检索结果-南通市图书馆

Adaptive Electrospinning System Based on Reinforcement Learning for Uniform‑Thickness Nanofiber Air Filters

Advanced Fiber Materials 2023年第2期5卷 617-631页

作者： Seok Hyeon Hwang Jin Yeong Song hyun il ryu Jae Hee Oh Seungwook Lee Donggeun Lee Dong Yong Park Sang Min Park School of Mechanical Engineering Pusan National University63‑2 Busan University‑roGeumjeong‑guBusan 46241South Korea Smart Manufacturing Technology R&D Group Korea Institute of Industrial Technology320 Techno Sunhwan‑roYuga‑eupDalseong‑gunDaegu 42994Republic of Korea

Electrospinning is a simple and versatile method to produce nanofiber ***,owing to bending instability that occurs during the electrospinning process,electrospinning has frequently produced a non-uniform-thickness nanofiber filter,which deteriorates its air ***,an adaptive electrospinning system based on reinforcement learning(E-RL)was developed to produce uniform-thickness nanofiber *** E-RL accomplished a real-time thickness measurement of an electrospun nanofiber filter by measuring the transmitted light through the nanofiber filter using a camera placed at the bottom of the collector and converting it into thickness using the Beer–Lambert *** on the measured thickness,the E-RL detected the non-uniformity of the nanofiber filter thickness and manipulated the movable collector to alleviate the non-uniformity of the thickness by a pre-trained reinforcement learning(RL)*** the training of the RL algo-rithm,the nanofiber production simulation software based on the empirical model of the deposition of the nanofiber filter was developed,and the training process of the RL algorithm was repeated until the optimal policy was *** the training process with the simulation software,the trained model was transferred to the adaptive electrospinning *** the movement of the collector under the optimal strategy of RL algorithm,the non-uniformity of such nanofiber filters was significantly reduced by approximately five times in standard deviation and error for both simulation and *** finding has great potential in improving the reliability of electrospinning process and nanofiber filters used in research and industrial fields such as environment,energy,and biomedicine.

关键词： Electrospinning Nanofiber filter Uniform thickness Reinforcement learning Deep Q-network

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bone-targeted lipoplex-loaded three-dimensional bioprinting bilayer scaffold enhanced bone regeneration

引用

Regenerative Biomaterials 2024年第4期3卷 138-148页

作者： Woo-Jin Kim Jeong-hyun ryu Ji Won Kim Ki-Tae Kim Hye-Rim Shin Heein Yoon hyun-Mo Ryoo Young-Dan Cho Department of Molecular Genetics School of Dentistry and Dental Research InstituteSeoul National UniversitySeoul03080Republic of Korea Department of Periodontology School of Dentistry and Dental Research InstituteSeoul National University and Seoul National University Dental HospitalSeoul03080Republic of Korea

Clinical bone-morphogenetic protein 2(BMP2)treatment for bone regeneration,often resulting in complications like soft tissue inflammation and ectopic ossification due to high dosages and non-specific delivery systems,necessitates research into improved biomaterials for better BMP2 stability and *** tackle this challenge,we introduced a groundbreaking bone-targeted,lipoplex-loaded,three-dimensional bioprinted bilayer scaffold,termed the polycaprolactone-bioink-nanoparticle(PBN)scaffold,aimed at boosting bone *** encapsulated BMP2 within the fibroin nanoparticle based lipoplex(Fibroplex)and functionalized it with DSS6 for bone tissue-specific targeting.3D printing technology enables customized,porous PCL scaffolds for bone healing and soft tissue growth,with a two-step bioprinting process creating a cellular lattice structure and a bioink grid using gelatin-alginate hydrogel and DSS6-Fibroplex,shown to support effective nutrient exchange and cell growth at specific pore *** PBN scaffold is predicted through in silico analysis to exhibit biased BMP2 release between bone and soft tissue,a finding validated by in vitro osteogenic differentiation *** PBN scaffold was evaluated for critical calvarial defects,focusing on sustained BMP2 delivery,prevention of soft tissue cell infiltration and controlled fiber membrane pore size in *** PBN scaffold demonstrated a more than eight times longer BMP2 release time than that of the collagen sponge,promoting osteogenic differentiation and bone regeneration in a calvarial defect *** findings suggest that the PBN scaffold enhanced the local concentration of BMP2 in bone defects through sustained release and improved the spatial arrangement of bone formation,thereby reducing the risk of heterotopic ossification.

关键词： 3D bioprinting bone-targeting lipoplex BMP2 bone regeneration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein Arginine Methyltransferase 1 Ablation in Motor Neurons Causes Mitochondrial Dysfunction Leading to Age-related Motor Neuron Degeneration with Muscle Loss

引用

Research 2024年第1期2023卷 637-649页

作者： hyun-Kyung So Hyebeen Kim Jinwoo Lee Chang-Lim You Chae-Eun Yun Hyeon-Ju Jeong Eun-Ju Jin Yunju Jo Dongryeol ryu Gyu-Un Bae Jong-Sun Kang Department of Molecular Cell Biology Sungkyunkwan University School of MedicineSuwonKorea Single Cell Network Research Center Sungkyunkwan University School of MedicineSuwonKorea Research Institute of Aging-Related Diseases AniMusCureInc.SuwonKorea Drug Information Research Institute Muscle Physiome Research CenterCollege of PharmacySookmyung Women’s UniversitySeoulKorea

Neuromuscular dysfunction is tightly associated with muscle wasting that occurs with age or due to degenerative ***,the molecular mechanisms underlying neuromuscular dysfunction are currently *** studies have proposed important roles of Protein arginine methyltransferase 1(Prmt1)in muscle stem cell function and muscle *** the current study,we set out to determine the role of Prmt1 in neuromuscular function by generating mice with motor neuron-specific ablation of Prmt1(mnKO)using *** exhibited age-related motor neuron degeneration and neuromuscular dysfunction leading to premature muscle loss and ***1 deficiency also impaired motor function recovery and muscle reinnervation after sciatic nerve *** transcriptome analysis of aged mnKO lumbar spinal cords revealed alterations in genes related to inflammation,cell death,oxidative stress,and ***,mnKO lumbar spinal cords of sciatic nerve injury model or aged mice exhibited elevated cellular stress response in motor ***,Prmt1 inhibition in motor neurons elicited mitochondrial *** findings demonstrate that Prmt1 ablation in motor neurons causes agerelated motor neuron degeneration attributing to muscle ***,Prmt1 is a potential target for the prevention or intervention of sarcopenia and neuromuscular dysfunction related to aging.

关键词： degeneration impaired prevention

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Positive regulation of cell proliferation by the miR-1290-EHHADH axis in hepatocellular carcinoma

引用

Cancer Communications 2024年第6期44卷 705-709页

作者： Jinkwon Lee Gyeonghwa Kim Tae-Su Han Eunsun Jung Taesang Son Kwangho Kim Kiyoon Kwon Yuna Roh Tae Young ryu In Hwan Tae Yunsang Kang Byungheon Lee Yu Rim Lee Soo Young Park Won Young Tak Dae-Soo Kim Mi-Young Son Keun Hur hyun-Soo Cho Stem Cell Convergence Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeonRepublic of Korea Department of Bioscience Korea University of Science and TechnologyDaejeonRepublic of Korea Department of Biochemistry and Cell Biology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Biological Science Sungkyunkwan UniversitySuwonRepublic of Korea Department of Internal Medicine School of MedicineKyungpook National University HospitalDaeguRepublic of Korea Department of Biomedical Convergence Science and Technology School of ConvergenceKyungpook National UniversityDaeguRepublic of Korea

Hepatocellular carcinoma(HCC)is the second most common cancer and the third leading cause of cancer-related death worldwide[1].Recently,HCC incidence and mortality rates have further increased due to changes in the global social environment and dietary habits[2].HCC is treated by surgical resection or combination chemotherapy,but the overall survival rate of HCC patients has not improved,and the recurrence rate is still high due to strong invasiveness and resistance to chemotherapy[3].

关键词： chemotherapy mortality cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Correction to:Adaptive Electrospinning System Based on Reinforcement Learning for Uniform‑Thickness Nanofiber Air Filters

引用

Advanced Fiber Materials 2023年第2期5卷 695-695页

Correction to:Advanced Fiber Materials https://***/10.1007/s42765-022-00247-3 In this article the author name Dong Yong Park was incorrectly written as Dong Young *** original article has been ***'s Note Springer Natu... 详细信息

关键词： Uniform neutral corrected

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Multiplanar reformations and minimum intensity projections using multi-detector row CT for assessing anomalies and disorders of the pancreaticobiliary tree

引用

World Journal of Gastroenterology 2007年第31期13卷 4177-4184页

作者： hyun Cheol Kim Dal Mo Yang Wook Jin Chang Woo ryu Jung Kyu ryu Sung il Park Seong Jin Park Hyeong Cheol Shin il Young Kim Department of Radiology East-West Neo Medical Center Kyung-Hee University Seoul Republic of Korea Department of Diagnostic Radiology Kwandong University Myongji Hospital Goyang Republic of Korea Department of Diagnostic Radiology Soonchunhyang University Bucheon Hospital Bucheon Republic of Korea Department of Diagnostic Radiology Soonchunhyang University Cheonan Hospital Cheonan Republic of Korea

CT scan is regarded as the imaging modality of choice in patients with pancreaticobiliary ductal abnormalities. However, the axial orientation of the CT images provides only limited anatomical view of pancreaticobiliary ductal abnormalities. The technological advances of multi-de-tector row CT and three-dimensional image processing in workstations allows rapid image acquisition and a short postprocessing time. In particular, multiplanar reforma-tions (MPR) and minimum intensity projections (MinIP) offer rapid and accurate images of the anatomy and ab-normalities of the pancreaticobiliary tree. Moreover, MPR and MinIP help determine the relationship between the pancreaticobiliary ductal anatomy and the surrounding structures. This pictorial review illustrates the wide spec-trum of images obtained by the MPR and MinIP of the anomalies and disorders of the pancreaticobiliary tree.

关键词： Multi-detector CT Bile Ducts Biliary System Pancreas Computer Applications-3D

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of tellurium on the microstructure and mechanical properties of Fe-14Cr oxide-dispersion-strengthened steels produced by additive manufacturing

引用

Journal of Materials Science & Technology 2021年第36期95卷 114-126页

作者： Barton Mensah Arkhurst Jee Hwan Bae Min Young Na Hye Jung Chang hyun Gil Kim il hyun Kim Ho Jin ryu Jeoung Han Kim School of Materials Science and Engineering University of New South Wales SydneyNSW 2052Australia Advanced Analysis Center Korea Institute of Science and Technology SeoulSeongbuk-guRepublic of Korea LWR Fuel Technology Division Korea Atomic Energy Research InstituteDaejeonYuseong-guRepublic of Korea Department of Nuclear and Quantum Engineering KAISTDaejeonYuseong-guRepublic of Korea Department of Materials Science&Engineering Hanbat National UniversityRepublic of Korea

Conventionally,Te has primarily been used to improve the machinability of steel and its *** this work,Te was used to refine the grains of an oxide-dispersion-strengthened(ODS)steel produced by additive manufacturing(AM)with fixed processing *** of Te to the raw powder produced an ODS steel with a fine-grained microstructure,in contrast to the ODS steel manufactured without ***,the addition of Te resulted in superior yield strength and ultimate tensile strength,which was attributed to the combined effects of grain refinement and the finer nanoparticles(NPs)composed of Terich composite NPs and Cr-rich *** the first time,the AM technique was used to obtain grain and nanoparticle sizes of~3.4μm and 6 nm,respectively,from the Te-added ODS steel.

关键词： Additive manufacturing Directed energy deposition Oxide-dispersion-strengthened steel Nanoparticle Tellurium

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gene expression analysis of primary normal human hepatocytes infected with human hepatitis B virus

引用

World Journal of Gastroenterology 2006年第31期12卷 4986-4995页

作者： hyun Mi ryu Sung Gyoo Park Sung Su Yea Won Hee Jang Young-il Yang Guhung Jung School of Biological SciencesSeoul National University Seoul151-742Korea School of Biological Sciences and Institute of MicrobiologySeoul National University Seoul151-742Korea The Paik-Inje Memorial Institute for Biomedical ScienceInje University Pusanjin-guPusan 614-735Korea Department of PathologyCollege of Medicine Inje UniversityPaik HospitalPusan 614-735Korea

AIM： To find the relationship between hepatitis B virus （HBV） and hepatocytes during the initial state of infection by cDNA microarray. METHODS： Primary normal human hepatocytes （PNHHs） were isolated and infected with HBV. From the PNHHs, RNA was isolated and inverted into complement DNA （cDNA） with Cy3- or Cy5- labeled dUTP for microarray analysis. The labeled cDNA was hybridized with microarray chip, including 4224 cDNAs. From the image of the microarray, expression profiles were produced and some of them were confirmed by RT-PCR, immunoblot analysis, and NF-κB luciferase reporter assay. RESULTS： From the cDNA microarray, we obtained 98 differentially regulated genes. Of the 98 genes, 53 were up regulated and 45 down regulated. Interestingly, in the up regulated genes, we found the TNF signaling pathway-related genes： LT-α, TRAF2, and NIK. By using RT-PCR, we confirmed the up-regulation of these genes in HepG2, HuhT, and Chang liver cells, which were transfected with pHBV1.2x, a plasmid encoding all HBV messages. Moreover, these three genes participated in HBV- mediated NF-κB activation. CONCLUSION： During the initial state of HBV infection, hepatocytes facilitate the activation of NF-κB through up regulation of LT-α, TRAF2, and NIK.

关键词： cDNA microarray Primary normal human hepatocytes LT-α TRAF2 NIK NF-κB

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mo and Ta addition in NbTiZr medium entropy alloy to overcome tensile yield strength-ductility trade-off

引用

Journal of Materials Science & Technology 2022年第14期109卷 176-185页

作者： Muhammad Akmal hyun Woo Seong Ho Jin ryu Department of Materials Science and Engineering KAISTDaejeonYuseong-gu 34141South Korea Department of Nuclear and Quantum Engineering KAISTDaejeonYuseong-gu 34141South Korea

In this study,single-phase NbTiZr and NbTiZr(MoTa)_(0.1) medium-entropy alloys(MEAs)were investigated for their use in biomedical *** alloys were prepared by arc melting,and were then cold-rolled,annealed,and characterized in terms of phase analysis,mechanical properties,fractography,and wear *** alloys showed a single body-centered cubic phase with superior mechanical,and tribological properties compared to commercially available biomedical *** and Ta-containing MEAs showed higher tensile yield strength(1060±18 MPa)and higher tensile ductility(~20%),thus overcoming the strength-ductility trade-off with no signs of transformation-induced plasticity,twinning,or *** generalized stacking fault energy(GSFE)calculations on the{112}slip system by the first-principles calculations based on density functional theory showed that the addition of less than0.2 molar fraction of Mo and Ta lowers the GSFE *** behavior posits the increase in ductility of the alloy by facilitating slips although strength is also increased by solid solution *** wear resistance of both alloys against hardened steel surfaces was superior to that of commercial biomedical ***,we concluded that NbTiZr(MoTa)_(0.1)MEA with good tensile ductility is a potential candidate for biomedical implants.

关键词： Medium-entropy alloys Wear-resistant Biomedical implants Solid solution hardening Staking fault energy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Simple method for extracting the seasonal signals of photochemical reflectance index and normalized difference vegetation index measured using a spectral reflectance sensor

引用

Journal of Integrative Agriculture 2021年第7期20卷 1969-1986页

作者： Jae-hyun ryu Dohyeok OH Jaeil CHO Department of Applied Plant Science Chonnam National UniversityGwangju 61186Republic of Korea

A spectral reflectance sensor(SRS)fixed on the near-surface ground was developed to support the continuous monitoring of vegetation indices such as the normalized difference vegetation index(NDVI)and photochemical reflectance index(PRI).NDVI is useful for indicating crop growth/phenology,whereas PRI was developed for observing physiological ***,the seasonal change patterns of NDVI and PRI are two valuable pieces of information in a crop-monitoring ***,capturing the seasonal patterns is considered challenging because the vegetation index values estimated by the reflection from vegetation are often governed by meteorological conditions,such as solar irradiance and ***,unlike growth/phenology,the physiological condition has diurnal changes as well as seasonal *** study proposed a novel filtering method for extracting the seasonal signals of SRS-based NDVI and PRI in paddy rice,barley,and ***,the measurement accuracy of SRSs was compared with handheld spectrometers,and the R^(2)values between the two devices were 0.96 and 0.81 for NDVI and PRI,***,the experimental study of threshold criteria with respect to meteorological variables(i.e.,insolation,cloudiness,sunshine duration,and precipitation)was conducted,and sunshine duration was the most useful one for excluding distorted values of the vegetation *** data processing based on sunshine duration,the R^(2)values between the measured vegetation indices and the extracted seasonal signals of vegetation indices increased by approximately 0.002–0.004(NDVI)and 0.065–0.298(PRI)on the three crops,and the seasonal signals of vegetation indices became noticeably *** method will contribute to an agricultural monitoring system by identifying the seasonal changes in crop growth and physiological conditions.

关键词： photochemical reflectance index normalized difference vegetation index vegetation remote sensing spectral reflectance sensor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：