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The homeostatic γc cytokines IL-7 and IL-15 suppress the induction of CD4^(+) CD8αα^(+) intraepithelial T cells in the gut

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Cellular & Molecular Immunology 2022年第6期19卷 751-753页

作者： Can Li Praveen Prakhar jung-hyun park Experimental Immunology Branch Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesdaMD20892USA

All T cells require cytokine signaling for their development and maintenance, and CD8αα^(+) IEL T cells are noted for their requirement for IL-15 [8]. This IL-15 dependency was demonstrated by the paucity of CD8αα^(+) T cells among SI IELs in Il15–/– mice (Fig. 1d and Fig. S1a). However, the cytokine requirements of CD8αα^(+)CD4^(+) T cells are currently unclear. Because of the shared phenotype of CD8αα expression with CD8αα^(+) IELs, we postulated that CD4^(+)CD8αα^(+) IELs would also depend on IL-15.

关键词： CD8α cytokine cytokines

Improvement of Shape Recognition Performance of Sendzimir Mill Control Systems Using Echo State Neural Networks

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Journal of Iron and Steel Research International 2014年第3期21卷 321-327页

作者： jung-hyun park Seong-ik HAN Jong-shik KIM School of Mechanical Engineering Pusan National University School of Electrical Engineering Pusan National University

High rigidity twenty-high Sendzimir mills （ZRMs） are widely used for rolling stainless steels, silicon sheets, etc. A ZRM uses a small diameter work roll to produce massive rolling forces. Since a work roll with a small diameter can be bent easily, strips often have complex shapes with mixed quarter and deep edge waves in the shape of plates. In order to solve this problem, fuzzy neural network controls are generally used for shape： recognition in ZRM control systems. Among various neural network types, the multi-layer perceptron （MLP） is typically used in current ZRMs. However, an MLP causes the loss of a large amount of shape recognition data. To improve the shape recognition per- formance of ZRM control systems, echo state networks （ESNs） are proposed to be used. Through simulation re- sults, it is found that shape recognition performance could be improved using the proposed ESN method.

关键词： Sendzimir mill neural network multi-layer perceptron echo state network shape recognition

Exosome-based strategy against colon cancer using small interfering RNA-loaded vesicles targeting soluble a proliferationinducing ligand

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World Journal of Stem Cells 2024年第11期16卷 956-973页

作者： hyung-Jin Kim Do Sang Lee jung hyun park Ha-Eun Hong Ho Joong Choi Ok-Hee Kim Say-June Kim Department of Surgery Eunpyeong St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 03312South Korea Department of Surgery Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Catholic Central Laboratory of Surgery College of MedicineThe Catholic University of KoreaSeoul 06591South Korea Translational Research Team Surginex Co.Ltd.Seoul 06591South Korea

BACKGROUND Recent advancements in nanomedicine have highlighted the potential of exosome(Ex)-based therapies,utilizing naturally derived nanoparticles,as a novel approach to targeted cancer *** To explore the targetability and anticancer effectiveness of small interfering peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 RNA(siPIN1)-loaded soluble a proliferation-inducing ligand(sAPRIL)-targeted Exs(designated as tEx[p])in the treatment of colon cancer *** tEx was generated by harvesting conditioned media from adipose-derived stem cells that had undergone transformation using pDisplay vectors encoding sAPRIL-binding peptide ***,tEx[p]were created by incorporating PIN1 siRNA into the tEx using the Exofect *** therapeutic efficacy of these Exs was evaluated using both in vitro and in vivo models of colon *** The tEx[p]group exhibited superior anticancer effects in comparison to other groups,including tEx,Ex[p],and Ex,demonstrated by the smallest tumor size,the slowest tumor growth rate,and the lightest weight of the excised tumors observed in the tEx[p]group(P<0.05).Moreover,analyses of the excised tumor tissues,using western blot analysis and immunohistochemical staining,revealed that tEx[p]treatment resulted in the highest increase in Ecadherin expression and the most significant reduction in the mesenchymal markers Vimentin and Snail(P<0.05),suggesting a more effective inhibition of epithelial-mesenchymal transition tEx[p],likely due to the enhanced delivery of *** The use of bioengineered Exs targeting sAPRIL and containing siPIN1 demonstrated superior efficacy in inhibiting tumor growth and epithelial-mesenchymal transition,highlighting their potential as a therapeutic strategy for colon cancer.

关键词： Colon cancer Drug delivery system Exosome Soluble a proliferation-inducing ligand Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Targeted therapy

Superior gallstone dissolubility and safety of tert-amyl ethyl ether over methyl-tertiary butyl ether

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World Journal of Gastroenterology 2019年第39期25卷 5936-5952页

作者： Dong Do You Suk Joon Cho Ok-Hee Kim Jin Sook Song Kyu-Seok Hwang Sang Chul Lee Kee-Hwan Kim Ho Joong Choi Ha-Eun Hong Haeyeon Seo Tae Ho Hong jung hyun park Tae Yoon Lee Joseph Ahn Jae-Kyung jung Kwan-Young jung Say-June Kim Department of Surgery St.Vincent's HospitalCollege of MedicineThe Catholic University of KoreaSeoul 16247South Korea College of Pharmacy Chungbuk National UniversityCheongju 28644South Korea Department of Surgery Seoul St.Mary’s HospitalCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Catholic Central Laboratory of Surgery Institute of Biomedical IndustryCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Bio and Drug Discovery Division Korea Research Institute of Chemical TechnologyDaejeon 34114South Korea Department of Surgery Daejeon St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaSeoul 34943South Korea Department of Surgery Uijeongbu St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaSeoul 11765South Korea Department of Biomedicine and Health Science College of Medicinethe Catholic University of KoreaSeoul 06591South Korea Department of Surgery Eunpyeong St.Mary’s HospitalCollege of Medicinethe Catholic University of KoreaSeoul 03312South Korea Department of Medicinal Chemistry and Pharmacology University of Science and TechnologyDaejeon 34113South Korea

BACKGROUND The use of methyl-tertiary butyl ether(MTBE)to dissolve gallstones has been limited due to concerns over its toxicity and the widespread recognition of the safety of laparoscopic *** adverse effects of MTBE are largely attributed to its low boiling point,resulting in a tendency to ***,if there is a material with a higher boiling point and similar or higher dissolubility than MTBE,it is expected to be an attractive alternative to *** To determine whether tert-amyl ethyl ether(TAEE),an MTBE analogue with a relatively higher boiling point(102°C),could be used as an alternative to MTBE in terms of gallstone dissolubility and *** The in vitro dissolubility of MTBE and TAEE was determined by measuring the dry weights of human gallstones at predetermined time intervals after placing them in glass containers with either of the two *** in vivo dissolubility was determined by comparing the weights of solvent-treated gallstones and control(dimethyl sulfoxide)-treated gallstones,after the direct infusion of each solvent into the gallbladder in both hamster models with cholesterol and pigmented *** The in vitro results demonstrated a 24 h TAEE-dissolubility of 76.7%,56.5%and 38.75%for cholesterol,mixed,and pigmented gallstones,respectively,which represented a 1.2-,1.4-,and 1.3-fold increase in dissolubility compared to that of *** the in vitro experiment,the 24 h-dissolubility of TAEE was 71.7%and 63.0%for cholesterol and pigmented gallstones,respectively,which represented a 1.4-and 1.9-fold increase in dissolubility compared to that of *** addition,the results of the cell viability assay and western blot analysis indicated that TAEE had a lower toxicity towards gallbladder epithelial cells than *** We demonstrated that TAEE has higher gallstone dissolubility properties and safety than those of *** such,TAEE could present an attractive alternative to MTBE if our findings

关键词： Tert-amyl ethyl ether Gallstones Methyl-tert-butyl ether Contact litholytic agent

Interstitial tissue-specific gene expression in mouse testis by intra-tunica albuguineal injection of recombinant baculovirus

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Asian Journal of Andrology 2009年第3期11卷 342-350页

作者： hyun jung park Won Young Lee Jin Hoi Kim Jae Hwan Kim Hun Jong jung Nam hyung Kim Bo Kyung Kim Hyuk Song Department of Animal Science College of Natural Science Konkuk University Chung-ju 380-701 Korea CHA Stem Cell Institute Graduate School of Life Science and Biotechnology Pochon CHA University Seoul 135-907 Korea Department of Animal Biotechnology College of Animal Biotechnology Konkuk University Seoul 143-701 Korea Occupation and Environment Department Medical School Konkuk University Chung-ju 380-704 Korea Department of Animal Science College of Agriculture Chungbuk National University Choung-ju Chung-buk 361-763 Korea Department of Physiology Medical School Konkuk University Chung-ju 380-701 Korea

The purpose of this study is to establish a gene delivery system for interstitial tissue-specific protein expression in mice testes using modified recombinant baculovirus. Green fluorescent protein （GFP）-expressing recombinant baculovirus （GFP-baculovirus）, in which the insect cell-specific polyhedron promoter was replaced by the cytomegalovirus （CMV）-IE promoter, was used to transfect testicular cells in vitro, and for intra-tunica albuguineal injection of the interstitial tissue of the testis. GFP expression was monitored in frozen testes sections by fluorescence microscopy. Expression of GFP in testicular tissues was also assessed by reverse transcription polymerase chain reaction （RT-PCR）, and protein expression was assessed by Western blot. Testicular cells in vitro were infected efficiently by modified recombinant GFP-baculovirus. lntra-tunica albuguineal injection of GFP- baculovirus into the mouse testis resulted in a high level of GFP expression in the interstitial tissues. RT-PCR analysis clearly showed GFP gene expression in the testis, particularly interstitial tissues. Intra-tunica albuguineal injection of a modified baculovirus that encoded recombinant rat insulin-like growth factor binding protein （IGFBP）-5 resulted in an increase in IGFBP-5 in testis and semen. In conclusion, we have developed an efficient delivery system for gene expression in vivo in testicular cells, particularly cells of the interstitial tissue using intratunica albuguineal injection of a modified recombinant baculovirus. This method will be particularly relevant for application that requires gene delivery and protein expression in the testicular cells of the outer seminiferous tubule of the testis.

关键词： intra-tunica albuguineal injection recombinant baculovirus testis gene delivery

Control of Mechanical Properties According to Content Ratio of Copper Coated Carbon Nanotubes in Alumimum Composites

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Journal of Chemistry and Chemical Engineering 2012年第5期6卷 455-461页

作者： Jae Deuk Kim Ju hyung Kim Xiao Hui Zhang jung hyun park Joo Ho Cha Seung Il jung Future Industry R＆D Center DH Holdings Co. LTD Seoul 135-080 Korea

The main objective of this study is to enhance the strength of CNTs （carbon nanotubes） which reinforced AI matrix composites by introducing an appropriate amount of Copper（Cu） into the composite material. AI-Cu/MWCNTs （multi-walled carbon nanotubes） nanocomposites were produced via compaction, sintering and hot extrusion process of AI-Cu/MWCNTs powders, which were fabricated by a conventional ball mill process with AI powders and Cu-MWCNTs composite powders which were synthesized by molecular level mixing technique. Also the change of mechanical properties with different content ratio of Cu/MWCNT composite powders in A1 matrix is analyzed. It is found that the addition of the proper Cu/MWCNTs powders which are well distributed in AI matrix leads to high mechanical stiffness. The 2 wt% Cu/MWCNTs reinforced A1 composites which exhibited 3.2 times higher tensile strength and 4.4 times higher yield strength than pure AI.

关键词： CNT AI composite tensile strength ball-mill spark plasma sintering hot extrusion.

Gender Differences in Rapid Eye Movement-Related Sleep Disordered Breathing

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Health 2015年第1期7卷 106-111页

作者： Minjung Youn Joo Young Kwon Kyu Sun Lee jung hyun park Hyang Woon Lee Department of Neurology Ewha Womans University School of Medicine and Ewha Medical Research Institute Seoul Korea Department of Neurology Ajou University School of Medicine Suwon Korea

Sleep disordered breathing (SDB) is an independent risk factor for cardiovascular disease. It is known to be associated more frequently with men than women, particularly in the premenopausal age range. The goal of this study is to evaluate gender differences among Korean patients diagnosed with SBD. This study included 309 patients who visited our Sleep Clinic due to sleep-related symptoms and were diagnosed with SDB by overnight polysomnography (PSG). We analyzed age, gender, body mass index, various PSG indices including sleep stages, apnea-hypopnea index (AHI) and AHI ratio in rapid eye movement (REM) versus non-REM (NREM) sleep stages (R:N ratio). Of those 309 patients diagnosed with obstructive sleep apnea, 217 (70.2%) were men (mean age 51.05 ± 12.64 years) and 92 (29.8%) were women (mean age 64.53 ± 10.43 years). The mean AHI during total sleep time was 30.34 ± 21.17 in men and 21.47 ± 17.14 in women (P P P = 0.402). REM SDB with R:N ratio higher than 2.0 was more frequently observed in women than in men, 34.8% (32/92) of women, compared with 11.9% (26/217) in men (P 60 years old. These findings suggest the possibility of different pathophysiologic mechanisms of SDB between genders and also between NREM versus REM sleep, which can be partly explained by the influence of female sex hormones.

关键词： Women Sleep Disordered Breathing Obstructive Sleep Apnea Rapid Eye Movement Sleep Apnea-Hypopnea Index

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服饰中的礼仪:英藏李氏朝鲜《蔡济恭像》

美成在久 2015年第4期 78-83页

作者： hyun-jung park 杨难得韩国全州大学

朝鲜王朝(公元一三九二~一九一○年)的肖像画拉近了视觉、材质与文献研究之间的联系。在分析大英博物馆朝鲜收藏中的《蔡济恭像》时,笔者将先追溯服饰和纺织史中的线索,再转向与该主题相关的历史文献。此幅画作在追溯前述线索方面尤为重... 详细信息

朝鲜王朝(公元一三九二~一九一○年)的肖像画拉近了视觉、材质与文献研究之间的联系。在分析大英博物馆朝鲜收藏中的《蔡济恭像》时,笔者将先追溯服饰和纺织史中的线索,再转向与该主题相关的历史文献。此幅画作在追溯前述线索方面尤为重要,仔细审视,可获取许多关于朝鲜王朝艺术与社会的信息[图一]。同朝鲜王朝全身像中常见的一样,此画中的蔡济恭也是双腿盘坐于垫上。他头戴乌纱帽,身穿宽大的浅粉色团领衣,双手置于腿上。

关键词：李氏朝鲜大英博物馆朝鲜王朝蔡济恭

Tremella Fuciformis prevented TMT-induced memory impairment in the rats

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Tremella Fuciformis prevented TMT-induced memory impairment ...