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World Journal of Clinical Cases 2019年第20期7卷 3271-3275页

作者： Dae Hoon Kim Hanlim Choi Ki Bae Kim hyo yung yun Joung-Ho Han Department of Surgery Chungbuk National University HospitalChungbuk National University College of MedicineCheongju-si 28644South Korea Department of Internal Medicine Chungbuk National University HospitalChungbuk National University College of MedicineCheongju-si 28644South Korea

BACKGROUND A penetrating injury of a hollow viscus is an obvious indication for an exploratory laparotomy,but is not typically an indication for endoscopic *** SUMMARY A 27-year-old man visited the emergency department with a self-inflicted abdominal stab *** to the colon and ileum were detected,but an injury to the second portion of the duodenum was *** the day following admission to our institution,the patient became hemodynamically unstable with massive hematochezia,although there was no evidence of bleeding in the Levin tube or Jackson-Pratt *** thus performed an upper gastrointestinal endoscopy and discovered a missed duodenal injury that was actively *** endoscopic band ligation was performed for hemostasis and closure of the *** patient was subsequently discharged without any *** A penetrating injury of the duodenum can be overlooked,so careful abdominal exploration is very *** a missed duodenal injury is suspected,a cautious endoscopic approach may be helpful.

关键词： Penetrating abdominal injury Endoluminal treatment Unrecognized duodenal injury Case report

Preoperative CA 125 is significant indicator of curative resection in gastric cancer patients

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World Journal of Gastroenterology 2015年第4期21卷 1216-1221页

作者： Dae Hoon Kim hyo yung yun Dong Hee Ryu Hye-Suk Han Joung-Ho Han Soon Man Yoon Sei Jin Youn Department of Surgery Chungbuk National University College of MedicineCheongju 361-763South Korea Internal Medicine Chungbuk National University College of MedicineCheongju 361-763South Korea

AIM: To investigate the correlation among tumor markers, curative resection, and recurrence in gastric ***: The patients with preoperative tumormakers [Carcinoembryonic antigen, Carbohydrate antigen(CA) 19-9, and CA 125] and elective gastrectomy between January 2000 and December 2009 at Chungbuk National University Hospital were enrolled in this study. We analyzed the relationship among the tumor makers, curative resection and recurrence, ***: Among the 679 patients with gastric cancer, curative resection was 93.6%(n = 636) and noncurative resection was 6.4%(n = 43). The independent risk factors for the non-curative resection were tumor location and the positivity of preoperative serum CA 19-9 and CA 125 levels. After curative resection, the independent prognostic risk factors for recurrence in curative resection were gender, stage, and preoperative increased serum CA 125 level(HR = 2.431, P =0.020), in a multivariate analysis. CONCLUSION: Preoperative CA 125 is a useful predictive biomarker for curative resection and prognostic biomarker for recurrence in gastric cancer patients.

关键词： Gastric Cancer Tumor Marker Carcinoembryonic antig

Long-term survival after gastrectomy and metastasectomy for gastric cancer with synchronous bone metastasis

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World Journal of Gastroenterology 2018年第1期24卷 150-156页

作者： Young Jin Choi Dae Hoon Kim Hye Suk Han Joung-Ho Han Seung-Myoung Son Dong Soo Kim hyo yung yun Department of Surgery Chungbuk National University Hospital Chungbuk National University College of Medicine Department of Internal Medicine Chungbuk National University Hospital Chungbuk National University College of Medicine Department of Pathology Chungbuk National University Hospital Chungbuk National University College of Medicine Department of Orthopedics Chungbuk National University Hospital Chungbuk National University College of Medicine

Bone metastasis is a rare event in patients with gastric cancer, but pathologic fracture, paralysis, pain and hematological disorders associated with the bone metastasis may influence the quality of life. We report herein the case of a 53-year-old man who presented with primary remnant gastric cancer with bone metastasis. The patient requested further investigations after detection of a metastatic lesion in the 2 nd lumbar vertebra during evaluation for back pain that had persisted for 3 mo. No other metastatic lesions were detected. He underwent total gastrectomy and palliative metastasectomy to aid in reduction of symptoms, and he received combination chemotherapy with tegafur(S-1) and cisplatin. The patient survived for about 60 mo after surgery. Currently, there is no treatment guideline for gastric cancer with bone metastasis, and we believe that gastrectomy plus metastasectomy may be an effective therapeutic option for improving qualityof life and survival in patients with resectable primary gastric cancer and bone metastasis.

关键词： Stomach neoplasms Gastrectomy Bone neoplasms Neoplasm metastasis Metastasectomy

Evaluation of the relationship between dietary factors,CagA-positive Helicobacter pylori infection,and RUNX3 promoter hypermethylation in gastric cancer tissue

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World Journal of Gastroenterology 2013年第11期19卷 1778-1787页

作者： Yan-Wei Zhang Sang-Yong Eom Dong-Hyuk Yim Young-Jin Song hyo-yung yun Joo-Seung Park Sei-Jin Youn Byung-Sik Kim Yong-Dae Kim Heon Kim Department of Preventive Medicine and Medical Research Institute College of MedicineChungbuk National UniversityCheongju 361-763South Korea Department of Surgery College of MedicineChungbuk National UniversityCheongju 361-763South Korea Department of Surgery College of MedicineEulji UniversityDaejon 461-713South Korea Department of Internal Medicine College of MedicineChungbuk National UniversityCheongju 361-763South Korea Department of Surgery Asan Medical CenterCollege of MedicineUlsan UniversitySeoul 138-736South Korea

AIM:To evaluate the relationship among Helicobacter pylori(***) infection,CagA status,and dietary factors with RUNX3 promoter ***:Gastric cancer tissue samples were collected from 184 South Korean *** patients were interviewed following a semi-quantitative food frequency *** average frequencies of intake and portion sizes of 89 common food items were documented,and total intakes of calories,nutrients,vitamins,and minerals were calculated for each *** was extracted from gastric cancer tissue samples,and amplification of the HSP60 gene was performed to detect *** *** polymerase chain reaction(PCR) was used to detect the presence of the CagA ***3 gene expression was measured by reverse transcription-PCR,and RUNX3 methylation status was evaluated by methylation-specific *** odds ratios(ORs) and 95%CI associated with RUNX3 promoter hypermethylation status were estimated for each of the food groups,lifestyle factors,and the interaction between dietary and lifestyle factors with CagA status of *** ***:Overall,164 patients(89.1%) were positive for *** DNA,with the CagA gene detected in 59(36%) of these ***-positive *** all,106(57.6%) patients with gastric cancer demonstrated CpG island hypermethylation at the RUNX3 ***3 expression was undetectable in 52(43.7%) of the 119 gastric cancer tissues sampled.A high consumption of eggs may increase the risk of RUNX3 methylation in gastric cancer patients,having a mean OR of 2.15(range,1.14-4.08).A significantly increased OR of 4.28(range,1.19-15.49) was observed with a high consumption of nuts in patients with CagA-positive *** *** intakes of carbohydrate,vitamin B1,and vitamin E may decrease the risk of RUNX3 methylation in gastric cancer tissue,particularly in CagA-or ***-negative infection,with OR of 0.41(0.19-0.90),0.42(0.20-0.89),and 0.29(0.13-0.62),respectively.A high consumpt

关键词： Gastric cancer RUNX3 Helicobacter pylori CagA Dietary factors

Dietary vitamin D intake and vitamin D related genetic polymorphisms are not associated with gastric cancer in a hospital-based case-control study in Korea

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The Journal of Biomedical Research 2018年第4期32卷 257-263页

作者： Sang-Yong Eom Dong-Hyuk Yim Dae-Hoon Kim hyo-yung yun Young-Jin Song Sei-Jin Youn Taisun Hyun Joo-Seung Park Byung Sik Kim Yong-Dae Kim Heon Kim Departments of Preventive Medicine and Medical Research Institute College of Medicine Departments of Preventive Medicine and Surgery College of Medicine Departments of Preventive Medicine and Internal Medicine College of Medicine Dartment of Food and Nutrition Chungbuk National UniversityCheongju 28644Korea Department of Surgery College of MedicineEulji UniversityDaejon 301746Korea Department of Surgery Asan Medical CenterCollege of MedicineUlsan UniversitySeoul 138736Korea

There have been few studies on the association between vitamin D levels and gastric cancer in Asian populations,but no studies have been performed on the interactions between vitamin D intake and polymorphisms in the vitamin D *** effects of vitamin D intake,vitamin D related genetic polymorphisms,and their association with the incidence of gastric cancer were investigated in a hospital case-control study,including 715 pairs of newly diagnosed gastric cancer patients and controls matched for age and *** between vitamin D intake and plasma vitamin D concentrations were also assessed in a subset of *** statistically significant difference was observed in the dietary intake of vitamin D between the patients and controls,nor were there any evident associations between vitamin D intake and risk of gastric cancer in multivariate *** D intake significantly correlated with the circulating 25-hydroxyvitamin D levels,but not with the active form of the vitamin,1,25-dihydroxyvitamin *** were no statistically significant interactions between vitamin D intake,and VDR or TXNIP *** study suggests that dietary vitamin D intake is not associated with gastric cancer risk,and the genetic polymorphisms of vitamin D-related genes do not modulate the effect of vitamin D with respect to gastric carcinogenesis.

关键词： gastric cancer vitamin D vitamin D receptor gene-environment interaction

ITGA1 polymorphisms and haplotypes are associated with gastric cancer risk in a Korean population

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World Journal of Gastroenterology 2013年第35期19卷 5870-5876页

作者： Dong-Hyuk Yim Yan-Wei Zhang Sang-Yong Eom Sun In Moon hyo-yung yun Young-Jin Song Sei-Jin Youn Taisun Hyun Joo-Seung Park Byung Sik Kim Jong-Young Lee Yong-Dae Kim Heon Kim Department of Preventive Medicine and Medical Research Institute College of Medicine Chungbuk National University Center for Disease Control and Prevention Department of Surgery College of Medicine Chungbuk National University Department of Internal Medicine College of MedicineChungbuk National University Department of Food and Nutrition Chungbuk National University Department of Surgery College of MedicineEulji University Department of Surgery Asan Medical Center College of Medicine Ulsan University Center for Genome Science National Institute of Health

AIM:To evaluate the association between the geneticpolymorphisms and haplotypes of the ITGA1 gene and the risk of gastric ***:The study subjects were 477 age-and sex-matched case-control *** was performed for 15 single nucleotide polymorphisms(SNPs)in *** associations between gastric cancer and these SNPs and haplotypes were analyzed with multivariate conditional logistic regression *** testing corrections were carried out following methodology for controlling the false discovery ***-based association tests were performed using the versatile gene-based association study(VEGAS)***:In the codominant model,the ORs for SNPs rs2432143(1.517;95%CI:1.144-2.011)and rs2447867(1.258;95%CI:1.051-1.505)were statistically *** the dominant model,polymorphisms of rs1862610 and rs2447867 were found to be significant risk factors,with ORs of 1.337(95%CI:1.029-1.737)and 1.412(95%CI:1.061-1.881),*** the recessive model,only the rs2432143 polymorphism was significant(OR=1.559,95%CI:1.150-2.114).The C-C type of ITGA1 haplotype block 2 was a significant protective factor against gastric cancer in the both codominant model(OR=0.602,95%CI:0.212-0.709,P=0.021)and the dominant model(OR=0.653,95%CI:0.483-0.884).The ITGA1 gene showed a significant gene-based association with gastric cancer in the VEGAS *** the dominant model,the A-T type of ITGA1 haplotype block 2 was a significant risk factor(OR=1.341,95%CI:1.034-1.741).SNP rs2447867 might be related to the severity of gastric epithelial injury due to inflammation and,thus,to the risk of developing gastric ***:ITGA1 gene SNPs rs1862610,rs2432143,and rs2447867 and the ITGA1 haplotype block that includes SNPs rs1862610 and rs2432143 were significantly associated with gastric cancer.

关键词： Integrin ITGA1 Gastric cancer Polymorphism Haplotype

Risk of gastric cancer is associated with PRKAA1 gene polymorphisms in Koreans

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World Journal of Gastroenterology 2014年第26期20卷 8592-8598页

作者： Yong-Dae Kim Dong-Hyuk Yim Sang-Yong Eom Sun In Moon hyo-yung yun Young-Jin Song Sei-Jin Youn Taisun Hyun Joo-Seung Park Byung Sik Kim Jong-Young Lee Hee Kwan Won Heon Kim Department of Preventive Medicine College of MedicineChungbuk National University Department of Surgery College of MedicineChungbuk National University Department of Internal Medicine College of MedicineChungbuk National University Department of Food and Nutrition Chungbuk National University Department of Surgery College of MedicineEulji University Department of Surgery Asan Medical CenterCollege of MedicineUlsan University Center for Genome Science National Institute of Health Department of Internal Medicine Division of Endocrinology and MetabolismSchool of MedicineKonyang University

AIM: To evaluate the association between genetic polymorphisms of the gene encoding AMP-activated protein kinase (PRKAA1) and the risk of gastric cancer.

关键词： AMP-activated protein kinase Gastric cancer PRKAA1 Single nucleotide polymorphism Case-control study

Sex-dependent alterations in extracellular vesicles linking chronic spinal cord injury to brain neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第2期20卷 483-484页

作者： yun Li Junfang Wu Department of Anesthesiology&Shock Trauma and Anesthesiology Research(STAR)CenterUniversity of Maryland School of MedicineBaltimoreMDUSA

Traumatic spinal cord injury(SCI)is a devastating exogenous injury with long-lasting consequences and a leading cause of death and disability *** in assistive technology,rehabilitative interventions,and the ability to identify and intervene in secondary conditions have significantly increased the long-term survival rate of SCI patients,with some people even living well into their seventh or eighth *** survival changes have led neurotrauma researchers to examine how SCI interacts with brain *** health and epidemiological data showed that patients with long-term SCI can have a lower life expectancy and quality of life,along with a higher risk of comorbidities and complications.

关键词： alterations inflammation injury

IoT Empowered Early Warning of Transmission Line Galloping Based on Integrated Optical Fiber Sensing and Weather Forecast Time Series Data

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Computers, Materials & Continua 2025年第1期82卷 1171-1192页

作者： Zhe Li yun Liang Jinyu Wang Yang Gao State Grid Henan Electric Power Company Electric Power Scientific Research Institute State Grid Henan Electric Power CompanyZhengzhou450052China

Iced transmission line galloping poses a significant threat to the safety and reliability of power systems,leading directly to line tripping,disconnections,and power *** early warning methods of iced transmission line galloping suffer from issues such as reliance on a single data source,neglect of irregular time series,and lack of attention-based closed-loop feedback,resulting in high rates of missed and false *** address these challenges,we propose an Internet of Things(IoT)empowered early warning method of transmission line galloping that integrates time series data from optical fiber sensing and weather ***,the method applies a primary adaptive weighted fusion to the IoT empowered optical fiber real-time sensing data and weather forecast data,followed by a secondary fusion based on a Back Propagation(BP)neural network,and uses the K-medoids algorithm for clustering the fused ***,an adaptive irregular time series perception adjustment module is introduced into the traditional Gated Recurrent Unit(GRU)network,and closed-loop feedback based on attentionmechanism is employed to update network parameters through gradient feedback of the loss function,enabling closed-loop training and time series data prediction of the GRU network ***,considering various types of prediction data and the duration of icing,an iced transmission line galloping risk coefficient is established,and warnings are categorized based on this ***,using an IoT-driven realistic dataset of iced transmission line galloping,the effectiveness of the proposed method is validated through multi-dimensional simulation scenarios.

关键词： Optical fiber sensing multi-source data fusion early warning of galloping time series data IoT adaptive weighted learning irregular time series perception closed-loop attention mechanism

Coordinated Control Strategy of New Energy Power Generation System with Hybrid Energy Storage Unit

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Energy Engineering 2025年第1期122卷 167-184页

作者： yun Zhang ZifenHan Biao Tian Ning Chen Yi Fan School of Mechano-Electronic Engineering Xidian UniversityXi’an710071China Electric Power Control Center State Grid Gansu Electric Power CompanyLanzhou730030China Electric Power Control Center State Grid Gansu Electric Power Company Zhangye Power Supply BranchZhangye734000China

The new energy power generation is becoming increasingly important in the power *** as photovoltaic power generation has become a research hotspot,however,due to the characteristics of light radiation changes,photovoltaic power generation is unstable and random,resulting in a low utilization rate and directly affecting the stability of the power *** solve this problem,this paper proposes a coordinated control strategy for a newenergy power generation system with a hybrid energy storage unit based on the lithium iron phosphate-supercapacitor hybrid energy storage ***,the variational mode decomposition algorithm is used to separate the high and low frequencies of the power signal,which is conducive to the rapid and accurate suppression of the power fluctuation of the energy storage ***,the fuzzy control algorithm is introduced to balance the power between energy *** this paper,the actual data is used for simulation,and the simulation results show that the strategy realizes the effective suppression of the bus voltage fluctuation and the accurate control of the internal state of the energy storage unit,effectively avoiding problems such as overshoot and over-discharge,and can significantly improve the stability of the photovoltaic power generation systemand the stability of the Direct Current *** is of great significance to promote the development of collaborative control technology for photovoltaic hybrid energy storage units.

关键词： Photovoltaic power suppression hybrid energy storage unit variationalmodal decomposition fuzzy control power distribution control