cellular alterations is *** this study,we report that SARSCoV-2 aberrantly elevates mitochondrial bioenergetics and activates the EGFR-mediated cell survival signal cascade during the early stage of viral ***-CoV-2 causes an increase in mitochondrial transmembrane potential via the SARS-CoV-2 RNAnucleocapsid cluster,thereby abnormally promoting mitochondrial elongation and the OXPHOS process,followed by enhancing ATP ***,SARS-CoV-2 activates the EGFR signal cascade and subsequently induces mitochondrial EGFR trafficking,contributing to abnormal OXPHOS process and viral *** EGFR inhibitors remarkably reduce SARS-CoV-2 propagation,among which vandetanib exhibits the highest antiviral *** of SARS-CoV-2-infected cells with vandetanib decreases SARS-CoV-2-induced EGFR trafficking to the mitochondria and restores SARS-CoV-2-induced aberrant elevation in OXPHOS process and ATP generation,thereby resulting in the reduction of SARS-CoV-2 ***,oral administration of vandetanib to SARS-CoV-2-infected hACE2 transgenic mice reduces SARS-CoV-2 propagation in lung tissue and mitigates SARS-CoV-2-induced lung *** also exhibits potent antiviral activity against various SARS-CoV-2 variants of concern,including alpha,beta,delta and omicron,in in vitro cell culture *** together,our findings provide novel insight into SARS-CoV-2-induced alterations in mitochondrial dynamics and EGFR trafficking during the early stage of viral infection and their roles in robust SARS-CoV-2 propagation,suggesting that EGFR is an attractive host target for combating COVID-19.

关键词： alterations aberrant thereby

Groundwater contamination and natural attenuation capacity at a petroleum spilled facility in Korea

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Journal of Environmental Sciences 2011年第10期23卷 1650-1659页

作者： hyun-mi Choi Jin-Yong Lee Department of Geology Kangwon National University

As a remedial option, the natural attenuation capacity of a petroleum contaminated groundwater at a military facility was examined. Hydrogeological conditions, such as high water level, permeable uppermost layer and frequent heavy rainfall, were favorable to natural attenuation at this site. The changes in the concentrations of electron acceptors and donors, as well as the relevant hydrochemical conditions, indicated the occurrence of aerobic respiration, denitrification, iron reduction, manganese reduction and sulfate reduction. The calculated BTEX expressed biodegradation capacity ranged between 20.52 and 33.67 mg/L, which appeared effective for the reduction of the contaminants levels. The contribution of each electron accepting process to the total biodegradation was in the order： denitrification 〉 iron reduction 〉 sulfate reduction 〉 aerobic respiration 〉 manganese reduction. The BTEX and benzene point attenuation rates were 0.0058-0.0064 and 0.0005-0.0032 day-1, respectively, and the remediation time was 0.7-1.2 and 2.5-30 years, respectively. The BTEX and benzene bulk attenuation rates were 8.69 × 10^-4 and 1.05 × 10^-3 day-l, respectively, and the remediation times for BTEX and benzene were 7.2 and 17.5 years, respectively. However, most of the natural attenuation occurring in this site can be attributed to dilution and dispersion. Consequently, the biodegradation and natural attenuation capacities were good enough to lower the contaminants levels, but their rates appeared to be insufficient to reach the remediation goal within a reasonable time frame. Therefore, some active remedial measures would be required.

关键词： petroleum contaminated site BTEX electron acceptor expressed biodegradation capacity natural attenuation

Mo and Ta addition in NbTiZr medium entropy alloy to overcome tensile yield strength-ductility trade-off

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Journal of Materials Science & Technology 2022年第14期109卷 176-185页

作者： Muhammad Akmal hyun Woo Seong Ho Jin ryu Department of Materials Science and Engineering KAISTDaejeonYuseong-gu 34141South Korea Department of Nuclear and Quantum Engineering KAISTDaejeonYuseong-gu 34141South Korea

In this study,single-phase NbTiZr and NbTiZr(MoTa)_(0.1) medium-entropy alloys(MEAs)were investigated for their use in biomedical *** alloys were prepared by arc melting,and were then cold-rolled,annealed,and characterized in terms of phase analysis,mechanical properties,fractography,and wear *** alloys showed a single body-centered cubic phase with superior mechanical,and tribological properties compared to commercially available biomedical *** and Ta-containing MEAs showed higher tensile yield strength(1060±18 MPa)and higher tensile ductility(~20%),thus overcoming the strength-ductility trade-off with no signs of transformation-induced plasticity,twinning,or *** generalized stacking fault energy(GSFE)calculations on the{112}slip system by the first-principles calculations based on density functional theory showed that the addition of less than0.2 molar fraction of Mo and Ta lowers the GSFE *** behavior posits the increase in ductility of the alloy by facilitating slips although strength is also increased by solid solution *** wear resistance of both alloys against hardened steel surfaces was superior to that of commercial biomedical ***,we concluded that NbTiZr(MoTa)_(0.1)MEA with good tensile ductility is a potential candidate for biomedical implants.

关键词： Medium-entropy alloys Wear-resistant Biomedical implants Solid solution hardening Staking fault energy

Simple method for extracting the seasonal signals of photochemical reflectance index and normalized difference vegetation index measured using a spectral reflectance sensor

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Journal of Integrative Agriculture 2021年第7期20卷 1969-1986页

作者： Jae-hyun ryu Dohyeok OH Jaeil CHO Department of Applied Plant Science Chonnam National UniversityGwangju 61186Republic of Korea

A spectral reflectance sensor(SRS)fixed on the near-surface ground was developed to support the continuous monitoring of vegetation indices such as the normalized difference vegetation index(NDVI)and photochemical reflectance index(PRI).NDVI is useful for indicating crop growth/phenology,whereas PRI was developed for observing physiological ***,the seasonal change patterns of NDVI and PRI are two valuable pieces of information in a crop-monitoring ***,capturing the seasonal patterns is considered challenging because the vegetation index values estimated by the reflection from vegetation are often governed by meteorological conditions,such as solar irradiance and ***,unlike growth/phenology,the physiological condition has diurnal changes as well as seasonal *** study proposed a novel filtering method for extracting the seasonal signals of SRS-based NDVI and PRI in paddy rice,barley,and ***,the measurement accuracy of SRSs was compared with handheld spectrometers,and the R^(2)values between the two devices were 0.96 and 0.81 for NDVI and PRI,***,the experimental study of threshold criteria with respect to meteorological variables(i.e.,insolation,cloudiness,sunshine duration,and precipitation)was conducted,and sunshine duration was the most useful one for excluding distorted values of the vegetation *** data processing based on sunshine duration,the R^(2)values between the measured vegetation indices and the extracted seasonal signals of vegetation indices increased by approximately 0.002–0.004(NDVI)and 0.065–0.298(PRI)on the three crops,and the seasonal signals of vegetation indices became noticeably *** method will contribute to an agricultural monitoring system by identifying the seasonal changes in crop growth and physiological conditions.

关键词： photochemical reflectance index normalized difference vegetation index vegetation remote sensing spectral reflectance sensor

Assessment of nutrient distributions in Lake Champlain using satellite remote sensing

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Journal of Environmental Sciences 2014年第9期26卷 1831-1836页

作者： Elizabeth M.Isenstein mi-hyun Park Department of Civil and Environmental Engineering University of Massachusetts AmherstMA01003USA

The introduction of nutrients to lakes causing eutrophic conditions is a major problem around the world. Proper monitoring and modeling are important to effectively manage eutrophication in lake waters. The goal is to develop remote sensing models for nutrients, total phosphorus and total nitrogen, in Lake Champlain. The remote sensing models were created using multivariate linear regression with the unique band combinations of Landsat Enhanced Thematic Mapper Plus （ETM＋） imagery based on the empirical relationship with the field observations. The resulting models successfully showed nutrient distributions in the most eutrophic part of Lake Champlain, missisquoi Bay, with reasonable adjusted coefficient of determination values （R2 = 0.81 and 0.75 for total phosphorus and total nitrogen, respectively）. The results show the feasibility and the utility of satellite imagery to detect spatial distributions of lake water quality constituents, which can be used to better understand nutrient distributions in Lake Champlain. This approach can be applicable to other lakes experiencing eutrophication assisting decision making when implementing Best Management Practices and other mitigation techniques to lakes.

关键词： Remote sensingMonitoringNutrientsPhosphorus