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Cellular & Molecular Immunology 2024年第5期21卷 466-478页

作者： hyo jeong kim Yun Sang Lee Bok-Soon Lee Chang-Hak Han Sang Gyu kim Chul-Ho kim Department of Otolaryngology School of MedicineAjou UniversitySuwonRepublic of Korea Department of Molecular Science and Technology Ajou UniversitySuwonRepublic of Korea

Inflammasomes are multiprotein complexes involved in the host immune response to pathogen ***,inflammasomes participate in many conditions,such as ***,it was shown that NETosis,a type of neutrophil cell death,is induced by bacterial infection and is involved in inflammatory diseases such as delayed wound healing in patients with ***,the relationship between inflammasomes and NETosis in the pathogenesis of inflammatory diseases has not been well *** this study,we determined whether NETosis is induced in ***-induced skin inflammation and whether activation of the nucleotide-binding domain,leucine-rich family,and pyrin domain-containing-3(NLRP3)inflammasome is one of the key factors involved in NETosis induction in a mouse model of acne skin *** found that NETosis was induced in ***-induced skin inflammation in mice and that inhibition of NETosis ameliorated ***-induced skin *** addition,our results demonstrated that inhibiting inflammasome activation could suppress NETosis induction in mouse *** results indicate that inflammasomes and NETosis can interact with each other to induce ***-induced skin inflammation and suggest that targeting NETosis could be a potential treatment for inflammasome-mediated diseases as well as NETosis-related diseases.

关键词： P.acnes NETosis NLRP3 inflammasome Skin inflammation

Metabolic signaling functions of the heme oxygenase/CO system in metabolic diseases

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Cellular & Molecular Immunology 2018年第12期15卷 1085-1087页

作者： hyo jeong kim Yeonsoo Joe Young-Joon Surh Hun Taeg Chung Department of Biological Sciences University of UlsanUlsanSouth Korea Tumor Microenvironment Global Core Research Center Research Institute of Pharmaceutical SciencesSeoul National UniversitySeoulSouth Korea

Immunometabolism is the intersection of immunology and *** heme oxygenase(HO)-1 and carbon monoxide(CO)(HO-1/CO)system can be induced by various stresses,including infection,and its function is to relieve stresses such as oxidative and inflammatory *** we demonstrate that the HO-1/CO system is intimately involved in the beneficial modulation of metabolic pathways via the production of ATF4 through an integrative stress response.

关键词： system monoxide oxidative

A Combined Approach for Urban Green Space System——Traditional and Digital Methods

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A Combined Approach for Urban Green Space System——Traditio...

Experimental assessment of two-phase bubble pump for solar water heating

第8届中日韩国际风景园林学术研讨会

作者： Kyoo-Seock LEE Seung-Mahn AHN Dong-Hoon SHIN Byung-Sun KAHNG Seung-Nyung HUR Jin-Min SHIN Sang-hwa LEE Mi-jeong LEE Yun-Ui JI hyo-jeong kim Ho-Kyung SONG Ki-Won KWON Byung-Key SUH Dept. of Landscape Arch. Sungkyunkwan University Dept. of Landscape Arch. Sungkyunkwan University Dept. of Landscape Arch. Sungkyunkwan University Dept. of Landscape Arch. Sungkyunkwan University Dept. of Landscape Arch. Sungkyunkwan University Dept. of Landscape Arch. Sungkyunkwan University Dept. of Forest Resources Chungnam University Dept. of Forest Resources Chungnam University Dept. of Forest Resources Chungnam University Dept. of Forest Resources Chungnam University Dept. of Forest Resources Chungnam University Dept. of Forest Resources Chungnam University School of Horticulture ＆ Landscape Arch. Paichai University

＜正＞This study aims to establish the urban green network using RS, GIS and GPS, together with the traditional vegetation survey and ultimately to contribute to the effective conservation of urban green spaces for ur... 详细信息

关键词： Green Network Remote Sensing GIS GPS Vegetation Analysis

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Journal of Central South University 2012年第6期19卷 1590-1599页

作者： CHUNG Han-shik WOO Ju-sik SHIN Yong-han kim Jun-hyo jeong hyo-min Institute of Marine Industry Department of Mechanical and Precision EngineeringGyeongsang National University445 Inpyeong DongTongyeongGyeongsangnamdo650-160Korea Department of Mechanical and Precision Engineering Gyeongsang National University445 Inpyeong DongTongyeongGyeongsangnamdo650-160Korea Division of Marine Engineering Mokpo National Maritime UniversityHaeyangdaehang-Ro 91Mokpo-siJeollanam-do530-729Korea

The research goal is to develop a new solar water heater system(SWHS) that uses a solar bubble pump instead of an electric *** pump is powered by the steam produced from an evacuated tube ***,heat could be transferred downward from the collector to a hot water storage *** designed system consists of two sets of heat-pipe evacuated tube collectors,a solar bubble pump installed at an upper level and a water storage tank with a heat exchanger at a lower *** heads of 1 and 5 m were *** bubble pump could operate at the collector temperature of about 90-100 ℃ and vapor gage pressure of 80-90 *** is found that water circulation within the SWHS depends on the incident solar intensity and system discharge *** investigations are conducted to obtain the system thermal efficiencies from the hourly,daily and long-term performance *** thermal performance of the proposed system is compared with conventional solar water *** results show that the proposed system achieves system characteristic efficiency of 10% higher than that of the conventional systems using electric pump if taking the consumption of electric power into *** the former is a zero carbon system.

关键词： two-phase bubble pump solar water heater system (SWHS) zero carbon

Reactive oxygen species involved in sulforaphane-induced STAT3 inactivation and apoptosis in DU145 prostate cancer cells

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Chinese Science Bulletin 2010年第34期55卷 3922-3928页

作者： KOH Wonil AHN Kwang Seok jeong Soo-Jin LEE hyo-Jung kim Minseok LEE hyo-jeong LEE Eun-Ok kim Sung-Hoon College of Oriental Medicine Kyung Hee University College of Dental Medicine Tufts UniversityBoston

Signal transducer and activator of transcription factor 3(STAT3)is a transcription factor that regulates various cellular processes such as proliferation,survival and angiogenesis in cancer *** the present study,we investigated the mechanisms whereby isothiocyanate sulforaphane(SFN)suppresses STAT3 activation in DU145 prostate cancer *** significantly inhibited SFN-inhibited STAT3 phosphorylation at Tyr705 as well as the deoxyribonucleic acid(DNA)binding capability in electrophoresis mobility shift assay(EMSA)in time-and concentration-dependent *** also abrogated the Janus activated kinase 2(JAK2)*** addition,SFN down-regulated STAT3-related gene products including Bcl-2,Bcl-xL,and cyclin D1 and vascular endothelial growth factor(VEGF),and inhibited the proliferation and induced ***,SFN mediated reactive oxygen species(ROS)production at the early ***,these results demonstrate that ROS generation may be involved in the inhibition of JAK2/STAT3 activation and apoptosis in DU145 cells.

关键词：前列腺癌细胞 STAT3 细胞凋亡活性氧活化诱导硫素萝卜

Endoscopic ultrasound-guided biliary drainage with placement of a fully covered metal stent for malignant biliary obstruction

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World Journal of Gastroenterology 2012年第20期18卷 2526-2532页

作者： Tae Hyeon kim Seong Hun kim hyo jeong Oh Young Woo Sohn Seung Ok Lee Department of Internal Medicine School of MedicineWonkwang UniversityIksanChonbuk 570-749 South Korea Department of Internal Medicine Chonbuk National University Medical School and HospitalJeonjuChonbuk 561-712South Korea Department of Internal Medicine School of MedicineWonkwang UniversitySanbon Gyounggi 570-749South Korea

AIM:To determine the utility of endoscopic ultrasoundguided biliary drainage(EUS-BD)with a fully covered self-expandable metal stent for managing malignant biliary stricture. METHODS:We collected data from 13 patients who presented with malignant biliary obstruction and underwent EUS-BD with a nitinol fully covered selfexpandable metal stent when endoscopic retrograde cholangiopancreatography(ERCP)***-guided choledochoduodenostomy(EUS-CD)and EUS-guided hepaticogastrostomy(EUS-HG)was performed in 9 patients and 4 patients,respectively. RESULTS:The technical and functional success rate was 92.3%(12/13)and 91.7%(11/12),respectively. Using an intrahepatic approach(EUS-HG,n=4),there was mild peritonitis(n=1)and migration of the metal stent to the stomach(n=1).With an extrahepatic approach(EUS-CD,n=10),there was pneumoperitoneum(n=2),migration(n=2),and mild peritonitis (n=1).All patients were managed conservatively with *** follow-up(range,1-12 mo),there was re-intervention(4/13 cases,30.7%)necessitated by stent migration(n=2)and stent occlusion(n=2). CONCLUSION:EUS-BD with a nitinol fully covered self-expandable metal stent may be a feasible and effective treatment option in patients with malignant biliary obstruction when ERCP fails.

关键词： Endoscopic ultrasound-guided Biliary drainage Metal stent Biliary obstruction

Acute myopathy associated with liver cirrhosis

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World Journal of Gastroenterology 2006年第14期12卷 2254-2258页

作者： Ok-Jae Lee Jee-Hyang Yoon Eun-jeong Lee Hyun-Jin kim Tae-hyo kim Department of Internal Medicine and Gyeongsang Institute of Health Science Gyeongsang National University College of Medicine JinjuRepublic of Korea

AIM： Many cirrhotic patients have muscular symptoms and rhabdomyolysis. However, myopathy associated with liver cirrhosis has not been established as a disease entity. We evaluated the clinical significance of acute myopathy associated with liver cirrhosis. METHODS： We retrospectively reviewed the medical records of 5440 cirrhotic patients who had been admitted to Gyeongsang National University Hospital from August 1997 to January 2003. Among these, 99 developed acute myopathies, and they were analyzed with respect to clinical and laboratory parameters, and outcomes. RESULTS： The Child-Pugh classification at the time of myopathy onset was A in 3（3.1%） cases, B in 33（33.3%）, and C in 63 （63.6%）. Infection was identified as the most predisposing factor to myopathy. Fifty percent of 18 idiopathic cases who were tested for influenza antibody were positive. Forty-two of the 99 cases were complicated by acute renal failure, and 25 （59.5%） of these expired. Apart from 6 cases lost to follow-up, 64 of 93 recovered, giving a mortality rate of 31.2%. Mortality was higher in Child-Pugh class C than in B or A. CONCLUSION： Acute myopathy can develop as a serious complication in liver cirrhosis. Its frequency, severity and mortality depend on underlying liver function, and are higher in decompensated liver cirrhosis. Influenza should be considered as an etiologic factor in idiopathic cases. It is proposed that acute myopathy associated with liver cirrhosis be called ＇hepatic myopathy; and that careful monitoring for hepatic myopathy is necessary in the patients with advanced liver cirrhosis.

关键词： Myopathy Rhabdomyolysis Liver cirrhosis

Blood transcriptomic markers associated with immune abnormalities and sleep quality

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Genes & Diseases 2024年第6期11卷 111-114页

作者： Sang-Min Park hyo-jeong Ban Minsung Lee Soo Yeon kim Siwoo Lee Hee-jeong Jin College of Pharmacy Chungnam National UniversityDaejeon34134Republic of Korea Korean Medicine(KM)Data Division Korea Institute of Oriental MedicineDaejeon 34054Republicof Korea

The prevalence of sleep disorders is increasing worldwide,prompting greater efforts to understand the biological mechanisms underlying *** the growing interest in this area,a continuous transcriptome analysis for studying sleep quality is still *** study performed a regression analysis of the Pittsburgh sleep quality index(PsQ)from the blood transcriptome to identify marker genes associated with sleep quality.

关键词： sleep Blood prevalence

Effectiveness of antidepressant repetitive transcranial magnetic stimulation in a patient with refractory psychogenic dysphagia:A case report and review of literature

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World Journal of Clinical Cases 2023年第28期11卷 6850-6856页

作者： Chang Gok Woo Ji hyoun kim jeong Hwan Lee hyo Jong kim Department of Pathology Chungbuk National University HospitalChungbuk National University College of MedicineCheongju 28644South Korea Department of Internal Medicine Chungbuk National University HospitalChungbuk National University College of MedicineCheongju 28644South Korea Department of Psychiatry Chungbuk National University HospitalChungbuk National University College of MedicineCheongju 28644South Korea Department of Rehabilitation Medicine Chungbuk National University HospitalChungbuk National University College of MedicineCheongju 28644South Korea

BACKGROUND Dysphagia is a common condition in older as well as young patients,and a variety of treatments have been reported depending on the ***,clinicians are challenged when the cause is *** is the case with psychogenic dysphagia,which has typically been treated with supportive psychotherapy,medi-cation,swallowing exercise,and dysphagia rehabilitation ***,we aimed to relieve the symptoms of a patient with refractory psychogenic dysphagia,who was unresponsive to conventional swallowing therapy,with repetitive transcranial magnetic stimulation(rTMS).CASE SUMMARY A relatively calm-looking 35-year-old female patient presented with a 2-year history of *** showed little improvement with conventional swallowing treatments over the past 2 *** was relatively compliant with inhospital dysphagia therapy,but uncooperative with home exercise and *** particular,since she was resistant to drug treatment,we had to take a different approach than the treatment she had been receiving for the past 2 *** much deliberation,we decided to initiate antidepressant rTMS treatment with her consent(IRB No.2023-05-021).Antidepressant rTMS treatment was performed twice weekly for a total of 20 sessions over 10 *** results showed improvement in subjective symptoms and video fluoroscopic swallowing study *** the best of our knowledge,this is the first report of symptomatic improvement using antidepressant rTMS protocol for refractory psychogenic *** This case demonstrates that rTMS with antidepressant protocol can be used to improve swallowing in patients with refractory psychogenic dysphagia.

关键词： Deglutition disorder Depression Health Rehabilitation Transcranial magnetic stimulation Case report

Investigation of prodromal features in metabolic syndrome based on transcriptome analysis

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Genes & Diseases 2023年第3期10卷 708-711页

作者： Sang-Min Park Musun Park hyo-jeong Ban Su-Jin Baek Soo Yeon kim Siwoo Lee Hee-jeong Jin Korean Medicine(KM)Data Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea College of Pharmacy Chungnam National UniversityDaejeon 34134Republic of Korea

Metabolic syndrome(MetS)is a complex condition that significantly increases the risk of several diseases,including heart disease and *** with MetS show both pro-inflammatory and pro-thrombotic states;however,the state... 详细信息

关键词： diseases Metabolic Patients