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Tacrolimus for children with refractory nephrotic syndrome:a one-year prospective,multicenter,and open-label study of Tacrobell®,a generic formula

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World Journal of Pediatrics 2016年第1期12卷 60-65页

作者： Eun Mi Yang Sang Taek Lee hyun jin choi Hee Yeon Cho Joo Hoon Lee Hee Gyung Kang Young Seo Park Hae Il Cheong Il-Soo Ha Department of Pediatrics Chonnam National University HospitalGawngjuKorea Department of Pediatrics Seoul National University Children's HospitalSeoulKorea Department of Pediatrics Samsung Medical CenterSungkynkwan University School of MedicineSeoulKorea Department of Pediatrics Asan Medical Center Children's HospitalUniversity of Ulsan College of MedicineSeoulKorea Research Coordination Center for Rare Diseases Seoul National University HospitalSeoulKorea Kidney Research Institute Medical Research CenterSeoul National University College of MedicineSeoulKorea

Background:Cyclosporine A and tacrolimus(TAC)are often used as a second-line treatment for children with refractory nephrotic syndrome(NS).This study was undertaken to investigate the efficacy and safety of Tacrobell®,a locally produced generic form of ***:This study was a one-year prospective,open-label,single-arm,multicenter ***-four children with steroid-dependent NS(SDNS)and 33 children with steroid-resistant NS(SRNS)were *** primary endpoints were defined as the remission rates,whereas the secondary endpoints were recognized as the duration of remission and adverse effects of ***:After one-year treatment,34(77.3%)of the 44 patients with SDNS were in complete remission,and 6(13.6%)were in partial ***(43.2%)patients did not relapse during the study;for those who did relapse,the mean duration of remission was 4.6±2.9 *** number of relapse episodes during the study period(0.90 per patient-year)was significantly lower than that in the preceding year(2.8 per patientyear).After treatment for 3 and 6 months,12(36.4%)of the 33 patients with SRNS were in remission,and after treatment for 12 months,the number of patients had increased to 13(39.4%).The mean time to achieve remission was 4.0±3.2 *** remission(duration,3.7±2.7 months),12(54.5%)of 22 patients *** fasting blood glucose and blood pressure levels during the therapy were similar to those at the time of study ***:Treatment with Tacrobell®was effective and safe for children with refractory *** efficacy of this generic form of TAC was better than that of the original TAC formula.

关键词： generic drugs nephrotic syndrome tacrolimus

Effects of Carbon Dioxide Treatment and Modified Atmosphere Packaging on the Quality of Long Distance Transporting “Maehyang” Strawberry

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Agricultural Sciences 2016年第12期7卷 813-821页

作者： hyun jin choi Yeong Seuk Bae Jung Soo Lee Me Hea Park Ji Gang Kim Postharvest Technology Division National Institute of Horticultural and Herbal Science Rural Development Administration Wanju Republic of Korea

This study was conducted to investigate the effects of carbon dioxide (CO2) and modified atmosphere (MA) packaging on the quality of strawberry during long distance transportation. “Maehyang” strawberries (Fragaria x ananassa Duch.) with red color on 70% of the fruit surface were harvested in Gyeongnam province, Korea. The samples were placed in gas-tight chamber with 30% CO2 concentration for 3 hours at 3°C. Strawberry samples were then packaged with modified atmosphere-modified humidity (MA/MH) packaging film. Samples treated with CO2 alone and combined CO2 with MA packaging were stored for one day at 1°C, transported for 10 days at 1°C, and distributed for 3 days at 4°C. Carbon dioxide alone or combination with MA packaging was effective in maintaining quality of “Maehyang” strawberries. Carbon dioxide treatment significantly increased firmness and reduced softening index and decay rate during 14 day transportation and distribution. Samples treated with CO2 + MA had higher overall score with low softening index and weight loss after 14 days of transportation and low temperature distribution compared to CO2 treatment only. The results indicated that a short term application of CO2 or combination treatment of CO2 and MA could be good postharvest handling for maintaining freshness of “Maehyang” strawberries during long distance vessel export.

关键词： Carbon Dioxide Firmness Modified Atmosphere Quality Strawberry

Groundwater contamination and natural attenuation capacity at a petroleum spilled facility in Korea

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Journal of Environmental Sciences 2011年第10期23卷 1650-1659页

作者： hyun-Mi choi jin-Yong Lee Department of Geology Kangwon National University

As a remedial option, the natural attenuation capacity of a petroleum contaminated groundwater at a military facility was examined. Hydrogeological conditions, such as high water level, permeable uppermost layer and frequent heavy rainfall, were favorable to natural attenuation at this site. The changes in the concentrations of electron acceptors and donors, as well as the relevant hydrochemical conditions, indicated the occurrence of aerobic respiration, denitrification, iron reduction, manganese reduction and sulfate reduction. The calculated BTEX expressed biodegradation capacity ranged between 20.52 and 33.67 mg/L, which appeared effective for the reduction of the contaminants levels. The contribution of each electron accepting process to the total biodegradation was in the order： denitrification 〉 iron reduction 〉 sulfate reduction 〉 aerobic respiration 〉 manganese reduction. The BTEX and benzene point attenuation rates were 0.0058-0.0064 and 0.0005-0.0032 day-1, respectively, and the remediation time was 0.7-1.2 and 2.5-30 years, respectively. The BTEX and benzene bulk attenuation rates were 8.69 × 10^-4 and 1.05 × 10^-3 day-l, respectively, and the remediation times for BTEX and benzene were 7.2 and 17.5 years, respectively. However, most of the natural attenuation occurring in this site can be attributed to dilution and dispersion. Consequently, the biodegradation and natural attenuation capacities were good enough to lower the contaminants levels, but their rates appeared to be insufficient to reach the remediation goal within a reasonable time frame. Therefore, some active remedial measures would be required.

关键词： petroleum contaminated site BTEX electron acceptor expressed biodegradation capacity natural attenuation

Enhanced photocatalytic degradation of lindane using metal–semiconductor Zn@ZnO and ZnO/Ag nanostructures

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Journal of Environmental Sciences 2018年第12期30卷 107-115页

作者： Hyeon jin Jung Ravindranadh Koutavarapu Seulki Lee Ju hyun Kim hyun Chul choi Myong Yong choi Department of Chemistry (BK21+) and Research Institute of Natural Science Gyeongsang National University Department of Chemistry Chonnam National University

To achieve enhanced photocatalytic activity for the degradation of lindane, we prepared metal–semiconductor composite nanoparticles（NPs）. Zn@ZnO core–shell（CS） nanocomposites, calcined ZnO, and Ag-doped ZnO（ZnO/Ag） nanostructures were prepared using pulsed laser ablation in liquid, calcination, and photodeposition methods, respectively, without using surfactants or catalysts. The as-prepared catalysts were characterized by using X-ray diffraction（XRD）, field-emission scanning electron microscopy, high-resolution transmission electron microscopy, ultraviolet–visible（UV–vis） spectroscopy, and photoluminescence spectroscopy. In addition, elemental analysis was performed by energy dispersive X-ray spectroscopy. The obtained XRD and morphology results indicated good dispersion of Zn and Ag NPs on the surface of the ZnO nanostructures. Investigation of the photocatalytic degradation of lindane under UV–vis irradiation showed that Zn@ZnO CS nanocomposites exhibit higher photocatalytic activity than the other prepared samples. The maximum degradation rate of lindane was 99.5% in 40 min using Zn@ZnO CS nanocomposites. The radical trapping experiments verified that the hydroxyl radical（·OH） was the main reactive species for the degradation of lindane.

关键词： Zn@ZnO ZnO/Ag Lindane Pulsed laser ablation in liquid Photocatalysis

Web Tension Regulation of Multispan Roll-to-Roll System using Integrated Active Dancer and Load Cells for Printed Electronics Applications

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Chinese Journal of Mechanical Engineering 2014年第2期27卷 229-239页

作者： ZUBAIR Muhammad PONNIAH Ganeshthangaraj YANG Young jin choi Kyung hyun Department of Mechatronics Engineering Jeju National University

The mass production of primed electronics can be achieved by roll-to-roll（R2R） printing system, so highly accurate web tension is required that can minimize the register error and keep the thickness and roughness of printed devices in limits. The web tension of a R2R system is regulated by the use of integrated load cells and active dancer system for printed electronics applications using decentralized multi-input-single-output（MISO） regularized variable learning rate backpropagation artificial neural networks. The active dancer system is used before printing system to reduce disturbances in the web tension of process span. The classical PID control result in tension spikes with the change in roll diameter of winder and unwinder rolls. The presence of dancer in R2R system shows that improved web tension control in printing span and the web tension can be enhanced from 3.75 N to 4.75 N. The overshoot of system is less than ±2.5 N and steady state error is within ± 1 N where load cells have a signal noise of ±0.7 N. The integration of load cells and active dancer with self-adapting neural network control provide a solution to the web tension control of multispan roll-to-roll system.

关键词： roll-to-roll(R2R)system multispan printed electronics active dancer load cell artificial neural networks tension control,multi-input-single-output(MISO )

Improved photocatalytic activity of surface charge functionalized ZnO nanoparticles using aniline

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Journal of Materials Science & Technology 2021年第17期76卷 1-10页

作者： Chatchai Rodwihok Korakot Charoensri Duangmanee Wongratanaphisan Won Mook choi Seung hyun Hur hyun jin Park jin Suk Chung School of Chemical Engineering University of Ulsan680-749.South ICorea Department of Biotechnology College of Life Sciences andBiotechnologyKorea University145 Anam-roSeongbuk-guSeoul02841South Korea Research Center in Physics andAstronomy Faculty of ScienceChiang Mai UniversityChiang Mai50200Thailand

Functionalization of aniline molecules on zinc oxide(ZnO)nanoparticles is reported using a simple impregnation *** ZnO samples were systematically characterized based on morphology,surface and optical properties,and photocatalytic performance towards methyl orange(MO).Aniline functionalization increased the surface charge of the modified *** to pristine ZnO,the aniline-functionalized ZnO yielded faster photodegradation of MO,degrading 98.29%of MO in 60 min and superoxide radicals were the major species during the MO photodegradation *** results indicate that the improvement of photocatalytic degradation could be attributed to opposite charge-induced surface ***,protonated amine as a positively charged molecule was expected to increase the surface adsorption of MO(as an anionic dye)on ZnO nanoparticles surfaces,thereby increasing their photocatalytic degradation performance.

关键词： Photocatalysts Surface charge ZnO Aniline Methyl orange

Sulfur-doped hard carbon hybrid anodes with dual lithium-ion/metal storage bifunctionality for high-energy-density lithium-ion batteries

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Carbon Energy 2023年第1期5卷 71-81页

作者： Sungmin Cho Jong Chan hyun Son Ha Yeonhua choi Honggyu Seong Jaewon choi Hyoung-Joon jin Young Soo Yun Program in Environmental and Polymer Engineering Inha UniversityIncheonSouth Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoulSouth Korea Departmant of Chemistry and Research Institute of Natural Science Gyeongsang National UniversityJinjuSouth Korea Department of Polymer Science and Engineering Inha UniversityIncheonSouth Korea Division of Energy Engineering Kangwon National UniversityGangwon-doSouth Korea

Bifunctional hybrid anodes(BHAs),which are both a high-performance active host material for lithium-ion storage as well as a guiding agent for homogeneous lithium metal nucleation and growth,exhibit significant potential as anodes for next-generation high-energy-density lithium-ion batteries(LIBs).In this study,sulfur-doped hard carbon nanosphere assemblies(S-HCNAs)were prepared through a hydrothermal treatment of a liquid organic precursor,followed by high-temperature thermal annealing with elemental sulfur for application as BHAs for *** a carbonate-based electrolyte containing fluoroethylene carbonate additive,the S-HCNAs showed high lithium-ion storage capacities in sloping as well as plateau voltage sections,good rate capabilities,and stable *** addition,high average Coulombic efficiencies(CEs)of~96.9%were achieved for dual lithium-ion and lithium metal storage *** the LIB full-cell tests with typical NCM811 cathodes,the S-HCNA-based BHAs containing~400 mA h g^(−1) of excess lithium led to high energy and power densities of~500Wh kg^(−1) and~1695Wkg^(−1),respectively,and a stable cycling performance with~100%CEs was achieved.

关键词： hard carbon hybrid anode lithium-ion batteries lithium metal anode lithium metal batteries sulfur-doped carbon

Effects of oxygen concentration and flow rate on cognitive ability and physiological responses in the elderly

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Neural Regeneration Research 2013年第3期8卷 264-269页

作者： hyun-Jun Kim hyun-Kyung Park Dae-Woon Lim Mi-hyun choi hyun-Joo Kim In-Hwa Lee hyung-Sik Kim jin-Seung choi Gye-Rae Tack Soon-Cheol Chung Department of Obstetrics & Gynecology Konkuk University Department of Laboratory Medicine Seoul Clinical Laboratories Department of Information & Communication Engineering Dongguk University Department of Biomedical Engineering Research Institute of Biomedical EngineeringCollege of Biomedical & Health ScienceKonkuk University

The supply of highly concentrated oxygen positively affects cognitive processing in normal young adults. However, there have been few reports on changes in cognitive ability in elderly subjects following highly concentrated oxygen administration. This study investigated changes in cognitive ability, blood oxygen saturation （%）, and heart rate （beats/min） in normal elderly subjects at three different levels of oxygen [21% （1 L/min）, 93% （1 L/min）, and 93% （5 L/min）] administered during a 1-back task. Eight elderly male （75.3 ＋ 4.3 years old） and 10 female （71.1 ＋ 3.9 years old） subjects, who were normal in cognitive ability as shown by a score of more than 24 points in the Mini-Mental State Examination-Korea, participated in the experiment. The experiment consisted of an adaptation phase after the start of oxygen administration （3 minutes）, a control phase to obtain stable baseline measurements of heart rate and blood oxygen saturation before the task （2 minutes） and a task phase during which the 1-back task was performed （2 minutes）. Three levels of oxygen were administered throughout the three phases （7 minutes）. Blood oxygen saturation and heart rate were measured during each phase. Our results show that blood oxygen saturation increased, heart rate decreased, and response time in the 1-back task decreased as the concentration and amount of administered oxygen increased. This shows that administration of sufficient oxygen for optimal cognitive functioning increases blood oxygen saturation and decreases heart rate.

关键词： neural regeneration clinical practice highly concentrated oxygen cognitive task 1-back task cognitive ability blood oxygen saturation heart rate physiological responses elderly grant-supported paper neuroregeneration

Honokiol attenuates oxidative stress-induced cytotoxicity in human keratinocytes via activating AMPK signaling

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Asian Pacific Journal of Tropical Biomedicine 2021年第5期11卷 222-230页

作者： Yung hyun choi Anti-Aging Research Center Dong-eui UniversityBusan 47340Republic of Korea Department of Biochemistry College of Korean MedicineDong-eui UniversityBusan 47227Republic of Korea

Objective:To investigate the effect of honokiol on oxidative damage in HaCaT human ***:HaCaT cells were exposed to hydrogen peroxide(H_(2)O_(2)),following pretreatment with various concentrations of *** alleviating effects of honokiol on HaCaT cell viability and cell death,reactive oxygen species(ROS)production,DNA damage,mitochondrial dynamics,and inhibition of adenosine triphoaphate production against H_(2)O_(2)were *** blotting analysis was used to analyze the expression levels of specific ***:Honokiol suppressed H_(2)O_(2)-induced cytotoxicity and DNA damage by blocking abnormal ROS *** also prevented apoptosis by inhibiting loss of mitochondrial membrane potential and release of cytochrome c from the mitochondria into the cytosol,decreasing the Bax/Bcl-2 ratio,and reducing the activity of caspase-3 in H_(2)O_(2)-stimulated HaCaT *** addition,honokiol attenuated H_(2)O_(2)-induced reduction of adenosine triphosphate content,and activation of AMP-activated protein kinase(AMPK)was markedly promoted by honokiol in H_(2)O_(2)-stimulated ***,the anti-apoptosis and anti-proliferative activity of honokiol against H_(2)O_(2)was further enhanced by adding an activator of AMPK,indicating that honokiol activated AMPK in HaCaT keratinocytes to protect against oxidative ***:The present results indicate that honokiol may be useful as a potential therapeutic agent against various oxidative stress-related skin diseases.

关键词： Honokiol ROS DNA damage Apoptosis AMPK