检索结果-南通市图书馆

维普期刊数据库

A low-swelling hydrogel as a multirole sealant for efficient dural defect sealing and prevention of postoperative adhesion

在线全文

学校读者我要写书评

暂无评论

National Science Review 2024年第06期 294-307页

作者： Xueliang Cheng Zhen Zhang Hui Ren Zheng Zou yu Zhang Yang Qu Xuesi Chen Jianwu Zhao Chaoliang He CAS Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences Department of Orthopedics The Second Norman Bethune Hospital of Jilin University School of Applied Chemistry and Engineering University of Science and Technology of China

Dural defects and subsequent complications, including cerebrospinal fluid（CSF） leakage, are common in both spine surgery and neurosurgery, and existing clinical treatments are still unsatisfactory. In this study, a tissue-adhesive and low-swelling hydrogel sealant comprising gelatin and o-phthalaldehyde（OPA）-terminated 4-armed poly（ethylene glycol）(4aPEG-OPA) is developed via the OPA/amine condensation reaction. The hydrogel shows an adhesive strength of 79.9 ± 12.0 k Pa on porcine casing and a burst pressure of 208.0 ± 38.0 cm H2O. The hydrogel exhibits a low swelling ratio at physiological conditions, avoiding nerve compression in the limited spinal and intracranial spaces. In rat and rabbit models of lumbar and cerebral dural defects, the 4aPEG-OPA/gelatin hydrogel achieves excellent performance in dural defect sealing and preventing CSF leakage. Moreover, local inflammation, epidural fibrosis and postoperative adhesion in the defect areas are markedly reduced. Thus, these findings establish the strong potential of the hydrogel sealant for the effective watertight closure of dural defects.

关键词：

Enteromorpha prolifera polysaccharide-Fe(Ⅲ) complex promotes intestinal development as a new iron supplement

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Life Sciences 2024年

作者： Yingying Feng yuying Wu Jialu Wang Zhenglin Dong Qian yu Shuangshuang Xia Chunxue Liu Haihua Wang Xin Wu Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences CAS Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical Agriculture Chinese Academy of Sciences ANYOU Biotechnology Group Co.Ltd Qingdao Seawin Biotech Group Co. Ltd

Iron is a crucial micronutrient, and its deficiency can have detrimental effects on the health of infants. Dietary polysaccharide-iron(Ⅲ) complexes(PICs) are promising for addressing iron deficiency due to their minimal adverse reactions and high iron absorption rate. This study aimed to investigate the effects of dietary Enteromorpha prolifera polysaccharide-Fe(Ⅲ) complex(EP-Fe) on newborns, using 3-day weaned piglets as the iron-deficiency model. Results showed that EP-Fe improved iron levels and promoted intestinal development in piglets. Transcriptome sequencing revealed that EP-Fe increased the survival of intestinal epithelial cells under hypoxia by upregulating the expression of genes that promote the development of the vascular system. Additionally, EP-Fe enhanced the mucosal barrier functions by inhibiting myosin light chain kinase(MLCK)/phosphorylated myosin light chain(p-MLC)signaling pathway to increase the expression of intestinal tight junction proteins. Furthermore, the 16S rRNA gene sequencing of gut microbiota showed that EP-Fe promoted the enrichment of Bacteroides＿fragilis and other gut microbes that can metabolize carbohydrates. In conclusion, EP-Fe is an effective iron supplement for newborns, and it can be developed as a comprehensive nutritional supplement.

关键词：

Embryo Transfer Strategies for Women with Recurrent Implantation Failure During the Frozen-thawed Embryo Transfer Cycles:Sequential Embryo Transfer or Double-blastocyst Transfer?

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Current Medical Science 2024年第1期44卷 212-222页

作者： Qiao-hang ZHAO yu-wei SONG Jian CHEN Xiang ZHOU Ji-lai XIE Qiu-ping YAO Qi-yin DONG Chun FENG Li-ming ZHOU Wei-ping FU Min JIN The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou 310052China Jiaxing Maternity and Child Health Care Hospital Jiaxing 314051China Huzhou Maternity and Child Care Hospital Huzhou 313002China Ningbo Women and Children's Hospital Ningbo 315000China

Objective Both sequential embryo transfer(SeET)and double-blastocyst transfer(DBT)can serve as embryo transfer strategies for women with recurrent implantation failure(RIF).This study aims to compare the effects of SeET and DBT on pregnancy *** Totally,261 frozen-thawed embryo transfer cycles of 243 RIF women were included in this multicenter retrospective *** to different embryo quality and transfer strategies,they were divided into four groups:group A,good-quality SeET(GQ-SeET,n=38 cycles);group B,poor-quality or mixed-quality SeET(PQ/MQ-SeET,n=31 cycles);group C,good-quality DBT(GQ-DBT,n=121 cycles);and group D,poor-quality or mixed-quality DBT(PQ/MQ-DBT,n=71 cycles).The main outcome,clinical pregnancy rate,was compared,and the generalized estimating equation(GEE)model was used to correct potential confounders that might impact pregnancy *** GQ-DBT achieved a significantly higher clinical pregnancy rate(aOR 2.588,95%CI 1.267–5.284,P=0.009)and live birth rate(aOR 3.082,95%CI 1.482–6.412,P=0.003)than PQ/***,the clinical pregnancy rate was significantly higher in GQ-SeET than in PQ/MQ-SeET(aOR 4.047,95%CI 1.218–13.450,P=0.023).The pregnancy outcomes of GQ-SeET were not significantly different from those of GQ-DBT,and the same results were found between PQ/MQ-SeET and PQ/*** SeET relative to DBT did not seem to improve pregnancy outcomes for RIF patients if the embryo quality was comparable between the two *** clinical pregnancy outcomes could be obtained by transferring good-quality embryos,no matter whether in SeET or *** quality plays a more important role in pregnancy outcomes for RIF patients.

关键词： recurrent implantation failure sequential embryo transfer frozen-thawed embryo transfer embryo transfer strategies

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

奇经跷脉名实考辨

北京中医药大学学报 2024年第5期47卷 625-632页

作者：余君豪贺娟北京中医药大学北京100029

跷脉,古作“蹻脉”,属奇经八脉,因其相关理论处于经络学术研究的边缘地位,故学术价值和应用价值没有得到足够的关注和重视。本文基于《黄帝内经》相关理论,结合先秦出土文献及《黄帝内经》经脉理论体系中体现的各类医学流派的思想交融状... 详细信息

跷脉,古作“蹻脉”,属奇经八脉,因其相关理论处于经络学术研究的边缘地位,故学术价值和应用价值没有得到足够的关注和重视。本文基于《黄帝内经》相关理论,结合先秦出土文献及《黄帝内经》经脉理论体系中体现的各类医学流派的思想交融状态,考蹻脉名实。本团队认为,蹻脉的形成是中原医学长期探索运用导引按蹻术的结果,与导引按蹻术从“病筋调筋”到“由筋引气”的实践发展和临床思维相吻合。蹻脉之名应源于按蹻术之手足四肢抚按、伸展、抬举等各类肢体动作的含义,蹻脉原始的生理功能在于主导人体运动,生理层次应定位于人体之筋。而在《黄帝内经》时期的经脉理论与脏腑医学交融后,蹻脉与足太阳膀胱经、足少阴肾经不断交叉、混淆,蹻脉的定位和功能日渐模糊,这种认知混乱是蹻脉理论发展与应用长期受滞的根本原因,也提示《黄帝内经》理论研究应对先秦各种医学理论体系进行充分甄别、剖析和还原,以正本清源不同来源的理论。

关键词：蹻脉奇经黄帝内经导引按蹻筋

维普期刊数据库

Co-assembly of chiral copper(I) complexes and achiral polymer for enhanced circularly polarized luminescence

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年

作者： Ting Liu Muxin yu Yangxingyu Ye yunfang Zhao Zhijia Li Zhiyuan Wu Feilong Jiang Lian Chen Maochun Hong State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences (CAS) University of Chinese Academy of Sciences Organic Optoelectronics Engineering Research Center of Fujian's Universities College of Electronics and Information ScienceFujian Jiangxia University

Circularly polarized luminescence（CPL） has attracted growing attention for their promising applications in chiral functional devices. Achieving CPL materials with both high luminescence dissymmetry factors(glum) and emission efficiency is attractive but remains great challenges. In this study, a pair of chiral Cu（I） complexes named R/S-CuI with C2symmetry were synthesized,exhibiting no emission in solution and weak CPL with glum= ± 3.3×10-3in crystalline state. Transparent chiral films（R/S-CuIfilm） were developed through the co-assembly of R/S-CuI and achiral polymer PMMA. The films show bright green luminescence with the quantum yields about 200 times higher than those in crystalline state. Meanwhile, the maximum |glum| value is also amplified by approximately 2.5 times, reaching to 8.7×10-3. Mechanism investigation suggests that the notable enhancement of luminescence efficiency can be ascribed to the restriction of the intramolecular motions and the elimination of the oxygen quenching effect, while the improvement in glumvalues may be explained by the chirality transfer from the axially chiral molecule R/S-CuI to the achiral polymer PMMA. Furthermore, R/S-CuI-film were used for advanced information encryption applications based on its CPL characteristics. This work may provide new inspirations for the construction of CPL-active films with high performance, thereby expediting their further development.

关键词：

Exercise promotes osteogenic differentiation by activating the long non-coding RNA H19/microRNA-149 axis

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2024年第4期15卷 363-378页

作者： Xu-Chang Zhou Dong-Xue Wang Chun-yu Zhang Ya-Jing Yang Ruo-Bing Zhao Sheng-Yao Liu Guo-Xin Ni School of Sport Medicine and Rehabilitation Beijing Sport UniversityBeijing 100084China Department of Acupuncture and Moxibustion Hubei University of Chinese MedicineWuhan 430065Hubei ProvinceChina Department of Spinal Surgery The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510260Guangdong ProvinceChina Department of Rehabilitation Medicine The First Affiliated Hospital of Xiamen UniversityXiamen 361003Fujian ProvinceChina

BACKGROUND Regular physical activity during childhood and adolescence is beneficial to bone development,as evidenced by the ability to increase bone density and peak bone mass by promoting bone *** To investigate the effects of exercise on bone formation in growing mice and to investigate the underlying *** 20 growing mice were randomly divided into two groups:Con group(control group,n=10)and Ex group(treadmill exercise group,n=10).Hematoxylin-eosin staining,immunohistochemistry,and micro-CT scanning were used to assess the bone formation-related indexes of the mouse *** analysis was used to find potential miRNAs targets of long non-coding RNA H19(lncRNA H19).RT-qPCR and Western Blot were used to confirm potential miRNA target genes of lncRNA H19 and the role of lncRNA H19 in promoting osteogenic *** Compared with the Con group,the expression of bone morphogenetic protein 2 was also significantly *** micro-CT results showed that 8 wk moderate-intensity treadmill exercise significantly increased bone mineral density,bone volume fraction,and the number of trabeculae,and decreased trabecular segregation in the femur of *** of lncRNA H19 significantly upregulated the expression of miR-149 and suppressed the expression of markers of osteogenic *** addition,knockdown of lncRNA H19 significantly downregulated the expression of autophagy markers,which is consistent with the results of autophagy-related protein changes detected in mouse femurs by *** Appropriate treadmill exercise can effectively stimulate bone formation and promote the increase of bone density and bone volume in growing mice,thus enhancing the peak bone mass of *** lncRNA H19/miR-149 axis plays an important regulatory role in osteogenic differentiation.

关键词： Exercise Osteogenic differentiation Bone formation Bone mesenchymal stem cells Autophagy

Color center-rich γ-AlOpromotes propane dehydrogenation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2024年

作者： yu Wang Xiang Wang Mengfei Qiao Qingyuan Wu Kunlong Liu Xiaodong Yi Ruixuan Qin Gang Fu Nanfeng Zheng State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materialsand Department of Chemistry College of Chemistry and Chemical Engineering Xiamen University Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Material SciencesZhejiang Normal University Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM)

The PtSn/Al2O3catalyst is commonly used in commercial propane dehydrogenation （PDH） processes,but it faces challenges in the deactivation and periodic regeneration due to metal aggregation and coke deposition at high *** Al3+pentahas been proven to be beneficial for enhancing catalytic stability,bottom-up synthesis protocols usually restrict their ***,a facile post-treatment approach using acetic acid was applied to create color centers （electrons trapped within oxygen vacancies） on γ-Al3+***,the content of Alpentawas enriched to 18.3%.Then,the pre-established PtSn clusters were *** electrons facilitated the formation of ultrafine PtSn nanoparticles （～2 nm）,and the Al3+pentasites prevented the sintering of PtSn by constructing the strong Al3+penta–O–Sn ***,the catalytic durability of the catalyst prepared by conventional impregnation methods was remarkably extended from 186 h for the color center-free sample to 1,000 h using the HAc–*** facile post-modification was further successfully extended to commercial Al2O3pellets without altering their mechanical properties,highlighting its potential in industrial applications.

关键词：

Highly efficient nitrogen fixation over S-scheme heterojunction photocatalysts with enhanced active hydrogen supply

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2024年第05期 315-325页

作者： Tong Bao Yamin Xi Chaoqi Zhang Peiyang Du Yitong Xiang Jiaxin Li Ling yuan Chengzhong yu Chao Liu School of Chemistry and Molecular Engineering East China Normal University Australian Institute for Bioengineering and Nanotechnology The University of Queensland

Photocatalytic N2fixation is a promising strategy for ammonia（NH3） synthesis;however,it suffers from relatively low ammonia yield due to the difficulty in the design of photocatalysts with both high charge transfer efficiency and desirable N2adsorption/activation ***,an S-scheme CoSx/ZnS heterojunction with dual active sites is designed as an efficient N2fixation *** CoSx/ZnS heterojunction exhibits a unique pocket-like nanostructure with small ZnS nanocrystals adhered on a single-hole CoSxhollow *** the heterojunction,the ele ctronic interaction between ZnS and CoSxcreates electron-deficient Zn sites with enhanced N2chemisorption and electron-sufficient Co sites with active hydrogen supply for N2hydrogenation,cooperatively reducing the energy barrier for *** combination with the promoted photogenerated electron-hole separation of the S-scheme heterojunction and facilitated mass transfer by the pocket-like nanostructure,an excellent N2fixation performance with a high NH3yield of 1175.37 μmol g-1h-1is *** study provides new insights into the design of hetero junction photocatalysts for N2fixation.

关键词：

TL1A Promotes Fibrogenesis in Colonic Fibroblasts via the TGF-β1/Smad3 Signaling Pathway

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Current Medical Science 2024年第3期44卷 519-528页

作者： Jia SONG Dong-lei SUN Chen-yang LI yu-xin LUO Qian LIU yue YAO Hong ZHANG Ting-ting YANG Mei SONG Xin-li BAI Xiao-lan ZHANG Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesShijiazhuang050000China Department of Pediatrics The Second Hospital of Hebei Medical UniversityShijiazhuang050000China

Objective Intestinal fibrosis is a refractory complication of inflammatory bowel disease(IBD).Tumor necrosis factor ligand-related molecule-1A(TL1A)is important for IBD-related intestinal fibrosis in a dextran sodium sulfate(DSS)-induced experimental colitis *** study aimed to explore the effects of TL1A on human colonic *** A trinitrobenzene sulfonic acid(TNBS)-induced experimental colitis model of LCK-CD2-TL1A-GFP transgenic(Tg)or wild-type(WT)mice was established to determine the effect and mechanism of TL1A on intestinal *** human colonic fibroblast CCD-18Co cell line was treated concurrently with TL1A and human peripheral blood mononuclear cell(PBMC)*** proliferation and activation of CCD-18Co cells were detected by BrdU assays,flow cytometry,immunocytochemistry and Western *** metabolism was tested by Western blotting and real-time quantitative polymerase chain reaction(RT-qPCR).Results The level of collagen metabolism in the TNBS+ethyl alcohol(EtOH)/Tg group was greater than that in the TNBS+EtOH/WT *** growth factor-β1(TGF-β1)and p-Smad3 in the TNBS+EtOH/Tg group were upregulated as compared with those in the TNBS+EtOH/WT *** proliferation of CCD-18Co cells was promoted by the addition of human PBMC supernatant supplemented with 20 ng/mL TL1A,and the addition of human PBMC supernatant and TL1A increased CCD-18Co proliferation by 24.4%at 24 ***1A promoted cell activation and increased the levels of COL1A2,COL3A1,and TIMP-1 in CCD-18Co *** of CCD-18Co cells with TL1A increased the expression of TGF-β1 and *** TL1A promotes TGF-β1-mediated intestinal fibroblast activation,proliferation,and collagen deposition and is likely related to an increase in the TGF-β1/Smad3 signaling pathway.

关键词： tumor necrosis factor ligand-related molecule-1A fibrosis inflammatory bowel disease myofibroblasts transforming growth factor-β1