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Plasma Levels of Monocyte Chemotactic Protein 3 and Beta-Nerve Growth Factor Increase with Amnestic Mild Cognitive Impairment

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Cellular & Molecular Immunology 2009年第2期6卷 143-147页

作者： Kang Soo Lee Ji Hyung Chung Kyung hye Lee Min-Jeong shin Byoung Hoon Oh Soo Hyung Lee Chang Hyung Hong Department of Psychiatry Yonsei University College of Medicine Institution of Behavioral Science in Medicine Yonsei University College of Medicine Yonsei University Research Institute of Science for Aging Yonsei University Department of Food and Nutrition College of Health Science Korea University Department of Family Medicine Seoul Medical Center Department of Psychiatry Ajou University School of Medicine Memory Impairment Center Ajou University Hospital Ajou University School of Medicine

A number of studies have investigated peripheral inflammatory indices, including plasma cytokines and related molecules according to subtypes of dementia, but not in mild cognitive impairment （MCI）. In this study, we used multiplex cytokine assay to assess the plasma levels of 22 cytokines in patients with MCI subtyped as amnestic and non-amnestic, according to cognitive features. When comparing the levels of plasma growth factors, chemokines and cytokines, plasma levels of monocyte chemotactic protein 3 （MCP-3）, and beta-nerve growth factor （β-NGF） in these two groups, they were found to be significantly higher in amnestic MCI patients than in non-amnestic MCI patients, after adjusting for age and gender. This suggests that plasma MCP-3 and β-NGF may be useful in differentiating subtypes of MCI.

关键词： mild cognitive impairment cytokine plasma inflammation biomarker

位错环对液氮淬火2524铝合金微观组织与力学性能影响(英文)

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Transactions of Nonferrous Metals Society of China 2024年

作者：余晖田丽平权力伟刘超黄礼新徐玉棱余炜蒋滨安 Kwang-seon shin 河北工业大学材料科学与工程学院天津市材料层状复合与界面控制技术重点实验室广州汇天智能科技有限公司宝玛克(合肥)科技有限公司合肥工业大学材料科学与工程学院中国人民解放军陆军炮兵防空兵学院 Department of Materials Science and Engineering， Seoul National University

利用透射电子显微镜研究了液氮淬火处理2524铝合金的显微组织与力学性能并与冷水淬火合金相对比。结果表明，液氮淬火可有效诱导位错环形成。时效15 min时位错环尺寸较大且分布不均匀，时效1 h时位错环被其上析出的粗化S相钉扎而无法被... 详细信息

利用透射电子显微镜研究了液氮淬火处理2524铝合金的显微组织与力学性能并与冷水淬火合金相对比。结果表明，液氮淬火可有效诱导位错环形成。时效15 min时位错环尺寸较大且分布不均匀，时效1 h时位错环被其上析出的粗化S相钉扎而无法被观察到。与冷水淬火合金相比，液氮淬火合金显微硬度更高且峰时效响应显著加快；短时效后其抗拉强度可达488 MPa。性能改善主要归因于大量弥散分布、尺寸细小的GPB区及位错环上非均质形核S相的共同作用。

关键词： 2524铝合金液氮淬火位错环 GPB区 S相

Fluorescent nanoswitch for monitoring specific pluripotency-related microRNAs of induced pluripotent stem cells： Development of polyethyleneimine- oligonucleotide hybridization probes

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Nano Research 2017年第8期10卷 2545-2559页

作者： Seungmin Han hye Young Son Byunghoon Kang Eunji Jang Jisun Ki Na Geum Lee Jongjin Park Moo-Kwang shin Byeonggeol Mun Jeong-Ki Min Seungjoo Haam Department of Chemical and Biomolecular Engineering College of Engineering Yonsei University Seou1120-749 Republic of Korea Department of Radiology College of Medicine Yonsei University Seou1120-752 Republic of Korea Severance Biomedical Science Institute College of Medicine Yonsei University Seou1120-752 Republic of Korea Biotherapeutics Translational Research Center Korea Research Institute of Bioscience and Biotechnology Daejeon 34141 Republic of Korea Department of Biomolecular Science University of Science & Technology Daejeon 34113 Republic of Korea

The isolation of high-grade （i.e. high-pluripotency） human induced pluripotent stem cells （hiPSCs） is a decisive factor for enhancing the purity of hiPSC populations or differentiation efficiency. A non-invasive imaging system that can monitor microRNA （miRNA） expression provides a useful tool to identify and analyze specific cell populations. However, previous studies on the monitoring/isolation of hiPSCs by miRNA expression have limited hiPSCs＇ differentiation system owing to long-term incubation with miRNA imaging probe-nanocarriers. Therefore, we focused on monitoring high-grade hiPSCs without influencing the pluripotency of hiPSCs. We reduced nanoparticle transfection time, because hiPSCs are prone to spontaneous differentiation under external factors during incubation. The fluorescent nanoswitch （＂ON＂ with target miRNA）, which can be applied for either imaging or sorting specific cells by fluorescence signals, contains an miRNA imaging probe （miP） and a PEI-PEG nanoparticle （miP-P）. Consequently, this nanoswitch can sense various endogenous target miRNAs within 30 min in vitro, and demonstrates strong potential for not only imaging but also sorting pluripotent hiPSCs without affecting pluripotency. Moreover, miP-P-treated hiPSCs differentiate well into endothelial cells, indicating that miP-P does not alter the pluripotency of hiPSCs. We envisage that this miRNA imaging system could be valuable for identifying and sorting high-grade hiPSCs for improved practical applications.

关键词： induced pluripotent stem cells (iPSCs) pluripotency microRNA (miRNA) fluorescence imaging nanoparticle

Comparative assessment of physicochemical properties of unripe peach(Prunus persica) and Japanese apricot(Prunus mume)

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Asian Pacific Journal of Tropical Biomedicine 2014年第2期4卷 97-103页

作者： hye-Ryun Kim II-Doo Kim Sanjeev Kumar Dhungana Mi-Ok Kim Dong-Hyun shin Division of Plant Biosciences.School of Plant Biosciences Kyungpook National UniversityDaegu 702-701.Korea Institute of Agricultural Science and Technology Kyungpook national universityDaegu 702-701.Korea Department of Hotel Restaurant.Culinary ArtsDaegu Health CollageDaegu 702-722.Korea

Objective:To investigate the physicochemical properties of unripe peach-Pruuns persica ***(Mibaekdo) and Prunus persica *** Hakuho(Nagasawa Hakuho) as an alternative to fowl supplement while Japanese apricot(Prunus mume ***)(Backaha) was used as a control ***:The unripe fruits were analyzed for soluble solid(Brix).titratable ***,total polyphenol content,1,1-diphenyl-2-pierylhydrazyl(DPPH) radical scavenging activity,amygdalin content,free amino acid content,organic acid content,free sugar content,and α-amylase ***:Total polyphenol content of unripe peach ranged between 137.27-151.64 μg/g whereas that of apricot was 160.73 μg/*** radical scavenging activities of Rackaha was the highest189.16%.) followed by Mibaekdo(85.03%) and Nagasawa Hakuho(41.30%).The highest amount of oxalic acid 1612.8 mg/100 g) was observed in Mibaekdo while that of Nagasawa llakuho and Backaha were(184.6±18.1) and(334.8±16.1) mg/100 g,*** contents of *** Hakuho and Backaha were 486.61,548.60 and 174.28 μg/g,***:The results suggest that the unripe fruit of peach has a significant biochemical potential of using as a food supplement with potential health benefit for human health.

关键词： Amygdalin Japanese apricot(Backaha) Physicochemical properties Unripe peach(Mibaekdo Nagasawa Hakuho)

A General Synthesis Method for Covalent Organic Framework and Inorganic 2D Materials Hybrids

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Precision Chemistry 2024年第8期2卷 398-405页

作者： Yifan Zhu Yunrui Yan Yuren Feng Yifeng Liu Chen-Yang Lin Qing Ai Tianshu Zhai Bongki shin Rui Xu Hongchen Shen Qiyi Fang Xiang Zhang Dayanni Bhagwandin Yimo Han Hanyu Zhu Nicholas R.Glavin Pulickel M Ajayan Qilin Li Jun Lou Department of Materials Science and Nanoengineering Rice UniversityHoustonTexas 77005United States Department of Civil and Environmental Engineering Rice UniversityHoustonTexas 77005United States NSF Nanosystems Engineering Research Center Nanotechnology-Enabled Water Treatment Rice UniversityHoustonTexas 77005United States UES Inc.BeavercreekOhio 45432United States Materials and Manufacturing Directorate Air Force Research LaboratoryWright-Patterson AFBOhio 45433United States Department of Chemistry Rice UniversityHoustonTexas 77005United States

Two-dimensional(2D)inorganic/organic hybrids provide a versatile platform for diverse applications,including electronic,catalysis,and energy storage *** recent surge in 2D covalent organic frameworks(COFs)has introduced an organic counterpart for the development of advanced 2D organic/inorganic hybrids with improved electronic coupling,charge separation,and carrier ***,existing synthesis methods have primarily focused on few-layered film structures,which limits scalability for practical ***,we present a general synthesis approach for a range of COF/inorganic 2D material hybrids,utilizing 2D inorganic materials as both catalysts and inorganic building *** leveraging the intrinsic Lewis acid sites on the inorganic 2D materials such as hexagonal boron nitride(hBN)and transition metal dichalcogenides,COFs with diverse functional groups and topologies can grow on the surface of inorganic 2D *** controlled 2D morphology and excellent solution dispersibility of the resulting hybrids allow for easy processing into films through vacuum *** proof of concept,hBN/COF films were employed as filters for Rhodamine 6G removal under flow-through conditions,achieving a removal rate exceeding 93%.The present work provides a simple and versatile synthesis method for the scalable fabrication of COF/inorganic 2D hybrids,offering exciting opportunities for practical applications such as water treatment and energy storage.

关键词： Covalent organic frameworks Transition-metal dichalcogenides Lewis acid catalysts Hexagonal boron nitride Hybrid Materials

Characteristics of High Speed Electro-thermal Jet Activated by Pulsed DC Discharge

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Chinese Journal of Aeronautics 2010年第5期23卷 518-522页

作者： Jichul shin Department of Aerospace Engineering University of Ulsan

Experimental study of synthetic jet produced by pulsed direct current （DC） discharge is presented. High velocity jet is acti- vated electro-thermally by high frequency pulsed DC discharge in small cavity. A cavity of 2.38 mm diameter cylinder bounded by circular electrode is made in a ceramic plate and a small orifice of 1.78 mm diameter is drilled in the middle of cavity. High frequency pulsed DC discharge instantaneously heats air in the cavity and produces high velocity jet at the exit of the orifice. Schlieren imaging at high framing rate of 100 kHz reveals the presence of supersonic precursor shock followed by the jet emerg- ing from the orifice. The jet velocity reaches as high as about 300 m/s. Jet with smaller cavity volume produces lesser effect and jet velocity reaches maximum at certain cavity volume with given discharge current and orifice size. As duty time of pulse increases from 5 to 20 μs at fixed frequency of 5 kHz, the jet velocity also increases and becomes nearly constant with further increase in duty time. At fixed duty time of 20 μs, higher frequency pulsing of 10 kHz produces degradation of the jet as the discharge pulse continues. The jet developed in this study is demonstrated to be strong enough to penetrate deep into supersonic boundary layer and to produce a bow shock when the jet is issued into Mach 3 supersonic flow.

关键词： synthetic jet pulsed DC plasma supersonic flow actuation

Delivery of nitric oxide-releasing silica nanoparticles for in vivo revascularization and functional recovery after acute peripheral nerve crush injury

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Neural Regeneration Research 2022年第9期17卷 2043-2049页

作者： Jung Il Lee Ji Hun Park Yeong-rim Kim Kihak Gwon Hae Won Hwang Gayoung Jung Joo-Yup Lee Jeong-Yun Sun Jong Woong Park Jae Ho shin Myoung-Ryul Ok Department of Orthopedic Surgery College of MedicineKorea UniversitySeoulRepublic of Korea Medical Sensor Biomaterial Research Institute Kwangwoon UniversitySeoulRepublic of Korea Center for Biomaterials Korea Institute of Science&TechnologySeoulRepublic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoulRepublic of Korea Department of Orthopedic Surgery College of MedicineCatholic UniversitySeoulRepublic of Korea Department of Chemistry Kwangwoon UniversitySeoulRepublic of Korea

Nitric oxide(NO)has been shown to promote revascularization and nerve regeneration after peripheral nerve ***,in vivo application of NO remains challenging due to the lack of stable carrier materials capable of storing large amounts of NO molecules and releasing them on a clinically meaningful time ***,a silica nanoparticle system capable of reversible NO storage and release at a controlled and sustained rate was *** this study,NO-releasing silica nanoparticles(NO-SNs)were delivered to the peripheral nerves in rats after acute crush injury,mixed with natural hydrogel,to ensure the effective application of NO to the *** using a polymer dye and immunohistochemical staining for the detection of CD34(a marker for revascularization)results showed that NO-releasing silica nanoparticles increased revascularization at the crush site of the sciatic *** sciatic functional index revealed that there was a significant improvement in sciatic nerve function in NO-treated *** and anatomical analyses showed that the number of myelinated axons in the crushed sciatic nerve and wet muscle weight excised from NO-treated rats were ***,muscle function recovery was improved in rats treated with *** together,our results suggest that NO delivered to the injured sciatic nerve triggers enhanced revascularization at the lesion in the early phase after crushing injury,thereby promoting axonal regeneration and improving functional recovery.

关键词： crush injury nerve injury,nerve regeneration nitric oxide peripheral nerve revascularization silica nanoparticles

T cell epitopes in SARS-CoV-2 proteins are substantially conserved in the Omicron variant

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Cellular & Molecular Immunology 2022年第3期19卷 447-448页

作者： Seong Jin Choi Dong-Uk Kim Ji Yun Noh Sangwoo Kim Su-Hyung Park hye Won Jeong Eui-Cheol shin Division of Infectious Disease Department of Internal MedicineSeoul National University HospitalSeoulRepublic of Korea Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)DaejeonRepublic of Korea Division of Infectious Diseases Department of Internal MedicineKorea University College of MedicineSeoulRepublic of Korea Department of Biomedical Systems Informatics Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulRepublic of Korea Department of Internal Medicine Chungbuk National University College of MedicineCheongjuRepublic of Korea The Center for Viral Immunology Korea Virus Research InstituteInstitute for Basic Science(IBS)DaejeonRepublic of Korea

In November 2021,the Omicron variant(B.1.1.529)emerged and was designated a variant of concern(VOC)by the World Health ***,Omicron was reported to extensively escape neutralizing antibodies elicited by COVID-19 vaccination or natural infection[1,2,3].However,whether Omicron evades the T cell immunity elicited by COVID-19 vaccination or natural infection remains to be *** address this issue,we analyzed the amino acid sequences of T cell epitopes identified from the original SARS-CoV-2 strain(Wuhan-Hu-1)in the Omicron variant(hCoV-19/South Africa/CERI-KRISP-K032284/2021).

关键词： neutral conserved elucidated

Facial Expression Recognition of Various Internal States via Manifold Learning

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Journal of Computer Science & Technology 2009年第4期24卷 745-752页

作者： Young-Suk shin IEEE Department of Information and Communication Engineering Chosun University

Emotions are becoming increasingly important in human-centered interaction architectures. Recognition of facial expressions, which are central to human-computer interactions, seems natural and desirable. However, facial expressions include mixed emotions, continuous rather than discrete, which vary from moment to moment. This paper represents a novel method of recognizing facial expressions of various internal states via manifold learning, to achieve the aim of humancentered interaction studies. A critical review of widely used emotion models is described, then, facial expression features of various internal states via the locally linear embedding （LLE） are extracted. The recognition of facial expressions is created with the pleasure-displeasure and arousal-sleep dimensions in a two-dimensional model of emotion. The recognition result of various internal state expressions that mapped to the embedding space via the LLE algorithm can effectively represent the structural nature of the two-dimensional model of emotion. Therefore our research has established that the relationship between facial expressions of various internal states can be elaborated in the two-dimensional model of emotion, via the locally linear embedding algorithm.

关键词： manifold learning locally linear embedding dimension model pleasure-displeasure dimension arousal-sleep dimension