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Icariin on relaxation effect of corpus cavernosum smooth muscle

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Chinese Science Bulletin 2001年第14期46卷 1186-1191页

作者： XIN Zhongcheng kim Euikyung TIAN Zhenji LIN Guiting QUO Yinglu Department of Urology The First HospitalPeking UniversityBeijing100034China Department of Life Science Pohang University of Science and TechnologyPohangKorea

NO-cGMP pathway in penile corpus cavernosal smooth muscle plays an important role in penile erection. The level of cGMP is regulated by a balance between the rate of synthesis by guanylate cyclase and the rate of hydrolytic breakdown to guanosine 5’ monophosphate (GMP) by phos-phodiesterase 5(PDE5). Icariin is isolated from natural drug Epimedii herba, it is shown to have the relaxation effect on corpus cavernosal smooth muscle of rabbit (IC50: 4×10-4 mol/L), and the mechanism of the relaxation effect of Icariin on corpus cavernosum believed to have the inhibiting effect on PDE5 and activation of NO-cGMP pathway to enhancing penile erection.

关键词： Icariin corpus cavernosm cGMP erection.

Chungtaejeon, a Korean fermented tea, prevents the risk of atherosclerosis in rats fed a high-fat atherogenic diet

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Journal of Integrative Medicine 2016年第2期14卷 134-142页

作者： Keshav Raj Paudel Ung-Won Lee Dong-Wook kim Department of Oriental Medicine Resources Mokpo National University Department of Physics Mokpo National University

OBJECTIVE： Hypercholesterolemia is one of the well-established risk factors for cardiovascular mortality and morbidity in coronary heart disease. The aim of this study was to investigate the anti-atherogenic effect of Chungtaejeon（CTJ, a Korean fermented tea） aqueous extract on proliferation and migration of human aortic smooth muscle cells（HASMCs） in vivo and in ***： The authors used high-fat atherogenic diet（HFAD） to induce hyperlipidemia in Wistar rats in in vivo animal experiments and used HASMCs for in vitro cell experiments. For the in vitro cell experiment, the proliferation of HASMCs was evaluated using the MTT assay. Similarly, the expression of matrix metalloproteinases（MMPs） in HASMCs was measured using gelatin zymography. Antimigratory activity of CTJ was revealed using the wound-healing model and Boyden＇s chamber assay. In the in vivo experiment, CTJ was administered in three different doses for 20 d from the initiation of the HFAD. After 20 d, the serum lipid profile and total lipid contents in liver were ***： Treatment with CTJ for 24 h dose-dependently inhibited the proliferation and migration of HASMCs and expression of MMP-2 in HASMCs. The oral administration of CTJ at concentrations of 200 and 400 mg/kg decreased the levels of low-density lipoprotein cholesterol, total serum cholesterol and hepatic cholesterol of HFAD-fed ***： CTJ possessed strong antiproliferative, antimigratory, as well as lipid-lowering activities. Thus, CTJ can be considered as a therapeutic option in the treatment of high-fat diet-induced atherosclerosis.

关键词： hypercholesterolemia atherosclerosis Chungtaejeon proliferation migration

Telomerase turns telomere dysfunction from bad to worse

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Asian Journal of Andrology 2012年第5期14卷 665-666页

作者： Sahn-Ho kim Evelyn R Barrack G Prem Veer Reddy Vattikuti Urology Institute Henry Ford HospitalDetroitMI 48202USA

Telomere integrity is critical for proli- feration and survival of cells. Telomere dysfunction, often resulting from telomere attrition, causes genomic instability leading to cell death or malignant transformation. Telomerase is essential for maintaining te- lomere length and to immortalize cancer cells. While telomere shortening is evident in early stages of prostate cancer,

关键词： CANCER TRF2

New hope for hepatitis C virus:Summary of global epidemiologic changes and novel innovations over 20 years

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World Journal of Gastroenterology 2021年第29期27卷 4818-4830页

作者： Brittany B Dennis Leen Naji Yasmin Jajarmi Aijaz Ahmed Donghee kim Department of Medicine McMaster UniversityHamilton L8S 4L8ONCanada Division of Gastroenterology and Hepatology Stanford University School of MedicineStanfordCA 94304United States Department of Family Medicine McMaster UniversityHamilton L8P 1H6ONCanada Department of Health Research Methods Evidence and ImpactMcMaster UniversityHamilton L8S 4K1ONCanada

Hepatitis C virus(HCV)is a global health concern associated with significant morbidity and *** the approval of second-generation direct-acting antiviral agents(DAAs),interferon therapy and liver transplantation constituted the mainstay of *** introduction of well-tolerated oral DAAs in late 2013 has revolutionized HCV management with over 95%cure *** predominance of HCV-related liver transplantations has declined following the widespread approval of *** the unparallel efficacy observed among these novel therapies,pharmaceutical costs continue to limit equitable access to healthcare and likely contribute to the differential HCV infection rates observed *** reduce the burden of disease worldwide,essential agenda items for all countries must include the prioritization of integrated care models and access to DAAs *** transparent negotiations with the pharmaceutical industry,the consideration for compassionate release of medications to promote equitable division of care is *** we provide a literature review of HCV,changes in epidemiologic trends,access issues for current therapies,and global inequities in disease burden.

关键词： Hepatitis C virus Direct-acting antivirals Global health Liver transplantation People who inject drugs Liver cirrhosis

Foreign institutional investors and stock return comovement

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Frontiers of Business Research in China 2018年第3期12卷 203-233页

作者： Li Jiang Jeong-Bon kim Lei Pang School of Accounting and Finance Hong Kong Polytechnic University Hong Kong China Department of Accountancy City University of Hong Kong Hong Kong China Hang Seng Investment Management Hong Kong China

We investigate whether foreign institutional investors facilitate firm-specific information flow in the global market. Specifically, using annual institutional ownership data from firms across 40 countries, we find that foreign institutional ownership is negatively associated with excess stock return comovement. Our results are more pronounced when foreign institutional investors originate from common-law countries and hold a large equity stake in invested firms; and when the invested firms are located in civil-law countries. Overall, the evidence suggests that foreign institutional investors from countries with strong investor protection play an important informational role in mitigating excess stock return comovement around the world.

关键词： Foreign institutional investors Stock return comovement Firm-specificinformation Investor protection

Cellular Localization of Rice SUMO/SUMO Conjugates and in vitro Sumoylation Using Rice Components

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Rice science 2020年第1期27卷 1-4页

作者： Joungsu JOO Dong Hee CHOI Sang Hyon kim Sang Ik SONG Department of Bioscience and Bioinformatics Myongji University

Many proteins are regulated by post-translational modifications,such as the reversible covalent attachment of ubiquitin and ubiquitin-like proteins in eukaryotes(Kerscher et al, 2006). Post-translational modification of proteins by the SUMO protein family is involved in diverse cellular processes, including development, hormonal responses, and biotic and abiotic stress signaling(Park et al, 2011). SUMO modification can modulate protein-protein interactions, intracellular localization or the activities of the protein(Gareau and Lima, 2010).

关键词： SUMO modification translational

Red cell distribution width/albumin ratio and 90-day mortality after burn surgery

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Burns & Trauma 2022年第1期10卷 768-777页

作者： Young Joo Seo Jihion Yu Jun-Young Park Narea Lee Jiwoong Lee Ji Hyun Park Hee Yeong kim Yu-Gyeong Kong Young-Kug kim Department of Anesthesiology and Pain Medicine Hangang Sacred Heart HospitalHallym University College of MedicineSeoul 07247Republic of Korea Department of Anesthesiology and Pain Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea Department of Anesthesiology and Pain Medicine National Medical CenterSeoul 04564Republic of Korea Department of Anesthesiology and Pain Medicine CHA Gangnam Medical CenterCHA University School of MedicineSeoul 06135Republic of Korea

Background:Red cell distribution width(RDW)and serum albumin concentration are associated with postoperative ***,the usefulness of the RDW/albumin ratio in burn surgery remains ***,we evaluated the association between RDW/albumin ratio and 90-day mortality after burn ***:Between 2013 and 2020,a retrospective review of patients in a burn intensive care unit(ICU)was *** operating characteristic curve,multivariate Cox logistic regression,multivariate logistic regression and Kaplan-Meier analyses were conducted to evaluate the associ-ation between RDW/albumin ratio and 90-day mortality after burn ***,prolonged ICU stay rate(>60 days)and ICU stay were ***:Ninety-day mortality was 22.5%(210/934)in burn *** factors for 90-day mortality were RDW/albumin ratio at postoperative day 1,age,American Society of Anesthesiologists physical status,diabetes mellitus,inhalation injury,total body surface area burned,hypotensive event and red blood cell transfusion *** area under the curve of the RDW/albumin ratio at postoperative day 1 to predict 90-day mortality,after adjusting for age and total body surface area burned,was 0.875(cut-off value,6.8).The 90-day mortality was significantly higher in patients with RDW/albumin ratio>6.8 than in those with RDW/albumin ratio≤6.8(49.2%vs 12.3%,p6.8 than in those with RDW/albumin ratio≤6.8(34.5%vs 26.5%;21[11-38]vs 18[7-32]days).Conclusion:RDW/albumin ratio>6.8 on postoperative day 1 was associated with higher 90-day mortality,higher prolonged ICU stay rate and longer ICU stay after burn surgery.

关键词： Red cell distribution width Albumin ratio Mortality Mortality Burn Risk factor Surgery

Tenofovir *** in reducing hepatocellular carcinoma risk in patients with chronic HBV infection?-Still an unsolved question

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Hepatobiliary Surgery and Nutrition 2021年第1期10卷 119-122页

作者： Hyun-Seok kim Hashem B.El-Serag Section of Gastroenterology and Hepatology Baylor College of MedicineHoustonTXUSA U.S.Michael E.DeBakey Veterans Affairs Medical Center HoustonTXUSA

Chronic hepatitis B virus(CHB)infection affects approximately 250 million persons worldwide(1).CHB is a major risk factor for liver failure,cirrhosis,and hepatocellular carcinoma(HCC),accounting for 45-55%of HCC cases(1).The incidence rates of HCC among CHB patients are 0.02-0.2 per 100 person-years in inactive carriers,0.3-0.6 per 100 person-years in those without cirrhosis,and 2.2-3.7 per 100 person-years for those with compensated cirrhosis(2).

关键词： patients hepatocellular infection

A critical regulation of Th2 cell responses by RORa in allergic asthma

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Science China(Life Sciences) 2021年第8期64卷 1326-1335页

作者： Jeong-Eun Lee Garam Cho Minkyoung Cho Daehong kim Mi-Ock Lee Yeonseok Chung Laboratory of Immune Regulation Research Institute of Pharmaceutical SciencesCollege of PharmacySeoul National UniversitySeoul 08826Republic of Korea BK21 Plus Program College of PharmacySeoul National UniversitySeoul 08826Republic of Korea

Allergic asthma is a chronic inflammatory disease of the lung and the airway,which is characterized by aberrant type 2 immune responses to otherwise unharmful *** the central role of Th2 cells and type 2 cytokines in the pathogenesis of allergic asthma is well documented,the regulation and plasticity of Th2 cells remain incompletely *** using an animal model of allergic asthma in IL-4-reporter mice,we found that Th2 cells in the lung expressed higher levels of Rora than those in the lymph nodes,and that treatment with an RORa agonist SRI 078 resulted in diminished Th2 cell responses in *** determine the T cell-intrinsic role of RORa in allergic asthma in vivo,we established T cell-specific RORa-deficient^(f/f)fyf(Cd4creRora^(f/f))*** intranasal allergen challenges,Cd4creRora^(f/f)mice exhibited a significantly increased Th2 cells in the lungs and the airway and showed an enhanced eosinophilic inflammation compared to littermate control *** with Foxp3^(YFP-cre)Rora^(f/f)mice and CD^(8+)T cell depletion showed that the increased Th2 cell responses in the Cd4creRora^(f/f)mice were independent of Treg cells and CD^(8+)T *** findings demonstrate a critical regulatory role of RORa in Th2 cells,which suggest that RORa agonists could be effective for the treatment of allergic diseases.

关键词： Th2 allergic critical