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Journal of Magnesium and Alloys 2019年第4期7卷 648-660页

作者： jong Un Lee Ye Jin Kim Sang-Hoon Kim Jeong Hun Lee Min-Seong Kim Shi-Hoon Choi Byoung Gi Moon Young Min Kim Sung hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Ulsan Regional Division Korea Institute of Industrial TechnologyUlsan 44413Republic of Korea Department of Printed Electronics Engineering Sunchon National UniversitySuncheonJeonnam 57922Republic of Korea Implementation Research Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea

In this study,the texture of a rolled Mg alloy is effectively modified through the application of precompression and subsequent annealing treatment,leading to a remarkable improvement in the bending formability of the alloy at room *** induces lattice reorientation through{10-12}twinning,and annealing treatment reduces the stored strain energy of the precompressed material,which results in the formation of a stable grain structure with two dominant texture *** an increase in precompression,the tensile strain in the outer region of the bending samples is accommodated to a greater extent due to more pronounced{10-12}twinning and basal *** a result,the bending formability of the material at room temperature improves with greater *** variation in microstructure,texture,and bending behavior in relation to the degree of precompression is discussed in detail.

关键词： Magnesium Bending Formability Twinning Texture

Roles of humidity and heat treatment temperatures on YBa_2Cu_3O_(7-x) coated conductors by trifluoroacetic acid-metal organic deposition process

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中国有色金属学会会刊：英文版 2009年第4期19卷 956-960页

作者： Seok-Hern JANG Jun-Hyung LIM Chang-Min LEE Eui-Cheol PARK Soo-Min HWANG Jun-hyuk CHOI jong-Hyun SHIM Jin-Hyun PARK Won KIM Jinho JOO School of Advanced Materials Science and Engineering Sungkyunkwan University

YBa2Cu3O7-x(YBCO) films were fabricated on an LAO substrate using the trifluoroacetic acid-metal organic deposition(TFA-MOD) method and the effects of the humidity and heat treatment temperatures on the microstructure,degree of texture and critical properties of the films were *** order to understand the combined effects of the humidity and the calcining and firing temperatures on critical properties,heat-treatment was performed at various temperatures with the other processing variables *** films were calcined at 400-430 ℃ and fired at 750-800 ℃ in a 0-12.1% humidified Ar-O2 *** texture was determined by pole-figure *** amount of the BaF2 phase was effectively reduced and a sharp and strong biaxial texture was formed under a humidified atmosphere,which led to increased critical *** addition,the microstructure varied significantly with firing temperature but changed little with calcining *** highest IC of 40 A/cm-width,which corresponds to JC value of 1.8 MA/cm2,was obtained for the films fired at 775 ℃(in 12.1% humidity) after calcining at 400-430 ℃.It is likely that the highest IC value is due to the formation of a more pure YBCO phase,c-axis grains,and a denser microstructure.

关键词： YBa2Cu3O7 热处理温度三氟乙酸沉积过程湿度涂层导体有机金属微观结构变化

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Polyelectrolyte complex micelles by self-assembly of polypeptide-based triblock copolymer for doxorubicin delivery

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Asian Journal of Pharmaceutical Sciences 2014年第4期9卷 191-198页

作者： Jeong Hwan Kim Thiruganesh Ramasamy Tuan Hiep Tran Ju Yeon Choi hyuk Jun Cho Chul Soon Yong jong Oh Kim College of Pharmacy Yeungnam University214-1Dae-DongGyongsan 712-749South Korea

Polyelectrolyte complex micelles were prepared by self-assembly of polypeptide-based triblock copolymer as a new drug carrier for cancer *** triblock copolymer,poly(L-aspartic acid)-b-poly(ethylene glycol)-b-poly(L-aspartic acid)(PLD-b-PEG-b-PLD),spontaneously self-assembled with doxorubicin(DOX)via electrostatic interactions to form spherical micelles with a particle size of 60e80 nm(triblock ionomer complexes micelles,TBIC micelles).These micelles exhibited a high loading capacity of 70%(w/w)at a drug/polymer ratio of 0.5 at pH *** showed pH-responsive release patterns,with higher release at acidic pH than at physiological ***,DOX-loaded TBIC micelles exerted less cytotoxicity than free DOX in the A-549 human lung cancer cell *** microscopy in A-549 cells indicated that DOX-loaded TBIC micelles were transported into lysosomes via *** micelles possessed favorable pharmacokinetic characteristics and showed sustained DOX release in ***,these findings indicate that PLDb-PEG-b-PLD polypeptide micelles are a promising approach for anti-cancer drug delivery.

关键词： Polyelectrolyte Micelles Drug delivery Poly(L-aspartic acid) Poly(ethylene glycol)

金属间化合物厚度对静液挤压Al/Cu蜂窝状棒材各向异性的影响（英文）

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Transactions of Nonferrous Metals Society of China 2016年第2期26卷 456-463页

作者： Tae-hyuk LEE Moon-soo SIM Sin-hyeong JOO Kyoung-tae PARK Ha-guk JEONG jong-hyeon LEE Graduate School of Department of Advanced Materials Engineering Chungnam National University Rapidly Solidified Materials Research Center Chungnam National University Graduate School of Energy Science & Technology Chungnam National University Rare Metal R&D Group Korea Institute of Industrial Technology Advanced Fusion Process R&D Group Korea Institute of Industrial Technology

研究了金属间化合物厚度对蜂窝状棒材热性能和力学性能的影响。在200℃下采用重复静液挤压制备Al/Cu蜂窝状棒材。在制备过程中,Al/Cu界面生成1μm厚的金属间化合物层。经420℃退火0.5-2 h后续热处理后,可获得不同厚度的金属间化合物层,... 详细信息

研究了金属间化合物厚度对蜂窝状棒材热性能和力学性能的影响。在200℃下采用重复静液挤压制备Al/Cu蜂窝状棒材。在制备过程中,Al/Cu界面生成1μm厚的金属间化合物层。经420℃退火0.5-2 h后续热处理后,可获得不同厚度的金属间化合物层,最厚可达10.1μm。经鉴定,金属间化合物层为Al2Cu（θ）、AlCu（η2）和Al4Cu9（γ1）相。随着金属间化合物层厚度的增加,纵向和截面方向上的热导率分别减小11.9%（从（268±4.8）到（236±4.4）W/（m·K））和10.4%（从（210±3.2）到（188±2.8）W/（m·K））,Al/Cu蜂窝状棒材的抗拉强度和伸长率分别是（103±8.4）MPa和（73±6.2）%。当金属间化合物层厚度达到7.7μm时,抗拉强度增加至（131±6.5）MPa,随着金属间化合物层厚度增加至10.1μm时,抗拉强度降低至（124±3.9）MPa。随着金属间化合物层厚度增加,蜂窝状棒材的伸长率急剧下降至（29±2.5）%。

关键词：金属间化合物 Al/Cu蜂窝状棒材各向异性热导率拉伸强度静液挤压

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M-IDM: A Multi-Classication Based Intrusion Detection Model in Healthcare IoT

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Computers, Materials & Continua 2021年第5期 1537-1553页

作者： Jae Dong Lee Hyo Soung Cha Shailendra Rathore jong hyuk Park Healthcare AI Team National Cancer CenterGoyang-si10408Korea Department of Computer Science and Engineering Seoul National University of Science and Technology(SeoulTech)Seoul01811Korea

In recent years,the application of a smart city in the healthcare sector via loT systems has continued to grow exponentially and various advanced network intrusions have emerged since these loT devices are being *** studies focused on security threat detection and blocking technologies that rely on testbed data obtained from a single medical IoT device or simulation using a well-known dataset,such as the NSL-KDD ***,such approaches do not reect the features that exist in real medical scenarios,leading to failure in potential threat *** address this problem,we proposed a novel intrusion classication architecture known as a Multi-class Classication based Intrusion Detection Model(M-IDM),which typically relies on data collected by real devices and the use of convolutional neural networks(i.e.,it exhibits better performance compared with conventional machine learning algorithms,such as naïve Bayes,support vector machine(SVM)).Unlike existing studies,the proposed architecture employs the actual healthcare IoT environment of National Cancer Center in South Korea and actual network data from real medical devices,such as a patient’s monitors(i.e.,electrocardiogram and thermometers).The proposed architecture classies the data into multiple classes:Critical,informal,major,and minor,for intrusion ***,we experimentally evaluated and compared its performance with those of other conventional machine learning algorithms,including naïve Bayes,SVM,and logistic regression,using neural networks.

关键词： Smart city healthcare IoT neural network intrusion classication machine learning

Inhibition of BET selectively eliminates undifferentiated pluripotent stem cells

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Science Bulletin 2018年第8期63卷 477-487页

作者： Jung Hyun Im Seon In Hwang jong-Wan Kim soon-Jung Park Kyu-ree Kang Jueng Soo You Kee Pyo Kim Sung-Hwan Moon hyuk-Jin Cha Hyung-Min Chung Hans R. Scholer Jung Keun Hyun DongWook Han Department of Stem Cell Biology School of Medicine Konkuk University Seoul 05029 Republic of Korea Department of Nanobiomedical Science Dankook University Graduate School Cheonan 330714 Republic of Korea Department of Biochemistry School of Medicine Konkuk University Seoul 05029 Republic of Korea Department of Cell and Developmental Biology Max Planck Institute for Molecular Biomedicine 48149 Munster Germany Department of Life Sciences College of Natural Sciences Sogang University Seoul 04107 Republic of Korea KU Open-lnnovation Center. Institute of Biomedical Science & Technology Konkuk University Seoul 05029 Republic of Korea Department of Advanced Translational Medicine School of Medicine Konkuk University Seoul 05029 Republic of Korea

Embryonic stem cells(ESCs) maintain their cellular identity through the systematic regulation of master transcription factors and chromatin remodeling complexes. Recent work has shown that the unusually large-scale enhancers—namely super-enhancers(SEs), on which BRD4, a member of the bromodomain and extraterminal domain(BET) family is highly enriched—could regulate pluripotency-related transcription factors. Moreover, inhibition of BRD4 binding on SEs has been shown to induce the differentiation of ESCs. However, the underlying mechanism of BRD4 inhibition-mediated stem cell differentiation remains elusive. Here we show that both mouse and human ESCs lose their capacity for self-renewal upon treatment with JQ1, a selective inhibitor of BET family including BRD4, with rapid suppression of pluripotency-associated genes. Notably, a high concentration of JQ1 could selectively eliminate ESCs via apoptosis, without affecting the functionality of differentiated somatic cells from ESCs, suggesting that inhibition of BET may have a beneficial effect on the development of pluripotent stem cell-based cell therapy.

关键词：干细胞 apoptosis 细胞治疗字符建筑群染色质约束力证明

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Unexpected anterograde amnesia associated with Buscopan used as a predmedication for endocscopy

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World Journal of Gastroenterology 2007年第28期13卷 3895-3896页

作者： hyuk Lee Hee Jung Son Poong-Lyul Rhee Jae J Kim jong Chul Rhee Departments of Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 135-710Korea Departments of Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 135-710Korea Center for Health PromotionSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 135-710Korea

It has been known that peripheral adverse event is caused by peripheral antimuscarinic action, from hyoscine butylbromide (Buscopan; Boehringer Ingelheim, Germany) used as a premedication for endoscopy. However, symptoms or signs associated with the central nervous system are rarely reported in the field of anesthesiology and peripartum labor. This central anticholinergic syndrome is likely caused by blockade of muscarinic cholinergic receptors in the central nervous system. There is no report on Buscopan-induced central anticholinergic syndrome in endoscopy room so far. Three middle-aged females unexpectedly suffered from anterograde amnesia after intramuscular injection of hyoscine butylbromide as an antispasmodic premedication for endoscopy at our endoscopy unit in the Health Promotion Center.

关键词：内窥镜检查东莨菪碱丁基溴化物抗胆碱能药综合症健忘症顺行性遗忘

Intraductal papillary bile duct adenocarcinoma and gastrointestinal stromal tumor in a case of neurofibromatosis type 1

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World Journal of Gastroenterology 2018年第4期24卷 537-542页

作者： Jung Min Lee Jae Min Lee jong Jin Hyun hyuk Soon Choi Eun Sun Kim Bora Keum Yoon Tae Jeen Hoon Jai Chun Hong Sik Lee Chang Duck Kim Dong Sik Kim Joo Young Kim Division of Gastroenterology and Hepatology Department of Internal Medicine Institute of Gastrointestinal Medical Instrument Research Korea University College of Medicine Division of Gastroenterology and Hepatology Department of Internal Medicine Korea University Anam Hospital Division of HBP Surgery and Liver Trans- plantation Department of Surgery Korea University College of Medicine Department of Pathology Korea University College of Medicine

We report our experience with a synchronous case of gastrointestinal stromal tumor(GIST) and intraductal papillary neoplasm of the bile duct(IPNB) in anelderly woman with neurofibromatosis type 1(NF-1). A 72-year-old woman presented with a 2-mo history of right upper abdominal pain unrelated to diet and indigestion. Fourteen years earlier, she had been diagnosed with NF-1, which manifested as café au lait spots and multiple nodules on the skin. Computed tomography(CT) revealed a multilocular low-density mass with septation, and mural nodules in the right hepatic lobe, as well as a 1.7-cm-sized well-demarcated enhancing mass in the third portion of the duodenum. The patient subsequently underwent right hepatectomy and duodenal wedge resection. We present here the first report of a case involving a synchronous IPNB and GIST in a patient with NF-1. Our findings demonstrate the possibility of various tumors in NF-1 patients and the importance of diagnosis at an early

关键词： Neurofibromatosis type 1 Intraductal papillary neoplasm of the bile duct Gastrointestinal stromal tumor Synchronous

Pilot study of postoperative adjuvant chemoradiation for advanced gastric cancer:Adjuvant 5-FU/cisplatin and chemoradiation with capecitabine

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World Journal of Gastroenterology 2006年第4期12卷 603-607页

作者： Hyung-SikLee YoungminChoi Won-JooHur Hyo-JinKim hyuk-ChanKwon Sung-HyunKim Jae-SeokKim jong-Hoon Lee Ghap-JoongJung Min-ChanKim Department of Radiation Oncology Dong-A University College of MedicineBusanSouth Korea Department of Medical Oncology Dong-A Universityéollege of MedicineBusanSouth Korea Department of Gastroenterology Dong-A University College of MedicineBusanSouth Korea Department of Surgery Dong-A University College of MedicmeBusanSouth Korea

瞄准：为先进胃的癌症追随者药品切除术在放射期间用 FP 化疗和口头的 capecitabine 评估手术后的 chemoradiation 的功效和毒性。方法：有的 31 个病人经历了一潜在地药品为阶段 III 和 IV (M0 ) 的切除术胃的癌症被注册。治疗由 FP ... 详细信息

瞄准：为先进胃的癌症追随者药品切除术在放射期间用 FP 化疗和口头的 capecitabine 评估手术后的 chemoradiation 的功效和毒性。方法：有的 31 个病人经历了一潜在地药品为阶段 III 和 IV (M0 ) 的切除术胃的癌症被注册。治疗由 FP 的一个周期组成(5-FU 的连续注入 d 上的 1000 mg/m (2 ) 1 ～ 5 并且 cisplatin d 上的 60 mg/m (2 ) 1 ) 与 capecitabine (在整个放射疗法的 1650 mg/m (2 ) 日报) 由 4500 cGy (180 cGy/d ) 列在后面。在放射疗法的结束以后的四 wk，病人们收到了 FP 的三个另外的周期每三 wk。中部的后续持续时间是 22.2 瞬间。结果：免费的 3 年的疾病和在这研究的全面幸存分别地是 82.7% 和 83.4% 。四个病人(12.9%) 在后续期间显示出恶化。八个病人没完成所有计划辅助治疗。等级 3/4 毒性在 50.2% 的包括的嗜中性白血球减少症，在 12.9% 的贫血症，在 3.2% 的血小板减少和在 3.2% 的恶心 / 呕吐。任何一等级 3/4 手脚症候群也不治疗都没联系热性的嗜中性白血球减少症或死亡被观察。结论：这些初步的结果建议在 capecitabine 和并发的放射疗法前后的 FP 的这手术后的辅助 chemoradiation 政体显得很好容忍了并且把可比较的毒性侧面提供给在 INT-0116 利用的 chemoradiation 政体。这种治疗形式允许成功的疯子地区性的控制率和 3 年的全面幸存。

关键词：手术治疗胃癌顺铂病理机制

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由情感触发的家居电器美学

工业设计 2022年第7期 20-20页

作者： jong hyuk Bae 不详

设计师提出了一个问题,即现代住宅中的一切都具有情感设计元素。购买家居装饰纯粹是出于个人品味和情感,电器也应该效仿。Belyse就符合这样的理念,其以白色和灰色为主色调,使外表看起来干净又整洁。上部的白色元素用作净化器,而底部则... 详细信息

设计师提出了一个问题,即现代住宅中的一切都具有情感设计元素。购买家居装饰纯粹是出于个人品味和情感,电器也应该效仿。Belyse就符合这样的理念,其以白色和灰色为主色调,使外表看起来干净又整洁。上部的白色元素用作净化器,而底部则作为充电座。净化器可以挂在烹饪区或用餐区,甚至可以兼作一盏灯。此外,还可以在“空气清洗模式”下使用它,或将其放置在充电底座上。虽然空气净化器并没有真正打破功能部分的壁垒,但这是由情感线索触发的美学尝试。

关键词：空气净化器家居装饰现代住宅情感线索情感设计触发电器美学

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